Gene: AFM

173
ALB2|ALBA|ALF
afamin
protein-coding
4q13.3
Ensembl:ENSG00000079557 MIM:104145 Vega:OTTHUMG00000130004 UniprotKB:P43652
NC_000004.12
PubMed
0   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.392e-1 (AD)  7.572e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACSM2B0.513
OR4C150.509
APCS0.498
SPP20.498
TMIGD10.481
FGA0.475
FGB0.471
C8A0.471
UGT2B100.434
RETNLB0.429

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLITRK2-0.286
FAT1-0.261
PCDHGB1-0.253
CADM1-0.252
PRICKLE4-0.252
POU3F2-0.252
PCDHGA3-0.25
CA8-0.249
SLC24A3-0.248
LGR4-0.244

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of AFM mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AFM mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of AFM mRNA"20959002
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of AFM mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of AFM mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of AFM mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AFM protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AFM mRNA21641981|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AFM gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AFM mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of AFM mRNA21298039
D000638AmiodaroneAmiodarone affects the expression of AFM mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AFM mRNA16483693
D001553BenzbromaroneBenzbromarone affects the expression of AFM mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AFM mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of AFM mRNA19770486
D004958EstradiolEstradiol results in decreased expression of AFM mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of AFM mRNA25181051
D002104CadmiumAFM protein binds to Cadmium23896426
D002994ClofibrateClofibrate affects the expression of AFM mRNA19483382
D003300CopperAFM protein binds to Copper23896426
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of AFM mRNA17654400
D016572CyclosporineCyclosporine results in decreased expression of AFM mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of AFM mRNA19770486
D002945CisplatinCisplatin results in increased secretion of AFM protein28885000
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of AFM mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of AFM mRNA]17942915
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AFM mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of AFM mRNA19638242
D004317DoxorubicinDoxorubicin results in increased secretion of AFM protein28885000
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AFM mRNA26159488
D004726EndosulfanEndosulfan results in decreased expression of AFM mRNA26159488
D005001EthionineEthionine affects the expression of AFM mRNA19483382
D005485FlutamideFlutamide results in decreased expression of AFM mRNA24136188
D005485FlutamideFlutamide results in increased expression of AFM mRNA24793618
C056933fumonisin B1fumonisin B1 results in decreased expression of AFM mRNA16221962
D005897GlafenineGlafenine results in decreased expression of AFM mRNA24136188
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of AFM mRNA22401849
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of AFM mRNA25380136
C051752nefazodonenefazodone results in decreased expression of AFM mRNA24136188
C012655nimesulidenimesulide results in decreased expression of AFM mRNA24136188
C076029olanzapineolanzapine affects the phosphorylation of AFM protein25821032
D009853OmeprazoleOmeprazole affects the expression of AFM mRNA19483382
C016030pantogabpantogab results in decreased expression of AFM mRNA17379144
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of AFM mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of AFM mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of AFM mRNA16221962|2381119
C006253pirinixic acidpirinixic acid affects the expression of AFM mRNA19483382
D011192Potassium DichromatePotassium Dichromate results in decreased expression of AFM mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of AFM mRNA28903501
D011441PropylthiouracilPropylthiouracil affects the expression of AFM mRNA19483382
C089730rosiglitazonerosiglitazone results in decreased expression of AFM mRNA25572481
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AFM mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AFM mRNA20106945|2615948
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AFM mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AFM mRNA20959002|2121527
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AFM mRNA28943392
D013853ThioacetamideThioacetamide affects the expression of AFM mRNA19483382
D014635Valproic AcidValproic Acid results in decreased expression of AFM mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of AFM gene29154799
D014640VancomycinVancomycin results in increased expression of AFM mRNA18930951

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI26902720  
GO:0008431vitamin E binding-IDA15952736  
GO:0008431vitamin E binding-IPI12463752  
GO ID GO Term Qualifier Evidence PubMed
GO:0050821protein stabilization-IDA26902720  
GO:0051180vitamin transport-IDA12463752  19046407  
GO:0071693protein transport within extracellular region-IMP26902720  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS7517938  
GO:0005615extracellular space-HDA16502470  
GO:0005615extracellular space-IDA12463752  15952736  19046407  26902720  
GO:0070062extracellular exosome-HDA23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23437071Human alpha4beta2 nicotinic acetylcholine receptor as a novel target of oligomeric alpha-synuclein. (2013)Liu QPLoS One
19013262Smoking and Parkinson's disease: does nicotine affect alpha-synuclein fibrillation? (2009 Feb)Hong DPBiochim Biophys Acta
23108866The effect of cigarette smoke extract on thrombomodulin-thrombin binding: an atomic force microscopy study. (2012 Oct)Wei YSci China Life Sci
27706263Gene-Activated Titanium Surfaces Promote In Vitro Osteogenesis. (2017 Mar/Apr)Atluri KInt J Oral Maxillofac Implants
29089568Alzheimer's disease and cigarette smoke components: effects of nicotine, PAHs, and Cd(II), Cr(III), Pb(II), Pb(IV) ions on amyloid-beta peptide aggregation. (2017 Oct 31)Wallin CSci Rep