Gene: DNAH8

1769
ATPase|hdhc9
dynein axonemal heavy chain 8
protein-coding
6p21.2
Ensembl:ENSG00000124721 MIM:603337 Vega:OTTHUMG00000016253 UniprotKB:Q96JB1
NG_041805.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.388e-1 (AD)  5.119e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4714198chr6:38909829 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLDN160.665
MAP100.656
C5orf340.652
PLK40.65
ZNF7200.637
RFC30.632
ARMCX50.628
TSNAX0.624
BAAT0.623
LARP1B0.621

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC102A-0.392
MTRNR2L9-0.365
HIGD1B-0.358
MYL3-0.347
HVCN1-0.344
WSCD1-0.341
BGN-0.336
AKR1C3-0.336
EYA2-0.335
LCAT-0.334

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNAH8 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNAH8 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNAH8 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNAH8 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNAH8 mRNA"25510870
C496492abrineabrine results in decreased expression of DNAH8 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of DNAH8 mRNA17585979
D020106AcrylamideAcrylamide results in decreased expression of DNAH8 mRNA28959563
D001151ArsenicArsenic affects the methylation of DNAH8 gene25304211
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of DNAH8 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of DNAH8 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of DNAH8 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DNAH8 mRNA21569818
C006780bisphenol Abisphenol A affects the expression of DNAH8 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of DNAH8 mRNA27178563
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DNAH8 mRNA24982889
D003042CocaineDNAH8 gene SNP affects the susceptibility to Cocaine18438686
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of DNAH8 mRNA15149470
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of DNAH8 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DNAH8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DNAH8 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of DNAH8 mRNA12832660
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of DNAH8 mRNA27935865
D010100OxygenOxygen deficiency results in increased expression of DNAH8 mRNA26516004
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DNAH8 mRNA"25510870
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of DNAH8 mRNA27935865
C017947sodium arsenitesodium arsenite affects the methylation of DNAH8 gene28589171
D012969Sodium FluorideSodium Fluoride results in increased expression of DNAH8 mRNA27862939
D012969Sodium FluorideSodium Fluoride results in increased expression of DNAH8 protein28918527
D013619TacrineTacrine results in increased expression of DNAH8 mRNA12832660
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DNAH8 mRNA21998131
C009495titanium dioxidetitanium dioxide results in decreased expression of DNAH8 mRNA23409001|2776080
C009495titanium dioxidetitanium dioxide results in increased expression of DNAH8 mRNA23557971
D014635Valproic AcidValproic Acid results in increased methylation of DNAH8 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003777microtubule motor activity-NAS9373155  
GO:0005524ATP binding-IEA-  
GO:0008569ATP-dependent microtubule motor activity, minus-end-directed-IBA21873635  
GO:0045503dynein light chain binding-IBA21873635  
GO:0045505dynein intermediate chain binding-IBA21873635  
GO:0051959dynein light intermediate chain binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007018microtubule-based movement-IBA21873635  
GO:0036158outer dynein arm assembly-IBA21873635  
GO:0060285cilium-dependent cell motility-NAS9373155  
GO ID GO Term Qualifier Evidence PubMed
GO:0005858axonemal dynein complex-NAS9373155  
GO:0005874microtubule-IEA-  
GO:0030286dynein complex-IBA21873635  
GO:0030286dynein complex-IDA22863569  
GO:0036157outer dynein arm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal