Gene: DNAH6

1768
DNHL1|Dnahc6|HL-2|HL2
dynein axonemal heavy chain 6
protein-coding
2p11.2
Ensembl:ENSG00000115423 MIM:603336 Vega:OTTHUMG00000128957 UniprotKB:Q9C0G6
NG_050957.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.209e-1 (AD)  8.622e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17759625chr2:84588560 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPEF20.863
RYR20.857
ZNF6670.855
LRRC70.845
LMLN0.84
LMO70.836
DRD10.835
DGKI0.834
CACNA1E0.83
ZNF3820.827

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.486
COPZ2-0.464
TMEM102-0.45
PPP1R14B-0.45
MAPKAPK3-0.45
C4orf19-0.449
MSX1-0.44
MYL3-0.437
S100A16-0.437
EMP3-0.436

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of DNAH6 mRNA"19162173
D000082AcetaminophenAcetaminophen results in increased expression of DNAH6 mRNA26690555
D001280AtrazineAtrazine results in increased expression of DNAH6 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DNAH6 mRNA27195522
C006780bisphenol Abisphenol A results in decreased expression of DNAH6 mRNA25181051|2909715
C018475butyraldehydebutyraldehyde results in increased expression of DNAH6 mRNA26079696
D003471CuprizoneCuprizone results in increased expression of DNAH6 mRNA26577399
D004041Dietary FatsDietary Fats results in increased expression of DNAH6 mRNA25016146
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DNAH6 mRNA29097150
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of DNAH6 mRNA26752646
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DNAH6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DNAH6 mRNA"25554681
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of DNAH6 mRNA28511854
C006253pirinixic acidpirinixic acid results in increased expression of DNAH6 mRNA20813756
D012969Sodium FluorideSodium Fluoride results in increased expression of DNAH6 protein28918527
C009495titanium dioxidetitanium dioxide results in decreased expression of DNAH6 mRNA23557971
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of DNAH6 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased methylation of DNAH6 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005524ATP binding-IEA-  
GO:0008569ATP-dependent microtubule motor activity, minus-end-directed-IBA21873635  
GO:0045503dynein light chain binding-IBA21873635  
GO:0045505dynein intermediate chain binding-IBA21873635  
GO:0051959dynein light intermediate chain binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001539cilium or flagellum-dependent cell motility-IEA-  
GO:0007018microtubule-based movement-IBA21873635  
GO:0060271cilium assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005858axonemal dynein complex-IEA-  
GO:0005874microtubule-IEA-  
GO:0005929cilium-IBA21873635  
GO:0030286dynein complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal