Gene: DLD

1738
DLDD|DLDH|E3|GCSL|LAD|PHE3
dihydrolipoamide dehydrogenase
protein-coding
7q31.1
Ensembl:ENSG00000091140 MIM:238331 Vega:OTTHUMG00000154813 UniprotKB:P09622
NG_008045.1
PubMed
0   ANCO-SNPs
ND|AD
6   
8.285e-1 (AD)  8.249e-1 (ND)   (Frontal_Cortex)
3.760e-1 (AD)  4.709e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLAT0.949
COPS80.944
ATAD10.941
LAMTOR30.935
ATXN100.935
NARS0.934
OAT0.932
UQCRC20.932
UBE2N0.932
ATMIN0.932

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.676
OR4F29-0.618
CSAG1-0.399
TRPV5-0.349
ANXA13-0.339
SPINK8-0.338
SH2D1A-0.325
MTRNR2L6-0.317
TGFB3-0.314
SGMS2-0.314

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of DLD mRNA"21354444
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DLD mRNA"21346803
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of DLD protein26194647
C0179063-dinitrobenzene[5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid]21551353
C0084005-methoxyindole-2-carboxylic acid[5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid]21551353
C0084005-methoxyindole-2-carboxylic acid5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein21551353
D000082AcetaminophenAcetaminophen results in decreased expression of DLD mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of DLD protein21329376
D000242Cyclic AMPDLD protein results in increased abundance of Cyclic AMP25981801
C029936adenosine diphosphate-ferric chelateDLD protein results in increased reduction of adenosine diphosphate-ferric chelate1454754
D000625Aminooxyacetic Acid"Aminooxyacetic Acid inhibits the reaction [S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased activity of DLD protein]"2360207
D000625Aminooxyacetic Acid"Aminooxyacetic Acid inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in decreased activity of DLD protein]"2360207
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DLD mRNA24449571
D001280AtrazineAtrazine results in decreased expression of DLD mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DLD mRNA22228805
C006780bisphenol Abisphenol A affects the expression of DLD mRNA25181051
C006780bisphenol A[Fructose co-treated with bisphenol A] results in decreased expression of DLD protein26930160
D001761BleomycinBleomycin results in increased expression of DLD protein25933445
D002065BuspironeBuspirone results in decreased expression of DLD mRNA24136188
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of DLD protein23736079
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of DLD mRNA18804290
D002104CadmiumALB protein inhibits the reaction [Cadmium results in increased phosphorylation of and results in decreased activity of DLD protein]27289041
D002104CadmiumCadmium results in increased phosphorylation of and results in decreased activity of DLD protein27289041
D002104CadmiumCadmium results in decreased expression of DLD protein25981801
D002104CadmiumCadmium results in increased expression of DLD mRNA17327699
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DLD protein24527689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DLD mRNA23741332
D019256Cadmium ChlorideCadmium Chloride affects the expression of DLD mRNA18804290
D019256Cadmium ChlorideCadmium Chloride affects the expression of DLD mRNA18636176
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DLD mRNA21699967
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DLD protein21699967|2598180
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DLD mRNA17327699
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of DLD mRNA23650126
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of DLD protein21791222
D002994ClofibrateClofibrate results in increased expression of DLD protein16470657
D002995Clofibric AcidClofibric Acid affects the expression of DLD mRNA17602206
D003300CopperCopper deficiency results in increased expression of DLD protein18993053
D016572CyclosporineCyclosporine results in decreased expression of DLD mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DLD mRNA]27941970
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of DLD mRNA"25908611
C016366dibenzothiophenedibenzothiophene results in increased expression of DLD mRNA23656968
C000944dicrotophosdicrotophos results in decreased expression of DLD mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DLD protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DLD mRNA22079256
D000431EthanolEthanol results in increased expression of DLD protein19609968
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DLD mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of DLD mRNA23649840
D015025ZearalenoneZearalenone results in increased expression of DLD protein25058043
D005485FlutamideFlutamide results in increased expression of DLD mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of DLD mRNA23649840
D005632Fructose[Fructose co-treated with bisphenol A] results in decreased expression of DLD protein26930160
D019833GenisteinGenistein results in decreased expression of DLD mRNA24967385
D005839GentamicinsGentamicins results in increased expression of DLD mRNA22061828
C001335hexachlorobutadiene"hexachlorobutadiene affects the reaction [S-pentachlorobuta-1,3-dien-yl-cysteine results in decreased activity of DLD protein]"2360207
C001335hexachlorobutadienehexachlorobutadiene results in decreased activity of DLD protein2360207
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of DLD protein23178681
D006861Hydrogen PeroxideHydrogen Peroxide promotes the reaction [DLD protein results in increased abundance of Oxygen]1454754
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of DLD protein23178681
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DLD mRNA25613284
C051890irinotecanirinotecan affects the expression of DLD mRNA20097248
D007854LeadLead results in decreased expression of DLD protein25981801
C008261lead acetatelead acetate results in decreased expression of DLD protein25981801
C052901lemongrass oillemongrass oil affects the expression of DLD mRNA25976427
D008345ManganeseManganese results in decreased expression of DLD protein25981801
C025340manganese chloridemanganese chloride results in decreased expression of DLD protein25981801
D008694MethamphetamineMethamphetamine results in increased expression of DLD protein19826936
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DLD mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DLD mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DLD mRNA"25554681
D009581NitrofuransDLD protein results in increased reduction of Nitrofurans2173592
C025256nonylphenolnonylphenol results in decreased expression of DLD protein19260726
D010100OxygenDLD protein results in increased abundance of Oxygen1454754
D010100OxygenHydrogen Peroxide promotes the reaction [DLD protein results in increased abundance of Oxygen]1454754
D010126OzoneOzone results in decreased expression of DLD mRNA16183385
D010269ParaquatParaquat results in decreased expression of DLD mRNA21371552
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of DLD protein26879310
D010578PetroleumPetroleum affects the expression of DLD mRNA25208076
D010695PhlorhizinPhlorhizin results in decreased expression of DLD mRNA22538082
D010795Phthalic AcidsPhthalic Acids results in increased expression of DLD mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of DLD mRNA23811191
D010936Plant ExtractsPlant Extracts results in increased expression of DLD mRNA23557933
C043435polylactic acid-polyglycolic acid copolymer[Rotenone co-treated with polylactic acid-polyglycolic acid copolymer] results in decreased activity of DLD protein23816754
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DLD mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DLD mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of DLD mRNA11678601
D011374ProgesteroneDLD protein results in increased abundance of Progesterone25981801
D011794QuercetinQuercetin results in decreased expression of DLD mRNA21632981
C059514resveratrolresveratrol affects the secretion of DLD protein24802182
C059514resveratrolresveratrol results in increased expression of DLD mRNA15582268
D015474IsotretinoinIsotretinoin results in decreased expression of DLD mRNA20436886
C089730rosiglitazonerosiglitazone affects the expression of DLD mRNA22013433
C089730rosiglitazonerosiglitazone affects the expression of DLD protein21347706
C089730rosiglitazonerosiglitazone results in increased expression of DLD mRNA15520860
C089730rosiglitazonerosiglitazone results in increased expression of DLD protein15520860
D012402Rotenone[Rotenone co-treated with polylactic acid-polyglycolic acid copolymer] results in decreased activity of DLD protein23816754
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"Aminooxyacetic Acid inhibits the reaction [S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased activity of DLD protein]"2360207
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased activity of DLD protein"2360207
C039961S-(1,2-dichlorovinyl)cysteine"Aminooxyacetic Acid inhibits the reaction [S-(1,2-dichlorovinyl)cysteine results in decreased activity of DLD protein]"2360207
C039961S-(1,2-dichlorovinyl)cysteine"S-(1,2-dichlorovinyl)cysteine results in decreased activity of DLD protein"2360207
D012524SarinSarin results in decreased expression of DLD protein28973502
D012906SmokeSmoke results in increased metabolism of DLD protein19133281
C039330S-pentachlorobuta-1,3-dien-yl-cysteine"hexachlorobutadiene affects the reaction [S-pentachlorobuta-1,3-dien-yl-cysteine results in decreased activity of DLD protein]"2360207
C039330S-pentachlorobuta-1,3-dien-yl-cysteine"S-pentachlorobuta-1,3-dien-yl-cysteine results in decreased activity of DLD protein"2360207
D013311StreptozocinStreptozocin results in increased expression of DLD protein21136691
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in increased expression of DLD protein]21136691
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DLD mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DLD mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of DLD mRNA22378314
D008063Thioctic Acid[5-methoxyindole-2-carboxylic acid results in decreased activity of DLD protein] inhibits the reaction [3-dinitrobenzene results in decreased abundance of Thioctic Acid]21551353
D014212TretinoinTretinoin results in decreased expression of DLD mRNA18230668
C012589trichostatin Atrichostatin A results in decreased expression of DLD mRNA15901671
D014266TrientineTrientine inhibits the reaction [Streptozocin results in increased expression of DLD protein]21136691
D014415TunicamycinTunicamycin results in decreased expression of DLD mRNA22378314
D014635Valproic AcidValproic Acid results in decreased expression of DLD mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of DLD mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DLD gene25487561
C029297vinylidene chloridevinylidene chloride results in decreased expression of DLD mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of DLD mRNA"25208076
D015032ZincZinc deficiency results in increased expression of DLD protein9573368
D015032ZincZinc results in increased activity of DLD protein17768676

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004148dihydrolipoyl dehydrogenase activity-IDA16442803  
GO:0004148dihydrolipoyl dehydrogenase activity-TAS-  
GO:0005515protein binding-IPI16263718  16442803  
GO:0009055electron transfer activity-IEA-  
GO:0034604pyruvate dehydrogenase (NAD+) activitycontributes_toIDA9242632  
GO:0043544lipoamide binding-IEA-  
GO:0050660flavin adenine dinucleotide binding-IEA-  
GO:0051287NAD binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:00061032-oxoglutarate metabolic process-IEA-  
GO:0006120mitochondrial electron transport, NADH to ubiquinone-IEA-  
GO:0006508proteolysis-IEA-  
GO:0007369gastrulation-IEA-  
GO:0007568aging-IEA-  
GO:0009106lipoate metabolic process-IEA-  
GO:0042391regulation of membrane potential-IEA-  
GO:0045454cell redox homeostasis-IEA-  
GO:0048240sperm capacitation-IEA-  
GO:0051068dihydrolipoamide metabolic process-IEA-  
GO:0061732mitochondrial acetyl-CoA biosynthetic process from pyruvate-IC9242632  
GO:0106077histone succinylation-IDA29211711  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA29211711  
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-HDA20833797  
GO:0005739mitochondrion-IDA29211711  
GO:0005759mitochondrial matrix-TAS-  
GO:0031514motile cilium-IEA-  
GO:0043159acrosomal matrix-IEA-  
GO:0043209myelin sheath-IEA-  
GO:0045252oxoglutarate dehydrogenase complex-IDA29211711  
GO:0045254pyruvate dehydrogenase complex-IDA9242632  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00020Citrate cycle (TCA cycle)
hsa00260Glycine, serine and threonine metabolism
hsa00280Valine, leucine and isoleucine degradation
hsa00620Pyruvate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-204174Regulation of pyruvate dehydrogenase (PDH) complexTAS
R-HSA-389661Glyoxylate metabolism and glycine degradationTAS
R-HSA-5362517Signaling by Retinoic AcidTAS
R-HSA-6783984Glycine degradationTAS
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-70268Pyruvate metabolismTAS
R-HSA-70895Branched-chain amino acid catabolismTAS
R-HSA-71064Lysine catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-71403Citric acid cycle (TCA cycle)TAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27225143Chronic Bronchitis and Chronic Obstructive Pulmonary Disease (COPD) Among Textile Workers in Karachi, Pakistan. (2016 May)Nafees AAJ Coll Physicians Surg Pak
21210228Nicotine enhances colon cancer cell migration by induction of fibronectin. (2011 Jun)Wei PLAnn Surg Oncol
19474681Tobacco-specific carcinogen enhances colon cancer cell migration through alpha7-nicotinic acetylcholine receptor. (2009 Jun)Wei PLAnn Surg
27993294The effect of habitual waterpipe tobacco smoking on pulmonary function and exercise capacity in young healthy males: A pilot study. (2017 Jan)Hawari FIRespir Med
12584750Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines. (2003 Apr 20)Wang WInt J Cancer
26826017HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL. (2016 Apr)Regeling ABiochim Biophys Acta