Gene: DLG4

1742
PSD95|SAP-90|SAP90
discs large MAGUK scaffold protein 4
protein-coding
17p13.1
Ensembl:ENSG00000132535 MIM:602887 Vega:OTTHUMG00000134327 UniprotKB:P78352
NG_008391.2
PubMed
0   ANCO-SNPs
OD|ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.581e-1 (AD)  1.196e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEPT50.973
JPH40.973
PACSIN10.969
JPH30.968
DMTN0.967
SYNPO0.966
KCNAB20.96
RUNDC3A0.955
DLGAP40.955
CDK160.955

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.684
OR4F29-0.626
TFPI2-0.501
KCNJ15-0.485
IL18RAP-0.475
CST7-0.458
CXCR2-0.45
FOLR3-0.45
FCGR3B-0.445
PROK2-0.439

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00536GuanidineSmall Molecule113-00-8ApprovedTarget
DB01972Guanosine-5'-MonophosphateSmall Molecule85-32-5ExperimentalTarget
ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of DLG4 mRNA28329830
C5822121NMPP1 compound[NTRK2 protein mutant form results in increased susceptibility to 1NMPP1 compound] which results in decreased expression of DLG4 mRNA27417517
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with APP protein modified form] results in decreased expression of DLG4 protein"26480858
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with APP protein modified form] results in decreased expression of DLG4 protein"26480858
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with APP protein modified form] results in decreased expression of DLG4 protein"26480858
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of DLG4 protein"26215117
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with APP protein modified form] results in decreased expression of DLG4 protein"26480858
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyhalothrin results in increased expression of DLG4]26969072
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with APP protein modified form] results in decreased expression of DLG4 protein"26480858
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of DLG4 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLG4 mRNA"27188386
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide results in increased expression of DLG4 mRNA20829426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLG4 mRNA"27188386
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DLG4 mRNA25607892
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 mRNA]28153600
D000638AmiodaroneAmiodarone results in increased expression of DLG4 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DLG4 mRNA16483693
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DLG4 mRNA25607892
D001280AtrazineAtrazine results in increased expression of DLG4 mRNA22378314
D004958EstradiolEstradiol results in increased expression of DLG4 protein22342969
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of DLG4 protein22342969
D004958Estradiolcyhalothrin inhibits the reaction [Estradiol results in increased expression of DLG4 protein]26969072
D004958EstradiolEstradiol results in increased expression of DLG4 protein26969072
C044887beta-methylcholinebeta-methylcholine affects the expression of DLG4 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DLG4 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of DLG4 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DLG4 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of DLG4 protein23490186|2352374
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DLG4 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of DLG4 mRNA25607892
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of DLG4 mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of DLG4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DLG4 gene28505145
C013418bromfenacoumbromfenacoum results in increased expression of DLG4 protein28903499
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DLG4 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of DLG4 mRNA25607892
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of DLG4 mRNA25607892
C584509C646 compoundC646 compound results in decreased expression of DLG4 mRNA26191083
D004390ChlorpyrifosChlorpyrifos results in decreased expression of DLG4 mRNA20350560
D019343Citric Acid[Citric Acid co-treated with Silver analog] results in decreased expression of DLG4 protein25447321
D003042CocaineCocaine results in decreased expression of DLG4 mRNA14980210
D003042CocaineDLG4 protein results in decreased susceptibility to Cocaine14980210
D003042CocaineCocaine affects the expression of DLG4 mRNA20187946
D003042CocaineCocaine affects the expression of DLG4 protein20534846
D003042CocaineCocaine results in increased expression of DLG4 protein19629758|2060017
D003042CocaineILK mutant form inhibits the reaction [Cocaine results in increased expression of DLG4 protein]19629758
C037304cyhalothrin2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyhalothrin results in increased expression of DLG4]26969072
