Gene: SYNPO2

171024
-
synaptopodin 2
protein-coding
4q26
Ensembl:ENSG00000172403 Vega:OTTHUMG00000161165 UniprotKB:Q9UMS6
NC_000004.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.704e-1 (AD)  8.913e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4834729chr4:118943912 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EXOC60.858
SORBS20.855
SLIT30.85
PLCB40.838
SETBP10.837
OSBPL100.837
MEF2A0.832
SLC16A140.829
RASAL20.825
RNF1110.822

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.55
GPR143-0.509
ACSF2-0.508
TLCD1-0.506
CYP11A1-0.505
STON2-0.497
IMPA2-0.497
ABHD1-0.497
MAPKAPK3-0.482
RGS20-0.481

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SYNPO2 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SYNPO2 mRNA24449571
D001152ArsenicalsArsenicals results in increased expression of SYNPO2 mRNA28625800
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SYNPO2 mRNA21839799
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of SYNPO2 mRNA20660070
D004958EstradiolEstradiol results in increased expression of SYNPO2 mRNA19167446
D004958EstradiolEstradiol results in decreased expression of SYNPO2 mRNA19484750
C044887beta-methylcholinebeta-methylcholine affects the expression of SYNPO2 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of SYNPO2 mRNA27685785
C006780bisphenol Abisphenol A results in increased methylation of SYNPO2 promoter27312807
C006780bisphenol Abisphenol A affects the expression of SYNPO2 mRNA25181051
D002330CarmustineSYNPO2 mRNA affects the susceptibility to Carmustine16365179
D002737ChloropreneChloroprene results in decreased expression of SYNPO2 mRNA23125180
D003042CocaineCocaine results in decreased expression of SYNPO2 mRNA17898221
D000069439DasatinibDasatinib results in increased expression of SYNPO2 mRNA20579391
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of SYNPO2 protein23811945
D003907DexamethasoneDexamethasone results in increased expression of SYNPO2 mRNA25047013
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SYNPO2 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of SYNPO2 mRNA22023808
D004237DiuronDiuron results in increased expression of SYNPO2 mRNA21551480
D017313FenretinideFenretinide results in decreased expression of SYNPO2 mRNA28973697
D017313FenretinideFenretinide results in increased expression of SYNPO2 mRNA28973697
D008713MethimazoleMethimazole results in increased expression of SYNPO2 mRNA22504374
D008777MethyltestosteroneMethyltestosterone results in decreased expression of SYNPO2 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SYNPO2 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SYNPO2 mRNA"25554681
D009532NickelNickel results in decreased expression of SYNPO2 mRNA24768652|2558310
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SYNPO2 mRNA27935865
D010100OxygenOxygen deficiency results in increased expression of SYNPO2 mRNA20880076
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of SYNPO2 mRNA27935865
D011192Potassium DichromatePotassium Dichromate results in increased expression of SYNPO2 mRNA23608068
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of SYNPO2 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of SYNPO2 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of SYNPO2 mRNA22504374
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of SYNPO2 mRNA21427059
D012715Sesame OilSesame Oil results in increased expression of SYNPO2 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SYNPO2 mRNA23806026
C009277sodium arsenatesodium arsenate results in increased expression of SYNPO2 mRNA21795629
C047246temozolomideSYNPO2 mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SYNPO2 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SYNPO2 mRNA22298810
C009495titanium dioxidetitanium dioxide results in decreased expression of SYNPO2 mRNA23557971
D014212TretinoinTretinoin results in increased expression of SYNPO2 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of SYNPO2 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of SYNPO2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of SYNPO2 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of SYNPO2 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IBA21873635  
GO:0005515protein binding-IPI21643011  
GO:0031005filamin binding-IDA20554076  
GO:0051371muscle alpha-actinin binding-ISS-  
GO:0051393alpha-actinin binding-IDA20554076  
GO:007188914-3-3 protein binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000045autophagosome assembly-IEA-  
GO:0032233positive regulation of actin filament bundle assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001725stress fiber-IBA21873635  
GO:0001725stress fiber-IDA20554076  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS-  
GO:0005829cytosol-IDA-  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesion-IDA20554076  
GO:0015629actin cytoskeleton-IBA21873635  
GO:0015629actin cytoskeleton-IDA-  
GO:0030018Z disc-IBA21873635  
GO:0030018Z disc-IDA20554076  
GO:0030018Z disc-ISS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0099023tethering complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal