Gene: AGER

177
RAGE|SCARJ1
advanced glycosylation end-product specific receptor
protein-coding
6p21.32
Ensembl:ENSG00000204305 MIM:600214 Vega:OTTHUMG00000031120 UniprotKB:Q15109
NG_029868.1
PubMed|SNP Mapped
2   ANCO-SNPs
OD|ND|AD
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs999chr6:32186109 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs1800624chr6:32184610 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MOV100.738
HDAC70.733
UNC13D0.725
SAP250.721
STK380.714
MEF2B0.71
SLC8B10.71
ASCC20.706
CDK30.704
FSTL30.704

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXPH2-0.442
NEK2-0.439
CNTN6-0.432
EPHA5-0.425
MCHR2-0.425
HS6ST3-0.422
PLS1-0.42
KNCN-0.419
GRIN3A-0.417
CNTN5-0.417

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased expression of AGER protein]21807062
C4574992-chloro-5-nitrobenzanilide[2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [resveratrol results in increased expression of AGER protein]20372816
C5811822-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione"2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione results in decreased expression of AGER protein"23500658
C5490664-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [S100B protein results in increased expression of AGER protein]"23541064
C5490664-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine"4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine results in decreased expression of AGER protein"23541064
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased expression of AGER protein]"21807062
D000082AcetaminophenAcetaminophen results in decreased expression of AGER mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of AGER mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of AGER mRNA24747151
D000171AcroleinAcrolein results in increased expression of AGER protein23296102
D000447AldehydesAldehydes results in decreased expression of AGER mRNA25014914
C004471allyl isothiocyanateallyl isothiocyanate results in decreased expression of AGER mRNA24036144
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AGER mRNA16483693
D000667AmpicillinAmpicillin results in decreased expression of AGER mRNA24747151
D000872AnthocyaninsAnthocyanins inhibits the reaction [Dietary Fats results in increased expression of AGER protein]24795233
D001151ArsenicArsenic results in increased expression of AGER protein29155576
D001379AzathioprineAzathioprine results in increased expression of AGER mRNA24184165
C547126AZM551248AZM551248 results in increased expression of AGER mRNA22323515
D001397AzoxymethaneAGER protein results in increased susceptibility to [Azoxymethane co-treated with Glucose co-treated with Linoleic Acid]22467055
D001397AzoxymethaneAzoxymethane results in increased expression of AGER protein22467055
D001397AzoxymethaneGlucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]22467055
D001397AzoxymethaneGlucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]22467055
D001397AzoxymethaneLinoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]22467055
D001397AzoxymethaneLinoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]22467055
D001397AzoxymethaneLosartan inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
D001397AzoxymethaneLosartan inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
D001397AzoxymethaneMetformin inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
D001397AzoxymethaneMetformin inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
C044946benazeprilbenazepril results in decreased expression of AGER mRNA19018797
C044946benazeprilbenazepril results in decreased expression of AGER protein19018797
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of AGER protein]15878629
D004958EstradiolEstradiol results in increased expression of AGER mRNA15878629
D004958EstradiolEstradiol results in increased expression of AGER protein15878629
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of AGER protein]15878629
C006780bisphenol Abisphenol A results in decreased expression of AGER mRNA25181051
D001761BleomycinBleomycin results in decreased expression of AGER protein25582705|2593344
D001761Bleomycinprotocatechualdehyde inhibits the reaction [Bleomycin results in decreased expression of AGER protein]25582705
C018475butyraldehydebutyraldehyde results in decreased expression of AGER mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of AGER promoter22457795
D002220CarbamazepineCarbamazepine results in increased expression of AGER mRNA22790970
D002713ChlorineChlorine results in decreased expression of AGER mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of AGER mRNA18636392
D002784CholesterolAGER protein affects the abundance of Cholesterol20372816
D002945CisplatinCisplatin results in decreased expression of AGER mRNA27392435
D004008DiclofenacDiclofenac results in increased expression of AGER mRNA28138970
D004008DiclofenacDiclofenac results in increased expression of AGER mRNA24747151
D004009DicloxacillinAGER protein affects the reaction [Dicloxacillin results in increased expression of GPT protein]24747151
D004009DicloxacillinDicloxacillin results in increased expression of AGER mRNA24747151
D004041Dietary FatsAnthocyanins inhibits the reaction [Dietary Fats results in increased expression of AGER protein]24795233
D004041Dietary FatsDietary Fats results in increased expression of AGER protein23821548|2479523
D004041Dietary Fats[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of AGER mRNA26042203
D004041Dietary FatsRALBP1 affects the reaction [Dietary Fats results in increased expression of AGER protein]23821548
D019422Dietary Sucrose[GPX4 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Dietary Sucrose]] which results in increased expression of AGER mRNA26042203
C552122dimerumic aciddimerumic acid results in decreased expression of AGER mRNA24036144
C552122dimerumic acidNFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of AGER mRNA]24036144
D015118Eicosapentaenoic Acid[Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of AGER mRNA22169119
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of AGER protein]22101032
D004964EstriolEstriol results in increased expression of AGER protein15878629
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AGER mRNA15878629
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AGER protein15878629
D004997Ethinyl EstradiolSP1 protein promotes the reaction [Ethinyl Estradiol results in increased expression of AGER mRNA]15878629
D005485FlutamideFlutamide results in increased expression of AGER mRNA28138970
D005485FlutamideFlutamide results in increased expression of AGER mRNA24747151
D005632FructoseFructose results in increased expression of AGER protein21704028
D005632FructoseGenistein inhibits the reaction [Fructose results in increased expression of AGER protein]21704028
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of AGER protein]15878629
C039281furanfuran results in increased methylation of AGER gene22079235
D005690GalactoseGalactose results in increased expression of AGER mRNA22687555
D005690GalactoseGalactose results in increased expression of AGER protein22687555
D005707Gallic AcidGallic Acid inhibits the reaction [ALB modified form results in increased expression of AGER protein]24309158
D019833GenisteinGenistein inhibits the reaction [Fructose results in increased expression of AGER protein]21704028
D005947GlucoseGLO1 inhibits the reaction [Glucose promotes the reaction [RELA protein binds to AGER promoter]]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose results in increased expression of AGER mRNA]19833897
D005947GlucoseGLO1 inhibits the reaction [Glucose results in increased expression of AGER protein]19833897
D005947GlucoseGlucose promotes the reaction [RELA protein binds to AGER promoter]19833897
D005947GlucoseGlucose results in increased expression of AGER mRNA19557821|1983389
D005947GlucoseGlucose results in increased expression of AGER protein19833897
D005947GlucoseLuteolin inhibits the reaction [Glucose results in increased expression of AGER mRNA]19557821
D005947GlucoseQuercetin inhibits the reaction [Glucose results in increased expression of AGER mRNA]19557821
D005947GlucoseRELA promotes the reaction [Glucose results in increased expression of AGER mRNA]19833897
D005947GlucoseRutin inhibits the reaction [Glucose results in increased expression of AGER mRNA]19557821
D005947GlucoseSOD2 inhibits the reaction [Glucose results in increased expression of AGER mRNA]19833897
D005947GlucoseSOD2 inhibits the reaction [Glucose results in increased expression of AGER protein]19833897
D005947GlucoseUCP1 inhibits the reaction [Glucose results in increased expression of AGER mRNA]19833897
D005947GlucoseUCP1 inhibits the reaction [Glucose results in increased expression of AGER protein]19833897
D005947GlucoseAGER protein results in increased susceptibility to [Azoxymethane co-treated with Glucose co-treated with Linoleic Acid]22467055
D005947GlucoseGlucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]22467055
D005947GlucoseGlucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]22467055
D005947GlucoseGlucose results in increased expression of AGER protein19759273
D005947GlucoseLinoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]22467055
D005947GlucoseLosartan inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
D005947GlucoseLosartan inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
D005947GlucoseMetformin inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
D005947GlucoseMetformin inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
C005499honokiolhonokiol affects the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]26723916
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of AGER protein19885844
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AGER mRNA25613284
C468270Kangen-karyuKangen-karyu inhibits the reaction [Streptozocin results in increased expression of AGER protein]19397970
C045463leflunomideleflunomide results in decreased expression of AGER mRNA19751817
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of AGER mRNA24747151
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of AGER protein17038636|2242981
D008070Lipopolysaccharideslycopene inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]22429818
D008070LipopolysaccharidesSimvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]17038636
D008070Lipopolysaccharides[Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of AGER mRNA22169119
D008070LipopolysaccharidesLipopolysaccharides affects the expression of AGER mRNA22169119
D019808LosartanLosartan inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
D019808LosartanLosartan inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
C485003LR-90LR-90 inhibits the reaction [S100B protein results in increased expression of AGER mRNA]17327432
