Gene: DNM1

1759
DNM|EIEE31
dynamin 1
protein-coding
9q34.11
Ensembl:ENSG00000106976 MIM:602377 Vega:OTTHUMG00000020733 UniprotKB:Q05193
NG_029726.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.172e-2 (AD)  1.082e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SV2A0.983
SCAMP50.982
STXBP10.979
ATP1A30.976
STX1B0.976
SYN10.975
ATCAY0.974
RAB3A0.974
KLC20.974
SYT70.972

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.593
OR4F29-0.551
RAI14-0.497
REST-0.492
TFPI2-0.487
WWTR1-0.475
HEY2-0.472
CNN2-0.47
YES1-0.467
MBNL3-0.462

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of DNM1 protein"21673325
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the expression of DNM1 protein"24680724
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of DNM1 mRNA"21394737
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of DNM1 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of DNM1 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of DNM1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of DNM1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DNM1 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of DNM1 mRNA25929836
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DNM1 mRNA18164116
D004958EstradiolEstradiol results in increased expression of DNM1 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of DNM1 mRNA27685785|2927551
C006780bisphenol Abisphenol A results in decreased expression of DNM1 mRNA25181051
D002994ClofibrateClofibrate results in decreased expression of DNM1 mRNA17585979
D003042CocaineCocaine affects the expression of DNM1 mRNA20187946
D016572CyclosporineCyclosporine results in decreased expression of DNM1 mRNA27989131
D002945CisplatinCisplatin results in decreased expression of DNM1 mRNA27392435
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of DNM1 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DNM1 mRNA]17854601
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DNM1 mRNA18164116
D002117CalcitriolCalcitriol results in decreased expression of DNM1 mRNA26485663
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of DNM1 mRNA25198161
C100264enniatinsenniatins results in decreased expression of DNM1 mRNA27163883
C118739entinostatentinostat results in increased expression of DNM1 mRNA27188386
C062669epicatechin gallateARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1 protein]]29061316
C045651epigallocatechin gallateARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1 protein]]29061316
D005411Flame RetardantsFlame Retardants results in increased expression of DNM1 protein18550172
D005419FlavonoidsFlavonoids results in increased expression of DNM1 mRNA18035473
D005707Gallic AcidARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1 protein]]29061316
C057580gallocatecholARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1 protein]]29061316
C089796hexabromocyclododecanehexabromocyclododecane affects the expression of DNM1 protein24680724
D017313FenretinideFenretinide results in decreased expression of DNM1 mRNA28973697
D006861Hydrogen PeroxideARNTL protein affects the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of DNM1 protein]]29061316
C503753Indolinone AIndolinone A results in increased expression of DNM1 mRNA15712243
D007649KetamineKetamine results in increased expression of DNM1 mRNA20080153
D007657Ketone BodiesKetone Bodies results in increased expression of DNM1 mRNA16807920
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of DNM1 mRNA"24972896
D008694MethamphetamineMethamphetamine results in increased expression of DNM1 mRNA26307267
C004925methylmercuric chloridemethylmercuric chloride affects the expression of DNM1 protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DNM1 protein25809596
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DNM1 mRNA"20188158|2625132
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of DNM1 protein18550172
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DNM1 mRNA19710929
D011441PropylthiouracilPropylthiouracil results in decreased expression of DNM1 mRNA24780913
D015474IsotretinoinIsotretinoin results in increased expression of DNM1 mRNA20436886
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of DNM1 mRNA21427059
D014212TretinoinTretinoin results in increased expression of DNM1 mRNA17045167
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of DNM1 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of DNM1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DNM1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of DNM1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of DNM1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DNM1 gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of DNM1 mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0003924GTPase activity-IBA21873635  
GO:0005515protein binding-IPI9148966  10206341  10542231  11872741  15252009  15703209  
15834155  16137687  16234328  16432212  17474147  17500595  
18353773  18539136  19781630  21706016  24282027  
GO:0005525GTP binding-IEA-  
GO:0008017microtubule binding-IBA21873635  
GO:0008022protein C-terminus binding-IEA-  
GO:0017124SH3 domain binding-IEA-  
GO:0019901protein kinase binding-ISS-  
GO:0031749D2 dopamine receptor binding-IEA-  
GO:0042802identical protein binding-IPI20428113  20700106  21927000  21962517  26302298  
GO:0044877protein-containing complex binding-IEA-  
GO:0046983protein dimerization activity-IEA-  
GO:0050998nitric-oxide synthase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002031G-protein coupled receptor internalization-IEA-  
GO:0006897endocytosis-IMP19706678  
GO:0006897endocytosis-TAS16648839  
GO:0006898receptor-mediated endocytosis-IMP10521508  
GO:0007032endosome organization-IMP19706678  
GO:0007605sensory perception of sound-IEA-  
GO:0008344adult locomotory behavior-IEA-  
GO:0010020chloroplast fission-IBA21873635  
GO:0016185synaptic vesicle budding from presynaptic endocytic zone membrane-IBA21873635  
GO:0016185synaptic vesicle budding from presynaptic endocytic zone membrane-IEA-  
GO:0016559peroxisome fission-IBA21873635  
GO:0031623receptor internalization-IBA21873635  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0048285organelle fission-IBA21873635  
GO:0050803regulation of synapse structure or activity-IBA21873635  
GO:0051262protein tetramerization-IEA-  
GO:0051932synaptic transmission, GABAergic-IEA-  
GO:0072583clathrin-dependent endocytosis-IEA-  
GO:0098884postsynaptic neurotransmitter receptor internalization-IBA21873635  
GO:1900244positive regulation of synaptic vesicle endocytosis-IEA-  
GO:1901998toxin transport-IEA-  
GO:1904645response to amyloid-beta-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001917photoreceptor inner segment-IEA-  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005777peroxisome-IBA21873635  
GO:0005794Golgi apparatus-IEA-  
GO:0005874microtubule-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0008021synaptic vesicle-IEA-  
GO:0009507chloroplast-IBA21873635  
GO:0014069postsynaptic density-IBA21873635  
GO:0015630microtubule cytoskeleton-IBA21873635  
GO:0016020membrane-IBA21873635  
GO:0030117membrane coat-IEA-  
GO:0030424axon-IBA21873635  
GO:0031410cytoplasmic vesicle-IBA21873635  
GO:0043196varicosity-IEA-  
GO:0043197dendritic spine-IBA21873635  
GO:0043209myelin sheath-IEA-  
GO:0044327dendritic spine head-IBA21873635  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IBA21873635  
GO:0070062extracellular exosome-HDA23533145  
GO:0098844postsynaptic endocytic zone membrane-IBA21873635  
KEGG ID KEGG Term
hsa04144Endocytosis
hsa04666Fc gamma R-mediated phagocytosis
hsa05100Bacterial invasion of epithelial cells
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-157858Gap junction trafficking and regulationTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-177504Retrograde neurotrophin signallingIEA
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-190828Gap junction traffickingTAS
R-HSA-190873Gap junction degradationTAS
R-HSA-196025Formation of annular gap junctionsTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-373760L1CAM interactionsTAS
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-437239Recycling pathway of L1TAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18987626Detection of genetic association and a functional polymorphism of dynamin 1 gene with nicotine dependence in European and African Americans. (2009 Apr)Xu QNeuropsychopharmacology