Gene: DIO2

1734
5DII|D2|DIOII|SelY|TXDI2
iodothyronine deiodinase 2
protein-coding
14q31.1
Ensembl:ENSG00000211448 MIM:601413 Vega:OTTHUMG00000171443 UniprotKB:Q92813
NC_000014.9
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.828e-1 (AD)  3.888e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CXCL140.751
PYGM0.73
MMD20.722
SFXN50.722
TSPAN120.718
WNT7B0.711
NT5E0.703
TNNT10.7
SLC13A50.698
OLFM20.697

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAP-0.445
ACAN-0.436
RASEF-0.431
TTC29-0.422
DPP4-0.408
HSD11B2-0.408
OLFML2B-0.405
SH2D1B-0.401
TSPAN19-0.398
DEPDC1B-0.395

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5171131,1-bis(4-hydroxyphenyl)cyclohexane"1,1-bis(4-hydroxyphenyl)cyclohexane results in decreased expression of DIO2 mRNA"28167136
C4776942,2',4,4',5-brominated diphenyl ether"2,2',4,4',5-brominated diphenyl ether results in decreased expression of DIO2 mRNA"25544063
C4776942,2',4,4',5-brominated diphenyl ether"2,2',4,4',5-brominated diphenyl ether inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]"26004626
C4776942,2',4,4',5-brominated diphenyl ether"2,2',4,4',5-brominated diphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]"26004626
C4776942,2',4,4',5-brominated diphenyl ether"2,2',4,4',5-brominated diphenyl ether metabolite results in decreased activity of and results in increased degradation of DIO2 protein"26004626
C4776942,2',4,4',5-brominated diphenyl ether"2,2',4,4',5-brominated diphenyl ether metabolite results in decreased expression of DIO2 mRNA"26004626
C4776942,2',4,4',5-brominated diphenyl ether"2,2',4,4',5-brominated diphenyl ether results in decreased activity of and results in increased degradation of DIO2 protein"26004626
C4776942,2',4,4',5-brominated diphenyl ether"2,2',4,4',5-brominated diphenyl ether results in decreased expression of DIO2 mRNA"26004626
C4776942,2',4,4',5-brominated diphenyl ether"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [2,2',4,4',5-brominated diphenyl ether results in decreased activity of DIO2 protein]"26004626
C4776942,2',4,4',5-brominated diphenyl ether"[Cycloheximide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] inhibits the reaction [2,2',4,4',5-brominated diphenyl ether metabolite results in decreased activity of DIO2 protein]"26004626
C4776942,2',4,4',5-brominated diphenyl ether"Cycloheximide promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [2,2',4,4',5-brominated diphenyl ether results in decreased activity of DIO2 protein]]"26004626
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of DIO2 mRNA"22546086|2417757
C5112952,2',4,4'-tetrabromodiphenyl ether"[perchlorate co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in increased expression of DIO2 mRNA"24177579
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]"26004626
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether metabolite results in decreased activity of and results in increased degradation of DIO2 protein"26004626
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether metabolite results in decreased expression of DIO2 mRNA"26004626
C5451212-((4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy)methyl)quinoline2-((4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy)methyl)quinoline results in increased expression of DIO2 mRNA27247380
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DIO2 mRNA"24878560
C0415253,3',4,5'-tetrahydroxystilbene"3,3',4,5'-tetrahydroxystilbene results in decreased activity of DIO2 protein"17327447
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of DIO2 mRNA"28167136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIO2 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of DIO2 mRNA19191707
C0415944-nonylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DIO2 mRNA23626723
C1052604-tert-octylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DIO2 mRNA23626723
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIO2 mRNA"27188386
C043377acetochloracetochlor results in decreased expression of DIO2 mRNA19577311
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Hydrogen Peroxide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein]]18420745
D020106AcrylamideAcrylamide results in increased expression of DIO2 mRNA18430446
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DIO2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DIO2 gene27153756
D003913DextroamphetamineDextroamphetamine results in increased expression of DIO2 mRNA19194377
C519728archazolid Barchazolid B results in decreased expression of DIO2 mRNA25218289
D001280AtrazineAtrazine results in decreased expression of DIO2 mRNA27413107
D001280AtrazineAtrazine results in increased expression of DIO2 mRNA18461179
D001374AzacitidineAzacitidine results in decreased expression of DIO2 mRNA20823114
D001507BeclomethasoneBeclomethasone results in increased expression of DIO2 mRNA23656298
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of DIO2 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DIO2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DIO2 mRNA22178795
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DIO2 mRNA"20018196|2038263
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of DIO2 mRNA"19150397
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [2,2',4,4',5-brominated diphenyl ether results in decreased activity of DIO2 protein]"26004626
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide results in decreased activity of DIO2 protein]11425850
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]11425850
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]"26004626
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of and results in increased activity of DIO2 protein11425850
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DIO2 protein26004626
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde"[Cycloheximide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] inhibits the reaction [2,2',4,4',5-brominated diphenyl ether metabolite results in decreased activity of DIO2 protein]"26004626
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde[Cycloheximide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased activity of DIO2 protein26004626
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde"Cycloheximide promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [2,2',4,4',5-brominated diphenyl ether results in decreased activity of DIO2 protein]]"26004626
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehyde"Cycloheximide promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]]"26004626
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased activity of DIO2 protein17615150
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of DIO2 mRNA20823114
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of DIO2 mRNA20660070
D004958EstradiolEstradiol results in increased expression of DIO2 mRNA21795739
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of DIO2 mRNA17404688
D004958EstradiolEstradiol results in increased expression of DIO2 mRNA19484750
D004958Estradiol[metolachlor co-treated with Estradiol] results in increased expression of DIO2 mRNA21081129
C006780bisphenol Abisphenol A results in decreased expression of DIO2 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DIO2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of DIO2 mRNA25181051|2816713
C006780bisphenol Abisphenol A results in increased expression of DIO2 mRNA22504913
C492482bisphenol Bbisphenol B results in decreased expression of DIO2 mRNA28167136
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DIO2 mRNA28628672
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of and results in increased activity of DIO2 protein11425850
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein18420745
D0151248-Bromo Cyclic Adenosine MonophosphateAcetylcysteine inhibits the reaction [Hydrogen Peroxide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein]]18420745
D0151248-Bromo Cyclic Adenosine MonophosphateHydrogen Peroxide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein]18420745
D0151248-Bromo Cyclic Adenosine MonophosphateSodium Selenite inhibits the reaction [Hydrogen Peroxide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein]]18420745
C040918buteinbutein results in decreased activity of DIO2 protein17327447
D019328Buthionine SulfoximineButhionine Sulfoximine inhibits the reaction [Colforsin results in increased activity of DIO2 protein]18420745
C006698carbendazimcarbendazim results in decreased expression of DIO2 mRNA25304545|2605522
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of DIO2 mRNA12832660
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of DIO2 mRNA16720020
D004390ChlorpyrifosChlorpyrifos results in decreased expression of DIO2 mRNA21356183
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of DIO2 mRNA21356183
C039671ciglitazoneciglitazone results in increased activity of DIO2 protein19036883
C039671ciglitazonePPARG protein promotes the reaction [ciglitazone results in increased activity of DIO2 protein]19036883
D002994ClofibrateClofibrate results in decreased expression of DIO2 mRNA16896063
C018021cobaltous chloridecobaltous chloride results in increased activity of DIO2 protein17615150
D005576ColforsinColforsin results in increased activity of DIO2 protein19036883
D005576ColforsinButhionine Sulfoximine inhibits the reaction [Colforsin results in increased activity of DIO2 protein]18420745
D005576ColforsinColforsin results in increased expression of DIO2 mRNA18420745
D005576ColforsinHydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]18420745
