Gene: DHFR

1719
DHFRP1|DYR
dihydrofolate reductase
protein-coding
5q14.1
Ensembl:ENSG00000228716 MIM:126060 Vega:OTTHUMG00000162529 UniprotKB:P00374
NG_023304.1
PubMed
0   ANCO-SNPs
ND|AD
3   
1.823e-1 (AD)  3.454e-1 (ND)   (Frontal_Cortex)
2.498e-1 (AD)  3.707e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
URI10.668
ZBTB140.659
ZNF6640.658
PTPN110.652
DYNC1LI20.651
ZFP910.648
BRD70.635
TRAK20.63
SPAG90.627
ZEB20.626

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.374
OR4F5-0.299
AQP8-0.244
ALOXE3-0.218
MUC6-0.211
CRYBB2-0.211
GLIS1-0.207
VCX3A-0.203
LYG2-0.198
HES7-0.195

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB00205PyrimethamineSmall Molecule58-14-0Approved|InvestigationalTarget
DB00440TrimethoprimSmall Molecule738-70-5ApprovedTarget
DB00563MethotrexateSmall Molecule59-05-2ApprovedTarget
DB00642PemetrexedSmall Molecule137281-23-3Approved|InvestigationalTarget
DB00798GentamicinSmall Molecule1403-66-3ApprovedTarget
DB01131ProguanilSmall Molecule500-92-5ApprovedTarget
DB01157TrimetrexateSmall Molecule52128-35-5Approved|InvestigationalTarget
DB021042,4-Diamino-5-Methyl-6-[(3,4,5-Trimethoxy-N-Methylanilino)Methyl]Pyrido[2,3-D]PyrimidineSmall MoleculeExperimentalTarget
DB024272,4-Diamino-6-[N-(2',5'-Dimethoxybenzyl)-N-Methylamino]QuinazolineSmall MoleculeExperimentalTarget
DB025596-(Octahydro-1h-Indol-1-Ylmethyl)Decahydroquinazoline-2,4-DiamineSmall MoleculeExperimentalTarget
DB02583N6-(2,5-Dimethoxy-Benzyl)-N6-Methyl-Pyrido[2,3-D]Pyrimidine-2,4,6-TriamineSmall Molecule175354-76-4ExperimentalTarget
DB029192,4-Diamino-6-[N-(3',4',5'-Trimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]PyrimidineSmall MoleculeExperimentalTarget
DB03060Sri-9662Small MoleculeExperimentalTarget
DB031252,4-Diamino-5-(3,4,5-Trimethoxy-Benzyl)-Pyrimidin-1-IumSmall MoleculeExperimentalTarget
DB03351Sri-9439Small MoleculeExperimentalTarget
DB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall MoleculeExperimentalTarget
DB03695PiritreximSmall Molecule72732-56-0InvestigationalTarget
DB03886BiopterinSmall MoleculeExperimentalTarget
DB039872,4-Diamino-6-[N-(3',5'-Dimethoxybenzyl)-N-Methylamino]Pyrido[2,3-D]PyrimidineSmall MoleculeExperimentalTarget
DB06358IclaprimSmall Molecule192314-93-5InvestigationalTarget
DB06813PralatrexateSmall Molecule146464-95-1Approved|InvestigationalTarget
DB071405-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineSmall MoleculeExperimentalTarget
DB071415-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineSmall MoleculeExperimentalTarget
DB071425-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineSmall MoleculeExperimentalTarget
DB071445-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamineSmall MoleculeExperimentalTarget
DB082345-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamineSmall MoleculeExperimentalTarget
DB08406[N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINESmall MoleculeExperimentalTarget
DB08448(4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-olSmall MoleculeExperimentalTarget
DB08642(2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamineSmall MoleculeExperimentalTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalEnzyme
DB00563MethotrexateSmall Molecule59-05-2ApprovedEnzyme
DB08878AminopterinSmall Molecule54-62-6Investigational|WithdrawnEnzyme
ID Drug Name Action PubMed
C0902031,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene"1,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene results in increased mutagenesis of DHFR gene"1465420|2062855|
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of DHFR mRNA"22101062
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone results in increased expression of DHFR mRNA"19167446
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DHFR mRNA"19167446
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of DHFR mRNA"20005886
C5022392-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct"[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct] which results in increased mutagenesis of DHFR gene"8199311
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of DHFR mRNA25088246
C0587062-desamino-2-methylaminopterin2-desamino-2-methylaminopterin analog binds to and results in decreased activity of DHFR protein1313737
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct] which results in increased mutagenesis of DHFR gene"8199311
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased mutagenesis of DHFR gene"8199311
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased mutagenesis of DHFR gene"8199311
C0761453-(1-deoxyribofuranosyl)benzamide3-(1-deoxyribofuranosyl)benzamide results in decreased expression of DHFR protein22954684
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of DHFR mRNA]"19467301
C5294473-O-(3,4,5-trimethoxybenzoyl)epicatechin"3-O-(3,4,5-trimethoxybenzoyl)epicatechin binds to DHFR protein"20054477
C0303715,6,7,8-tetrahydrofolic acid"DHFR protein results in increased chemical synthesis of 5,6,7,8-tetrahydrofolic acid"17413111
C4833216-bromoindirubin-3'-oxime[6-bromoindirubin-3'-oxime co-treated with DHFR mRNA] affects the expression of CTNNB1 protein19727391
C0548527-hydroxystaurosporine7-hydroxystaurosporine results in increased activity of DHFR protein14653808
C0548527-hydroxystaurosporine7-hydroxystaurosporine results in increased expression of DHFR mRNA14653808
D000082AcetaminophenAcetaminophen results in increased expression of DHFR mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of DHFR mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DHFR gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DHFR mRNA19770486
D000393Air PollutantsAir Pollutants analog results in increased expression of DHFR mRNA21757418
C025154alpha-cobratoxinalpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]12588870
C025154alpha-cobratoxinalpha-cobratoxin results in decreased expression of DHFR mRNA12588870
D000630AminopterinAminopterin results in decreased activity of DHFR protein24417268
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DHFR mRNA16483693
D000970Antineoplastic AgentsAntineoplastic Agents results in decreased expression of DHFR mRNA20652976
D000970Antineoplastic AgentsAntineoplastic Agents results in decreased expression of DHFR protein20652976
D001151ArsenicArsenic affects the methylation of DHFR gene25304211
D001151ArsenicDHFR gene SNP affects the susceptibility to Arsenic25759212
C015001arsenitearsenite results in decreased expression of DHFR mRNA18929588
D001280AtrazineAtrazine results in increased expression of DHFR mRNA25929836
C100366benzamide adenine nucleotidebenzamide adenine nucleotide results in decreased activity of DHFR protein22954684
C089231benzo(g)chrysene-11,12-dihydrodiol-13,14-epoxide"benzo(g)chrysene-11,12-dihydrodiol-13,14-epoxide results in increased mutagenesis of DHFR exon"7586212
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DHFR mRNA20064835|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DHFR protein18495319
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DHFR mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of DHFR mRNA"19150397
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of DHFR mRNA24657404
D004958EstradiolEstradiol results in increased expression of DHFR mRNA19167446
C006780bisphenol Abisphenol A results in decreased expression of DHFR mRNA29275510
D002087ButyratesButyrates results in decreased expression of DHFR mRNA20072153
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DHFR mRNA20360939
D002220CarbamazepineCarbamazepine affects the expression of DHFR mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of DHFR mRNA17484886
D002437CefazolinCefazolin results in decreased activity of DHFR protein25418905
C043266cefepimecefepime results in decreased activity of DHFR protein25418905
D002442CeftazidimeCeftazidime results in decreased activity of DHFR protein25418905
D015296CeftizoximeCeftizoxime results in decreased activity of DHFR protein25418905
D002443CeftriaxoneCeftriaxone results in decreased activity of DHFR protein25418905
D002699ChlorambucilDHFR protein polymorphism results in decreased susceptibility to Chlorambucil12872145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DHFR mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of DHFR mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of DHFR mRNA19376846
D009249NADPNADP analog results in decreased activity of DHFR protein22954684
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of DHFR mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of DHFR mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of DHFR mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DHFR mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of DHFR mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of DHFR mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of DHFR mRNA19770486|2330838
D003561CytarabineCytarabine results in increased expression of DHFR mRNA19194470
D000069439DasatinibDasatinib results in decreased expression of DHFR mRNA20579391
D013759DronabinolDronabinol results in decreased expression of DHFR mRNA18454173
D003703DemecolcineDemecolcine results in decreased expression of DHFR mRNA23649840
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of DHFR protein"18495319
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DHFR mRNA17361019|2126653
D002945CisplatinCisplatin promotes the reaction [Piroxicam results in decreased expression of DHFR mRNA]21858171
D002945CisplatinCisplatin results in increased expression of DHFR mRNA27594783
D004008DiclofenacDiclofenac affects the expression of DHFR mRNA24752500
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in decreased expression of DHFR mRNA15784690
D004026DieldrinDieldrin results in decreased expression of DHFR mRNA28385952
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of DHFR mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of DHFR mRNA19467301
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of DHFR mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of DHFR mRNA]19850644
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of DHFR mRNA20360939
C010920dihydrofolateDHFR protein results in increased metabolism of dihydrofolate17413111
D004642EmodinEmodin results in decreased expression of DHFR mRNA16045814
C062669epicatechin gallateepicatechin gallate binds to and results in decreased activity of DHFR protein20054477
C045651epigallocatechin gallateepigallocatechin gallate binds to and results in decreased activity of DHFR protein20054477
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DHFR mRNA22079256
C007630estradiol 17 beta-cypionateestradiol 17 beta-cypionate results in increased expression of DHFR mRNA22497863
D000431EthanolEthanol results in decreased expression of DHFR mRNA28986285
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DHFR mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DHFR mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHFR mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased mutagenesis of DHFR gene8417332
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of DHFR gene8417332
C004999ferulic acidferulic acid results in decreased activity of DHFR protein25418905
D005472FluorouracilFluorouracil affects the expression of DHFR mRNA16557594
D005472FluorouracilFluorouracil results in increased expression of DHFR mRNA15109396|2181478
D005492Folic AcidDHFR gene mutant form results in decreased abundance of Folic Acid21310277
D005492Folic AcidFolic Acid affects the expression of DHFR mRNA17311948
D005492Folic Acid[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of DHFR mRNA22975265
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of DHFR mRNA24657277
D005492Folic AcidLeucovorin inhibits the reaction [DHFR gene mutant form results in decreased abundance of Folic Acid]21310277
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DHFR mRNA20938992
D005492Folic AcidDHFR protein results in increased reduction of Folic Acid17413111
D005493Folic Acid AntagonistsDHFR protein polymorphism results in decreased susceptibility to Folic Acid Antagonists12872145
D005557FormaldehydeFormaldehyde results in decreased expression of DHFR mRNA23649840
D002955LeucovorinLeucovorin inhibits the reaction [DHFR gene mutant form results in decreased abundance of Folic Acid]21310277
D002955LeucovorinLeucovorin results in increased expression of DHFR protein16712799
D019833GenisteinGenistein results in decreased expression of DHFR mRNA21048042
D005839GentamicinsGentamicins results in decreased expression of DHFR mRNA22061828
D017313FenretinideFenretinide results in increased expression of DHFR mRNA28973697
D007213IndomethacinIndomethacin results in increased expression of DHFR mRNA18299717
D007213Indomethacinrebamipide inhibits the reaction [Indomethacin results in increased expression of DHFR mRNA]18299717
D007529IsoflavonesIsoflavones results in decreased expression of DHFR mRNA17374662
C410337K 7174K 7174 results in decreased expression of DHFR mRNA24086573
C045463leflunomideleflunomide results in increased expression of DHFR mRNA24136188
D064704LevofloxacinLevofloxacin results in decreased activity of DHFR protein25418905
D008464MecamylamineMecamylamine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]12588870
D008464MecamylamineMecamylamine results in decreased expression of DHFR mRNA12588870
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DHFR mRNA20938992
D008727MethotrexateDHFR protein mutant form inhibits the reaction [Methotrexate results in decreased expression of CDK2 mRNA]17519396
D008727MethotrexateDHFR protein mutant form inhibits the reaction [Methotrexate results in decreased expression of CYCE mRNA]17519396
D008727MethotrexateDHFR protein mutant form inhibits the reaction [Methotrexate results in decreased expression of MCM6 mRNA]17519396
D008727MethotrexateDHFR protein mutant form inhibits the reaction [Methotrexate results in decreased expression of MDR65 mRNA]17519396
D008727MethotrexateDHFR protein mutant form inhibits the reaction [Methotrexate results in decreased expression of SLBP mRNA]17519396
D008727MethotrexateDHFR protein mutant form inhibits the reaction [Methotrexate results in decreased expression of STAI mRNA]17519396
D008727MethotrexateDHFR protein mutant form inhibits the reaction [Methotrexate results in increased expression of ANCE mRNA]17519396
D008727MethotrexateDHFR protein mutant form inhibits the reaction [Methotrexate results in increased expression of OBP99A mRNA]17519396
D008727MethotrexateDHFR protein mutant form results in decreased susceptibility to Methotrexate17519396
D008727MethotrexateDHFR protein results in decreased susceptibility to Methotrexate17519396
D008727Methotrexate[ADAR protein results in increased expression of DHFR protein] which results in decreased susceptibility to Methotrexate28188287
D008727Methotrexate[DHFR 3' UTR SNP affects the expression of DHFR protein] which affects the susceptibility to Methotrexate17686970|1768697
D008727Methotrexate[DHFR 3' UTR SNP affects the stability of DHFR mRNA] which affects the susceptibility to Methotrexate17686970|1768697
D008727MethotrexateDHFR 3' UTR SNP affects the susceptibility to Methotrexate17686970
D008727MethotrexateDHFR mRNA results in decreased susceptibility to Methotrexate18694510|1973243
D008727MethotrexateDHFR protein results in decreased susceptibility to Methotrexate14679136|2818828
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of DHFR mRNA24657277
D008727MethotrexateMethotrexate results in decreased expression of DHFR mRNA23897011|2465727
D008727MethotrexateMethotrexate results in increased expression of DHFR mRNA23838799|2473698
D008727MethotrexateMethotrexate results in increased expression of DHFR protein19570950|2248437
D008727Methotrexate[[MIR125A mRNA binds to DHFR 3' UTR] which results in decreased expression of DHFR protein] which results in increased susceptibility to Methotrexate28188287|2818828
D008727Methotrexate[[MIR25 mRNA binds to DHFR 3' UTR] which results in decreased expression of DHFR protein] which results in increased susceptibility to Methotrexate28188287|2818828
D008727MethotrexateMethotrexate results in decreased activity of DHFR protein24417268
D008727MethotrexateDHFR mRNA results in decreased susceptibility to Methotrexate16918715
D008727MethotrexateDHFR protein results in decreased susceptibility to Methotrexate16918715
D008727MethotrexateMethotrexate promotes the reaction [E2F1 protein binds to DHFR promoter]22484375
D008727MethotrexateMethotrexate results in increased expression of DHFR protein22484375
D008727MethotrexateMethotrexate affects the activity of DHFR protein1793349
D008727MethotrexateMethotrexate binds to DHFR protein7057425
D008727MethotrexateMethotrexate results in decreased activity of DHFR protein1363493|17519396
D008748MethylcholanthreneMethylcholanthrene results in increased expression of DHFR mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DHFR mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of DHFR mRNA18367466
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of DHFR protein26558463
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DHFR mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of DHFR mRNA24810058
C008493methylselenic acidmethylselenic acid results in decreased expression of DHFR mRNA12517777
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DHFR mRNA"25620056
C005274naringinnaringin results in decreased activity of DHFR protein25418905
C078255N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased mutagenesis of DHFR gene"8199311
D009532NickelNickel results in increased expression of DHFR mRNA25583101
D009538Nicotinealpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]12588870
D009538NicotineMecamylamine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]12588870
D009538NicotineNicotine results in decreased expression of DHFR mRNA12588870
D009538NicotineTubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]12588870
C012655nimesulidenimesulide results in decreased expression of DHFR mRNA24136188
D009588Nitrogen Mustard CompoundsDHFR protein polymorphism results in decreased susceptibility to Nitrogen Mustard Compounds12872145
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of DHFR mRNA20971185
C437965olmesartanolmesartan results in increased expression of DHFR protein17170375
C090046olomoucineolomoucine results in increased activity of DHFR protein14653808
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DHFR mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of DHFR mRNA25729387
C016030pantogabpantogab results in decreased expression of DHFR mRNA17379144
D000068437Pemetrexed[Folic Acid affects the susceptibility to Pemetrexed] which affects the expression of DHFR mRNA22975265
D000068437PemetrexedPemetrexed results in decreased activity of DHFR protein17465208
D010416PentachlorophenolPentachlorophenol results in decreased expression of DHFR mRNA24642059
D010433Pentylenetetrazole[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of DHFR mRNA21503142
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of DHFR mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of DHFR mRNA23978341
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of DHFR mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of DHFR mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of DHFR mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of DHFR mRNA17426115
D010894PiroxicamCisplatin promotes the reaction [Piroxicam results in decreased expression of DHFR mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of DHFR mRNA21858171
D059808PolyphenolsPolyphenols results in decreased expression of DHFR mRNA16293270
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DHFR mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of DHFR mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of DHFR mRNA18332044
C005556propionaldehydepropionaldehyde results in decreased expression of DHFR mRNA26079696
C052785rebamipiderebamipide inhibits the reaction [Indomethacin results in increased expression of DHFR mRNA]18299717
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of DHFR mRNA19167446
C059514resveratrolresveratrol results in increased expression of DHFR protein25505154
D015474IsotretinoinIsotretinoin results in decreased expression of DHFR mRNA20436886
C104586roscovitineroscovitine results in increased activity of DHFR protein14653808
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of DHFR mRNA25895662
C017947sodium arsenitesodium arsenite results in increased mutagenesis of DHFR gene12802802
C017947sodium arsenitesodium arsenite results in decreased expression of DHFR protein19072884
D053260SootSoot results in increased expression of DHFR mRNA26551751
C030000stallimycinstallimycin analog results in decreased expression of DHFR protein21814787
C030000stallimycinstallimycin results in decreased expression of DHFR mRNA21814787
C030000stallimycinstallimycin results in decreased expression of DHFR protein21814787
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of DHFR mRNA"26680231
C001945syringic acidsyringic acid results in decreased activity of DHFR protein25418905
D013629TamoxifenTamoxifen results in increased expression of DHFR mRNA15590111
D013629TamoxifenTamoxifen affects the expression of DHFR mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DHFR mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHFR mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DHFR mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DHFR mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DHFR mRNA16054898
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DHFR mRNA23724145|2806579
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DHFR mRNA25729387
D019772TopotecanTopotecan results in decreased expression of DHFR mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of DHFR mRNA"19682533
