Gene info: ID 1786

Gene: DNMT1

GENE ID: 1786

Description: DNA methyltransferase 1

Gene type: protein-coding

Location: 19p13.2

dbXrefs: Ensembl:ENSG00000130816 MIM:126375 Vega:OTTHUMG00000180397 UniprotKB:P26358

RefSeq: NG_028016.3

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND|AD

# Publications: 21

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.842e-1 (AD) 7.618e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
POLG	0.928
ATXN2L	0.919
FLII	0.911
GGA3	0.909
KPNA6	0.906
PRPF8	0.906
DDX27	0.906
DHX16	0.905
VPS16	0.905
SEC24C	0.905

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.567
OR4F29	-0.54
PON3	-0.333
TRDN	-0.318
ASB4	-0.306
IL20RA	-0.306
LRAT	-0.304
MTRNR2L10	-0.301
MTRNR2L6	-0.296
OR4F16	-0.294

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00928	Azacitidine	Small Molecule	320-67-2	Approved\|Investigational	Target
DB01035	Procainamide	Small Molecule	51-06-9	Approved	Target
DB01099	Flucytosine	Small Molecule	2022-85-7	Approved\|Investigational	Target
DB01262	Decitabine	Small Molecule	2353-33-5	Approved\|Investigational	Target
DB05668	Palifosfamide	Small Molecule	31645-39-3	Investigational	Target
DB12116	Epigallocatechin Gallate	Small Molecule	989-51-5	Investigational	Target

