Gene info: ID 1781

Gene: DYNC1I2

GENE ID: 1781

Synonyms: DIC74|DNCI2|IC2

Description: dynein cytoplasmic 1 intermediate chain 2

Gene type: protein-coding

Location: 2q31.1

dbXrefs: Ensembl:ENSG00000077380 MIM:603331 Vega:OTTHUMG00000154061 UniprotKB:Q13409

RefSeq: NC_000002.12

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.305e-1 (AD) 8.153e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs17427473	chr2:171719501 (GRCh38.p7)	A>G	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CSDE1	0.925
SCARB2	0.923
YWHAQ	0.92
RNF146	0.917
TARDBP	0.914
RAD21	0.91
RNF20	0.91
SMARCE1	0.906
SMARCA5	0.906
SERINC1	0.905

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.75
OR4F5	-0.735
MTRNR2L6	-0.236
MTRNR2L10	-0.231
C8orf74	-0.217
OR4F16	-0.21
MTRNR2L9	-0.203
MTRNR2L3	-0.194
MTRNR2L8	-0.182
TTLL10	-0.17

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of DYNC1I2 mRNA"	19162173
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of DYNC1I2 mRNA"	21346803
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of DYNC1I2 mRNA"	23195993
D001151	Arsenic	Arsenic affects the methylation of DYNC1I2 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of DYNC1I2 mRNA	15894607
D001280	Atrazine	Atrazine results in decreased expression of DYNC1I2 mRNA	25929836
C019264	avermectin	avermectin results in increased expression of DYNC1I2 mRNA	26541719
C019264	avermectin	avermectin results in increased expression of DYNC1I2 protein	26541719
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of DYNC1I2 mRNA"	26238291
C095105	bexarotene	bexarotene results in decreased expression of DYNC1I2 mRNA	16648578
C006780	bisphenol A	bisphenol A results in increased expression of DYNC1I2 mRNA	25181051
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DYNC1I2 mRNA	28628672
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of DYNC1I2 mRNA	23650126
C100187	chloropicrin	chloropicrin results in decreased expression of DYNC1I2 mRNA	28476498
D019327	Copper Sulfate	Copper Sulfate results in increased expression of DYNC1I2 mRNA	19549813
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DYNC1I2 mRNA	28628672
C000944	dicrotophos	dicrotophos results in decreased expression of DYNC1I2 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in increased expression of DYNC1I2 mRNA	19030233
D004041	Dietary Fats	rimonabant inhibits the reaction [Dietary Fats results in increased expression of DYNC1I2 mRNA]	19030233
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of DYNC1I2 mRNA"	22485181
D005485	Flutamide	Flutamide results in decreased expression of DYNC1I2 mRNA	24793618
D005485	Flutamide	Flutamide results in increased expression of DYNC1I2 mRNA	24136188
D005839	Gentamicins	Gentamicins results in increased expression of DYNC1I2 mRNA	22061828
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DYNC1I2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DYNC1I2 mRNA	28628672
C410337	K 7174	K 7174 results in increased expression of DYNC1I2 mRNA	24086573
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of DYNC1I2 mRNA	28001369
D009532	Nickel	Nickel results in decreased expression of DYNC1I2 mRNA	23195993
C028007	nickel monoxide	nickel monoxide results in decreased expression of DYNC1I2 mRNA	19167457
D052638	Particulate Matter	Particulate Matter results in decreased expression of DYNC1I2 protein	17922515
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of DYNC1I2 protein	19954255
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of DYNC1I2 protein	19954255
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of DYNC1I2 protein	26879310
C089032	rimonabant	rimonabant inhibits the reaction [Dietary Fats results in increased expression of DYNC1I2 mRNA]	19030233
C017947	sodium arsenite	[sodium arsenite co-treated with sodium arsenite deficiency] results in decreased methylation of DYNC1I2 promoter	28336213
C017947	sodium arsenite	[sodium arsenite co-treated with sodium arsenite deficiency] results in increased expression of DYNC1I2 mRNA	28336213
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DYNC1I2 mRNA	21570461
C014215	tetrahydropalmatine	tetrahydropalmatine results in decreased expression of DYNC1I2 protein	20109541
C009495	titanium dioxide	titanium dioxide results in decreased expression of DYNC1I2 mRNA	23409001
D014635	Valproic Acid	Valproic Acid results in decreased methylation of DYNC1I2 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of DYNC1I2 mRNA	17963808
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of DYNC1I2 protein	17922515
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of DYNC1I2 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003777	microtubule motor activity	-	NAS	8522607
GO:0005515	protein binding	-	IPI	25416956
GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	CONTRIBUTES_TO	IBA	21873635
GO:0045503	dynein light chain binding	-	IBA	21873635
GO:0045504	dynein heavy chain binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	-
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	-
GO:0007018	microtubule-based movement	-	IBA	21873635
GO:0007018	microtubule-based movement	-	NAS	8522607
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	-
GO:0010970	transport along microtubule	-	IBA	21873635
GO:0016032	viral process	-	IEA	-
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	-
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	-
GO:2000582	positive regulation of ATP-dependent microtubule motor activity, plus-end-directed	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	NAS	8522607
GO:0005813	centrosome	-	IDA	21399614
GO:0005829	cytosol	-	TAS	-
GO:0005868	cytoplasmic dynein complex	-	IBA	21873635
GO:0005874	microtubule	-	IDA	21525035
GO:0030286	dynein complex	-	IBA	21873635
GO:0031982	vesicle	-	IDA	20682791

KEGG ID	KEGG Term
hsa04145	Phagosome
hsa04962	Vasopressin-regulated water reabsorption

Reactome ID	Reactome Term	Evidence
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-141424	Amplification of signal from the kinetochores	TAS
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1640170	Cell Cycle	TAS
R-HSA-168256	Immune System	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-199977	ER to Golgi Anterograde Transport	TAS
R-HSA-199991	Membrane Trafficking	TAS
R-HSA-2132295	MHC class II antigen presentation	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-2467813	Separation of Sister Chromatids	TAS
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	TAS
R-HSA-2555396	Mitotic Metaphase and Anaphase	TAS
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	TAS
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)	TAS
R-HSA-380259	Loss of Nlp from mitotic centrosomes	TAS
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	TAS
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome	TAS
R-HSA-380287	Centrosome maturation	TAS
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-446203	Asparagine N-linked glycosylation	TAS
R-HSA-453274	Mitotic G2-G2/M phases	TAS
R-HSA-5617833	Cilium Assembly	TAS
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-5663220	RHO GTPases Activate Formins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6807878	COPI-mediated anterograde transport	TAS
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	TAS
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	TAS
R-HSA-68877	Mitotic Prometaphase	TAS
R-HSA-68882	Mitotic Anaphase	TAS
R-HSA-68886	M Phase	TAS
R-HSA-69275	G2/M Transition	TAS
R-HSA-69278	Cell Cycle, Mitotic	TAS
R-HSA-69618	Mitotic Spindle Checkpoint	TAS
R-HSA-69620	Cell Cycle Checkpoints	TAS
R-HSA-8854518	AURKA Activation by TPX2	TAS
R-HSA-8856688	Golgi-to-ER retrograde transport	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-948021	Transport to the Golgi and subsequent modification	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal