Gene info: ID 174

Gene: AFP

GENE ID: 174

Synonyms: AFPD|FETA|HPAFP

Description: alpha fetoprotein

Gene type: protein-coding

Location: 4q13.3

dbXrefs: Ensembl:ENSG00000081051 MIM:104150 Vega:OTTHUMG00000130011 UniprotKB:P02771

RefSeq: NG_023028.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 81

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.519e-1 (AD) 7.440e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EXTL2	0.641
ASAH2B	0.64
NELL1	0.638
VSTM5	0.638
STAMBPL1	0.638
RBM11	0.637
BMPER	0.636
SEPT6	0.635
INSM2	0.634
PPL	0.634

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MYOM1	-0.431
HEY2	-0.42
MBNL3	-0.415
EYA2	-0.415
HPR	-0.412
ASB4	-0.409
STON2	-0.404
LRAT	-0.402
TMEM100	-0.402
NFIA	-0.4

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C045575	1,2,4-triazole	"1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]"	28693887
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Diethylnitrosamine] results in increased expression of AFP mRNA"	21391223
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of AFP mRNA"	27413110
C035702	17-desoxyestradiol	17-desoxyestradiol binds to AFP protein	23013281\|2534933
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of AFP mRNA	19933214
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AFP mRNA"	19114083
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of AFP mRNA"	20713471
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of AFP mRNA"	21346803
C016617	2-nitropropane	2-nitropropane results in increased expression of AFP protein	15804453
C016617	2-nitropropane	diphenyldiselenide inhibits the reaction [2-nitropropane results in increased expression of AFP protein]	15804453
C033932	2-sec-butylphenol	2-sec-butylphenol binds to AFP protein	23013281\|2534933
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of AFP mRNA"	20959002
C012587	3,5,6-trichloro-2-pyridinol	"3,5,6-trichloro-2-pyridinol affects the expression of AFP mRNA"	25137620
C012587	3,5,6-trichloro-2-pyridinol	"3,5,6-trichloro-2-pyridinol results in increased expression of AFP mRNA"	23220036
C468910	3-hydroxyflavanone	3-hydroxyflavanone binds to AFP protein	23013281\|2534933
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane affects the expression of AFP mRNA"	9327722
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFP mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFP mRNA"	27188386
C527833	4-(heptyloxy)phenol	4-(heptyloxy)phenol binds to AFP protein	25349334
C427824	4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl	"4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl binds to AFP protein"	23013281\|2534933
C451019	4-hydroxychalcone	4-hydroxychalcone binds to AFP protein	23013281\|2534933
C561448	4'-hydroxychalcone	4'-hydroxychalcone binds to AFP protein	23013281\|2534933
C561123	4'-hydroxyflavanone	4'-hydroxyflavanone binds to AFP protein	23013281\|2534933
C041594	4-nonylphenol	4-nonylphenol binds to AFP protein	23013281\|2534933
C080417	4-octylphenol	4-octylphenol binds to AFP protein	23013281\|2534933
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFP mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFP mRNA"	27188386
C059353	7-hydroxyflavanone	7-hydroxyflavanone binds to AFP protein	23013281\|2534933
D000082	Acetaminophen	Acetaminophen results in decreased expression of AFP protein	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of AFP mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of AFP protein	70250
D019342	Acetic Acid	Acetic Acid results in decreased expression of AFP protein	21296659
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]	18098314
D012436	S-Adenosylmethionine	S-Adenosylmethionine results in decreased expression of AFP mRNA	18098314
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of AFP mRNA	20036727
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of AFP gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of AFP mRNA	20036727\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of AFP mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of AFP mRNA	11133813
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of AFP protein	28442411
D016604	Aflatoxin B1	ebselen inhibits the reaction [Aflatoxin B1 results in increased expression of AFP mRNA]	11133813
C006463	allyl alcohol	allyl alcohol results in increased expression of AFP protein	70250
C006463	allyl alcohol	allyl alcohol results in increased expression of AFP protein	61145
C034499	allyl formate	allyl formate results in increased expression of AFP protein	61145
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of AFP mRNA	21298039
D000607	Aminoacetonitrile	Aminoacetonitrile inhibits the reaction [Carbon Tetrachloride results in increased expression of AFP protein]	61145
D000638	Amiodarone	Amiodarone results in increased expression of AFP mRNA	24489787
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of AFP mRNA	16483693
D047310	Apigenin	Apigenin binds to AFP protein	23013281\|2534933
D001149	Arsenates	Arsenates results in increased expression of AFP mRNA	15345372
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of AFP mRNA	23382965
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of AFP protein	23382965
C015001	arsenite	arsenite results in increased expression of AFP mRNA	15345372\|1899193
D001374	Azacitidine	Azacitidine results in increased expression of AFP mRNA	27590069
C406592	azaspiracid	azaspiracid results in decreased expression of AFP mRNA	28939011
C006680	baicalein	baicalein binds to AFP protein	23013281\|2534933
C487081	belinostat	belinostat results in decreased expression of AFP mRNA	26272509
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of AFP mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of AFP mRNA	19770486\|2071347
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of AFP mRNA"	26238291
C057775	benzylparaben	benzylparaben binds to AFP protein	23013281\|2534933
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of AFP protein	18497072
D004958	Estradiol	AFP protein results in increased susceptibility to Estradiol	22720075
D004958	Estradiol	Diethylstilbestrol inhibits the reaction [Estradiol binds to AFP protein]	9748407
D004958	Estradiol	Estradiol binds to AFP protein	23013281\|2534933
C006780	bisphenol A	bisphenol A results in increased expression of AFP mRNA	27271280
C006780	bisphenol A	IGF1 protein affects the reaction [bisphenol A results in increased expression of AFP mRNA]	27271280
C006780	bisphenol A	bisphenol A results in increased expression of AFP mRNA	17785945
C006780	bisphenol A	bisphenol A affects the expression of AFP mRNA	14967926
C006780	bisphenol A	bisphenol A results in increased expression of AFP protein	26146954
C006780	bisphenol A	bisphenol A results in decreased expression of AFP mRNA	25181051
C099813	bromochloroacetic acid	bromochloroacetic acid results in decreased expression of AFP protein	21296659
C083806	brucine	brucine inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]	24060683
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of AFP mRNA	15345372
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of AFP mRNA	25993096
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of AFP promoter	22457795
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of AFP mRNA	17668883\|2328805
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of AFP protein	16965562\|70250
D002251	Carbon Tetrachloride	Diethylnitrosamine promotes the reaction [Carbon Tetrachloride results in increased expression of AFP mRNA]	23288052
D002251	Carbon Tetrachloride	"1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]"	28693887
D002251	Carbon Tetrachloride	[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of AFP protein	11813887
D002251	Carbon Tetrachloride	Aminoacetonitrile inhibits the reaction [Carbon Tetrachloride results in increased expression of AFP protein]	61145
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein	28935427
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of AFP protein	16965562\|61145
D002251	Carbon Tetrachloride	[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein	28693887
D002251	Carbon Tetrachloride	Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]	28935427
D002251	Carbon Tetrachloride	"N,N'-diphenyl-4-phenylenediamine inhibits the reaction [Carbon Tetrachloride results in increased expression of AFP protein]"	61145
C524865	carfilzomib	carfilzomib inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]	24632418
D002599	Chalcone	Chalcone binds to AFP protein	23013281\|2534933
D002737	Chloroprene	Chloroprene results in increased expression of AFP mRNA	23125180
C023676	chloroquine diphosphate	chloroquine diphosphate inhibits the reaction [Thioacetamide results in increased expression of AFP protein]	29133031
C023676	chloroquine diphosphate	chloroquine diphosphate promotes the reaction [Doxorubicin inhibits the reaction [Thioacetamide results in increased expression of AFP protein]]	29133031
C023676	chloroquine diphosphate	Doxorubicin promotes the reaction [chloroquine diphosphate inhibits the reaction [Thioacetamide results in increased expression of AFP protein]]	29133031
D002746	Chlorpromazine	Chlorpromazine analog results in decreased expression of AFP mRNA	15924885
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of AFP mRNA	25137620
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AFP mRNA	20938992
D002794	Choline	[2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of AFP protein	6187438
C043561	chrysin	chrysin binds to AFP protein	23013281\|2534933
D002994	Clofibrate	Clofibrate results in decreased expression of AFP mRNA	17585979
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of AFP mRNA	24386269
D003042	Cocaine	Cocaine results in increased expression of AFP mRNA	27899881
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of AFP mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of AFP mRNA	19549813
D003375	Coumestrol	Coumestrol binds to AFP protein	23013281\|2534933
D003471	Cuprizone	Cuprizone results in increased expression of AFP mRNA	27523638
D003520	Cyclophosphamide	Cyclophosphamide affects the expression of AFP protein	6177358
D016572	Cyclosporine	Cyclosporine results in decreased expression of AFP mRNA	25562108\|2798913