C099150trabectedintrabectedin results in decreased expression of DHFR mRNA15961672
D014212TretinoinTretinoin results in decreased expression of DHFR mRNA18230668
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of DHFR mRNA19042947
D014295Trimethoprim[Trimethoprim results in decreased activity of DHFR protein] which results in increased susceptibility to Valproic Acid8318756
D016597TrimetrexateDHFR protein polymorphism results in decreased susceptibility to Trimetrexate12872145
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DHFR mRNA"26179874
D014403TubocurarineTubocurarine inhibits the reaction [Nicotine results in decreased expression of DHFR mRNA]12588870
D014403TubocurarineTubocurarine results in decreased expression of DHFR mRNA12588870
D014520UrethaneUrethane results in decreased expression of DHFR mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of DHFR gene29154799
D014635Valproic Acid[Trimethoprim results in decreased activity of DHFR protein] which results in increased susceptibility to Valproic Acid8318756
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DHFR gene25560391
D020888Vigabatrin[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of DHFR mRNA21503142
D014750VincristineVincristine results in decreased expression of DHFR mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of DHFR mRNA26682919
C111237vorinostatvorinostat results in decreased expression of DHFR mRNA20072153
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in decreased expression of DHFR mRNA15784690

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000900translation repressor activity, mRNA regulatory element binding-IDA8490020  
GO:0003729mRNA binding-IDA21876184  
GO:0004146dihydrofolate reductase activity-IBA21873635  
GO:0004146dihydrofolate reductase activity-IDA2303423  12096917  21876184  23707606  
GO:0004146dihydrofolate reductase activity-ISS-  
GO:0004146dihydrofolate reductase activity-NAS6687716  
GO:0005542folic acid binding-IDA2303423  
GO:0008144drug binding-IDA12096917  15039552  
GO:0033560folate reductase activity-TAS-  
GO:0050661NADP binding-IBA21873635  
GO:0051870methotrexate binding-IDA2303423  
GO:0070402NADPH binding-IDA2303423  
GO:1990825sequence-specific mRNA binding-IDA8490020  
GO ID GO Term Qualifier Evidence PubMed
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle-TAS-  
GO:0006729tetrahydrobiopterin biosynthetic process-IMP23707606  
GO:0006729tetrahydrobiopterin biosynthetic process-ISS-  
GO:0006730one-carbon metabolic process-IEA-  
GO:0017148negative regulation of translation-IDA8490020  
GO:0031103axon regeneration-ISS-  
GO:0031427response to methotrexate-ISS-  
GO:0046452dihydrofolate metabolic process-IBA21873635  
GO:0046452dihydrofolate metabolic process-IDA2303423  23707606  
GO:0046653tetrahydrofolate metabolic process-IDA12096917  21876184  
GO:0046654tetrahydrofolate biosynthetic process-IBA21873635  
GO:0046654tetrahydrofolate biosynthetic process-IDA2303423  
GO:0046654tetrahydrofolate biosynthetic process-IEA-  
GO:0046655folic acid metabolic process-IBA21873635  
GO:0046655folic acid metabolic process-ISS-  
GO:0046655folic acid metabolic process-TAS-  
GO:0051000positive regulation of nitric-oxide synthase activity-ISS-  
GO:0055114oxidation-reduction process-IDA23707606  
GO:2000121regulation of removal of superoxide radicals-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00670One carbon pool by folate
hsa00790Folate biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-1474151Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulationIEA
R-HSA-1640170Cell CycleTAS
R-HSA-196757Metabolism of folate and pterinesTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsIEA
R-HSA-453279Mitotic G1-G1/S phasesTAS
R-HSA-539107Activation of E2F1 target genes at G1/STAS
R-HSA-69205G1/S-Specific TranscriptionTAS
R-HSA-69206G1/S TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8978934Metabolism of cofactorsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25702197Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: results from the German Investigation on Neurobiology in Alcoholism (GINA). (2015 Mar)Semmler AAlcohol
27822090The Danish Heart Failure Registry. (2016)Schjodt IClin Epidemiol
23724145Long-term exposure to cigarette smoke extract induces hypomethylation at the RUNX3 and IGF2-H19 loci in immortalized human urothelial cells. (2013)Chen LMPLoS One