ID	Drug Name	Action	PubMed
C517232	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of DNMT1 mRNA"	23958786
C517232	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of DNMT1 mRNA"	24375616
C031763	1,3-butadiene	"1,3-butadiene results in decreased expression of DNMT1 mRNA"	25237060
C031763	1,3-butadiene	"1,3-butadiene results in decreased expression of DNMT1 protein"	21147608
C517943	1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone	"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in decreased phosphorylation of DNMT1 protein"	27026707
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of DNMT1 mRNA"	25614096
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DNMT1 mRNA"	19167446
C057349	2,4-decadienal	"2,4-decadienal results in increased expression of DNMT1 mRNA"	22363721
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of DNMT1 mRNA"	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of DNMT1 protein"	22581815
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of DNMT1 mRNA"	12097258
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane results in decreased expression of DNMT1 mRNA"	24466240
C569675	5-(N,N-dimethylaminomethyl)-3-(4-nitrophenyl)-4,5-dihydroisoxazole	"5-(N,N-dimethylaminomethyl)-3-(4-nitrophenyl)-4,5-dihydroisoxazole results in decreased activity of DNMT1 protein"	21958292
C067134	8-oxo-7-hydrodeoxyguanosine	DNMT1 gene SNP affects the abundance of 8-oxo-7-hydrodeoxyguanosine	19896490
D000082	Acetaminophen	Acetaminophen results in increased expression of DNMT1 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of DNMT1 mRNA	17562736
D019342	Acetic Acid	Acetic Acid results in decreased expression of DNMT1 protein	17065238
D012435	S-Adenosylhomocysteine	S-Adenosylhomocysteine results in decreased activity of DNMT1 protein	16037419
D012435	S-Adenosylhomocysteine	S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]	22064374
D012435	S-Adenosylhomocysteine	S-Adenosylhomocysteine results in decreased activity of DNMT1 protein	22064374
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]	22558281
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT1 protein]	22558281
D006710	Homocysteine	DNMT1 protein affects the reaction [Homocysteine results in decreased expression of CCNA1 mRNA]	17698632
D006710	Homocysteine	Homocysteine results in decreased activity of DNMT1 protein	17698632
D000639	Amitriptyline	Amitriptyline results in decreased activity of DNMT1 protein	19924110
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of DNMT1 mRNA"	22863853
D001151	Arsenic	Arsenic affects the methylation of DNMT1 gene	25304211
D001151	Arsenic	Arsenic results in increased expression of DNMT1 mRNA	27838757
D001151	Arsenic	DNMT1 gene SNP affects the susceptibility to Arsenic	27292127
D001151	Arsenic	Arsenic results in decreased expression of DNMT1 protein	9380733
D001151	Arsenic	Arsenic results in increased expression of DNMT1 mRNA	9380733
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]	22558281
C006632	arsenic trioxide	arsenic trioxide results in decreased activity of DNMT1 protein	20596618
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of DNMT1 mRNA	16613325\|1749052
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of DNMT1 protein	21687957\|2255828
C006632	arsenic trioxide	arsenic trioxide results in increased expression of DNMT1 mRNA	25534098
C006632	arsenic trioxide	S-Adenosylmethionine inhibits the reaction [arsenic trioxide inhibits the reaction [DNMT1 protein binds to ESR1 promoter]]	22558281
C006632	arsenic trioxide	S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT1 protein]	22558281
C006632	arsenic trioxide	[arsenic trioxide co-treated with Tamoxifen] results in decreased expression of DNMT1 mRNA	23159075
C006632	arsenic trioxide	[arsenic trioxide co-treated with Tamoxifen] results in decreased expression of DNMT1 protein	23159075
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of DNMT1 mRNA	23159075
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of DNMT1 protein	19679824\|2315907
D001280	Atrazine	Atrazine results in increased expression of DNMT1 mRNA	25929836
D001280	Atrazine	Atrazine results in decreased expression of DNMT1 mRNA	22378314
D001374	Azacitidine	Azacitidine results in decreased expression of DNMT1 mRNA	15547111
D001374	Azacitidine	pifithrin inhibits the reaction [Azacitidine results in decreased expression of DNMT1 mRNA]	15547111
D001374	Azacitidine	[SLC28A1 protein results in increased uptake of Azacitidine] which results in decreased expression of DNMT1 protein	19139132
D001374	Azacitidine	TP53 protein promotes the reaction [Azacitidine results in decreased expression of DNMT1 mRNA]	15547111
D001374	Azacitidine	[Azacitidine co-treated with entinostat] results in decreased expression of DNMT1 protein	21224363
D001374	Azacitidine	Azacitidine results in decreased expression of DNMT1 protein	19723570\|2122436
D001374	Azacitidine	[Cisplatin co-treated with Azacitidine] results in decreased expression of DNMT1 protein	19723570
D053119	Benzophenanthridines	Benzophenanthridines analog results in decreased expression of DNMT1 mRNA	23117580
D001564	Benzo(a)pyrene	AHR2 gene mutant form affects the reaction [Benzo(a)pyrene results in decreased expression of DNMT1 mRNA]	28583304
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DNMT1 mRNA	26001963\|2858330
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DNMT1 protein	28329817
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased degradation of DNMT1 protein	21150308
D001564	Benzo(a)pyrene	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Benzo(a)pyrene results in increased degradation of DNMT1 protein]	21150308
D001564	Benzo(a)pyrene	Benzo(a)pyrene inhibits the reaction [[DNMT1 protein binds to HDAC1 protein] which binds to CYP1A1 promoter]	17682057
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DNMT1 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DNMT1 mRNA	22228805
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Benzo(a)pyrene results in increased degradation of DNMT1 protein]	21150308
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [quinoline analog results in increased degradation of DNMT1 protein]	19417133
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of DNMT1 protein]	23395981
D001599	Berberine	Berberine results in decreased expression of DNMT1 mRNA	27311644
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]	20631324
D004958	Estradiol	Estradiol results in decreased expression of DNMT1 mRNA	22952798
D004958	Estradiol	Estradiol results in decreased phosphorylation of DNMT1 protein	27026707
D004958	Estradiol	resveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]	20631324
D004958	Estradiol	[sodium arsenite co-treated with Estradiol] results in decreased expression of DNMT1 mRNA	22952798
D004958	Estradiol	Estradiol results in increased expression of DNMT1 mRNA	28406523
D001622	Betaine	Betaine inhibits the reaction [CPT1A protein mutant form results in decreased expression of DNMT1 mRNA]	22945834
D001622	Betaine	Betaine results in increased expression of DNMT1 mRNA	22945834
D001622	Betaine	[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA	28445388
C006780	bisphenol A	bisphenol A affects the expression of DNMT1 mRNA	27101439
C006780	bisphenol A	bisphenol A results in decreased expression of DNMT1 mRNA	26562050\|2712049
C006780	bisphenol A	bisphenol A results in increased expression of DNMT1 mRNA	26911650\|2902798
C006780	bisphenol A	bisphenol A results in increased methylation of DNMT1 promoter	27120497
C006780	bisphenol A	bisphenol A results in increased expression of DNMT1 mRNA	27474941
C006780	bisphenol A	bisphenol A results in decreased expression of DNMT1 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of DNMT1 mRNA	28765096
C006780	bisphenol A	bisphenol A affects the expression of DNMT1 mRNA	23716699
C006780	bisphenol A	bisphenol A affects the methylation of DNMT1 exon	23716699
C006780	bisphenol A	bisphenol A results in decreased expression of DNMT1 mRNA	21980460\|2213105
C006780	bisphenol A	bisphenol A results in decreased expression of DNMT1 protein	27502578
C006780	bisphenol A	bisphenol A results in increased expression of DNMT1 mRNA	25385582\|2849603
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT1 mRNA]	22131059
C006780	bisphenol A	bisphenol A affects the expression of DNMT1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of DNMT1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of DNMT1 mRNA	23791455
C006780	bisphenol A	bisphenol A results in increased methylation of DNMT1 gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased phosphorylation of DNMT1 protein	22174045
D001761	Bleomycin	DNMT1 protein affects the susceptibility to Bleomycin	17991895
D020148	Butyric Acid	"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 mRNA]"	24792773
D020148	Butyric Acid	"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 protein]"	24792773
D002104	Cadmium	DNMT1 gene SNP affects the susceptibility to Cadmium	22382075
D002104	Cadmium	Cadmium results in decreased activity of DNMT1 protein	21449042
D019256	Cadmium Chloride	Cadmium Chloride results in increased activity of and results in increased expression of DNMT1 protein	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of ERCC1 mRNA	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of MSH2 mRNA	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of OGG1 mRNA	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of XRCC1 mRNA	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of ERCC1 promoter	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of MSH2 promoter	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of OGG1 promoter	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of XRCC1 promoter	22112500
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of DNMT1 mRNA	22112500\|2544881
D019256	Cadmium Chloride	decitabine inhibits the reaction [Cadmium Chloride results in increased expression of DNMT1 mRNA]	22112500
D019256	Cadmium Chloride	decitabine inhibits the reaction [Cadmium Chloride results in increased expression of DNMT1 protein]	22112500
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of DNMT1 mRNA	23741332
D002110	Caffeine	Caffeine results in increased expression of DNMT1 mRNA	24717552
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of DNMT1 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of DNMT1 mRNA	22841775\|2421142
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of DNMT1 protein	22841775
D002392	Catechin	Catechin results in decreased activity of DNMT1 protein	16037419
D017338	Cladribine	Cholecalciferol promotes the reaction [Cladribine results in decreased expression of DNMT1 mRNA]	21801466
