Gene: DHPS

1725
DHS|DS|MIG13
deoxyhypusine synthase
protein-coding
19p13.13
Ensembl:ENSG00000095059 MIM:600944 Vega:OTTHUMG00000182618 UniprotKB:P49366
NC_000019.10
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.850e-1 (AD)  2.902e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WIPI20.962
ASNA10.96
IDH3B0.958
DCTN30.958
NDUFS20.956
HAGH0.955
CCT70.954
MDH20.954
LRRC470.953
ARL8A0.952

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.718
OR4F29-0.681
MTRNR2L6-0.41
MTRNR2L9-0.389
MTRNR2L10-0.378
KCNJ15-0.361
IL18RAP-0.36
P2RY14-0.354
KLRB1-0.352
EBF1-0.349

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB036391-Guanidinium-7-AminoheptaneSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of DHPS mRNA"18648102
D020106AcrylamideAcrylamide results in increased expression of DHPS mRNA28959563
C006780bisphenol Abisphenol A affects the expression of DHPS mRNA21786754
C006780bisphenol Abisphenol A affects the expression of DHPS mRNA21786754
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of DHPS mRNA15336504
D002220CarbamazepineCarbamazepine affects the expression of DHPS mRNA25979313
C018021cobaltous chloridecobaltous chloride results in decreased expression of DHPS mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of DHPS mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of DHPS mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of DHPS mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether affects the expression of DHPS mRNA24834073
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DHPS mRNA21266533
D004317DoxorubicinDoxorubicin results in increased expression of DHPS mRNA16404146
D005947GlucoseDHPS protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency]21124846
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of DHPS mRNA22634610
D007213IndomethacinIndomethacin results in increased expression of DHPS mRNA28201806
D007854LeadLead results in decreased expression of DHPS mRNA19921347
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of DHPS mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DHPS mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DHPS mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DHPS mRNA"25554681
D009538NicotineNicotine results in decreased expression of DHPS mRNA16949557
C025256nonylphenolnonylphenol results in increased expression of DHPS mRNA22982499
D010100OxygenDHPS protein results in decreased susceptibility to [Oxygen deficiency co-treated with Glucose deficiency]21124846
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of DHPS mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of DHPS mRNA19270015|1948288
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of DHPS mRNA19244175
D012643SeleniumSelenium results in increased expression of DHPS mRNA19244175
C016104sodium bichromatesodium bichromate results in increased expression of DHPS mRNA22561333
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of DHPS mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to DHPS promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DHPS mRNA18796159|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DHPS mRNA21215274
D013893ThiramThiram results in increased expression of DHPS mRNA20530235
D014212TretinoinTretinoin results in increased expression of DHPS mRNA17218384
C012589trichostatin Atrichostatin A results in increased expression of DHPS mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of DHPS mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DHPS mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of DHPS mRNA15901671
C025643vinclozolinvinclozolin results in increased methylation of DHPS promoter22570695
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of DHPS mRNA19244175
D014810Vitamin EVitamin E results in increased expression of DHPS mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI14622290  16189514  19060904  23602568  25416956  25852190  
26496610  27107014  
GO:0034038deoxyhypusine synthase activity-EXP7673224  9188485  
GO:0034038deoxyhypusine synthase activity-IBA21873635  
GO:0034038deoxyhypusine synthase activity-IDA23525104  
GO:0042802identical protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006412translation-TAS7673224  
GO:0008216spermidine metabolic process-IDA23525104  
GO:0008284positive regulation of cell proliferation-TAS8549832  
GO:0008612peptidyl-lysine modification to peptidyl-hypusine-IBA21873635  
GO:0008612peptidyl-lysine modification to peptidyl-hypusine-IDA23525104  
GO:0008612peptidyl-lysine modification to peptidyl-hypusine-TAS-  
GO:0042102positive regulation of T cell proliferation-IEA-  
GO:0042593glucose homeostasis-IEA-  
GO:0046203spermidine catabolic process-IEA-  
GO:0051289protein homotetramerization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activationTAS
R-HSA-204626Hypusine synthesis from eIF5A-lysineTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21084778Pneumocystis jiroveci dihydropteroate synthase gene mutations among colonized individuals and Pneumocystis pneumonia patients from Spain. (2010 Nov)Friaza VPostgrad Med
10515293Discriminative and affective stimulus effects of dihydropyridine calcium channel modulators: relationship to antialcohol effects. (1999 Oct)De Vry JPharmacol Biochem Behav