Gene info: ID 1717

Gene: DHCR7

GENE ID: 1717

Synonyms: SLOS

Description: 7-dehydrocholesterol reductase

Gene type: protein-coding

Location: 11q13.4

dbXrefs: Ensembl:ENSG00000172893 MIM:602858 Vega:OTTHUMG00000167346 UniprotKB:Q9UBM7

RefSeq: NG_012655.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.356e-1 (AD) 4.529e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MSMO1	0.824
LSS	0.788
CADM4	0.779
INSIG1	0.775
FDFT1	0.77
TMEM189	0.762
ZNF672	0.757
RNH1	0.756
YIF1A	0.752
PPIF	0.751

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.583
OR4F29	-0.554
OR6C74	-0.264
LCE2A	-0.256
C17orf112	-0.249
FER1L6	-0.243
PZP	-0.242
TBX4	-0.24
MTRNR2L6	-0.234
FMO1	-0.23

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00157	NADH	Small Molecule	58-68-4	Approved\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of DHCR7 mRNA"	15302862
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in decreased expression of DHCR7 mRNA	28329830
C003585	22-hydroxycholesterol	22-hydroxycholesterol results in decreased expression of DHCR7 mRNA	19426978
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of DHCR7 mRNA"	21724226
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of DHCR7 mRNA"	28433925
C021296	2-ethoxyethanol	2-ethoxyethanol results in increased expression of DHCR7 mRNA	19643169
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of DHCR7 mRNA"	23196670
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of DHCR7 mRNA"	21346803
C016705	7-dehydrocholesterol	[BM 15766 results in decreased activity of DHCR7 protein] which results in increased abundance of 7-dehydrocholesterol	16365879\|1682476
C016705	7-dehydrocholesterol	DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol	16446309
C016705	7-dehydrocholesterol	DHCR7 results in increased reduction of 7-dehydrocholesterol	15896653
C016705	7-dehydrocholesterol	DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol	16446309
C016705	7-dehydrocholesterol	Simvastatin inhibits the reaction [DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol]	16446309
D000082	Acetaminophen	Acetaminophen results in decreased expression of DHCR7 mRNA	22230336\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of DHCR7 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of DHCR7 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DHCR7 mRNA]	17585979
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of DHCR7 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of DHCR7 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of DHCR7 mRNA	19770486
C430898	AGN 194204	AGN 194204 results in increased expression of DHCR7 mRNA	15302862
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of DHCR7 mRNA	16483693
D016718	Arachidonic Acid	Arachidonic Acid results in decreased expression of DHCR7 mRNA	16704987
D001151	Arsenic	Arsenic affects the methylation of DHCR7 gene	25304211
D001280	Atrazine	Atrazine results in decreased expression of DHCR7 mRNA	25929836
C406592	azaspiracid	azaspiracid results in increased expression of DHCR7 mRNA	28939011
D001548	Benzalkonium Compounds	Benzalkonium Compounds results in decreased activity of DHCR7 protein	26919959
D001548	Benzalkonium Compounds	Benzalkonium Compounds results in increased expression of DHCR7 mRNA	26919959
D001548	Benzalkonium Compounds	Benzalkonium Compounds results in decreased activity of DHCR7 protein	26919959
D001554	Benzene	Benzene affects the expression of DHCR7 mRNA	15878777
D019324	beta-Naphthoflavone	AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of DHCR7 mRNA]	22234961
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of DHCR7 mRNA	22234961
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DHCR7 mRNA	20106945\|2163298
D004958	Estradiol	Estradiol results in increased expression of DHCR7 mRNA	19167446
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid affects the expression of DHCR7 mRNA	18192240
C095105	bexarotene	bexarotene results in increased expression of DHCR7 mRNA	16648578
D001629	Bezafibrate	Bezafibrate affects the expression of DHCR7 mRNA	17719200
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of DHCR7 mRNA	27685785
C006780	bisphenol A	bisphenol A affects the expression of DHCR7 mRNA	21786754\|2355768
C006780	bisphenol A	bisphenol A results in increased expression of DHCR7 protein	20189630
C006780	bisphenol A	bisphenol A results in increased expression of DHCR7 mRNA	29275510
C006780	bisphenol A	bisphenol A affects the expression of DHCR7 mRNA	21636974
C006780	bisphenol A	bisphenol A results in increased expression of DHCR7 mRNA	25270620
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of DHCR7 mRNA"	28433925
C006780	bisphenol A	bisphenol A affects the expression of DHCR7 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of DHCR7 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of DHCR7 mRNA	15901920
C006780	bisphenol A	bisphenol A results in increased methylation of DHCR7 gene	28505145
C047457	BM 15766	BM 15766 results in decreased activity of DHCR7 protein	16365879\|1682476
C047457	BM 15766	[BM 15766 results in decreased activity of DHCR7 protein] which results in increased abundance of 7-dehydrocholesterol	16365879\|1682476
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of DHCR7 mRNA	22079614
C584509	C646 compound	C646 compound results in decreased expression of DHCR7 mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of DHCR7 mRNA	23741332
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of DHCR7 mRNA	24982889
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of DHCR7 promoter	22457795
D002110	Caffeine	Caffeine results in decreased expression of DHCR7 mRNA	25868845
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of DHCR7 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of DHCR7 mRNA	24381012
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of DHCR7 mRNA	24763279
C026690	cerous chloride	cerous chloride affects the expression of DHCR7 mRNA	23139204
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of DHCR7 mRNA	21356183
D002784	Cholesterol	DHCR7 mutant form affects the susceptibility to Cholesterol	19365639
D002784	Cholesterol	DHCR7 mutant form results in decreased abundance of Cholesterol	16446309
D002784	Cholesterol	DHCR7 results in increased chemical synthesis of Cholesterol	15896653
D002784	Cholesterol	Simvastatin promotes the reaction [DHCR7 results in increased chemical synthesis of Cholesterol]	15896653
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of DHCR7 mRNA	27344345
D002793	Cholic Acids	[Cyclosporine co-treated with Cholic Acids] affects the expression of DHCR7 mRNA	27344345
D002793	Cholic Acids	[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of DHCR7 mRNA	27344345
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DHCR7 mRNA	20938992
D002922	Ciguatoxins	Ciguatoxins affects the expression of DHCR7 mRNA	18353800
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of DHCR7 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DHCR7 mRNA]	17585979
D003024	Clozapine	Clozapine results in increased expression of DHCR7 mRNA	17052361
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of DHCR7 mRNA	24612858
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of DHCR7 mRNA	19320972
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of DHCR7 mRNA	20971185
D003300	Copper	Copper results in decreased expression of DHCR7 mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of DHCR7 mRNA	19549813
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of DHCR7 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of DHCR7 mRNA	19167446
D003471	Cuprizone	Cuprizone results in decreased expression of DHCR7 mRNA	27523638
D003474	Curcumin	Curcumin affects the expression of DHCR7 mRNA	27208389
D003474	Curcumin	Curcumin results in decreased expression of DHCR7 mRNA	27208389
D016572	Cyclosporine	[Cyclosporine co-treated with Cholic Acids] affects the expression of DHCR7 mRNA	27344345
D016572	Cyclosporine	Cyclosporine results in decreased expression of DHCR7 mRNA	20106945\|2163298
D016572	Cyclosporine	Cyclosporine results in increased expression of DHCR7 mRNA	27989131
D013759	Dronabinol	Dronabinol results in decreased expression of DHCR7 mRNA	18454173
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DHCR7 mRNA]	27941970
C049098	diallyl phthalate	diallyl phthalate results in increased expression of DHCR7 protein	20189630
C016366	dibenzothiophene	dibenzothiophene results in increased expression of DHCR7 mRNA	23656968
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of DHCR7 mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of DHCR7 mRNA	21266533\|2174549
D002945	Cisplatin	Cisplatin affects the expression of DHCR7 mRNA	27594783
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of DHCR7 mRNA	27392435
D002945	Cisplatin	[Cisplatin co-treated with Paclitaxel] results in increased expression of DHCR7 mRNA	20705681
D002945	Cisplatin	Cisplatin results in decreased expression of DHCR7 mRNA	24280081
D002945	Cisplatin	Cisplatin results in decreased expression of DHCR7 mRNA	24280081
D004041	Dietary Fats	Dietary Fats affects the expression of DHCR7 mRNA	19680557
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of DHCR7 mRNA	28433925
D004041	Dietary Fats	Dietary Fats results in decreased expression of DHCR7 mRNA	19030233\|2260994
D004041	Dietary Fats	Dietary Fats results in increased expression of DHCR7 mRNA	25016146
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of DHCR7 mRNA	28433925
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of DHCR7 mRNA"	28433925
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of DHCR7 mRNA	24535843
C115058	difenoconazole	difenoconazole results in increased expression of DHCR7 mRNA	28263823
C089799	diheptyl phthalate	diheptyl phthalate results in decreased expression of DHCR7 mRNA	22112501
D002117	Calcitriol	Calcitriol results in increased expression of DHCR7 mRNA	26485663
C012125	diisononyl phthalate	diisononyl phthalate results in decreased expression of DHCR7 mRNA	22112501
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of DHCR7 mRNA	17547211
C034171	di-n-pentyl phthalate	di-n-pentyl phthalate results in decreased expression of DHCR7 mRNA	22112501\|2505596
C034171	di-n-pentyl phthalate	[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of DHCR7 mRNA	25055962
D000431	Ethanol	Ethanol results in increased expression of DHCR7 mRNA	19167417
D000431	Ethanol	[Fish Oils co-treated with Ethanol] results in increased expression of DHCR7 mRNA	17347304
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of DHCR7 mRNA	16872691
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of DHCR7 mRNA	27344345
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of DHCR7 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHCR7 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of DHCR7 mRNA	23143038
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of DHCR7 mRNA	15901920
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of DHCR7 mRNA	16174780
C002994	ethylene dimethanesulfonate	ethylene dimethanesulfonate results in decreased expression of DHCR7 mRNA	22711419
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of DHCR7 mRNA	23649840
D005228	Fatty Acids, Essential	"Fatty Acids, Essential deficiency results in increased expression of DHCR7 mRNA"	23333450
C033789	fenarimol	fenarimol results in increased expression of DHCR7 mRNA	28970091
D005395	Fish Oils	[Fish Oils co-treated with Ethanol] results in increased expression of DHCR7 mRNA	17347304
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in decreased expression of DHCR7 mRNA	28329830
C007738	fluoranthene	fluoranthene results in decreased expression of DHCR7 mRNA	28329830
D005485	Flutamide	Flutamide results in increased expression of DHCR7 mRNA	19299419\|2413618
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DHCR7 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in decreased expression of DHCR7 mRNA	23649840
D005944	Glucosamine	Glucosamine results in increased expression of DHCR7 mRNA	17178593
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of DHCR7 mRNA	24763279
D006861	Hydrogen Peroxide	[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of DHCR7 mRNA	18032389
C492448	ICG 001	ICG 001 results in decreased expression of DHCR7 mRNA	26191083
C016527	isoquercitrin	[isoquercitrin co-treated with Hydrogen Peroxide] results in increased expression of DHCR7 mRNA	18032389
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of DHCR7 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of DHCR7 mRNA	27392435
D007654	Ketoconazole	Ketoconazole results in increased expression of DHCR7 mRNA	28263823
C045463	leflunomide	leflunomide results in decreased expression of DHCR7 mRNA	28988120
C045463	leflunomide	leflunomide results in increased expression of DHCR7 mRNA	24136188
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DHCR7 mRNA	20938992
D008731	Methoxychlor	Methoxychlor results in increased expression of DHCR7 mRNA	21276474
C005219	methyl cellosolve	methyl cellosolve results in increased expression of DHCR7 mRNA	19643169
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of DHCR7 mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of DHCR7 mRNA	22776087
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of DHCR7 mRNA	22401849
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate affects the expression of DHCR7	19560483
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate affects the expression of DHCR7 mRNA	16809437
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of DHCR7 mRNA	16809437
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of DHCR7 mRNA	24625837
C437683	motexafin gadolinium	motexafin gadolinium results in decreased expression of DHCR7 mRNA	16357179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of DHCR7 mRNA"	24389112
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of DHCR7 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of DHCR7 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of DHCR7 mRNA"	25620056
D009281	Naphthalenes	Naphthalenes results in decreased expression of DHCR7 protein	17337753
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of DHCR7 mRNA	27344345
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of DHCR7 mRNA	19812364
D009532	Nickel	Nickel results in decreased expression of DHCR7 mRNA	24768652
D005996	Nitroglycerin	Nitroglycerin results in decreased expression of DHCR7 mRNA	12102619
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in decreased expression of DHCR7 mRNA	17616710
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of DHCR7 mRNA	20971185
C464660	obeticholic acid	obeticholic acid results in increased expression of DHCR7 mRNA	27939613
C025589	ochratoxin A	ochratoxin A results in decreased expression of DHCR7 mRNA	19287073
D015525	Fatty Acids, Omega-3	"[Fatty Acids, Omega-3 deficiency co-treated with Vehicle Emissions] results in increased expression of DHCR7 mRNA"	29175182
D015525	Fatty Acids, Omega-3	"Fatty Acids, Omega-3 deficiency results in increased expression of DHCR7 mRNA"	29175182
C016340	o,p'-DDT	"o,p'-DDT affects the expression of DHCR7 mRNA"	17984292
D010126	Ozone	Ozone results in decreased expression of DHCR7 mRNA	16716893
D017239	Paclitaxel	[Cisplatin co-treated with Paclitaxel] results in increased expression of DHCR7 mRNA	20705681
D000073878	Palm Oil	Palm Oil affects the expression of DHCR7 mRNA	19680557
D010269	Paraquat	Paraquat results in decreased expression of DHCR7 mRNA	16328009
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of DHCR7 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of DHCR7 mRNA	23427857
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of DHCR7 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of DHCR7 mRNA	25868421
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of DHCR7 mRNA	19162173
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of DHCR7 mRNA	17097637
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of DHCR7 mRNA	26678675
D010634	Phenobarbital	Phenobarbital results in increased expression of DHCR7 mRNA	25270620
D010634	Phenobarbital	Phenobarbital results in increased expression of DHCR7 mRNA	19162173
D010656	Phenylephrine	Phenylephrine results in increased expression of DHCR7 mRNA	18158353
D010665	Phenylpropanolamine	Phenylpropanolamine results in increased expression of DHCR7 mRNA	27756839
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of DHCR7 mRNA	15728792
D010852	Picrotoxin	Picrotoxin results in decreased expression of DHCR7 mRNA	15170462
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DHCR7 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of DHCR7 mRNA	18445702
C006253	pirinixic acid	pirinixic acid results in increased expression of DHCR7 mRNA	11798191\|1742611
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of DHCR7 mRNA	23718831
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of DHCR7 protein	23718831
D011374	Progesterone	Progesterone results in increased expression of DHCR7 mRNA	23012394
D011374	Progesterone	Progesterone results in increased expression of DHCR7 mRNA	18070364
C045950	propiconazole	propiconazole results in increased expression of DHCR7 mRNA	17178688\|2127805
C045950	propiconazole	propiconazole results in increased expression of DHCR7 mRNA	28970091
D011441	Propylthiouracil	Propylthiouracil affects the expression of DHCR7 mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in decreased expression of DHCR7 mRNA	27029645
D011794	Quercetin	Quercetin results in decreased expression of DHCR7 mRNA	21632981
C502851	quinocetone	quinocetone results in increased expression of DHCR7 mRNA	27046791
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of DHCR7 mRNA	19167446
C059514	resveratrol	resveratrol results in increased expression of DHCR7 protein	25505154
D015474	Isotretinoin	Isotretinoin results in decreased expression of DHCR7 mRNA	20436886
D019438	Ritonavir	Ritonavir affects the expression of DHCR7 mRNA	17719200
D012643	Selenium	Selenium results in increased expression of DHCR7 mRNA	19244175
D019821	Simvastatin	DHCR7 mutant form affects the susceptibility to Simvastatin	19365639
D019821	Simvastatin	Simvastatin promotes the reaction [DHCR7 results in increased chemical synthesis of Cholesterol]	15896653
D019821	Simvastatin	Simvastatin inhibits the reaction [DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol]	16446309
D019821	Simvastatin	[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of DHCR7 mRNA	25055962
C017947	sodium arsenite	sodium arsenite results in increased expression of DHCR7 mRNA	25524072
C016104	sodium bichromate	sodium bichromate results in decreased expression of DHCR7 mRNA	24612858
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in decreased expression of DHCR7 mRNA	12815608
D053260	Soot	Soot results in decreased expression of DHCR7 mRNA	22461453
D053260	Soot	Soot results in increased expression of DHCR7 mRNA	22461453
C025462	sulindac sulfide	sulindac sulfide results in decreased expression of DHCR7 mRNA	16184548
C013698	tallow	tallow affects the expression of DHCR7 mRNA	19680557
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DHCR7 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of DHCR7 mRNA"	28433925
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHCR7 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DHCR7 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DHCR7 mRNA	21215274\|2172422
D019284	Thapsigargin	Thapsigargin results in decreased expression of DHCR7 mRNA	22378314
