Gene: SARDH

1757
BPR-2|DMGDHL1|SAR|SARD|SDH
sarcosine dehydrogenase
protein-coding
9q34.2
Ensembl:ENSG00000123453 MIM:604455 Vega:OTTHUMG00000020879 UniprotKB:Q9UL12
NG_008987.1
PubMed
0   ANCO-SNPs
ND
1   
3.164e-1 (AD)  4.322e-2 (ND)   (Frontal_Cortex)
8.950e-1 (AD)  4.518e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLIN50.832
PRDM160.83
MMP280.812
LDHD0.809
PRODH0.805
PBXIP10.805
GPR1430.797
PAPLN0.795
TLCD10.791
CABLES10.79

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF124-0.373
SYNPO2-0.366
TBC1D8B-0.365
TC2N-0.36
FGF10-0.359
PLA2G4A-0.357
VLDLR-0.357
PLCB4-0.356
SCARA5-0.335
PLS1-0.333

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of SARDH mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SARDH mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SARDH mRNA"25614096
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SARDH mRNA]"19467301
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of SARDH mRNA21983209
D000082AcetaminophenAcetaminophen results in decreased expression of SARDH mRNA25704631|2906747
D000082AcetaminophenAcetaminophen affects the expression of SARDH mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SARDH protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SARDH mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of SARDH protein26597043
D000638AmiodaroneAmiodarone results in increased expression of SARDH mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SARDH mRNA16483693
D001151ArsenicArsenic affects the expression of SARDH mRNA18414638
C547126AZM551248AZM551248 results in decreased expression of SARDH mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SARDH mRNA19770486
D004958EstradiolEstradiol affects the expression of SARDH mRNA23557687
C006780bisphenol Abisphenol A affects the expression of SARDH mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SARDH mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SARDH gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SARDH mRNA24982889
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SARDH mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SARDH protein17109383
D002273CarcinogensCarcinogens results in increased expression of SARDH mRNA22269147
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SARDH mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of SARDH mRNA24386269
D003300CopperCopper results in decreased expression of SARDH mRNA22465980
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SARDH mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of SARDH mRNA19467301
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SARDH mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SARDH mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SARDH mRNA17942748
C540355fenamidonefenamidone results in increased expression of SARDH mRNA27029645
C056933fumonisin B1fumonisin B1 results in decreased expression of SARDH mRNA16221962
C039281furanfuran results in increased expression of SARDH mRNA26194646
C039281furanfuran results in increased methylation of SARDH gene22079235
D017313FenretinideFenretinide results in decreased expression of SARDH mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SARDH mRNA26644586
C410337K 7174K 7174 results in decreased expression of SARDH mRNA24086573
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SARDH mRNA26011545
D009153MutagensMutagens results in increased expression of SARDH mRNA22269147
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of SARDH mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SARDH mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SARDH mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of SARDH mRNA24136188
C012655nimesulidenimesulide results in decreased expression of SARDH mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of SARDH protein19716841
D010100OxygenOxygen deficiency results in decreased expression of SARDH protein19579223
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of SARDH mRNA17097637
D010795Phthalic AcidsPhthalic Acids results in decreased expression of SARDH mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of SARDH mRNA16221962|1795077
C006253pirinixic acidpirinixic acid results in decreased expression of SARDH protein15226431
C006253pirinixic acidpirinixic acid results in decreased expression of SARDH mRNA17164430
D010936Plant ExtractsPlant Extracts results in decreased expression of SARDH mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of SARDH mRNA20726854
C005556propionaldehydepropionaldehyde results in increased expression of SARDH mRNA26079696
D012643SeleniumSelenium results in increased expression of SARDH mRNA19244175
C017947sodium arsenitesodium arsenite affects the methylation of SARDH gene28589171
D012999SomanSoman results in increased expression of SARDH mRNA19281266
D013629TamoxifenTamoxifen affects the expression of SARDH mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SARDH mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SARDH mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SARDH mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SARDH mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SARDH mRNA21215274
D013752TetracyclineTetracycline results in decreased expression of SARDH mRNA24489787
D013853ThioacetamideThioacetamide results in decreased expression of SARDH mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SARDH protein22609517
C012589trichostatin Atrichostatin A results in decreased expression of SARDH mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SARDH mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SARDH mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of SARDH protein18495193
D014520UrethaneUrethane results in decreased expression of SARDH mRNA28818685
D014520UrethaneUrethane results in increased expression of SARDH mRNA16289808
C406224valdecoxibvaldecoxib results in decreased expression of SARDH mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of SARDH mRNA15901671
D014640VancomycinVancomycin results in increased expression of SARDH mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SARDH gene25560391
C025643vinclozolinvinclozolin results in decreased expression of SARDH mRNA20566332
D015032ZincZinc deficiency results in decreased expression of SARDH mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008480sarcosine dehydrogenase activity-IBA21873635  
GO:0008480sarcosine dehydrogenase activity-TAS-  
GO:0016491oxidoreductase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0042426choline catabolic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO:1901053sarcosine catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-ISS-  
GO:0005759mitochondrial matrix-IBA21873635  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00260Glycine, serine and threonine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-6798163Choline catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22103680Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study. (2011 Nov 21)Wernimont SMBMC Med Genet