Gene: DIAPH2

1730
DIA|DIA2|DRF2|POF|POF2|POF2A
diaphanous related formin 2
protein-coding
Xq21.33
Ensembl:ENSG00000147202 MIM:300108 Vega:OTTHUMG00000022689 UniprotKB:O60879
NG_008433.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAN1A10.778
RAP2B0.752
MGAT4A0.743
DTWD10.741
DIAPH10.74
CHST150.738
LYST0.738
PLB10.736
DCLK30.732
TMTC10.731

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.341
PAQR6-0.336
BCAS1-0.333
S100A1-0.327
FXYD4-0.319
RBP1-0.317
HES6-0.316
PACSIN3-0.314
OR4F29-0.308
MOBP-0.307

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIAPH2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIAPH2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIAPH2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIAPH2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIAPH2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIAPH2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of DIAPH2 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of DIAPH2 mRNA17562736
D000117AcetylglucosamineAcetylglucosamine results in decreased expression of DIAPH2 mRNA18047607
D016604Aflatoxin B1Aflatoxin B1 affects the expression of DIAPH2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DIAPH2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DIAPH2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DIAPH2 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of DIAPH2 mRNA21757418
D001104ArbutinArbutin results in decreased expression of DIAPH2 mRNA17103032
D001151ArsenicArsenic results in decreased expression of DIAPH2 mRNA19654921
D001280AtrazineAtrazine results in decreased expression of DIAPH2 mRNA22378314
C487081belinostatbelinostat results in increased expression of DIAPH2 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIAPH2 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DIAPH2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of DIAPH2 mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DIAPH2 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of DIAPH2 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DIAPH2 mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of DIAPH2 mRNA"20382639
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of DIAPH2 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of DIAPH2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of DIAPH2 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of DIAPH2 mRNA25979313
D016572CyclosporineCyclosporine results in increased expression of DIAPH2 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of DIAPH2 mRNA19770486
C014347decitabinedecitabine affects the expression of DIAPH2 mRNA23300844
D002945CisplatinCisplatin affects the expression of DIAPH2 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DIAPH2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of DIAPH2 mRNA19561079|2739243
D004041Dietary FatsDietary Fats results in decreased expression of DIAPH2 mRNA18042831
C118739entinostatentinostat results in increased expression of DIAPH2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIAPH2 mRNA"27188386
D017313FenretinideFenretinide results in decreased expression of DIAPH2 mRNA28973697
D007545IsoproterenolIsoproterenol results in increased expression of DIAPH2 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DIAPH2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of DIAPH2 mRNA27392435
D048628KetolidesKetolides analog results in increased expression of DIAPH2 mRNA24967691
C008261lead acetatelead acetate results in increased expression of DIAPH2 mRNA21829687
C045463leflunomideleflunomide results in increased expression of DIAPH2 mRNA28988120
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DIAPH2 mRNA26011545
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of DIAPH2 mRNA20886546
D009151Mustard GasMustard Gas results in decreased expression of DIAPH2 mRNA25102026
D009151Mustard GasMustard Gas affects the expression of DIAPH2 mRNA15651846
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DIAPH2 mRNA"25620056
C029938nickel sulfatenickel sulfate results in decreased expression of DIAPH2 mRNA22714537
D000073878Palm OilPalm Oil results in decreased expression of DIAPH2 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIAPH2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of DIAPH2 mRNA26272509
D010634PhenobarbitalPhenobarbital affects the expression of DIAPH2 mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of DIAPH2 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of DIAPH2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of DIAPH2 mRNA19482888
D010936Plant ExtractsPlant Extracts results in increased expression of DIAPH2 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DIAPH2 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of DIAPH2 mRNA20864642
C009277sodium arsenatesodium arsenate results in increased expression of DIAPH2 mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of DIAPH2 mRNA22714537
C016104sodium bichromatesodium bichromate results in decreased expression of DIAPH2 mRNA17685462
C004648testosterone enanthatetestosterone enanthate affects the expression of DIAPH2 mRNA17440010
C024746tobacco tartobacco tar results in decreased expression of DIAPH2 mRNA19559774
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DIAPH2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of DIAPH2 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of DIAPH2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DIAPH2 mRNA23179753|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005102signaling receptor binding-TAS9497258  
GO:0017048Rho GTPase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007015actin filament organization-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0007292female gamete generation-TAS9497258  
GO:0048477oogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA-  
GO:0005769early endosome-IEA-  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005829cytosol-TAS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24037343Identification of genes promoting skin youthfulness by genome-wide association study. (2014 Mar)Chang ALSJ Invest Dermatol