C485003LR-90LR-90 results in decreased expression of AGER mRNA18317729
C485003LR-90LR-90 results in decreased expression of AGER protein17709884|1831772
D047311LuteolinLuteolin inhibits the reaction [Glucose results in increased expression of AGER mRNA]19557821
C015329lycopenelycopene inhibits the reaction [HMGB1 protein results in increased expression of AGER protein]22429818
C015329lycopenelycopene inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]22429818
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Streptozocin results in increased expression of AGER mRNA]19833897
C013592mangiferinmangiferin results in decreased expression of AGER mRNA24036348
C013592mangiferinmangiferin results in decreased expression of AGER protein24036348
D008463MebendazoleMebendazole results in increased expression of AGER mRNA24747151
D008687MetforminMetformin inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
D008687MetforminMetformin inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of AGER protein28821999
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of AGER25056787
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of AGER mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of AGER promoter"26251327
C031721naphthalenenaphthalene metabolite binds to AGER protein15892573
C005311nornicotinenornicotine results in increased expression of AGER mRNA17397323
C005311nornicotinenornicotine results in increased expression of AGER protein17397323
D019787Linoleic AcidAGER protein results in increased susceptibility to [Azoxymethane co-treated with Glucose co-treated with Linoleic Acid]22467055
D019787Linoleic AcidGlucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]22467055
D019787Linoleic AcidLinoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]22467055
D019787Linoleic AcidLinoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]22467055
D019787Linoleic AcidLosartan inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
D019787Linoleic AcidLosartan inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
D019787Linoleic AcidMetformin inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
D019787Linoleic AcidMetformin inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]22467055
D016627OxidopamineOxidopamine affects the expression of AGER protein26902637
D016627OxidopamineOxidopamine binds to AGER protein26902637
D009828Oleanolic AcidOleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of AGER protein]22386814
D010100OxygenOxygen results in decreased expression of AGER protein modified form17343756
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of AGER mRNA18636392
D010126Ozone[Ozone co-treated with Vehicle Emissions] results in increased expression of AGER mRNA20980218
D052638Particulate MatterParticulate Matter results in increased expression of AGER protein17520064
C046012pentanalpentanal results in decreased expression of AGER mRNA26079696
C004479pimagedinepimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]26723916
D011192Potassium DichromatePotassium Dichromate results in decreased expression of AGER mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of AGER mRNA19162173
C479580procyanidin B2procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of AGER protein]25199697
C479581procyanidin B3[Eicosapentaenoic Acid co-treated with procyanidin B3 co-treated with Lipopolysaccharides] results in increased expression of AGER mRNA22169119
C005556propionaldehydepropionaldehyde results in decreased expression of AGER mRNA26079696
D047428Protein Kinase Inhibitors[Protein Kinase Inhibitors results in decreased activity of PRKCZ protein] which results in decreased expression of AGER protein26833564
C005581protocatechualdehydeprotocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]17597607
C005581protocatechualdehydeprotocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein]17597607
C005581protocatechualdehydeprotocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of AGER protein]25582705
C005581protocatechualdehydeprotocatechualdehyde inhibits the reaction [Bleomycin results in decreased expression of AGER protein]25582705
D011765Pyruvaldehydeepigallocatechin gallate inhibits the reaction [Pyruvaldehyde results in increased expression of AGER protein]22101032
D011765Pyruvaldehydehonokiol affects the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]26723916
D011765Pyruvaldehydepimagedine inhibits the reaction [Pyruvaldehyde results in increased cleavage of AGER protein]26723916
D011765PyruvaldehydePyruvaldehyde results in increased cleavage of AGER protein26723916
D011765PyruvaldehydePyruvaldehyde results in increased expression of AGER protein22101032
D011794QuercetinQuercetin inhibits the reaction [Glucose results in increased expression of AGER mRNA]19557821
D017382Reactive Oxygen Species[Vitamin A results in increased abundance of Reactive Oxygen Species] which results in increased expression of AGER protein18396385
C059514resveratrol[2-chloro-5-nitrobenzanilide binds to and results in decreased activity of PPARG protein] inhibits the reaction [resveratrol results in increased expression of AGER protein]20372816
C059514resveratrolresveratrol inhibits the reaction [ALB protein modified form results in increased expression of AGER protein]23936610
C059514resveratrolresveratrol results in decreased expression of AGER protein20372816
