Gene: ACAN

176
AGC1|AGCAN|CSPG1|CSPGCP|MSK16|SEDK|SSOAOD
aggrecan
protein-coding
15q26.1
Ensembl:ENSG00000157766 MIM:155760 Vega:OTTHUMG00000171989 UniprotKB:P16112
NG_012794.1
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.685e-1 (AD)  3.474e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs8042108chr15:88861649 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs9630453chr15:88860691 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf1620.687
STXBP20.67
ARPC1B0.65
CD1630.65
PARVG0.642
CHEK20.638
ARHGAP90.638
C1R0.635
POLD10.631
HCLS10.63

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.456
DIO2-0.436
HPDL-0.423
ARSF-0.409
ZNF98-0.407
SLC13A5-0.401
FAM180B-0.386
FBXL22-0.374
PYGM-0.367
WIF1-0.367

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB02255GM6001Small MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0005949583,4,5-trihydroxy-N-(4-(thiazol-2-ylsulfamoyl)-phenyl)-benzamide"3,4,5-trihydroxy-N-(4-(thiazol-2-ylsulfamoyl)-phenyl)-benzamide results in increased expression of ACAN mRNA"26107568
C056498aceclofenacaceclofenac results in increased expression of ACAN protein11950021
D020106AcrylamideAcrylamide results in decreased expression of ACAN mRNA16876394
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ACAN gene27153756
C008970alginic acidalginic acid results in increased expression of ACAN mRNA16371897
D000584AmilorideAmiloride affects the expression of ACAN mRNA20454829
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ACAN mRNA24449571
C011669ascorbate-2-phosphateascorbate-2-phosphate results in increased expression of ACAN mRNA11852233
D001205Ascorbic AcidIL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA]26526931
D001205Ascorbic Acidresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA]]26526931
D001205Ascorbic Acid[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA26526931
C547126AZM551248AZM551248 results in increased expression of ACAN mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACAN mRNA22228805
D001599BerberineBerberine results in decreased expression of ACAN mRNA26478571
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ACAN mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACAN mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of ACAN mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ACAN mRNA29097150
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ACAN mRNA28628672
C038091butylparabenbutylparaben results in decreased expression of ACAN mRNA28527915
C018475butyraldehydebutyraldehyde results in decreased expression of ACAN mRNA26079696
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ACAN mRNA20360939
D000068579CelecoxibCelecoxib affects the expression of ACAN mRNA16273290
D048271Chitosan[Chitosan co-treated with polylactic acid-polyglycolic acid copolymer] results in increased expression of ACAN mRNA17607738
D003042CocaineCocaine affects the expression of ACAN mRNA20187946
D000069439DasatinibDasatinib results in increased expression of ACAN mRNA20579391
D003907DexamethasoneDexamethasone inhibits the reaction [BMP2 protein results in increased expression of ACAN mRNA]17502159
D003907DexamethasoneDexamethasone results in decreased expression of ACAN mRNA27608943
D003907DexamethasoneDexamethasone results in increased expression of ACAN mRNA21351055|2504701
D003907DexamethasoneIL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA]26526931
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ACAN mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACAN mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ACAN mRNA28628672
D003907Dexamethasoneresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA]]26526931
D003907Dexamethasone[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA26526931
C025292diacetylrheindiacetylrhein inhibits the reaction [IL1B protein results in decreased expression of ACAN mRNA]18321735
C025292diacetylrheindiacetylrhein results in increased expression of ACAN mRNA18321735
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ACAN mRNA20360939
D000431EthanolEthanol results in decreased expression of ACAN mRNA17920746
D005557FormaldehydeFormaldehyde results in decreased expression of ACAN mRNA17938736
D005707Gallic AcidGallic Acid results in decreased expression of ACAN mRNA25130855
D005707Gallic AcidGallic Acid results in decreased expression of ACAN mRNA26107568
D005944GlucosamineGlucosamine analog affects the expression of ACAN mRNA17337215
D005944GlucosamineGlucosamine analog affects the reaction [IL1B results in decreased expression of ACAN mRNA]17337215
D005944GlucosamineGlucosamine analog results in decreased expression of ACAN mRNA16300972
D005944GlucosamineGlucosamine analog results in increased expression of ACAN protein17337215
