Gene: DKC1

1736
CBF5|DKC|DKCX|NAP57|NOLA4|XAP101
dyskerin pseudouridine synthase 1
protein-coding
Xq28
Ensembl:ENSG00000130826 MIM:300126 Vega:OTTHUMG00000024242 UniprotKB:O60832
NG_009780.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPN10.926
PA2G40.925
ILF20.917
CCT6A0.908
MPHOSPH100.908
APTX0.906
SNW10.906
EIF3B0.906
SNRPB20.906
KARS0.905

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.741
OR4F29-0.724
OR4F16-0.187
MTRNR2L6-0.187
MTRNR2L9-0.187
PRDM14-0.187
LRRC52-0.176
MTRNR2L10-0.174
NXNL1-0.17
PRAMEF17-0.168

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of DKC1 mRNA"20453058
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DKC1 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DKC1 mRNA"21346803
C0194992-nitrofluorene2-nitrofluorene results in decreased expression of DKC1 mRNA15890375
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of DKC1 mRNA"21346803
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKC1 mRNA15890375
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of DKC1 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DKC1 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of DKC1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DKC1 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DKC1 mRNA15890375
D001151ArsenicArsenic results in decreased expression of DKC1 mRNA25460668
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DKC1 mRNA20498004
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DKC1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DKC1 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of DKC1 mRNA23019147
C053541bicalutamidebicalutamide results in decreased expression of DKC1 mRNA15638997
C006780bisphenol Abisphenol A affects the expression of DKC1 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased phosphorylation of DKC1 protein22174045
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of DKC1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of DKC1 mRNA15963578
C100187chloropicrinchloropicrin affects the expression of DKC1 mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DKC1 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of DKC1 mRNA24612858
C018021cobaltous chloridecobaltous chloride results in decreased expression of DKC1 mRNA19320972|1937684
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DKC1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of DKC1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of DKC1 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of DKC1 mRNA22147139
D016572CyclosporineCyclosporine results in increased expression of DKC1 mRNA20106945|2556210
C007262deoxynivalenoldeoxynivalenol results in decreased phosphorylation of DKC1 protein23811945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DKC1 mRNA]27941970
D002945CisplatinCisplatin results in increased phosphorylation of DKC1 protein22006019
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of DKC1 mRNA15890375
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of DKC1 mRNA15890375
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of DKC1 mRNA17374397
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of DKC1 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of DKC1 mRNA21233418
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of DKC1 mRNA23649840
D005054EugenolEugenol results in decreased expression of DKC1 mRNA17374397
D018120FinasterideFinasteride results in increased expression of DKC1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of DKC1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DKC1 gene20938992
C069837fullerene C60fullerene C60 results in decreased expression of DKC1 mRNA19167457
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of DKC1 mRNA22634610
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DKC1 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DKC1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DKC1 mRNA25982114
D007854LeadLead affects the expression of DKC1 mRNA28903495
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of DKC1 mRNA21641980
D008701MethapyrileneMethapyrilene results in increased expression of DKC1 mRNA15890375
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DKC1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DKC1 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of DKC1 mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DKC1 mRNA23649840
C008493methylselenic acidmethylselenic acid results in decreased expression of DKC1 mRNA18548127
D009151Mustard GasMustard Gas results in decreased expression of DKC1 mRNA25102026
D009151Mustard GasMustard Gas results in increased phosphorylation of DKC1 protein19845377
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DKC1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of DKC1 mRNA19812364
C119536nickel acetatenickel acetate affects the expression of DKC1 mRNA12915101
C022838nickel chloridenickel chloride results in increased expression of DKC1 mRNA24612858
C029938nickel sulfatenickel sulfate results in decreased expression of DKC1 mRNA16780908|1737439
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DKC1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of DKC1 mRNA25729387
D010081OxazoloneOxazolone results in decreased expression of DKC1 mRNA17374397
D010416PentachlorophenolPentachlorophenol results in increased expression of DKC1 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of DKC1 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of DKC1 mRNA23091169
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of DKC1 mRNA15890375
C006253pirinixic acidpirinixic acid results in increased expression of DKC1 mRNA15890375
D010936Plant ExtractsPlant Extracts results in decreased expression of DKC1 mRNA24677778
D010936Plant ExtractsPlant Extracts results in increased expression of DKC1 mRNA23557933
C030984pyrenepyrene results in increased expression of DKC1 mRNA15963578
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of DKC1 mRNA19167446
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DKC1 mRNA25895662
C016104sodium bichromatesodium bichromate results in increased expression of DKC1 mRNA24612858
D018038Sodium SeleniteSodium Selenite results in increased expression of DKC1 mRNA18175754
D012999SomanSoman results in increased expression of DKC1 mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of DKC1 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DKC1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DKC1 mRNA22903824
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DKC1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DKC1 mRNA20959002
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DKC1 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DKC1 mRNA25729387
D014520UrethaneUrethane results in decreased expression of DKC1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of DKC1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DKC1 mRNA19101580
D014635Valproic AcidValproic Acid results in decreased methylation of DKC1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of DKC1 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of DKC1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003720telomerase activity-IDA12135483  
GO:0003720telomerase activitycontributes_toIDA23685356  
GO:0003723RNA binding-HDA22658674  
GO:0003723RNA binding-IPI18082603  20351177  22527283  
GO:0005515protein binding-IPI16601202  16618814  18358808  19179534  19383767  23685356  
24965446  25467444  26496610  
GO:0009982pseudouridine synthase activity-IBA21873635  
GO:0009982pseudouridine synthase activity-IMP25219674  
GO:0034513box H/ACA snoRNA binding-IPI18082603  
GO:0070034telomerase RNA binding-IC26950371  
GO:0070034telomerase RNA binding-IPI18082603  20351177  22527283  
GO ID GO Term Qualifier Evidence PubMed
GO:0000455enzyme-directed rRNA pseudouridine synthesis-IMP25219674  
GO:0000495box H/ACA snoRNA 3'-end processing-IBA21873635  
GO:0006364rRNA processing-TAS10556300  
GO:0006396RNA processing-TAS9590285  
GO:0007004telomere maintenance via telomerase-IDA23685356  
GO:0007004telomere maintenance via telomerase-IMP26950371  
GO:0007004telomere maintenance via telomerase-TAS-  
GO:0008283cell proliferation-TAS10591218  
GO:0031118rRNA pseudouridine synthesis-IBA21873635  
GO:0031120snRNA pseudouridine synthesis-IBA21873635  
GO:0032212positive regulation of telomere maintenance via telomerase-IEA-  
GO:0051973positive regulation of telomerase activity-IMP25467444  
GO:0090666scaRNA localization to Cajal body-IMP25467444  
GO:0090669telomerase RNA stabilization-IMP25467444  26950371  
GO:1904851positive regulation of establishment of protein localization to telomere-IMP25467444  
GO:1904871positive regulation of protein localization to Cajal body-HMP25467444  
GO:1904872regulation of telomerase RNA localization to Cajal body-IMP26950371  
GO:1904874positive regulation of telomerase RNA localization to Cajal body-HMP25467444  
GO:1904874positive regulation of telomerase RNA localization to Cajal body-IMP25467444  
GO:1990481mRNA pseudouridine synthesis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005697telomerase holoenzyme complex-IDA12135483  18082603  
GO:0005697telomerase holoenzyme complex-TAS20351177  
GO:0005730nucleolus-TAS10556300  
GO:0005737cytoplasm-IEA-  
GO:0031429box H/ACA snoRNP complex-IBA21873635  
GO:0031429box H/ACA snoRNP complex-IDA18082603  
GO:0031429box H/ACA snoRNP complex-TAS22527283  
GO:0072589box H/ACA scaRNP complex-TAS22527283  
GO:0090661box H/ACA telomerase RNP complex-IDA18082603  
GO:0090661box H/ACA telomerase RNP complex-TAS22527283  
KEGG ID KEGG Term
hsa03008Ribosome biogenesis in eukaryotes
Reactome ID Reactome Term Evidence
R-HSA-157579Telomere MaintenanceTAS
R-HSA-1640170Cell CycleTAS
R-HSA-171319Telomere Extension By TelomeraseTAS
R-HSA-180786Extension of TelomeresTAS
R-HSA-6790901rRNA modification in the nucleus and cytosolTAS
R-HSA-72312rRNA processingTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-8868773rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20301779Dyskeratosis Congenita (1993)Savage SA-