C059514resveratrol[resveratrol results in increased activity of PPARG protein] which results in decreased expression of AGER protein20372816
C089730rosiglitazonerosiglitazone inhibits the reaction [AGT protein results in increased expression of AGER mRNA]18711692
D012431RutinRutin inhibits the reaction [Glucose results in increased expression of AGER mRNA]19557821
C093642SB 203580SB 203580 inhibits the reaction [Vitamin A results in increased expression of AGER protein]21807062
D012834SilverSilver results in increased expression of AGER mRNA26014281
D019821SimvastatinSimvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of AGER protein]17038636
D019821SimvastatinSimvastatin results in decreased expression of AGER protein17038636
D019821SimvastatinSimvastatin results in decreased expression of AGER19944163
C017947sodium arsenitesodium arsenite affects the expression of AGER mRNA17450228
D018038Sodium SeleniteSodium Selenite inhibits the reaction [Streptozocin results in increased expression of AGER protein]22476978
D013311StreptozocinAGER protein results in increased susceptibility to Streptozocin27109771
D013311Streptozocinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Streptozocin results in increased expression of AGER mRNA]19833897
D013311StreptozocinStreptozocin results in increased expression of AGER mRNA19833897
D013311StreptozocinKangen-karyu inhibits the reaction [Streptozocin results in increased expression of AGER protein]19397970
D013311Streptozocinprocyanidin B2 inhibits the reaction [Streptozocin results in increased expression of AGER protein]25199697
D013311StreptozocinSodium Selenite inhibits the reaction [Streptozocin results in increased expression of AGER protein]22476978
D013311StreptozocinStreptozocin results in increased expression of AGER protein22476978|2519969
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone promotes the reaction [HMGB1 protein binds to AGER protein]27413111
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased expression of AGER mRNA27413111
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased expression of AGER protein27413111
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AGER mRNA21570461|2637764
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]]23541064
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of AGER mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of AGER mRNA23557971
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of AGER protein"28329851
D014051Toluene 2,4-Diisocyanate"TSLP protein alternative form inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of AGER protein]"28329851
D014266TrientineTetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]]23541064
D014266TrientineTrientine inhibits the reaction [S100B protein results in increased expression of AGER protein]23541064
D014266TrientineTrientine results in decreased expression of AGER protein23541064
D014266TrientineTrientine results in decreased expression of AGER mRNA23541064
D014266TrientineTrientine results in decreased expression of AGER protein23541064
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of AGER mRNA29024780
D001335Vehicle EmissionsAGER mutant form inhibits the reaction [Vehicle Emissions results in increased localization of RELA protein]21087909
D001335Vehicle EmissionsAGER mutant form inhibits the reaction [Vehicle Emissions results in increased secretion of CCL2 protein]21087909
D001335Vehicle EmissionsAGER mutant form inhibits the reaction [Vehicle Emissions results in increased secretion of CXCL8 protein]21087909
D001335Vehicle Emissions[Ozone co-treated with Vehicle Emissions] results in increased expression of AGER mRNA20980218
D001335Vehicle EmissionsVehicle Emissions results in increased expression of AGER mRNA20980218|2108790
D001335Vehicle EmissionsVehicle Emissions results in increased expression of AGER protein17520064|2108790
C025643vinclozolinvinclozolin affects the expression of AGER mRNA19015723
D014801Vitamin A2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased expression of AGER protein]21807062
D014801Vitamin A"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Vitamin A results in increased expression of AGER protein]"21807062
D014801Vitamin ASB 203580 inhibits the reaction [Vitamin A results in increased expression of AGER protein]21807062
D014801Vitamin A[Vitamin A results in increased abundance of Reactive Oxygen Species] which results in increased expression of AGER protein18396385
D014801Vitamin AVitamin A results in increased expression of AGER protein18396385|2180706
D015032Zinc[Zinc deficiency co-treated with PTGS2 gene mutant form] results in increased expression of AGER protein20857495
D015032ZincZinc inhibits the reaction [[Zinc deficiency co-treated with PTGS2 gene mutant form] results in increased expression of AGER protein]20857495
D015032ZincZinc deficiency results in increased expression of AGER protein19111725
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of AGER protein]19111725

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-NAS18367618  
GO:0001540amyloid-beta binding-TAS15457210  
GO:0004888transmembrane signaling receptor activity-TAS1378843  
GO:0005044scavenger receptor activity-TAS11240025  
GO:0005515protein binding-IPI16061848  16716307  16954185  17474147  17660747  17726019  
18922799  19386136  19944695  21706016  24474694  25910212  
GO:0008201heparin binding-IEA-  
GO:0038023signaling receptor activity-IMP15457210  
GO:0042802identical protein binding-IPI24119142  
GO:0044548S100 protein binding-IPI15033494  
GO:0050785advanced glycation end-product receptor activity-NAS15457210  
GO:1904599advanced glycation end-product binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0001914regulation of T cell mediated cytotoxicity-IDA22473704  
GO:0001934positive regulation of protein phosphorylation-IGI15457210  
GO:0006898receptor-mediated endocytosis-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0007166cell surface receptor signaling pathway-TAS10835680  
GO:0007611learning or memory-IGI15457210  
GO:0009611response to wounding-TAS10399917  
GO:0010255glucose mediated signaling pathway-IDA25689357  
GO:0014002astrocyte development-IEA-  
GO:0031175neuron projection development-IGI10391939  
GO:0032693negative regulation of interleukin-10 production-IDA22473704  
GO:0032735positive regulation of interleukin-12 production-IMP15944249  
GO:0042104positive regulation of activated T cell proliferation-IMP15944249  
GO:0043507positive regulation of JUN kinase activity-IEA-  
GO:0045087innate immune response-TAS-  
GO:0046330positive regulation of JNK cascade-IGI20739563  
GO:0048167regulation of synaptic plasticity-TAS18367618  19221410  20739563  
GO:0050930induction of positive chemotaxis-IEA-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA10391939  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IGI15457210  
GO:0051101regulation of DNA binding-IEA-  
GO:0061890positive regulation of astrocyte activation-IGI15457210  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IGI15457210  
GO:0071639positive regulation of monocyte chemotactic protein-1 production-IEA-  
GO:0072657protein localization to membrane-IEA-  
GO:0090647modulation of age-related behavioral decline-IGI15457210  
GO:0150003regulation of spontaneous synaptic transmission-IGI15457210  
GO:1900271regulation of long-term synaptic potentiation-ISS-  
GO:1900272negative regulation of long-term synaptic potentiation-IGI15457210  
GO:1900272negative regulation of long-term synaptic potentiation-ISS-  
GO:1900453negative regulation of long term synaptic depression-IGI20739563  
GO:1900744regulation of p38MAPK cascade-ISS-  
GO:1900745positive regulation of p38MAPK cascade-IGI20739563  
GO:1901222regulation of NIK/NF-kappaB signaling-NAS15457210  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IGI15457210  
GO:1903980positive regulation of microglial cell activation-IGI15457210  
GO:1904597negative regulation of connective tissue replacement involved in inflammatory response wound healing-IEA-  
GO:1904604negative regulation of advanced glycation end-product receptor activity-IEA-  
GO:1904645response to amyloid-beta-ISS-  
GO:1904645response to amyloid-beta-TAS18367618  20739563  
GO:1904646cellular response to amyloid-beta-ISS-  
GO:2000514regulation of CD4-positive, alpha-beta T cell activation-IDA22473704  
GO:2001200positive regulation of dendritic cell differentiation-IMP15944249  
GO ID GO Term Qualifier Evidence PubMed
GO:0001650fibrillar center-IDA-  
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS15457210  
GO:0009986cell surface-NAS15457210  
GO:0016324apical plasma membrane-IDA26005850  
GO:0030054cell junction-IDA-  
GO:0098794postsynapse-TAS26224839  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1606322ZBP1(DAI) mediated induction of type I IFNsTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-1810476RIP-mediated NFkB activation via ZBP1TAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-3134963DEx/H-box helicases activate type I IFN and inflammatory cytokines production TAS
R-HSA-445989TAK1 activates NFkB by phosphorylation and activation of IKKs complexTAS
R-HSA-446652Interleukin-1 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-879415Advanced glycosylation endproduct receptor signalingTAS
R-HSA-879415Advanced glycosylation endproduct receptor signalingIEA
R-HSA-9020702Interleukin-1 signalingTAS
R-HSA-933542TRAF6 mediated NF-kB activationTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21339699Differing age related trajectories of dysfunction in several organ systems in opiate dependence. (2012 Feb)Reece ASAging Clin Exp Res
28287180Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. (2017 Mar 13)Morrow JDSci Rep
27117828Advanced glycation endproducts and their receptor in different body compartments in COPD. (2016 Apr 26)Hoonhorst SJRespir Res
22461431CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. (2012 Aug)Hardin MAm J Respir Cell Mol Biol
26503507Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias. (2015 Oct 26)Steele MPBMC Genomics
25306249The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes. (2014 Oct 12)Carolan BJRespir Res
26308105Expression and DNA methylation status of the Rap2B gene in human bronchial epithelial cells treated by cigarette smoke condensate. (2015)Zhang SInhal Toxicol
26771213Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. (2016 Jul 1)Hobbs BDAm J Respir Crit Care Med
17700210Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction. (2007 Sep)Park SCoron Artery Dis
23252485Genetic variation in the receptor for advanced glycation end-products (RAGE) gene and ischaemic stroke. (2013 Jun)Olsson SEur J Neurol
16728681Polymorphisms in the advanced glycosylation end product-specific receptor gene and risk of incident myocardial infarction or ischemic stroke. (2006 Jul)Zee RYStroke