Gene: DLST

1743
DLTS
dihydrolipoamide S-succinyltransferase
protein-coding
14q24.3
Ensembl:ENSG00000119689 MIM:126063 Vega:OTTHUMG00000171483 UniprotKB:P36957
NG_030313.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.759e-1 (AD)  2.580e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSAP0.95
GANAB0.949
CSNK1D0.941
RNF400.938
DDOST0.938
DDX19A0.938
OS90.937
VCP0.935
SEC24C0.935
SURF40.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.803
OR4F29-0.746
OR6C74-0.291
CTNNA3-0.255
MTRNR2L6-0.253
KLRC2-0.233
KLRB1-0.231
TNFRSF13B-0.229
MTRNR2L9-0.224
CETP-0.217

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DLST mRNA"19114083
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DLST mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of DLST mRNA"18648102
C027696acipimoxacipimox results in increased expression of DLST mRNA25352640
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DLST mRNA16483693
D001241AspirinAspirin results in decreased expression of DLST mRNA11906190
D001280AtrazineAtrazine results in increased expression of DLST mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DLST mRNA22316170
C044887beta-methylcholinebeta-methylcholine affects the expression of DLST mRNA21179406
C006780bisphenol Abisphenol A affects the expression of DLST mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of DLST mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of DLST mRNA26079696
C026690cerous chloridecerous chloride results in increased expression of DLST mRNA23573234
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of DLST mRNA23650126
D002994ClofibrateClofibrate results in increased expression of DLST protein19952500
D002994ClofibrateClofibrate results in decreased expression of DLST mRNA17585979
D002994ClofibrateClofibrate results in increased expression of DLST protein16470657
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in increased expression of DLST mRNA26873546
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of DLST mRNA18313992
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of DLST mRNA]"23626681
D004147DioxinsDioxins affects the expression of DLST mRNA20463971
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in increased expression of DLST mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of DLST mRNA26873546
D000431EthanolEthanol results in increased expression of DLST protein19609968
D005485FlutamideFlutamide results in increased expression of DLST mRNA24136188
D005839GentamicinsGentamicins results in increased expression of DLST protein22061828
D017313FenretinideFenretinide results in increased expression of DLST mRNA28973697
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of DLST mRNA19376150
D008148LovastatinLovastatin results in decreased expression of DLST mRNA20493250
D008344Maneb[Maneb co-treated with Paraquat] results in increased expression of DLST protein23562983
D008344ManebMinocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein]23562983
D008344Manebtetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein]23562983
D008694MethamphetamineMethamphetamine results in decreased expression of DLST mRNA19149911
D008694MethamphetamineMethamphetamine results in decreased expression of DLST protein19826936
D008694MethamphetamineValproic Acid inhibits the reaction [Methamphetamine results in decreased expression of DLST mRNA]19149911
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DLST mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased methylation of DLST promoter"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DLST mRNA"20188158|2625132
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DLST protein"23562983
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DLST protein]"23562983
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to DLST protein]17220478
D008911MinocyclineMinocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein]23562983
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DLST mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DLST mRNA"25620056
D010126OzoneOzone results in increased expression of DLST mRNA25838073
D010269Paraquat[Maneb co-treated with Paraquat] results in increased expression of DLST protein23562983
D010269ParaquatMinocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein]23562983
D010269Paraquattetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein]23562983
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of DLST protein26879310
C023036perfluorooctanoic acid"Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of DLST mRNA]"23626681
D010578PetroleumPetroleum affects the expression of DLST mRNA25208076
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DLST mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of DLST mRNA18301758|2081375
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of DLST mRNA28903501
C059514resveratrolresveratrol results in increased expression of DLST protein25505154
D015474IsotretinoinIsotretinoin results in increased expression of DLST protein15982314
C089730rosiglitazonerosiglitazone affects the expression of DLST mRNA22013433
D012524SarinSarin results in decreased expression of DLST protein28973502
C080703SK&F 83959SK&F 83959 results in increased expression of DLST protein25852303
C009277sodium arsenatesodium arsenate results in decreased expression of DLST mRNA23922661
D013311StreptozocinStreptozocin results in increased expression of DLST protein19634143|2113669
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in increased expression of DLST protein]19634143|2113669
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DLST mRNA21570461
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of DLST protein"25852303
C050950tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex"tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DLST protein]"23562983
C050950tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complextetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein]23562983
D014212TretinoinTretinoin results in increased expression of DLST protein15982314
D014266TrientineTrientine inhibits the reaction [Streptozocin results in increased expression of DLST protein]19634143|2113669
D014303TrinitrotolueneTrinitrotoluene affects the expression of DLST mRNA21346803
C080163trovafloxacintrovafloxacin results in decreased expression of DLST mRNA24136188
D014415TunicamycinTunicamycin results in increased expression of DLST mRNA17127020
D014635Valproic AcidValproic Acid results in increased expression of DLST mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of DLST mRNA17963808
D014635Valproic AcidValproic Acid inhibits the reaction [Methamphetamine results in decreased expression of DLST mRNA]19149911
D001335Vehicle EmissionsVehicle Emissions affects the methylation of DLST gene25560391
D014810Vitamin EVitamin E results in increased expression of DLST mRNA19244175
D014859WarfarinWarfarin results in decreased expression of DLST mRNA20493250
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of DLST mRNA"25208076
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of DLST mRNA18313992

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004149dihydrolipoyllysine-residue succinyltransferase activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006091generation of precursor metabolites and energy-TAS8009371  
GO:0006099tricarboxylic acid cycle-IEA-  
GO:00061032-oxoglutarate metabolic process-ISS-  
GO:0006104succinyl-CoA metabolic process-ISS-  
GO:0033512L-lysine catabolic process to acetyl-CoA via saccharopine-IEA-  
GO:0106077histone succinylation-IDA29211711  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IDA29211711  
GO:0005739mitochondrion-IDA29211711  
GO:0005759mitochondrial matrix-TAS-  
GO:0016020membrane-HDA19946888  
GO:0043209myelin sheath-IEA-  
GO:0045252oxoglutarate dehydrogenase complex-IDA29211711  
KEGG ID KEGG Term
hsa00020Citrate cycle (TCA cycle)
hsa00310Lysine degradation
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-389661Glyoxylate metabolism and glycine degradationTAS
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-71064Lysine catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-71403Citric acid cycle (TCA cycle)TAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23144319Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. (2013 Feb)Lee YCarcinogenesis