D005576ColforsinHydrogen Peroxide inhibits the reaction [Colforsin results in increased expression of DIO2 mRNA]18420745
D005576ColforsinSodium Selenite inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]]18420745
D005576ColforsinU 0126 inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]]18420745
D005576ColforsinU 0126 inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased expression of DIO2 mRNA]]18420745
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of DIO2 mRNA21356183
C057862cyanoginosin LRcyanoginosin LR results in decreased activity of DIO2 protein25778693
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of DIO2 mRNA25778693
C057862cyanoginosin LRcyanoginosin LR results in increased expression of DIO2 protein25497113
D003513Cycloheximidebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide results in decreased activity of DIO2 protein]11425850
D003513Cycloheximide"[Cycloheximide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] inhibits the reaction [2,2',4,4',5-brominated diphenyl ether metabolite results in decreased activity of DIO2 protein]"26004626
D003513Cycloheximide[Cycloheximide co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in decreased activity of DIO2 protein26004626
D003513Cycloheximide"Cycloheximide promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [2,2',4,4',5-brominated diphenyl ether results in decreased activity of DIO2 protein]]"26004626
D003513Cycloheximide"Cycloheximide promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]]"26004626
D003513CycloheximideCycloheximide results in decreased activity of DIO2 protein11425850
D003513Cycloheximidelactacystin inhibits the reaction [Cycloheximide results in decreased activity of DIO2 protein]11425850
D016572CyclosporineCyclosporine results in increased expression of DIO2 mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether affects the expression of DIO2 mRNA21901812
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of DIO2 mRNA21901812
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of DIO2 mRNA23899252
D003676DeferoxamineDeferoxamine results in increased activity of DIO2 protein17615150
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DIO2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DIO2 mRNA28628672
D003907Dexamethasone[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of DIO2 mRNA29288687
D003907Dexamethasone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of DIO2 mRNA29288687
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of DIO2 mRNA20823114
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DIO2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of DIO2 mRNA27392435
D003633Dichlorodiphenyl Dichloroethylene"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of DIO2 mRNA"24878560
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of DIO2 mRNA26924002
D004041Dietary Fats"[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of DIO2 mRNA"24872412
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DIO2 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of DIO2 mRNA22504913
D002117CalcitriolCalcitriol results in increased activity of DIO2 protein15471965
C056451dimethyl succinatedimethyl succinate results in increased activity of DIO2 protein17615150
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Oxygen deficiency results in increased activity of DIO2 protein]17615150
D0192972,4-Dinitrophenol"[2,4-Dinitrophenol co-treated with Dietary Fats] affects the expression of DIO2 mRNA"24872412
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DIO2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DIO2 mRNA16872691
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DIO2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DIO2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DIO2 mRNA17351261
D005031EthylenethioureaEthylenethiourea results in increased expression of DIO2 mRNA18801409
C017875fisetinfisetin results in increased activity of DIO2 protein17327447
D005411Flame RetardantsFlame Retardants results in increased expression of DIO2 mRNA19945756
D005411Flame RetardantsFlame Retardants results in increased expression of DIO2 mRNA21901812
D005557FormaldehydeFormaldehyde results in increased expression of DIO2 mRNA28937961
D019833GenisteinGenistein results in increased expression of DIO2 mRNA22504913
D005938GlucocorticoidsGlucocorticoids promotes the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]21068073
D005938GlucocorticoidsGlucocorticoids promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]21068073
D005938GlucocorticoidsGlucocorticoids results in increased activity of DIO2 protein21068073
D005938GlucocorticoidsGlucocorticoids results in increased expression of DIO2 mRNA21068073
D005938GlucocorticoidsMifepristone inhibits the reaction [Glucocorticoids promotes the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]]21068073
D005938GlucocorticoidsMifepristone inhibits the reaction [Glucocorticoids promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]21068073
D005938GlucocorticoidsMifepristone inhibits the reaction [Glucocorticoids results in increased activity of DIO2 protein]21068073
D005938GlucocorticoidsMifepristone inhibits the reaction [Glucocorticoids results in increased expression of DIO2 mRNA]21068073
C010974glyphosateglyphosate affects the expression of DIO2 mRNA27916585
C453899GW 7647GW 7647 results in increased activity of DIO2 protein19036883
C453899GW 7647PPARG protein promotes the reaction [GW 7647 results in increased activity of DIO2 protein]19036883
D006247HarmineHarmine results in increased expression of DIO2 protein27805061
C089796hexabromocyclododecanehexabromocyclododecane results in increased expression of DIO2 mRNA20200218
C409722hexaconazolehexaconazole results in increased expression of DIO2 mRNA23685399
D017313FenretinideFenretinide results in increased expression of DIO2 mRNA28973697
D006861Hydrogen PeroxideAcetylcysteine inhibits the reaction [Hydrogen Peroxide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein]]18420745
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein]18420745
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]18420745
D006861Hydrogen PeroxideHydrogen Peroxide inhibits the reaction [Colforsin results in increased expression of DIO2 mRNA]18420745
D006861Hydrogen PeroxideSB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of DIO2 mRNA]18420745
D006861Hydrogen PeroxideSodium Selenite inhibits the reaction [Hydrogen Peroxide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein]]18420745
D006861Hydrogen PeroxideSodium Selenite inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]]18420745
D006861Hydrogen PeroxideU 0126 inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]]18420745
D006861Hydrogen PeroxideU 0126 inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased expression of DIO2 mRNA]]18420745
D006861Hydrogen PeroxideU 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of DIO2 mRNA]18420745
D007052IbuprofenIbuprofen results in increased expression of DIO2 mRNA28201806
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DIO2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DIO2 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of DIO2 mRNA16184411
D007213Indomethacinrebamipide inhibits the reaction [Indomethacin results in increased expression of DIO2 mRNA]16184411
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DIO2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DIO2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of DIO2 mRNA29288687
D0150561-Methyl-3-isobutylxanthine[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of DIO2 mRNA29288687
D007545IsoproterenolIsoproterenol results in increased expression of DIO2 mRNA20003209
D007545IsoproterenolIsoproterenol results in increased activity of DIO2 protein15345674
D007545IsoproterenolIsoproterenol results in increased expression of DIO2 mRNA15345674
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DIO2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of DIO2 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of DIO2 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DIO2 mRNA25982114
C006552kaempferolkaempferol promotes the reaction [DIO2 protein results in increased activity of and results in increased abundance of Triiodothyronine]17327447
C006552kaempferolkaempferol results in increased activity of DIO2 protein17327447
C006552kaempferolkaempferol results in increased expression of DIO2 mRNA17327447
C067713lactacystinlactacystin inhibits the reaction [Cycloheximide results in decreased activity of DIO2 protein]11425850
C067713lactacystinlactacystin inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]11425850
C067713lactacystinlactacystin results in increased expression of and results in increased activity of DIO2 protein11425850
C008261lead acetatelead acetate results in increased expression of DIO2 mRNA22641619
C423914LG 268LG 268 results in decreased expression of DIO2 mRNA16306084
C423914LG 268LG 268 results in increased activity of DIO2 protein16306084
C423914LG 268RXRG protein promotes the reaction [LG 268 results in decreased expression of DIO2 mRNA]16306084
C432503licarin A[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of DIO2 mRNA29288687
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [RELA protein results in increased expression of DIO2 mRNA]16728495
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of DIO2 protein16728495
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of DIO2 mRNA16728495
D008070LipopolysaccharidesRELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]16728495
D008070LipopolysaccharidesSulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]16728495
D008070LipopolysaccharidesSulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]16728495
D008070LipopolysaccharidesGlucocorticoids promotes the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]21068073
D008070LipopolysaccharidesGlucocorticoids promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]21068073
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of DIO2 protein21068073
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of DIO2 mRNA21068073
D008070LipopolysaccharidesMifepristone inhibits the reaction [Glucocorticoids promotes the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]]21068073
D008070LipopolysaccharidesMifepristone inhibits the reaction [Glucocorticoids promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]21068073
D008070LipopolysaccharidesSulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]21068073
D008070LipopolysaccharidesSulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]21068073
D008095Lithocholic AcidLithocholic Acid results in increased activity of DIO2 protein19036883
D008095Lithocholic AcidLithocholic Acid results in increased expression of DIO2 mRNA19036883
D008095Lithocholic AcidN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithocholic Acid results in increased activity of DIO2 protein]19036883
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of DIO2 mRNA20823114
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of DIO2 mRNA20843944
D015122MercaptopurineMercaptopurine results in increased expression of DIO2 mRNA23358152
D008694MethamphetamineMethamphetamine results in increased expression of DIO2 mRNA19149911
C014055methyl iodidemethyl iodide results in decreased activity of DIO2 protein19519149
D008775MethylprednisoloneMethylprednisolone results in increased expression of DIO2 mRNA19192274
C051786metolachlor[metolachlor co-treated with Estradiol] results in increased expression of DIO2 mRNA21081129
C051786metolachlormetolachlor results in increased expression of DIO2 mRNA21081129
D015735MifepristoneMifepristone results in increased expression of DIO2 mRNA17584828
D015735MifepristoneMifepristone inhibits the reaction [Glucocorticoids promotes the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]]21068073
D015735MifepristoneMifepristone inhibits the reaction [Glucocorticoids promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]21068073
D015735MifepristoneMifepristone inhibits the reaction [Glucocorticoids results in increased activity of DIO2 protein]21068073
D015735MifepristoneMifepristone inhibits the reaction [Glucocorticoids results in increased expression of DIO2 mRNA]21068073
C517284monomethyl phthalatemonomethyl phthalate affects the expression of DIO2 mRNA26924002
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithocholic Acid results in increased activity of DIO2 protein]19036883
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DIO2 mRNA"24389112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DIO2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DIO2 mRNA"25554681
D009281NaphthalenesNaphthalenes results in increased expression of DIO2 protein17337753
C029938nickel sulfatenickel sulfate results in increased expression of DIO2 mRNA22714537
D009930Organic ChemicalsOrganic Chemicals results in decreased expression of DIO2 mRNA20526952
D010100Oxygendiphenyleneiodonium inhibits the reaction [Oxygen deficiency results in increased activity of DIO2 protein]17615150
D010100OxygenOxygen deficiency results in decreased degradation of and results in increased activity of DIO2 protein17615150
D052638Particulate MatterParticulate Matter results in decreased expression of DIO2 mRNA23085030
D052638Particulate MatterParticulate Matter results in decreased expression of DIO2 mRNA23126276
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of DIO2 mRNA22039834
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of DIO2 mRNA19945756
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of DIO2 mRNA26705709
C015421pentachloroanisolepentachloroanisole results in decreased expression of DIO2 mRNA25463847
D010416PentachlorophenolPentachlorophenol results in decreased expression of DIO2 mRNA25463847
D010416PentachlorophenolPentachlorophenol results in increased expression of DIO2 mRNA24001430
C494474perchlorate"[perchlorate co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in increased expression of DIO2 mRNA"24177579
C494474perchlorateperchlorate results in increased expression of DIO2 mRNA18801409
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of DIO2 mRNA22302310
C479228perfluorohexanoic acidperfluorohexanoic acid results in increased expression of DIO2 mRNA21212296
C101815perfluoro-n-heptanoic acidperfluoro-n-heptanoic acid results in increased expression of DIO2 mRNA21212296
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of DIO2 mRNA21212296
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of DIO2 mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of DIO2 mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of DIO2 mRNA19162173
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of DIO2 mRNA26678675
D010656PhenylephrinePhenylephrine results in increased activity of DIO2 protein15345674
D010656PhenylephrinePhenylephrine results in increased expression of DIO2 mRNA15345674
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DIO2 mRNA"27188386
C060836pioglitazonepioglitazone results in increased activity of DIO2 protein19036883
C060836pioglitazonePPARG protein promotes the reaction [pioglitazone results in increased activity of DIO2 protein]19036883
C060836pioglitazonepioglitazone results in increased activity of DIO2 protein19036883
C060836pioglitazonepioglitazone results in increased expression of DIO2 mRNA19036883
C006253pirinixic acidpirinixic acid results in decreased expression of DIO2 mRNA16985257
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DIO2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DIO2 mRNA22079256
D011239PrednisolonePrednisolone results in increased expression of DIO2 mRNA19192274
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of DIO2 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of DIO2 mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of DIO2 mRNA17404688
C010313pseudocumenepseudocumene results in increased expression of DIO2 protein17337753
D011794QuercetinQuercetin results in increased activity of DIO2 protein17327447
C052785rebamipiderebamipide inhibits the reaction [Indomethacin results in increased expression of DIO2 mRNA]16184411
C059514resveratrolresveratrol results in decreased activity of DIO2 protein17327447
C089730rosiglitazone[rosiglitazone affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of DIO2 mRNA29288687
C093642SB 203580SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of DIO2 mRNA]18420745
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in increased expression of DIO2 mRNA12818353
D012643SeleniumSelenium results in increased expression of and results in increased activity of DIO2 protein11425850
D012643SeleniumSelenium results in increased activity of DIO2 protein15471965
C009250sevofluranesevoflurane results in decreased expression of DIO2 mRNA26206149
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of DIO2 mRNA25895662
C009277sodium arsenatesodium arsenate results in decreased expression of DIO2 mRNA16882884|2392266
C009277sodium arsenatesodium arsenate results in decreased expression of DIO2 mRNA26393310
D018038Sodium SeleniteSodium Selenite inhibits the reaction [Hydrogen Peroxide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO2 protein]]18420745
D018038Sodium SeleniteSodium Selenite inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]]18420745
D012999SomanSoman results in increased expression of DIO2 mRNA19281266
D053260SootSoot results in increased expression of DIO2 mRNA26551751
D012460SulfasalazineSulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]16728495
D012460SulfasalazineSulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]16728495
D012460SulfasalazineSulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]21068073
D012460SulfasalazineSulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]21068073
D014284TriiodothyronineTriiodothyronine results in decreased expression of DIO2 mRNA26397822
D014284TriiodothyronineTriiodothyronine results in increased expression of DIO2 mRNA21212296
D014284Triiodothyronine"2,2',4,4',5-brominated diphenyl ether inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]"26004626
D014284Triiodothyronine"2,2',4,4',5-brominated diphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]"26004626
D014284Triiodothyronine"2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]"26004626
D014284Triiodothyronine[DIO1 protein co-treated with DIO2 protein co-treated with DIO3 protein] affects the abundance of Triiodothyronine23397585
D014284Triiodothyronine[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine26004626
D014284Triiodothyroninekaempferol promotes the reaction [DIO2 protein results in increased activity of and results in increased abundance of Triiodothyronine]17327447
D014284TriiodothyronineDIO2 protein results in increased chemical synthesis of Triiodothyronine17615150
D014284TriiodothyronineTriiodothyronine results in increased expression of DIO2 mRNA25646720
D014284TriiodothyronineDIO2 protein results in increased chemical synthesis of Triiodothyronine16935842
D013629TamoxifenTamoxifen results in increased expression of DIO2 mRNA25123088
C087114tebuconazoletebuconazole results in increased expression of DIO2 mRNA23685399
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DIO2 mRNA16443690
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DIO2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DIO2 mRNA17942748
D013893ThiramThiram results in increased expression of DIO2 mRNA20530235
D013974Thyroxine"2,2',4,4',5-brominated diphenyl ether inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]"26004626
D013974Thyroxine"2,2',4,4',5-brominated diphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]"26004626
D013974Thyroxine"2,2',4,4'-tetrabromodiphenyl ether metabolite inhibits the reaction [[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine]"26004626
D013974Thyroxinebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]11425850
D013974ThyroxineDIO2 protein mutant form affects the metabolism of Thyroxine11108274
D013974ThyroxineDIO2 protein results in increased metabolism of Thyroxine11108274|1142585
D013974Thyroxine[DIO2 protein results in increased metabolism of Thyroxine] which results in increased chemical synthesis of Triiodothyronine26004626
D013974Thyroxinelactacystin inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]11425850
D013974ThyroxineThyroxine results in decreased expression of and results in decreased activity of DIO2 protein11425850
D013974ThyroxineThyroxine results in decreased activity of DIO2 protein17615150
D013974ThyroxineDIO2 protein results in increased metabolism of and results in increased activity of Thyroxine16935842
D013963Thyroid HormonesDIO2 protein results in increased metabolism of Thyroid Hormones23397585
C009495titanium dioxidetitanium dioxide results in decreased expression of DIO2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of DIO2 mRNA20133372
D014285Triiodothyronine, Reverse"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]"26004626
D014285Triiodothyronine, Reverse"Cycloheximide promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of DIO2 protein]]"26004626
D014285Triiodothyronine, Reverse"Triiodothyronine, Reverse results in decreased activity of DIO2 protein"26004626
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DIO2 mRNA"26179874
C057693troglitazonePPARG protein promotes the reaction [troglitazone results in increased activity of DIO2 protein]19036883
C057693troglitazonetroglitazone results in increased activity of DIO2 protein19036883
C057693troglitazonetroglitazone results in decreased expression of DIO2 mRNA28973697
D017973Tungsten CompoundsTungsten Compounds results in decreased expression of DIO2 mRNA28666766
C113580U 0126U 0126 inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased activity of DIO2 protein]]18420745
C113580U 0126U 0126 inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Colforsin results in increased expression of DIO2 mRNA]]18420745
C113580U 0126U 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of DIO2 mRNA]18420745
C022884undecaneundecane results in increased expression of DIO2 protein17337753
D014635Valproic AcidValproic Acid results in decreased methylation of DIO2 gene29154799
D014638VanadatesVanadates results in decreased expression of DIO2 mRNA22714537
C025643vinclozolinvinclozolin results in decreased expression of DIO2 mRNA21126777
D014810Vitamin EVitamin E results in increased expression of DIO2 mRNA19244175
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of DIO2 mRNA"26950620
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of DIO2 mRNA"20526952
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of DIO2 mRNA"23246600
C088658zoledronic acidzoledronic acid results in decreased expression of DIO2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004800thyroxine 5'-deiodinase activity-IBA21873635  
GO:0004800thyroxine 5'-deiodinase activity-IDA19651899  
GO:0004800thyroxine 5'-deiodinase activity-TAS9837913  
GO:0008430selenium binding-IC9837913  
GO:0031625ubiquitin protein ligase binding-IPI19651899  
GO ID GO Term Qualifier Evidence PubMed
GO:0001514selenocysteine incorporation-NAS9837913  
GO:0006590thyroid hormone generation-TAS9837913  
GO:0042403thyroid hormone metabolic process-IBA21873635  
GO:0042403thyroid hormone metabolic process-IDA19651899  
GO:0042446hormone biosynthetic process-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-IC9837913  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-209776Amine-derived hormonesTAS
R-HSA-209968Thyroxine biosynthesisTAS
R-HSA-350864Regulation of thyroid hormone activityTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29694503Neonatal tobacco smoke reduces thermogenesis capacity in brown adipose tissue in adult rats. (2018)Peixoto TCBraz J Med Biol Res
17381351The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study. (2007 Mar)Maia ALThyroid