D013849	Thimerosal	Thimerosal results in decreased expression of DHCR7 mRNA	27188386
C009495	titanium dioxide	titanium dioxide results in increased expression of DHCR7 mRNA	23131501\|2355797
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of DHCR7 mRNA	28065790
C066340	tolcapone	tolcapone binds to DHCR7 protein	19783845
D001371	trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride	"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in decreased activity of DHCR7 protein"	16814115
D001371	trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride	"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in increased expression of DHCR7 mRNA"	26919959
D001371	trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride	"trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride results in decreased activity of DHCR7 protein"	26919959
D014212	Tretinoin	Tretinoin results in decreased expression of DHCR7 mRNA	23724009
C034613	triacsin C	triacsin C results in decreased expression of DHCR7 mRNA	16704987
C032910	triadimefon	triadimefon results in increased expression of DHCR7 mRNA	17178688
C012589	trichostatin A	trichostatin A results in increased expression of DHCR7 mRNA	15901671
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of DHCR7 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DHCR7 mRNA"	26179874
D014415	Tunicamycin	Tunicamycin results in decreased expression of DHCR7 mRNA	22378314
D014635	Valproic Acid	Valproic Acid results in increased expression of DHCR7 mRNA	15901671
D014635	Valproic Acid	Valproic Acid affects the expression of DHCR7 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of DHCR7 mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid affects the expression of DHCR7 mRNA	17292431
D014638	Vanadates	Vanadates results in decreased expression of DHCR7 mRNA	22714537
D001335	Vehicle Emissions	"[Fatty Acids, Omega-3 deficiency co-treated with Vehicle Emissions] results in increased expression of DHCR7 mRNA"	29175182
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of DHCR7 mRNA	29175182
C025643	vinclozolin	vinclozolin results in decreased expression of DHCR7 mRNA	23034163
C025643	vinclozolin	vinclozolin results in increased expression of DHCR7 mRNA	22570695
D014810	Vitamin E	Vitamin E affects the expression of DHCR7 mRNA	15370891
C111237	vorinostat	vorinostat results in decreased expression of DHCR7 mRNA	27188386
D019345	Zinc Acetate	Zinc Acetate results in decreased expression of DHCR7 mRNA	16357179
D015034	Zinc Oxide	Zinc Oxide affects the expression of DHCR7 mRNA	28648595
C088658	zoledronic acid	zoledronic acid results in increased expression of DHCR7 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0009918	sterol delta7 reductase activity	-	IBA	21873635
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	-	IBA	21873635
GO:0047598	7-dehydrocholesterol reductase activity	-	EXP	9465114
GO:0047598	7-dehydrocholesterol reductase activity	-	IBA	21873635
GO:0047598	7-dehydrocholesterol reductase activity	-	IDA	9465114
GO:0050661	NADP binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001568	blood vessel development	-	IEA	-
GO:0006695	cholesterol biosynthetic process	-	IBA	21873635
GO:0006695	cholesterol biosynthetic process	-	IMP	9465114
GO:0009791	post-embryonic development	-	IEA	-
GO:0016126	sterol biosynthetic process	-	IBA	21873635
GO:0016132	brassinosteroid biosynthetic process	-	IBA	21873635
GO:0030154	cell differentiation	-	IEA	-
GO:0030324	lung development	-	IEA	-
GO:0033489	cholesterol biosynthetic process via desmosterol	-	TAS	-
GO:0033490	cholesterol biosynthetic process via lathosterol	-	TAS	-
GO:0035264	multicellular organism growth	-	IEA	-
GO:0042127	regulation of cell proliferation	-	IEA	-
GO:0045540	regulation of cholesterol biosynthetic process	-	TAS	-
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005640	nuclear outer membrane	-	IDA	9878250
GO:0005783	endoplasmic reticulum	-	IDA	9878250
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005829	cytosol	-	IDA	-
GO:0016020	membrane	-	HDA	19946888
GO:0030176	integral component of endoplasmic reticulum membrane	-	IBA	21873635

KEGG ID	KEGG Term
hsa00100	Steroid biosynthesis
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	TAS
R-HSA-191273	Cholesterol biosynthesis	TAS
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-6807047	Cholesterol biosynthesis via desmosterol	TAS
R-HSA-6807062	Cholesterol biosynthesis via lathosterol	TAS
R-HSA-8957322	Metabolism of steroids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26275945	Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study. (2016 Nov)	Brouwer-Brolsma EM	J Steroid Biochem Mol Biol
24005870	Dietary, lifestyle, and genetic determinants of vitamin D status: a cross-sectional analysis from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study. (2014 Apr)	Kuhn T	Eur J Nutr