C037304cyhalothrincyhalothrin inhibits the reaction [Estradiol results in increased expression of DLG4 protein]26969072
C037304cyhalothrincyhalothrin results in increased expression of DLG4 protein26969072
C037304cyhalothrinfulvestrant inhibits the reaction [cyhalothrin results in increased expression of DLG4 protein]26969072
C037304cyhalothrincyhalothrin results in decreased expression of DLG4 protein28487251
D013759DronabinolDronabinol results in decreased expression of DLG4 mRNA21955143
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DLG4 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DLG4 mRNA28628672
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA25607892
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA25607892
D002945CisplatinCisplatin results in decreased expression of DLG4 mRNA27392435
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA25607892
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA25607892
D004041Dietary FatsDietary Fats results in increased expression of DLG4 mRNA18042831
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA25607892
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA25607892
D008559MemantineMemantine inhibits the reaction [Streptozocin results in decreased expression of DLG4 protein]24333387
D016291Dizocilpine MaleateDizocilpine Maleate results in increased expression of DLG4 mRNA11169168
D007980Levodopa[Oxidopamine co-treated with Levodopa] results in increased expression of DLG4 mRNA15703272
D007980Levodopa[Oxidopamine co-treated with Levodopa] results in increased expression of DLG4 protein15703272
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DLG4 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of DLG4 mRNA25607892
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of DLG4 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA25607892
D000431EthanolEthanol results in increased expression of DLG4 mRNA21955143
D000431EthanolEthanol results in increased expression of DLG4 mRNA20655511
D000431Ethanol"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in increased expression of DLG4 mRNA]"20655511
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of DLG4 mRNA28329830
C070081fulvestrantfulvestrant inhibits the reaction [cyhalothrin results in increased expression of DLG4 protein]26969072
D005978GlutathioneGlutathione inhibits the reaction [Particulate Matter results in decreased expression of DLG4 mRNA]28153600
D006582HexachloropheneHexachlorophene results in decreased expression of DLG4 mRNA29301063
D007052IbuprofenIbuprofen inhibits the reaction [Streptozocin results in decreased expression of DLG4 protein]24333387
C492448ICG 001ICG 001 results in decreased expression of DLG4 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DLG4 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DLG4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DLG4 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DLG4 mRNA28628672
D007530IsofluraneIGF1 protein inhibits the reaction [Isoflurane results in decreased expression of DLG4 protein]25597859
D007530IsofluraneIsoflurane results in decreased expression of DLG4 protein25597859
D007530IsofluranePF-4708671 promotes the reaction [Isoflurane results in decreased expression of DLG4 protein]25597859
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DLG4 mRNA24796395
C008261lead acetatelead acetate affects the expression of DLG4 protein27984133
C008261lead acetatelead acetate results in decreased expression of DLG4 protein27492863
C008261lead acetatelead acetate results in increased expression of DLG4 mRNA27984133
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA25607892
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA25607892
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of DLG4 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of DLG4 mRNA12057914
D008731MethoxychlorMethoxychlor results in increased expression of DLG4 mRNA20829426
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DLG4 protein25809596
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DLG4 protein27012723
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of DLG4 protein26965727
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of DLG4 mRNA24810058
D009020MorphineMorphine results in increased expression of DLG4 mRNA21955143
D009020MorphineMorphine results in decreased expression of DLG4 mRNA15183518
D009020MorphineMorphine results in decreased expression of DLG4 protein16598705
D009020MorphineMorphine results in increased expression of DLG4 mRNA15183518
D009020MorphineMorphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]22713680
D009020Morphineresveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]22713680
D009538NicotineNicotine results in decreased expression of DLG4 mRNA21955143
C520612N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in increased expression of DLG4 mRNA]"20655511
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DLG4 mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of DLG4 mRNA25607892