D017338	Cladribine	Cladribine promotes the reaction [Cholecalciferol results in decreased expression of DNMT1 mRNA]	21801466
D017338	Cladribine	Cladribine results in decreased expression of DNMT1 mRNA	21801466
D002794	Choline	Choline affects the activity of DNMT1 protein	16855792
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency co-treated with sodium arsenite] results in decreased expression of DNMT1 mRNA	20978746
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DNMT1 mRNA	20978746
D002794	Choline	[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA	28445388
D002857	Chromium	Chromium promotes the reaction [[DNMT1 protein binds to HDAC1 protein] which binds to CYP1A1 promoter]	17682057
D015283	Citalopram	Citalopram affects the expression of DNMT1 mRNA	21682946
D002994	Clofibrate	Clofibrate results in decreased expression of DNMT1 mRNA	28495587
D002994	Clofibrate	Clofibrate results in decreased expression of DNMT1 protein	28495587
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of DNMT1 mRNA	19320972
D003300	Copper	Copper results in decreased expression of DNMT1 mRNA	26293553
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of DNMT1 mRNA	20971185
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of DNMT1 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of DNMT1 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of DNMT1 mRNA	19167446
D003471	Cuprizone	Cuprizone results in increased expression of DNMT1 mRNA	26577399
D003474	Curcumin	Curcumin promotes the reaction [Quercetin results in increased activity of DNMT1 protein]	27132804
D003474	Curcumin	Curcumin results in decreased expression of DNMT1 mRNA	23593078
D003474	Curcumin	Curcumin results in decreased expression of DNMT1 protein	23593078
D003474	Curcumin	Curcumin results in increased activity of DNMT1 protein	27132804
D003474	Curcumin	Quercetin promotes the reaction [Curcumin results in increased activity of DNMT1 protein]	27132804
D003474	Curcumin	Curcumin analog results in decreased expression of DNMT1 protein	26991801
D003520	Cyclophosphamide	Cyclophosphamide promotes the reaction [KDM1A protein results in decreased methylation of and results in decreased degradation of DNMT1 protein]	22007908
D003520	Cyclophosphamide	Cyclophosphamide results in decreased methylation of DNMT1 protein	22007908
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of DNMT1 protein	22007908
D016572	Cyclosporine	Cyclosporine results in decreased expression of DNMT1 mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of DNMT1 mRNA	19770486
C004742	daidzein	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT1 mRNA	28964809
C013908	daidzin	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT1 mRNA	28964809
D003634	DDT	DDT results in decreased expression of DNMT1 mRNA	19797855
D003634	DDT	DDT results in increased expression of DNMT1 mRNA	25410620
D003634	DDT	DDT results in increased expression of DNMT1 protein	25410620
C014347	decitabine	[decitabine results in decreased activity of DNMT1 protein] which results in increased susceptibility to Cisplatin	18314485
C014347	decitabine	decitabine inhibits the reaction [Cadmium Chloride results in increased expression of DNMT1 mRNA]	22112500
C014347	decitabine	decitabine inhibits the reaction [Cadmium Chloride results in increased expression of DNMT1 protein]	22112500
C014347	decitabine	decitabine results in decreased expression of DNMT1 mRNA	16613325\|1762126
C014347	decitabine	decitabine results in decreased expression of DNMT1 protein	17571247\|1761670
C014347	decitabine	decitabine results in increased degradation of DNMT1 protein	19417133
C014347	decitabine	decitabine results in increased expression of DNMT1 mRNA	19117987
C014347	decitabine	DNMT1 protein affects the reaction [decitabine results in increased expression of H2AFX protein]	17991895
C014347	decitabine	DNMT1 protein affects the susceptibility to decitabine	17991895
C014347	decitabine	IL6 protein inhibits the reaction [decitabine results in decreased expression of DNMT1 mRNA]	17621267
C014347	decitabine	decitabine results in decreased expression of DNMT1 protein	19222872\|1967982
C014347	decitabine	DNMT1 affects the susceptibility to decitabine	14581508
C014347	decitabine	decitabine inhibits the reaction [TGFB1 protein results in increased expression of DNMT1 mRNA]	24211420
C014347	decitabine	decitabine inhibits the reaction [TGFB1 protein results in increased expression of DNMT1 protein]	24211420
C014347	decitabine	decitabine results in decreased activity of DNMT1 protein	21449042
C014347	decitabine	decitabine results in decreased expression of DNMT1 protein	23423710
C014347	decitabine	decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 mRNA]	29080797
C014347	decitabine	decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 protein]	29080797
C014347	decitabine	decitabine results in decreased activity of DNMT1 protein	19577553
D003676	Deferoxamine	Deferoxamine results in decreased expression of DNMT1 mRNA	23483119
D003676	Deferoxamine	Deferoxamine results in increased expression of DNMT1 mRNA	23483119
C007262	deoxynivalenol	deoxynivalenol affects the phosphorylation of DNMT1 protein	23352502\|2381194
D000072338	Dibenzofurans, Polychlorinated	"[Polychlorinated Biphenyls co-treated with Polychlorinated Dibenzodioxins co-treated with Dibenzofurans, Polychlorinated] results in decreased expression of DNMT1 mRNA"	15858227
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of DNMT1 mRNA	21266533
D003997	Dicarbethoxydihydrocollidine	Dicarbethoxydihydrocollidine results in increased expression of DNMT1 mRNA	18098314
D002945	Cisplatin	[decitabine results in decreased activity of DNMT1 protein] which results in increased susceptibility to Cisplatin	18314485
D002945	Cisplatin	DNMT1 protein results in decreased susceptibility to Cisplatin	18314485\|2145898
D002945	Cisplatin	[Cisplatin co-treated with Azacitidine] results in decreased expression of DNMT1 protein	19723570
D002945	Cisplatin	Cisplatin results in decreased expression of DNMT1 protein	19723570
D002945	Cisplatin	DNMT1 protein results in decreased susceptibility to Cisplatin	18314485
C000944	dicrotophos	dicrotophos results in increased expression of DNMT1 mRNA	28302478
D004041	Dietary Fats	"[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of DNMT1 mRNA"	12097258
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of DNMT1 mRNA	25280772
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of DNMT1 protein	25280772
D004052	Diethylnitrosamine	AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of DNMT1 mRNA]	19996281
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of DNMT1 mRNA	19996281
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of DNMT1 mRNA	17854601
D004052	Diethylnitrosamine	RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DNMT1 mRNA]	17854601
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of and affects the localization of DNMT1 protein	21163286
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of DNMT1 mRNA	16714842
D002117	Calcitriol	Calcitriol results in decreased expression of DNMT1 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of DNMT1 mRNA	21592394
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 protein"	21294050
D015127	9,10-Dimethyl-1,2-benzanthracene	"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 protein]"	21294050
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 mRNA"	24792773
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 protein"	24792773
D015127	9,10-Dimethyl-1,2-benzanthracene	"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 mRNA]"	24792773
D015127	9,10-Dimethyl-1,2-benzanthracene	"Butyric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 protein]"	24792773
D015127	9,10-Dimethyl-1,2-benzanthracene	"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 mRNA]"	24792773
D015127	9,10-Dimethyl-1,2-benzanthracene	"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 protein]"	24792773
D015127	9,10-Dimethyl-1,2-benzanthracene	"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 mRNA]"	24792773
D015127	9,10-Dimethyl-1,2-benzanthracene	"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 protein]"	24792773
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 mRNA"	12097258
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of DNMT1 mRNA"	27840820
C007482	dimethyl sulfate	dimethyl sulfate results in decreased expression of DNMT1 protein	11912126
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in decreased expression of DNMT1 protein	17065238
D004317	Doxorubicin	DNMT1 protein affects the susceptibility to Doxorubicin	17991895
D004317	Doxorubicin	Doxorubicin inhibits the reaction [DNMT1 binds to RELN promoter]	17065238
D004317	Doxorubicin	[Doxorubicin inhibits the reaction [DNMT1 binds to RELN promoter]] which results in increased expression of RELN mRNA	17065238
D004317	Doxorubicin	Doxorubicin promotes the reaction [DNMT1 protein binds to BIRC5 promoter]	17124180
D004317	Doxorubicin	Doxorubicin promotes the reaction [DNMT1 protein binds to CHEK1 protein]	17991895
D004317	Doxorubicin	Doxorubicin results in decreased expression of and results in decreased activity of DNMT1 protein	17065238
D004391	Dust	Dust results in decreased expression of DNMT1 mRNA	26342214
D004726	Endosulfan	Endosulfan results in increased expression of DNMT1 mRNA	29054638
D004726	Endosulfan	Endosulfan results in increased expression of DNMT1 protein	29054638
C118739	entinostat	[Azacitidine co-treated with entinostat] results in decreased expression of DNMT1 protein	21224363
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DNMT1 protein	23301498
C045651	epigallocatechin gallate	epigallocatechin gallate binds to and results in decreased activity of DNMT1 protein	14633667
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased activity of DNMT1 protein	16037419
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of DNMT1 mRNA	25839702
C045651	epigallocatechin gallate	Magnesium promotes the reaction [epigallocatechin gallate results in decreased activity of DNMT1 protein]	16037419
D000431	Ethanol	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of DNMT1 protein]	23395981
D000431	Ethanol	Ethanol results in decreased expression of DNMT1 mRNA	23395981
D000431	Ethanol	Ethanol results in decreased expression of DNMT1 protein	23395981
D000431	Ethanol	Ethanol results in increased degradation of DNMT1 protein	23395981
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of DNMT1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNMT1 mRNA	17942748
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased expression of DNMT1	21154115
D005047	Etoposide	DNMT1 protein results in decreased susceptibility to Etoposide	18314485
