Gene: DIO3

1735
5DIII|D3|DIOIII|TXDI3
iodothyronine deiodinase 3
protein-coding
14q32.31
Ensembl:ENSG00000197406 MIM:601038 Vega:OTTHUMG00000160681 UniprotKB:P55073
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.950e-1 (AD)  2.120e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TTC220.658
LRRC10B0.636
CCDC88C0.613
GPR10.581
SAG0.562
TMPRSS60.56
GPR1010.554
PYDC10.546
SLC35D30.545
MCOLN30.544

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POSTN-0.35
ADTRP-0.332
GLDN-0.332
CPA5-0.327
CPA4-0.326
CYP26A1-0.326
STMND1-0.324
THEMIS-0.314
NPFFR2-0.306
SOST-0.306

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09333Iopodic acidSmall Molecule5587-89-3Approved|Investigational|WithdrawnTarget
ID Drug Name Action PubMed
C0810141,2-bis(2,4,6-tribromophenoxy)ethane"1,2-bis(2,4,6-tribromophenoxy)ethane results in decreased expression of DIO3 mRNA"21893176
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DIO3 mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DIO3 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of DIO3 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DIO3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DIO3 mRNA"27188386
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[Hydrogen Peroxide co-treated with Sodium Selenite] promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO3 protein]]18420745
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO3 protein]]18420745
C103303alitretinoinalitretinoin results in increased activity of DIO3 protein16935842
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DIO3 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of DIO320368127
C547126AZM551248AZM551248 results in increased expression of DIO3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DIO3 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DIO3 mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DIO3 mRNA21839799
D004958EstradiolEstradiol affects the expression of DIO3 mRNA14699072
D004958EstradiolEstradiol results in increased activity of DIO3 protein16935842
C095105bexarotenebexarotene analog results in increased expression of DIO3 mRNA28689802
C053541bicalutamidebicalutamide results in increased expression of DIO3 mRNA15638997
C006780bisphenol A[potassium bromate co-treated with bisphenol A] affects the expression of DIO3 mRNA27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of DIO3 mRNA]27082013
C006780bisphenol Abisphenol A results in increased expression of DIO3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DIO3 gene28505145
D0151248-Bromo Cyclic Adenosine MonophosphateAcetylcysteine inhibits the reaction [[Hydrogen Peroxide co-treated with Sodium Selenite] promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO3 protein]]18420745
D0151248-Bromo Cyclic Adenosine MonophosphateAcetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO3 protein]]18420745
D0151248-Bromo Cyclic Adenosine MonophosphateHydrogen Peroxide promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO3 protein]18420745
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased activity of DIO3 protein18420745
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of DIO3 mRNA24763279
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of DIO3 mRNA16720020
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DIO3 gene20938992
D005576ColforsinColforsin promotes the reaction [Hydrogen Peroxide results in increased expression of DIO3 mRNA]18420745
D003471CuprizoneCuprizone results in decreased expression of DIO3 mRNA27523638
C057862cyanoginosin LRcyanoginosin LR results in increased activity of DIO3 protein25778693
C057862cyanoginosin LRcyanoginosin LR results in increased expression of DIO3 mRNA25778693
D003513CycloheximideCycloheximide inhibits the reaction [Hydrogen Peroxide results in increased activity of DIO3 protein]18420745
C000541cyclopaminecyclopamine results in decreased expression of DIO3 mRNA26825960
D003609DactinomycinDactinomycin inhibits the reaction [Hydrogen Peroxide results in increased activity of DIO3 protein]18420745
D003907DexamethasoneDexamethasone results in decreased activity of DIO3 protein16935842
D002945CisplatinCisplatin results in decreased expression of DIO3 mRNA22023808
D004041Dietary FatsDietary Fats results in increased expression of DIO3 mRNA25016146
C118739entinostatentinostat results in decreased expression of DIO3 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DIO3 mRNA"27188386
C082360fipronilfipronil results in increased expression of DIO3 mRNA23962444
D005419FlavonoidsFlavonoids results in increased expression of DIO3 mRNA18035473
D005473FluoxetineFluoxetine results in increased activity of DIO3 protein15456934
D005473FluoxetineFluoxetine results in increased expression of DIO3 mRNA15456934
D005473FluoxetineSB 203580 inhibits the reaction [Fluoxetine results in increased expression of DIO3 mRNA]15456934
D005473FluoxetineU 0126 inhibits the reaction [Fluoxetine results in increased activity of DIO3 protein]15456934
D005473FluoxetineU 0126 inhibits the reaction [Fluoxetine results in increased expression of DIO3 mRNA]15456934
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DIO3 gene20938992
C069837fullerene C60fullerene C60 results in decreased expression of DIO3 mRNA19167457
C039281furanfuran results in increased expression of DIO3 mRNA26194646
C010974glyphosateglyphosate results in decreased expression of DIO3 mRNA27916585
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of DIO3 mRNA24763279
D006861Hydrogen PeroxideAcetylcysteine inhibits the reaction [[Hydrogen Peroxide co-treated with Sodium Selenite] promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO3 protein]]18420745
D006861Hydrogen PeroxideAcetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO3 protein]]18420745
D006861Hydrogen PeroxideColforsin promotes the reaction [Hydrogen Peroxide results in increased expression of DIO3 mRNA]18420745
D006861Hydrogen PeroxideCycloheximide inhibits the reaction [Hydrogen Peroxide results in increased activity of DIO3 protein]18420745
D006861Hydrogen PeroxideDactinomycin inhibits the reaction [Hydrogen Peroxide results in increased activity of DIO3 protein]18420745
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO3 protein]18420745
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of DIO3 protein]18420745
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [Thyroxine results in increased activity of DIO3 protein]18420745
D006861Hydrogen PeroxideHydrogen Peroxide results in increased activity of DIO3 protein18420745
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of DIO3 mRNA18420745
D006861Hydrogen PeroxideSB 203580 inhibits the reaction [Hydrogen Peroxide results in increased activity of DIO3 protein]18420745
D006861Hydrogen PeroxideSB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of DIO3 mRNA]18420745
D006861Hydrogen PeroxideSodium Selenite inhibits the reaction [Hydrogen Peroxide results in increased activity of DIO3 protein]18420745
D006861Hydrogen PeroxideU 0126 inhibits the reaction [Hydrogen Peroxide results in increased activity of DIO3 protein]18420745
D006861Hydrogen PeroxideU 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of DIO3 mRNA]18420745
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of DIO3 mRNA16415329
D008070LipopolysaccharidesRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of DIO3 mRNA]16415329
D008095Lithocholic AcidLithocholic Acid results in increased activity of DIO3 protein19036883
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DIO3 gene20938992
D008731MethoxychlorMethoxychlor results in increased methylation of DIO3 gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DIO3 mRNA28001369
C031721naphthalenenaphthalene results in increased expression of DIO3 mRNA18978301
C015421pentachloroanisolepentachloroanisole results in increased expression of DIO3 mRNA25463847
D010416PentachlorophenolPentachlorophenol results in increased expression of DIO3 mRNA25463847
D010416PentachlorophenolPentachlorophenol results in decreased expression of DIO3 mRNA20654147
D010416PentachlorophenolPentachlorophenol results in increased expression of DIO3 mRNA20654147
C539348perfluorobutanesulfonic acidperfluorobutanesulfonic acid results in increased expression of DIO3 mRNA21212296
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of DIO3 mRNA21212296|2230231
C479228perfluorohexanoic acidperfluorohexanoic acid results in increased expression of DIO3 mRNA21212296
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of DIO3 mRNA17383973
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of DIO3 mRNA17383973
D010634PhenobarbitalPhenobarbital results in decreased expression of DIO3 mRNA19631232
C060836pioglitazonepioglitazone results in decreased activity of DIO3 protein19036883
D010936Plant ExtractsPlant Extracts results in decreased expression of DIO3 mRNA23557933
C019536potassium bromate[potassium bromate co-treated with bisphenol A] affects the expression of DIO3 mRNA27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of DIO3 mRNA]27082013
D017035PravastatinPravastatin results in decreased expression of DIO3 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of DIO3 mRNA27225895
D011374ProgesteroneProgesterone results in increased expression of DIO3 mRNA19690047
C045950propiconazolepropiconazole affects the expression of DIO3 mRNA17383973
D011441PropylthiouracilPropylthiouracil results in decreased expression of DIO3 mRNA24780913
D011899RanitidineRanitidine promotes the reaction [Lipopolysaccharides results in increased expression of DIO3 mRNA]16415329
C093642SB 203580SB 203580 results in decreased expression of DIO326825960
C093642SB 203580SB 203580 inhibits the reaction [Fluoxetine results in increased expression of DIO3 mRNA]15456934
C093642SB 203580SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased activity of DIO3 protein]18420745
C093642SB 203580SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of DIO3 mRNA]18420745
D018038Sodium SeleniteAcetylcysteine inhibits the reaction [[Hydrogen Peroxide co-treated with Sodium Selenite] promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased activity of DIO3 protein]]18420745
D018038Sodium SeleniteSodium Selenite inhibits the reaction [Hydrogen Peroxide results in increased activity of DIO3 protein]18420745
C446685systhanesysthane affects the expression of DIO3 mRNA17383973
D014284Triiodothyronine[DIO1 protein co-treated with DIO2 protein co-treated with DIO3 protein] affects the abundance of Triiodothyronine23397585
D014284TriiodothyronineTriiodothyronine results in increased expression of DIO3 mRNA23397585
D014284TriiodothyronineDIO3 protein results in increased metabolism of and results in decreased activity of Triiodothyronine16935842
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased activity of DIO3 protein16935842
D013755Tetradecanoylphorbol AcetateHydrogen Peroxide promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of DIO3 protein]18420745
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased activity of DIO3 protein18420745
D013853ThioacetamideThioacetamide results in decreased expression of DIO3 protein23586759
D013974ThyroxineHydrogen Peroxide promotes the reaction [Thyroxine results in increased activity of DIO3 protein]18420745
D013974ThyroxineThyroxine results in increased activity of DIO3 protein18420745
D013974ThyroxineDIO3 protein results in increased metabolism of and results in decreased activity of Thyroxine16935842
D013963Thyroid HormonesDIO3 protein results in increased metabolism of Thyroid Hormones23397585
D014212TretinoinTretinoin results in decreased activity of DIO3 protein16935842
D014212TretinoinTretinoin results in increased activity of DIO3 protein16935842
D014212TretinoinTretinoin results in increased expression of DIO3 mRNA20488242
C032910triadimefontriadimefon affects the expression of DIO3 mRNA17383973
C113580U 0126U 0126 results in decreased expression of DIO326825960
C113580U 0126U 0126 inhibits the reaction [Fluoxetine results in increased activity of DIO3 protein]15456934
C113580U 0126U 0126 inhibits the reaction [Fluoxetine results in increased expression of DIO3 mRNA]15456934
C113580U 0126U 0126 inhibits the reaction [Hydrogen Peroxide results in increased activity of DIO3 protein]18420745
C113580U 0126U 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of DIO3 mRNA]18420745
D014635Valproic AcidValproic Acid results in decreased expression of DIO3 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of DIO3 gene29154799
C551177vemurafenibvemurafenib results in decreased expression of DIO326825960

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004800thyroxine 5'-deiodinase activity-IBA21873635  
GO:0004800thyroxine 5'-deiodinase activity-NAS7593630  
GO:0004800thyroxine 5'-deiodinase activity-TAS-  
GO:0033798thyroxine 5-deiodinase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006590thyroid hormone generation-TAS-  
GO:0006915apoptotic process-IEA-  
GO:0008150biological_process-ND-  
GO:0040018positive regulation of multicellular organism growth-IEA-  
GO:0042403thyroid hormone metabolic process-IBA21873635  
GO:0042404thyroid hormone catabolic process-IEA-  
GO:0042446hormone biosynthetic process-IEA-  
GO:0046549retinal cone cell development-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0010008endosome membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-209776Amine-derived hormonesTAS
R-HSA-209968Thyroxine biosynthesisTAS
R-HSA-350864Regulation of thyroid hormone activityTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29435111Impact of DLK1-DIO3 imprinted cluster hypomethylation in smoker patients with lung cancer. (2018 Jan 12)Molina-Pinelo SOncotarget