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of DLG4 mRNA25607892
D016627OxidopamineOxidopamine affects the localization of DLG4 protein15703272
D016627Oxidopamine[Oxidopamine co-treated with Levodopa] results in increased expression of DLG4 mRNA15703272
D016627Oxidopamine[Oxidopamine co-treated with Levodopa] results in increased expression of DLG4 protein15703272
D016627OxidopamineOxidopamine results in decreased expression of DLG4 mRNA15703272
D016627OxidopamineOxidopamine results in decreased expression of DLG4 protein15703272
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of DLG4 mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of DLG4 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of DLG4 mRNA]"21673326
D000073878Palm OilPalm Oil results in increased expression of DLG4 mRNA18042831
D052638Particulate MatterAcetylcysteine inhibits the reaction [Particulate Matter results in decreased expression of DLG4 mRNA]28153600
D052638Particulate MatterGlutathione inhibits the reaction [Particulate Matter results in decreased expression of DLG4 mRNA]28153600
D052638Particulate MatterParticulate Matter results in decreased expression of DLG4 mRNA28153600
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with APP protein modified form] results in decreased expression of DLG4 protein"26480858
C552719PF-4708671PF-4708671 promotes the reaction [Isoflurane results in decreased expression of DLG4 protein]25597859
C006253pirinixic acidpirinixic acid results in increased expression of DLG4 mRNA20813756
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA25607892
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA25607892
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of DLG4 protein22342969
D011374ProgesteroneProgesterone results in increased expression of DLG4 protein22342969
C059514resveratrolresveratrol inhibits the reaction [APP protein modified form results in decreased expression of DLG4 protein]25654502
C059514resveratrolresveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]22713680
C084711S 20098S 20098 results in increased expression of DLG4 protein22160164
D012834SilverSilver results in decreased expression of DLG4 protein27593553
D012834Silver[Citric Acid co-treated with Silver analog] results in decreased expression of DLG4 protein25447321
D012834SilverSilver results in decreased expression of DLG4 protein25447321
C080703SK&F 83959SK&F 83959 results in decreased expression of DLG4 protein25852303
C017947sodium arsenitesodium arsenite results in decreased expression of DLG4 protein22421273
D018038Sodium SeleniteSodium Selenite results in decreased expression of DLG4 mRNA18175754
D013311StreptozocinIbuprofen inhibits the reaction [Streptozocin results in decreased expression of DLG4 protein]24333387
D013311StreptozocinMemantine inhibits the reaction [Streptozocin results in decreased expression of DLG4 protein]24333387
D013311StreptozocinStreptozocin results in decreased expression of DLG4 protein24333387
D013458Sulfur DioxideSulfur Dioxide affects the expression of DLG4 protein25534910
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DLG4 mRNA21570461
D019284ThapsigarginThapsigargin results in increased expression of DLG4 mRNA22378314
D014212Tretinoin[NTF3 protein co-treated with Tretinoin] results in increased expression of DLG4 protein16996685
D014212TretinoinTretinoin results in increased expression of DLG4 protein16944780
C015559trimellitic anhydridetrimellitic anhydride results in decreased methylation of DLG4 promoter24675093
D014415TunicamycinTunicamycin results in increased expression of DLG4 mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DLG4 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of DLG4 mRNA23179753|2627250
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] affects the expression of DLG4 mRNA25607892
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of DLG4 mRNA25607892
C025643vinclozolinvinclozolin affects the expression of DLG4 mRNA19015723
C111237vorinostatvorinostat results in decreased expression of DLG4 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005515protein binding-IPI7477295  10433268  10725395  10859302  11937501  12097473  
12477932  16767099  17360663  19118189  19243221  20018661  
22117215  23260144  25780553  
GO:0008022protein C-terminus binding-IPI7477295  
GO:0015276ligand-gated ion channel activity-TAS-  
GO:0019900kinase binding-IDA21119615  
GO:0019903protein phosphatase binding-ISS-  
GO:0030165PDZ domain binding-ISS-  
GO:0031697beta-1 adrenergic receptor binding-ISS-  
GO:0031748D1 dopamine receptor binding-ISS-  
GO:0031812P2Y1 nucleotide receptor binding-ISS-  
GO:0033130acetylcholine receptor binding-ISS-  
GO:0035255ionotropic glutamate receptor binding-IBA21873635  
GO:0035255ionotropic glutamate receptor binding-ISS-  
GO:0044877protein-containing complex binding-ISS-  
GO:0097109neuroligin family protein binding-ISS-  
GO:0097110scaffold protein binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0002091negative regulation of receptor internalization-ISS-  
GO:0007165signal transduction-TAS10364559  
GO:0007204positive regulation of cytosolic calcium ion concentration-ISS-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007399nervous system development-TAS9286702  
GO:0007612learning-TAS9853749  
GO:0016188synaptic vesicle maturation-ISS-  
GO:0034220ion transmembrane transport-IEA-  
GO:0035176social behavior-IEA-  
GO:0035418protein localization to synapse-IDA15496675  
GO:0035641locomotory exploration behavior-IEA-  
GO:0035865cellular response to potassium ion-ISS-  
GO:0043113receptor clustering-IBA21873635  
GO:0045184establishment of protein localization-IDA15496675  
GO:0045197establishment or maintenance of epithelial cell apical/basal polarity-IBA21873635  
GO:0046037GMP metabolic process-IEA-  
GO:0046710GDP metabolic process-IEA-  
GO:0048169regulation of long-term neuronal synaptic plasticity-ISS-  
GO:0050806positive regulation of synaptic transmission-ISS-  
GO:0050885neuromuscular process controlling balance-IEA-  
GO:0060997dendritic spine morphogenesis-ISS-  
GO:0061098positive regulation of protein tyrosine kinase activity-ISS17526495  
GO:0061098positive regulation of protein tyrosine kinase activity-TAS17526495  
GO:0065003protein-containing complex assembly-IDA15496675  
GO:0071625vocalization behavior-IEA-  
GO:0097113AMPA glutamate receptor clustering-IBA21873635  
GO:0097113AMPA glutamate receptor clustering-ISS-  
GO:0097113AMPA glutamate receptor clustering-TAS19914352  
GO:0097120receptor localization to synapse-IBA21873635  
GO:0097120receptor localization to synapse-ISS-  
GO:0098970postsynaptic neurotransmitter receptor diffusion trapping-IBA21873635  
GO:0150012positive regulation of neuron projection arborization-ISS-  
GO:2000310regulation of NMDA receptor activity-ISS-  
GO:2000463positive regulation of excitatory postsynaptic potential-ISS-  
GO:2000821regulation of grooming behavior-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-ISS-  
GO:0005783endoplasmic reticulum-ISS-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membranecolocalizes_withISS-  
GO:0005886plasma membrane-TAS-  
GO:0008021synaptic vesicle-ISS-  
GO:0008076voltage-gated potassium channel complexcolocalizes_withISS-  
GO:0008328ionotropic glutamate receptor complexCOLOCALIZES_WITHIBA21873635  
GO:0008328ionotropic glutamate receptor complexcolocalizes_withISS-  
GO:0014069postsynaptic density-ISS-  
GO:0016323basolateral plasma membrane-IBA21873635  
GO:0030054cell junction-IBA21873635  
GO:0030054cell junction-ISS-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0030863cortical cytoskeleton-IDA12151521  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-ISS-  
GO:0031594neuromuscular junction-IBA21873635  
GO:0032281AMPA glutamate receptor complex-ISS-  
GO:0032839dendrite cytoplasm-ISS-  
GO:0043005neuron projection-IBA21873635  
GO:0043197dendritic spine-ISS-  
GO:0044224juxtaparanode region of axon-ISS-  
GO:0044300cerebellar mossy fiber-IEA-  
GO:0044306neuron projection terminus-ISS-  
GO:0044309neuron spine-ISS-  
GO:0045202synapse-IDA15496675  
GO:0045211postsynaptic membrane-IDA12151521  
GO:0060076excitatory synapse-ISS-  
GO:0098839postsynaptic density membrane-IBA21873635  
GO:0098839postsynaptic density membrane-IEA-  
KEGG ID KEGG Term
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-112316Neuronal SystemTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-422475Axon guidanceIEA
R-HSA-438064Post NMDA receptor activation eventsTAS
R-HSA-438066Unblocking of NMDA receptor, glutamate binding and activationTAS
R-HSA-442729CREB phosphorylation through the activation of CaMKIITAS
R-HSA-442742CREB phosphorylation through the activation of RasTAS
R-HSA-442755Activation of NMDA receptor and postsynaptic eventsTAS
R-HSA-442982Ras activation upon Ca2+ influx through NMDA receptorTAS
R-HSA-447038NrCAM interactionsIEA
R-HSA-451306Ionotropic activity of kainate receptorsTAS
R-HSA-451308Activation of Ca-permeable Kainate ReceptorTAS
R-HSA-451326Activation of kainate receptors upon glutamate bindingTAS
R-HSA-5625900RHO GTPases activate CITTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5682910LGI-ADAM interactionsTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794361Neurexins and neuroliginsTAS
R-HSA-6794362Protein-protein interactions at synapsesIEA
R-HSA-6794362Protein-protein interactions at synapsesTAS
R-HSA-8849932Synaptic adhesion-like moleculesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17164261Fine mapping of a linkage region on chromosome 17p13 reveals that GABARAP and DLG4 are associated with vulnerability to nicotine dependence in European-Americans. (2007 Jan 15)Lou XYHum Mol Genet
24704371Epigenetic upregulation of PSD-95 contributes to the rewarding behavior by morphine conditioning. (2014 Jun 5)Wang ZEur J Pharmacol