D005944GlucosamineGlucosamine inhibits the reaction [IL1B protein results in decreased expression of ACAN mRNA]18321735
D005944GlucosamineGlucosamine results in decreased cleavage of and results in decreased secretion of ACAN protein19909832
D005944GlucosamineGlucosamine results in increased expression of ACAN mRNA12801482|1832173
D005944GlucosamineGlucosamine results in increased expression of ACAN protein12801482
D005944GlucosamineGlucosamine results in increased expression of ACAN mRNA16872674
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in decreased expression of ACAN mRNA]17109745
C065632glucosamine 3-O-sulfateglucosamine 3-O-sulfate results in decreased expression of ACAN mRNA16300972
D006820Hyaluronic Acid[Hyaluronic Acid co-treated with resveratrol] results in increased expression of ACAN mRNA23595953
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ACAN mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACAN mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ACAN mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of ACAN protein11950021
C005056isoascorbic acidisoascorbic acid results in increased expression of ACAN mRNA11852233
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ACAN mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ACAN mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ACAN mRNA28628672
C008261lead acetateBMP2 promotes the reaction [lead acetate results in increased expression of ACAN mRNA]17805416
C008261lead acetatelead acetate promotes the reaction [BMP2 results in increased expression of ACAN mRNA]17805416
C008261lead acetatelead acetate results in increased expression of ACAN mRNA17805416
D008550MelatoninMelatonin results in increased expression of ACAN mRNA20738756
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in increased expression of ACAN mRNA]18628692
D009151Mustard GasMustard Gas results in decreased expression of ACAN mRNA15674843
C502362N-butyrylglucosamineN-butyrylglucosamine results in increased expression of ACAN mRNA15240824
D010269ParaquatParaquat results in decreased expression of ACAN mRNA26108578
D010936Plant ExtractsPlant Extracts results in decreased expression of ACAN mRNA23557933
C043435polylactic acid-polyglycolic acid copolymer[Chitosan co-treated with polylactic acid-polyglycolic acid copolymer] results in increased expression of ACAN mRNA17607738
D011374ProgesteroneProgesterone results in increased expression of ACAN protein20673848
D011441PropylthiouracilPropylthiouracil results in decreased expression of ACAN mRNA24780913
C059514resveratrolresveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ACAN mRNA]]26526931
C059514resveratrol[Hyaluronic Acid co-treated with resveratrol] results in increased expression of ACAN mRNA23595953
C059514resveratrolresveratrol results in decreased expression of ACAN mRNA23772162
C059514resveratrolresveratrol results in decreased degradation of ACAN protein20825639
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in increased expression of ACAN mRNA]18628692
D019821SimvastatinNOG inhibits the reaction [Simvastatin results in increased expression of ACAN mRNA]18628692
D019821SimvastatinSimvastatin results in increased expression of ACAN mRNA18628692|1991265
C017947sodium arsenitesodium arsenite results in decreased expression of ACAN mRNA28206643
D018038Sodium SeleniteSodium Selenite results in decreased expression of ACAN mRNA18175754
D013420SulfamethoxazoleSulfamethoxazole results in decreased expression of ACAN mRNA26107568
D013605T-2 ToxinT-2 Toxin results in decreased expression of ACAN mRNA16624732|1819660
D013605T-2 ToxinT-2 Toxin results in decreased expression of ACAN protein16624732
D013605T-2 ToxinT-2 Toxin results in decreased expression of ACAN mRNA22800716
C061133tamibarotenetamibarotene affects the expression of ACAN mRNA15498508
D014212TretinoinTretinoin results in decreased expression of ACAN mRNA15498508
D014212TretinoinTretinoin results in decreased expression of ACAN mRNA16410076|2249843

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-TAS1569188  
GO:0005515protein binding-IPI17588949  
GO:0030021extracellular matrix structural constituent conferring compression resistance-HDA20551380  27068509  
GO:0030246carbohydrate binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-IBA21873635  
GO:0001501skeletal system development-NAS1569188  
GO:0006508proteolysis-NAS1569188  
GO:0007155cell adhesion-IEA-  
GO:0007417central nervous system development-IBA21873635  
GO:0018146keratan sulfate biosynthetic process-TAS-  
GO:0030198extracellular matrix organization-TAS-  
GO:0042340keratan sulfate catabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005796Golgi lumen-TAS-  
GO:0043202lysosomal lumen-TAS-  
GO:0062023collagen-containing extracellular matrix-HDA27068509  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal