Gene: CYB5R3

1727
B5R|DIA1
cytochrome b5 reductase 3
protein-coding
22q13.2
Ensembl:ENSG00000100243 MIM:613213 Vega:OTTHUMG00000150745 UniprotKB:P00387
NG_012194.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.991e-1 (AD)  9.175e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg27191921chr22:43042910CYB5R32.730e-10Maternal smoking in pregnancy27040690
cg27191921chr22:43042910CYB5R31.320e-13Maternal smoking in pregnancy27040690
cg19248564chr22:43042879CYB5R31.440e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD810.901
TMBIM60.898
ALDH20.894
SLC44A20.891
ZFAND30.889
HADHA0.887
CLU0.883
APH1A0.882
LAPTM4A0.871
FYN0.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.757
OR4F29-0.742
TYRP1-0.214
GABRG3-0.203
IL1RAPL2-0.184
CHRNB3-0.182
CACNA1S-0.175
TRPC5-0.173
ANKRD34C-0.173
OPRD1-0.173

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
DB03147Flavin adenine dinucleotideSmall Molecule146-14-5ApprovedTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of CYB5R3 mRNA"19162173
C5411312,2',3,3',4,4',5-heptachlorobiphenyl"2,2',3,3',4,4',5-heptachlorobiphenyl affects the expression of CYB5R3 mRNA"24050789
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CYB5R3 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of CYB5R3 mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CYB5R3 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CYB5R3 mRNA"21346803
C0194992-nitrofluorene2-nitrofluorene results in decreased expression of CYB5R3 mRNA14600272
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CYB5R3 mRNA14600272
D000082AcetaminophenAcetaminophen results in decreased expression of CYB5R3 mRNA17522070
D020106AcrylamideAcrylamide results in increased expression of CYB5R3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CYB5R3 mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of CYB5R3 mRNA28522335
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane results in increased expression of CYB5R3 mRNA17785943
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CYB5R3 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of CYB5R3 mRNA15725085
C053561benzamidoxime[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC1 protein] results in increased reduction of benzamidoxime22924387
C053561benzamidoxime[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC2 protein] results in increased reduction of benzamidoxime22924387
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of CYB5R3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CYB5R3 mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CYB5R3 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CYB5R3 mRNA"20018196
D001629BezafibrateBezafibrate affects the expression of CYB5R3 mRNA17719200
C099952bifenthrinbifenthrin results in increased expression of CYB5R3 mRNA26071804
C006780bisphenol Abisphenol A affects the expression of CYB5R3 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CYB5R3 mRNA25047013
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of CYB5R3 mRNA"28433925
C006780bisphenol Abisphenol A affects the expression of CYB5R3 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CYB5R3 mRNA28628672
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CYB5R3 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CYB5R3 mRNA17522070
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CYB5R3 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CYB5R3 mRNA20938992
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of CYB5R3 mRNA16197558
D002994ClofibrateClofibrate results in decreased expression of CYB5R3 mRNA12851107|1752207
D002995Clofibric AcidClofibric Acid affects the expression of CYB5R3 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of CYB5R3 mRNA24612858
D009243NADCYB5R3 protein binds to NAD16469290
D009243NAD[MARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine25170804
D009243NAD[MARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine25170804
D003300CopperCYB5R3 protein binds to Copper15359738
D019327Copper SulfateCopper Sulfate results in decreased expression of CYB5R3 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of CYB5R3 mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CYB5R3 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CYB5R3 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of CYB5R3 mRNA17522070
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of CYB5R3 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of CYB5R3 mRNA27594783
D002945CisplatinCisplatin results in increased expression of CYB5R3 mRNA21151649
D002945CisplatinCisplatin results in decreased expression of CYB5R3 mRNA18172885
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CYB5R3 mRNA28433925
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated results in decreased expression of CYB5R3 mRNA"23626681
D004042Dietary Fats, Unsaturated"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of CYB5R3 mRNA"23626681
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CYB5R3 mRNA28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of CYB5R3 mRNA"28433925
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYB5R3 mRNA18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYB5R3 mRNA18544905
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CYB5R3 mRNA"22485181
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene affects the expression of CYB5R3 mRNA"21785161
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of CYB5R3 mRNA14600272
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of CYB5R3 mRNA17522070
D000431EthanolEthanol results in increased activity of CYB5R3 protein28442378
D000431Ethanolzingerone inhibits the reaction [Ethanol results in increased activity of CYB5R3 protein]28442378
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CYB5R3 mRNA17108234
C024565ethylene dichlorideethylene dichloride results in decreased expression of CYB5R3 mRNA28189721
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of CYB5R3 mRNA"23333450
D005419FlavonoidsFlavonoids results in decreased expression of CYB5R3 mRNA18035473
D005485FlutamideFlutamide results in increased expression of CYB5R3 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CYB5R3 mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of CYB5R3 mRNA19167457
D019833GenisteinGenistein results in decreased expression of CYB5R3 mRNA24967385
D005897GlafenineGlafenine results in decreased expression of CYB5R3 mRNA24136188
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CYB5R3 mRNA17183730
D019811HydroxylamineCYB5R3 protein results in increased reduction of Hydroxylamine21447608
C492448ICG 001ICG 001 results in increased expression of CYB5R3 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CYB5R3 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of CYB5R3 mRNA18299717
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CYB5R3 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CYB5R3 mRNA23430699
D007649KetamineKetamine results in increased expression of CYB5R3 mRNA20080153
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of CYB5R3 mRNA18544905
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYB5R3 mRNA18544905
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CYB5R3 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CYB5R3 mRNA17961207|2345815
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CYB5R3 mRNA19465457
C010737N(4)-hydroxycytidine[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC1 protein] results in increased reduction of N(4)-hydroxycytidine22924387
C010737N(4)-hydroxycytidine[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC2 protein] results in increased reduction of N(4)-hydroxycytidine22924387
C021202N(4)-hydroxycytosine[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC1 protein] results in increased reduction of N(4)-hydroxycytosine22924387
C021202N(4)-hydroxycytosine[CYB5B protein co-treated with CYB5R3 protein co-treated with MARC2 protein] results in increased reduction of N(4)-hydroxycytosine22924387
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CYB5R3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CYB5R3 mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of CYB5R3 mRNA17522070
C028007nickel monoxidenickel monoxide results in decreased expression of CYB5R3 mRNA19167457
C025589ochratoxin Aochratoxin A results in decreased expression of CYB5R3 mRNA19287073
D052638Particulate MatterParticulate Matter results in decreased expression of CYB5R3 mRNA24769257
C410127PCB 180PCB 180 affects the expression of CYB5R3 mRNA24050789
C023036perfluorooctanoic acid"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in decreased expression of CYB5R3 mRNA"23626681
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CYB5R3 mRNA20118188|2362668
C023036perfluorooctanoic acidPPARA promotes the reaction [perfluorooctanoic acid results in increased expression of CYB5R3 mRNA]20118188
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CYB5R3 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of CYB5R3 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of CYB5R3 mRNA19162173
D010695PhlorhizinPhlorhizin results in decreased expression of CYB5R3 mRNA22538082
C014153pirimiphos methylpirimiphos methyl results in decreased expression of CYB5R3 mRNA27845199
C006253pirinixic acidpirinixic acid results in decreased expression of CYB5R3 mRNA23811191
C006253pirinixic acidpirinixic acid results in decreased expression of CYB5R3 mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CYB5R3 mRNA19162173
D011794QuercetinQuercetin results in increased expression of CYB5R3 mRNA21565894
D011802QuinidineQuinidine results in decreased expression of CYB5R3 mRNA17522070
C059514resveratrolresveratrol results in increased expression of CYB5R3 protein25505154
D019438RitonavirRitonavir affects the expression of CYB5R3 mRNA17719200
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CYB5R3 mRNA21427059
C017947sodium arsenitesodium arsenite results in increased expression of CYB5R3 mRNA20308225
C017947sodium arsenitesodium arsenite affects the expression of CYB5R3 mRNA29319823
C016104sodium bichromatesodium bichromate results in increased expression of CYB5R3 mRNA12325037
D012969Sodium FluorideSodium Fluoride results in decreased expression of CYB5R3 protein28918527
D012999SomanSoman results in increased expression of CYB5R3 mRNA19281266
C059873sulfamethoxazole hydroxylamine[MARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine25170804
C059873sulfamethoxazole hydroxylamine[MARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine25170804
D013629TamoxifenTamoxifen results in decreased expression of CYB5R3 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYB5R3 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CYB5R3 mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of CYB5R3 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYB5R3 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYB5R3 mRNA21354282|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYB5R3 mRNA21215274|2172422
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYB5R3 protein16548065
D013752TetracyclineTetracycline results in decreased expression of CYB5R3 mRNA17522070
D013849ThimerosalThimerosal results in decreased expression of CYB5R3 mRNA27188386
D013853ThioacetamideThioacetamide results in decreased expression of CYB5R3 mRNA23411599
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CYB5R3 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of CYB5R3 mRNA22378314
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CYB5R3 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of CYB5R3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of CYB5R3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CYB5R3 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CYB5R3 gene25560391
C025643vinclozolinvinclozolin affects the expression of CYB5R3 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of CYB5R3 mRNA22570695
D015032ZincZinc affects the expression of CYB5R3 mRNA16979875
C013738zingeronezingerone inhibits the reaction [Ethanol results in increased activity of CYB5R3 protein]28442378
C088658zoledronic acidzoledronic acid results in increased expression of CYB5R3 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004128cytochrome-b5 reductase activity, acting on NAD(P)H-TAS-  
GO:0005515protein binding-IPI23123858  
GO:0016208AMP binding-IEA-  
GO:0016491oxidoreductase activity-IBA21873635  
GO:0043531ADP binding-IEA-  
GO:0050660flavin adenine dinucleotide binding-IEA-  
GO:0051287NAD binding-IEA-  
GO:0071949FAD binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006695cholesterol biosynthetic process-IEA-  
GO:0008015blood circulation-TAS1400360  
GO:0019852L-ascorbic acid metabolic process-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005737cytoplasm-TAS9207238  
GO:0005739mitochondrion-HDA20833797  
GO:0005741mitochondrial outer membrane-TAS-  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005811lipid droplet-IDA14741744  
GO:0005833hemoglobin complex-TAS1400360  
GO:0016020membrane-HDA19946888  
GO:0035578azurophil granule lumen-TAS-  
KEGG ID KEGG Term
hsa00520Amino sugar and nucleotide sugar metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-196836Vitamin C (ascorbate) metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25225034Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women. (2014 Nov)Blanke KLCancer Causes Control