D016572	Cyclosporine	Cyclosporine results in increased expression of AFP mRNA	20106945
D003997	Dicarbethoxydihydrocollidine	Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA	18098314
D003997	Dicarbethoxydihydrocollidine	S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]	18098314
C000944	dicrotophos	dicrotophos results in decreased expression of AFP mRNA	28302478
D004028	Dienestrol	Dienestrol binds to AFP protein	23013281\|2534933
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of AFP mRNA	20307648
C014476	diethyl maleate	diethyl maleate results in increased expression of AFP mRNA	25270620
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of AFP mRNA	21527772
D004052	Diethylnitrosamine	"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Diethylnitrosamine] results in increased expression of AFP mRNA"	21391223
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine promotes the reaction [Carbon Tetrachloride results in increased expression of AFP mRNA]	23288052
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of AFP mRNA	15766596\|2453584
D004052	Diethylnitrosamine	"1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]"	28693887
D004052	Diethylnitrosamine	brucine inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]	24060683
D004052	Diethylnitrosamine	[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein	28935427
D004052	Diethylnitrosamine	carfilzomib inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]	24632418
D004052	Diethylnitrosamine	Diethylnitrosamine affects the expression of AFP mRNA	19822196
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein	28693887
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein	28414157
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of AFP mRNA	27565560
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of AFP protein	11818250\|1939465
D004052	Diethylnitrosamine	formylchromone analog inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]	24954034
D004052	Diethylnitrosamine	FR 118487 inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]	19394651
D004052	Diethylnitrosamine	Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]	28935427
D004052	Diethylnitrosamine	myrrh resin analog inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein]	28414157
D004052	Diethylnitrosamine	Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein]	28414157
D004052	Diethylnitrosamine	Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]	19446540
D004052	Diethylnitrosamine	thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]	24012840
C007379	diethyl phthalate	diethyl phthalate binds to AFP protein	23013281\|2534933
D004054	Diethylstilbestrol	[Diethylstilbestrol co-treated with sodium arsenite] results in increased expression of AFP mRNA	19665456
D004054	Diethylstilbestrol	Diethylstilbestrol binds to AFP protein	23013281\|2534933
D004054	Diethylstilbestrol	Diethylstilbestrol inhibits the reaction [Estradiol binds to AFP protein]	9748407
C048587	diethylstilbestrol monophosphate	diethylstilbestrol monophosphate results in increased expression of AFP protein	2442958
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of AFP mRNA	17072980
C024629	dimethyl phthalate	dimethyl phthalate binds to AFP protein	23013281\|2534933
C004839	dioxybenzone	dioxybenzone binds to AFP protein	23013281\|2534933
C061132	diphenyldiselenide	diphenyldiselenide inhibits the reaction [2-nitropropane results in increased expression of AFP protein]	15804453
D004317	Doxorubicin	Doxorubicin results in decreased expression of AFP protein	21251210
D004317	Doxorubicin	sodium nitrate inhibits the reaction [Doxorubicin results in decreased expression of AFP protein]	21251210
D004317	Doxorubicin	chloroquine diphosphate promotes the reaction [Doxorubicin inhibits the reaction [Thioacetamide results in increased expression of AFP protein]]	29133031
D004317	Doxorubicin	Doxorubicin inhibits the reaction [Thioacetamide results in increased expression of AFP protein]	29133031
D004317	Doxorubicin	Doxorubicin promotes the reaction [chloroquine diphosphate inhibits the reaction [Thioacetamide results in increased expression of AFP protein]]	29133031
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal affects the expression of AFP protein"	19850985
C042986	ebselen	ebselen inhibits the reaction [Aflatoxin B1 results in increased expression of AFP mRNA]	11133813
C070609	EMD 53998	EMD 53998 analog results in decreased expression of AFP mRNA	24977338
D060754	Equol	Equol binds to AFP protein	23013281\|2534933
D004964	Estriol	Estriol results in increased expression of AFP protein	18497072
D004964	Estriol	Estriol results in increased expression of AFP protein	2470397
D004964	Estriol	Estriol binds to AFP protein	23013281\|2534933
D004970	Estrone	Estrone binds to AFP protein	23013281\|2534933
D000431	Ethanol	Ethanol results in decreased expression of AFP protein	24646710
D004997	Ethinyl Estradiol	Ethinyl Estradiol binds to AFP protein	23013281\|2534933
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of AFP mRNA	17108234
D008656	Mestranol	Mestranol binds to AFP protein	23013281\|2534933
D005001	Ethionine	Ethionine results in increased expression of AFP protein	61145
C017875	fisetin	fisetin binds to AFP protein	23013281\|2534933
C028610	flavanone	flavanone binds to AFP protein	23013281\|2534933
D005419	Flavonoids	Flavonoids results in increased expression of AFP mRNA	18035473
D015073	2-Acetylaminofluorene	[2-Acetylaminofluorene co-treated with Carbon Tetrachloride] affects the expression of AFP protein	11813887
D015073	2-Acetylaminofluorene	[2-Acetylaminofluorene co-treated with Choline deficiency] results in increased expression of AFP protein	6187438
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of AFP mRNA	17538966
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of AFP protein	11350689\|1513385
D005472	Fluorouracil	Fluorouracil results in decreased expression of AFP	20448262
D005472	Fluorouracil	Fluorouracil results in decreased expression of AFP mRNA	26272751
D005472	Fluorouracil	Fluorouracil results in increased expression of AFP protein	21296659
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AFP mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of AFP protein	16966304
C502480	formylchromone	formylchromone analog inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]	24954034
C096036	FR 118487	FR 118487 inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]	19394651
C039281	furan	furan results in increased expression of AFP mRNA	24183702
C039281	furan	furan results in increased expression of AFP mRNA	25539665\|2619464
D005688	Galactosamine	Galactosamine results in increased expression of AFP protein	16965562\|61145
C056507	gemcitabine	gemcitabine results in decreased expression of AFP protein	20531411
D005944	Glucosamine	Glucosamine results in increased expression of AFP mRNA	17178593
D005947	Glucose	Glucose results in increased expression of AFP mRNA	17178593
D006063	Chorionic Gonadotropin	Chorionic Gonadotropin results in increased expression of AFP protein	18497072
D006569	Hesperidin	Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]	28935427
D006589	Hexestrol	Hexestrol binds to AFP protein	23013281
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased expression of AFP mRNA	19376150
C020758	indium trichloride	indium trichloride results in decreased expression of AFP protein	19539025
C040920	isoliquiritigenin	isoliquiritigenin binds to AFP protein	23013281
C410337	K 7174	K 7174 results in decreased expression of AFP mRNA	24086573
C006552	kaempferol	kaempferol results in decreased expression of AFP protein	26683311
C006552	kaempferol	kaempferol binds to AFP protein	23013281\|2534933
D007649	Ketamine	Ketamine results in increased expression of AFP mRNA	20080153
D064704	Levofloxacin	Levofloxacin results in decreased expression of AFP mRNA	24136188
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of AFP mRNA	27339419
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of AFP mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of AFP mRNA	26378955
D008345	Manganese	Manganese results in decreased expression of AFP mRNA	26745496
C025340	manganese chloride	manganese chloride results in decreased expression of AFP mRNA	26745496
D009637	Masoprocol	Masoprocol binds to AFP protein	23013281\|2534933
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFP mRNA"	27188386
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AFP mRNA	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of AFP mRNA	23179753\|2718838
D008767	Methylmercury Compounds	[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of AFP mRNA	20020106
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of AFP mRNA	20020106
D008770	Methylnitrosourea	AFP protein modified form results in decreased susceptibility to Methylnitrosourea	16322315
C006429	monobenzone	monobenzone binds to AFP protein	23013281
C091888	monoisoamyl-2,3-dimercaptosuccinate	"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of AFP mRNA]"	19615344
C091888	monoisoamyl-2,3-dimercaptosuccinate	"monoisoamyl-2,3-dimercaptosuccinate results in decreased expression of AFP mRNA"	19615344
C020300	monomethylarsonic acid	monomethylarsonic acid results in increased expression of AFP mRNA	15345372
C523799	MRK 003	AFP results in increased susceptibility to MRK 003	19903844
C040015	myricetin	myricetin binds to AFP protein	23013281\|2534933
C587573	myrrh resin	myrrh resin analog inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein]	28414157
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of AFP mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of AFP mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of AFP mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of AFP mRNA"	25554681
C005273	naringenin	naringenin binds to AFP protein	23013281\|2534933
C502362	N-butyrylglucosamine	N-butyrylglucosamine results in increased expression of AFP mRNA	16142878
D009532	Nickel	Nickel analog results in decreased expression of AFP protein	25144474
C022838	nickel chloride	nickel chloride affects the expression of AFP mRNA	22110744
C004845	N,N'-diphenyl-4-phenylenediamine	"N,N'-diphenyl-4-phenylenediamine inhibits the reaction [Carbon Tetrachloride results in increased expression of AFP protein]"	61145
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of AFP protein	16965562
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of AFP mRNA	20971185
D009705	Nucleosides	Nucleosides results in increased expression of AFP mRNA	15173389
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of AFP mRNA"	25137620
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of AFP mRNA"	23220036
D010126	Ozone	TTPA protein affects the reaction [Ozone results in increased expression of AFP mRNA]	19555225
C055778	panaxydol	panaxydol results in decreased secretion of AFP protein	19450571
D052638	Particulate Matter	Particulate Matter results in decreased expression of AFP protein	25144474
D010400	Penicillin G	Penicillin G affects the expression of AFP mRNA	25137620
D010400	Penicillin G	Penicillin G results in decreased expression of AFP mRNA	26272751
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP mRNA	24535843
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of AFP mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of AFP mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of AFP mRNA	19482888
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein	28414157
D010634	Phenobarbital	myrrh resin analog inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein]	28414157
D010634	Phenobarbital	Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein]	28414157
D019800	Phenol	Phenol results in increased expression of AFP protein	16966304
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AFP mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of AFP mRNA	26272509
D010672	Phenytoin	Phenytoin results in decreased expression of AFP mRNA	14741686
D010672	Phenytoin	Phenytoin results in decreased expression of AFP mRNA	26272751
D010693	Phloretin	Phloretin binds to AFP protein	23013281\|2534933
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of AFP mRNA	19710929
C006253	pirinixic acid	pirinixic acid affects the expression of AFP mRNA	23811191
D010936	Plant Extracts	Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein]	28414157
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]	19446540
D011078	Polychlorinated Biphenyls	[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of AFP mRNA	20020106
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in increased expression of AFP mRNA	20020106
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of AFP mRNA	27413110\|2890350
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of AFP protein	18497072
D011374	Progesterone	AFP protein results in increased susceptibility to Progesterone	22720075
D011794	Quercetin	Quercetin binds to AFP protein	23013281\|2534933
D012439	Saccharin	Saccharin results in increased expression of AFP mRNA	26272751
D012834	Silver	Silver results in increased expression of AFP mRNA	27131904
D019821	Simvastatin	Simvastatin results in increased expression of AFP mRNA	10365819
C017947	sodium arsenite	"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of AFP mRNA]"	19615344
C017947	sodium arsenite	sodium arsenite results in decreased expression of AFP mRNA	19615344
C017947	sodium arsenite	[Diethylstilbestrol co-treated with sodium arsenite] results in increased expression of AFP mRNA	19665456
C017947	sodium arsenite	sodium arsenite affects the expression of AFP mRNA	16507464
C017947	sodium arsenite	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of AFP mRNA	16368122
C017947	sodium arsenite	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of AFP protein	16368122
C017947	sodium arsenite	sodium arsenite results in increased expression of AFP mRNA	14691202\|1527641
C017947	sodium arsenite	sodium arsenite results in increased expression of AFP protein	16507464\|1707718
C017947	sodium arsenite	sodium arsenite results in increased expression of AFP mRNA	16876216
C017947	sodium arsenite	sodium arsenite results in increased expression of AFP protein	16876216
C031618	sodium nitrate	sodium nitrate inhibits the reaction [Doxorubicin results in decreased expression of AFP protein]	21251210
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of AFP mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of AFP mRNA	26378955
C028226	taleranol	taleranol binds to AFP protein	23013281\|2534933
D013629	Tamoxifen	Tamoxifen affects the expression of AFP mRNA	20937368
D013629	Tamoxifen	Tamoxifen results in increased expression of AFP mRNA	25123088
C003377	taxifolin	taxifolin binds to AFP protein	23013281\|2534933
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of AFP mRNA	20106945
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of AFP mRNA	16083274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of AFP protein	16083274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of AFP mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of AFP mRNA	19933214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of AFP protein	28922406
D013749	Tetrachlorodibenzodioxin	AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of AFP mRNA]	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of AFP mRNA	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of AFP mRNA	15644576
D013755	Tetradecanoylphorbol Acetate	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of AFP mRNA	16368122
D013755	Tetradecanoylphorbol Acetate	[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of AFP protein	16368122
D013853	Thioacetamide	chloroquine diphosphate inhibits the reaction [Thioacetamide results in increased expression of AFP protein]	29133031
D013853	Thioacetamide	chloroquine diphosphate promotes the reaction [Doxorubicin inhibits the reaction [Thioacetamide results in increased expression of AFP protein]]	29133031
D013853	Thioacetamide	Doxorubicin inhibits the reaction [Thioacetamide results in increased expression of AFP protein]	29133031
D013853	Thioacetamide	Doxorubicin promotes the reaction [chloroquine diphosphate inhibits the reaction [Thioacetamide results in increased expression of AFP protein]]	29133031
D013853	Thioacetamide	Thioacetamide results in increased expression of AFP protein	29133031\|61145
C003466	thymoquinone	thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]	24012840
C009495	titanium dioxide	titanium dioxide results in increased expression of AFP mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of AFP protein	19478969
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of AFP mRNA	20133372
D014212	Tretinoin	Tretinoin results in increased expression of AFP mRNA	21934132
D014212	Tretinoin	Tretinoin affects the expression of AFP mRNA	25137620
D014212	Tretinoin	Tretinoin results in increased expression of AFP mRNA	16619266\|2627275
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of AFP mRNA	29024780
D014508	Urea	Urea results in increased expression of AFP protein	16966304
D014635	Valproic Acid	Valproic Acid results in decreased expression of AFP mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in increased expression of AFP mRNA	25084468\|2800136
D014635	Valproic Acid	Valproic Acid results in decreased expression of AFP mRNA	26272751
D014635	Valproic Acid	Valproic Acid results in increased expression of AFP mRNA	25137620
C029297	vinylidene chloride	vinylidene chloride results in increased expression of AFP mRNA	26682919
D014801	Vitamin A	Vitamin A deficiency results in increased expression of AFP mRNA	7519440
C029659	zearalenol	zearalenol binds to AFP protein	23013281\|2534933
D015029	Zeranol	Zeranol binds to AFP protein	25349334
C016837	zinc chloride	zinc chloride results in decreased expression of AFP mRNA	18947441
C088658	zoledronic acid	zoledronic acid results in increased expression of AFP protein	28871336

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	26808496
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001542	ovulation from ovarian follicle	-	IEA	-
GO:0042448	progesterone metabolic process	-	IEA	-
GO:0043687	post-translational protein modification	-	TAS	-
GO:0044267	cellular protein metabolic process	-	TAS	-
GO:0060395	SMAD protein signal transduction	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IEA	-
GO:0005788	endoplasmic reticulum lumen	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-8957275	Post-translational protein phosphorylation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26190621	Spontaneous regression of diffuse intrahepatic recurrence with portal vein tumor thrombus after resection of hepatocellular carcinoma. (2011 Feb)	Okano A	Clin J Gastroenterol
8904471	Screening for Down's syndrome. (1995)	Chard T	J Perinat Med
21480302	Impact of smoking on maternal serum markers and prenatal screening in the first and second trimesters. (2011 Jun)	Zhang J	Prenat Diagn
25024612	Prognostic significance of preoperative fibrinogen in patients with colon cancer. (2014 Jul 14)	Sun ZQ	World J Gastroenterol
24159567	Epidemiology and surveillance of hepatocellular carcinoma. (2012 Jun)	Kim DY	Liver Cancer
22969856	Smoking and hepatocellular carcinoma mortality. (2012 Jan)	Siegel AB	Exp Ther Med
18609108	Reference intervals for carcinoembryonic antigen (CEA), CA125, MUC1, Alfa-foeto-protein (AFP), neuron-specific enolase (NSE) and CA19.9 from the NORIP study. (2008)	Bjerner J	Scand J Clin Lab Invest
7691391	False elevations of alpha-fetoprotein associated with liver dysfunction in germ cell tumors. (1993 Oct 15)	Germa JR	Cancer
21952001	First-trimester screening for trisomy 21 using alpha-fetoprotein. (2011)	Bredaki FE	Fetal Diagn Ther
24095974	Factors that affect accuracy of alpha-fetoprotein test in detection of hepatocellular carcinoma in patients with cirrhosis. (2014 May)	Gopal P	Clin Gastroenterol Hepatol
25785114	Risk factors for naturally-occurring early-onset hepatocellular carcinoma in patients with HBV-associated liver cirrhosis in China. (2015)	Li Y	Int J Clin Exp Med
27124371	Impact of maternal serum levels of Visfatin, AFP, PAPP-A, sFlt-1 and PlGF at 11-13 weeks gestation on small for gestational age births. (2017 Mar)	Birdir C	J Matern Fetal Neonatal Med
1711749	[Significant effects on alpha-fetoprotein (AFP) concentration in maternal serum in pregnancy]. (1991)	Greiff R	Zentralbl Gynakol
6083799	Does smoking influence serum alpha-fetoprotein levels in mid-trimester pregnancies? (1984 Dec)	Haddow JE	Br J Obstet Gynaecol
23623598	Association of folate deficiency and selected tumor marker concentrations in long-term hexavalent chromium exposed population. (2014 Jan)	Wang TC	Int J Hyg Environ Health
14706592	Predictors of development of anastomotic femoral pseudoaneurysms after aortobifemoral reconstruction for abdominal aortic aneurysm. (2004 Jan)	Ylonen K	Am J Surg
12399135	Hepatoid adenocarcinoma in the lung. (2002 Nov)	Hayashi Y	Lung Cancer
11026763	Risk factors for hepatocellular carcinoma in patients with liver cirrhosis. (2000 Jul)	Macias Rodriguez MA	Rev Esp Enferm Dig
28049244	False Positive Diagnosis of Hepatocellular Carcinoma in Liver Resection Patients. (2017 Feb)	Lee H	J Korean Med Sci
19890679	Serum alpha-fetoprotein levels in liver steatosis. (2009 Dec)	Babali A	Hepatol Int
7682315	Cigarette smoking and levels of maternal serum alpha-fetoprotein, unconjugated estriol, and hCG: impact on Down syndrome screening. (1993 May)	Palomaki GE	Obstet Gynecol
6185894	The fetal serum alpha-fetoprotein and its relationship to immunoglobulins and birth weight at term. (1983 Feb)	Cederqvist LL	Obstet Gynecol
20973883	Combined pre-S deletion and core promoter mutations related to hepatocellular carcinoma: A nested case-control study in China. (2011 Jan)	Qu LS	Hepatol Res
21809268	[Human placental alkaline phosphatase (hPLAP) is the most frequently elevated serum marker in testicular cancer]. (2011 Sep)	Neumann A	Aktuelle Urol
23885830	Implication of arylamine N-acetyltransferase (NAT2) polymorphism on levels of tumour markers CEA, AFP, CA 125, CA 19.9, and CA 15.3. (1999)	Necat Yilmaz A Sukru Aynacioglu Binnur Erbagci Ingolf Cascorbi Ivar Roots	Biomarkers
23247324	Improving screening for hepatocellular carcinoma by incorporating data on levels of alpha-fetoprotein, over time. (2013 Apr)	Lee E	Clin Gastroenterol Hepatol
6210034	Immunohistochemistry of hepatocellular carcinoma associated with cirrhosis. (1984 Nov-Dec)	Espinoza CG	Ann Clin Lab Sci
22156386	Maternal serum alpha-fetoprotein in normal pregnancy at 11-13 weeks' gestation. (2011)	Bredaki FE	Fetal Diagn Ther
21337313	Reference intervals for serum alpha-fetoprotein and carcinoembryonic antigen in Chinese Han ethnic males from the Fangchenggang Area Male Health and Examination Survey. (2011 Jan-Mar)	Qin X	Int J Biol Markers
24030743	Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature. (2014 Apr)	Haninger DM	Mod Pathol
18594168	[Establishment of reference intervals of tumor markers in Korean adults]. (2008 Jun)	Woo HY	Korean J Lab Med
20844957	Surveillance for hepatocellular carcinoma: development and validation of an algorithm to classify tests in administrative and laboratory data. (2010 Nov)	Richardson P	Dig Dis Sci
6202440	Alpha-fetoprotein assay in patients treated with low-dose oral contraceptives. (1984)	Dessole S	Clin Exp Obstet Gynecol
1376485	[Early diagnosis of hepatocellular carcinoma]. (1992 Jun 9)	Blum HE	Schweiz Rundsch Med Prax
9494915	Antenatal screening for Down's syndrome. (1997)	Wald NJ	J Med Screen
23845775	Evaluation of the impact of maternal smoking on ultrasound and endocrinological markers of first trimester placentation. (2013 Sep)	Jauniaux E	Early Hum Dev
14603825	Clinical and aetiological profile of hepatoma at a tertiary care centre. (2003 Apr-Jun)	Joshi N	Trop Gastroenterol
2420339	High maternal serum alpha-fetoprotein and low birthweight. A study concerning possible correlation between maternal weight, smoking, and serum alpha-fetoprotein and subsequent birthweight and gestational age. (1985 Apr)	Secher NJ	Am J Perinatol
10817024	The prediction of adverse pregnancy outcome using low unconjugated estriol in the second trimester of pregnancy without risk of Down's syndrome. (2000 Apr)	Kim SY	Yonsei Med J
9556039	The influence of smoking on maternal serum AFP and free beta hCG levels and the impact on screening for Down syndrome. (1998 Mar)	Spencer K	Prenat Diagn
25023357	Identification of two clinical hepatocellular carcinoma patient phenotypes from results of standard screening parameters. (2014 Jun)	Carr BI	Semin Oncol
22338215	[To investigate the relationship of alcohol intake and hepatocellular carcinoma among patients with hepatitis B virus infection]. (2011 Oct)	Zhu GT	Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
9491867	Association of low unconjugated estriol in the second trimester and adverse pregnancy outcome. (1998 Mar)	Kowalczyk TD	Obstet Gynecol
24440975	Peripheral blood microvesicles are potential biomarkers for hepatocellular carcinoma. (2013)	Wang W	Cancer Biomark
17288190	[Influence of tobacco smoking on the level of alfafetoprotein and circuleting immune complexes in serum of smokinig and nonsmoking women being in second trimester of pregnancy]. (2006)	Golda R	Przegl Lek
1716979	Cotinine-assisted intervention in pregnancy to reduce smoking and low birthweight delivery. (1991 Sep)	Haddow JE	Br J Obstet Gynaecol
25652769	Serum alpha-fetoprotein in the three trimesters of pregnancy: effects of maternal characteristics and medical history. (2015 Jul)	Bredaki FE	Ultrasound Obstet Gynecol
25803269	Maternal Smoking Dysregulates Protein Expression in Second Trimester Human Fetal Livers in a Sex-Specific Manner. (2015 Jun)	Filis P	J Clin Endocrinol Metab
19458807	Rural smokers - a prevention opportunity. (2009 May)	Chapman A	Aust Fam Physician
25064170	Association between altered placental human chorionic gonadotrophin (hCG) production and the occurrence of cryptorchidism: a retrospective study. (2014 Jul 26)	Chedane C	BMC Pediatr
2467849	Outcome of pregnancy in relation to maternal serum alpha-fetoprotein levels in the second trimester. An evaluation of a screening program and a longitudinal follow-up. (1988)	Bremme K	Gynecol Obstet Invest
19302335	Hepatitis B-related hepatocellular carcinoma: epidemiological characteristics and disease burden. (2009 Jul)	Nguyen VT	J Viral Hepat
27843477	Addition and Subtraction Theory of TCM Using Xiao-Chaihu-Decoction and Naturopathy in Predicting Survival Outcomes of Primary Liver Cancer Patients: A Prospective Cohort Study. (2016)	Dai M	Evid Based Complement Alternat Med
23529706	Maternal serum placental growth factor and alpha-fetoprotein testing in first trimester screening for Down syndrome. (2013 May)	Donalson K	Prenat Diagn
20445731	[Malignant peritoneal mesothelioma]. (2010 Jan-Mar)	Torrejon Reyes PN	Rev Gastroenterol Peru
14991931	Salvage therapy for hepatocellular carcinoma with thalidomide. (2004 Mar 1)	Wang TE	World J Gastroenterol
7684110	[Concentration of carcinoembryonic antigen, alpha-fetoprotein and beta-subunit of human chorionic gonadotropin in serum of workers employed directly in the production of coke]. (1993)	Snit M	Med Pr
9365042	Prognostic significance of serum anti-p53 antibody in patients with hepatocellular carcinoma. (1997 Oct)	Shiota G	J Hepatol
10087414	Influence of cigarette-smoking on the result of the triple test. (1999)	Hafner E	Gynecol Obstet Invest
27507647	Characteristics of hepatocellular carcinoma in Egyptian patients with primary Budd-Chiari syndrome. (2017 Mar)	Sakr M	Liver Int
11920904	Maternal smoking: age distribution, levels of alpha-fetoprotein and human chorionic gonadotrophin, and effect on detection of Down syndrome pregnancies in second-trimester screening. (2002 Mar)	Crossley JA	Prenat Diagn
25843735	A comparison of patients with hepatitis B- or hepatitis C-based advanced-stage hepatocellular carcinoma. (2015 Apr)	Carr BI	Semin Oncol
10719318	Co-variables in first trimester maternal serum screening. (2000 Mar)	de Graaf IM	Prenat Diagn
6192839	Smoking habits and maternal serum alpha-fetoprotein levels during the second trimester of pregnancy. (1983 Aug)	Thomsen SG	Br J Obstet Gynaecol
68118	Tumor-associated antigen levels (carcinoembryonic antigen, human chorionic gonadotropin, and alpha-fetoprotein) antedating the diagnosis of cancer in the Framingham study. (1977 Jun)	Williams RR	J Natl Cancer Inst
27805040	Personalized Risk Assessment in Never, Light, and Heavy Smokers in a prospective cohort in Taiwan. (2016 Nov 2)	Wu X	Sci Rep
23188220	alpha-fetoprotein-to-total tumor volume ratio predicts post-operative tumor recurrence in hepatocellular carcinoma. (2013 Apr)	Lee YH	J Gastrointest Surg
25677908	Long noncoding RNA CCAT2 correlates with smoking in esophageal squamous cell carcinoma. (2015 Jul)	Wang J	Tumour Biol
7681977	Adjustment formulae for maternal serum alpha-fetoprotein, human chorionic gonadotropin, and unconjugated oestriol to maternal weight and smoking. (1993 Feb)	Bartels I	Prenat Diagn
11987570	[Prediction of premature labor--multifactorial analysis of a prospective clinical study]. (2002 Mar)	Mara M	Ceska Gynekol
25241784	[Correlation of carcinoembryonic antigen with prognosis of hepatocellular carcinoma after hepatectomy]. (2014 Jun)	Zhao J	Zhonghua Zhong Liu Za Zhi
28840008	Differences between low and high grade fetal adenocarcinoma of the lung: a clinicopathological and molecular study. (2017 Jul)	Zhang J	J Thorac Dis
20084544	Maternal hormones during early pregnancy: a cross-sectional study. (2010 May)	Chen T	Cancer Causes Control
24226839	First trimester maternal serum alpha-fetoprotein is not raised in pregnancies with open spina bifida. (2014 Feb)	Spencer K	Prenat Diagn
2426436	Relationship between some obstetric landmarks and the concentration of alpha-fetoprotein in maternal blood. (1986)	Wajner M	J Perinat Med
23741761	Familial Porphyria Cutanea Tarda (1993)	Liu LU	-
26106266	Combination of PAPPA, fhCGbeta, AFP, PlGF, sTNFR1, and Maternal Characteristics in Prediction of Early-onset Preeclampsia. (2015)	Yliniemi A	Clin Med Insights Reprod Health
26577107	Factors affecting the recurrence and survival of hepatocellular carcinoma after hepatectomy: a retrospective study of 601 Chinese patients. (2016 Aug)	Zhang TT	Clin Transl Oncol
21323729	Natural history of chronic hepatitis B REVEALed. (2011 Apr)	Chen CJ	J Gastroenterol Hepatol
15912201	Clinical Profiles of Chronic Hepatitis C in a Major County Medical Center Outpatient Setting in United States. (2004)	Hu KQ	Int J Med Sci
1720459	WISC-test scores at the age of 10 for children born to women with risk pregnancies. (1991)	Lagerstrom M	J Perinat Med