D005047	Etoposide	DNMT1 protein results in decreased susceptibility to Etoposide	18314485
C017875	fisetin	[fisetin co-treated with COMT protein] results in decreased activity of DNMT1 protein	16037419
C024352	fludarabine	fludarabine results in decreased expression of DNMT1 mRNA	21801466
D005492	Folic Acid	Folic Acid affects the expression of DNMT1 mRNA	17311948
D005492	Folic Acid	Folic Acid affects the activity of DNMT1 protein	16855792
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency co-treated with sodium arsenite] results in decreased expression of DNMT1 mRNA	20978746
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DNMT1 mRNA	20978746
D005492	Folic Acid	[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA	28445388
D005557	Formaldehyde	Formaldehyde results in increased expression of DNMT1 mRNA	21745553
D005557	Formaldehyde	Formaldehyde results in increased expression of DNMT1 protein	21745553
C070081	fulvestrant	[fulvestrant co-treated with Sirolimus] results in decreased expression of DNMT1 mRNA	19016759
C070081	fulvestrant	fulvestrant results in decreased expression of DNMT1 mRNA	19016759
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT1 mRNA]	22131059
C056933	fumonisin B1	fumonisin B1 results in decreased activity of DNMT1 protein	24280379
C056507	gemcitabine	[DNMT1 protein binds to SFN promoter] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]	25189999
C056507	gemcitabine	DNMT1 protein inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]	25189999
C056507	gemcitabine	[gemcitabine results in decreased susceptibility to gemcitabine] inhibits the reaction [DNMT1 protein binds to SFN promoter]	25189999
C056507	gemcitabine	[gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of DNMT1 protein	25189999
C056507	gemcitabine	[UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]	25189999
D019833	Genistein	Genistein results in decreased expression of DNMT1 mRNA	16705744\|2359307
D019833	Genistein	Genistein results in decreased expression of DNMT1 protein	19221000\|2359307
D019833	Genistein	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT1 mRNA	28964809
C040641	genistin	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT1 mRNA	28964809
C086566	glycitein	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT1 mRNA	28964809
C433283	glycitin	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT1 mRNA	28964809
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins results in decreased expression of DNMT1 mRNA	22749965
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins results in decreased expression of DNMT1 protein	22749965
D005937	Glucaric Acid	"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 mRNA]"	24792773
D005937	Glucaric Acid	"Glucaric Acid affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 protein]"	24792773
D017313	Fenretinide	Fenretinide results in increased expression of DNMT1 mRNA	28973697
D006861	Hydrogen Peroxide	DNMT1 protein results in decreased susceptibility to Hydrogen Peroxide	18314485
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of DNMT1 mRNA	27655674
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of DNMT1 protein	18314485\|2765567
D006861	Hydrogen Peroxide	DNMT1 protein results in decreased susceptibility to Hydrogen Peroxide	18314485
C031927	hydroquinone	hydroquinone results in decreased expression of DNMT1 mRNA	22245671
C031927	hydroquinone	hydroquinone results in decreased expression of DNMT1 protein	27979589
D006918	Hydroxyurea	DNMT1 protein affects the susceptibility to Hydroxyurea	17991895
D006997	Hypochlorous Acid	Hypochlorous Acid results in decreased expression of DNMT1 mRNA	19376150
D007213	Indomethacin	Indomethacin results in decreased expression of DNMT1 mRNA	28201806
D015759	Ionomycin	[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of and results in increased activity of DNMT1 protein	23775084
D015759	Ionomycin	Okadaic Acid promotes the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of and results in increased activity of DNMT1 protein]	23775084
D015759	Ionomycin	PPP2CA protein affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of and results in increased activity of DNMT1 protein]	23775084
D015759	Ionomycin	PPP2CB protein affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of and results in increased activity of DNMT1 protein]	23775084
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DNMT1 mRNA	25613284
D007501	Iron	[1-Methyl-4-phenylpyridinium results in increased expression of DNMT1 protein] which results in increased transport of Iron	18191877
C410337	K 7174	K 7174 results in decreased expression of DNMT1 mRNA	24086573
C009765	lac dye	lac dye results in decreased activity of DNMT1 protein	23839987
D007854	Lead	Lead results in decreased expression of DNMT1 mRNA	22272629
D007854	Lead	Lead results in decreased expression of DNMT1 protein	22272629
D007854	Lead	Lead results in decreased expression of DNMT1 mRNA	27239543
D007854	Lead	Lead results in decreased expression of DNMT1 protein	27239543
C008261	lead acetate	lead acetate results in decreased expression of DNMT1 protein	21891863
C008261	lead acetate	lead acetate results in decreased expression of DNMT1 mRNA	21117136\|2276407
C008261	lead acetate	lead acetate results in decreased expression of DNMT1 protein	23246732
C008261	lead acetate	lead acetate results in increased expression of DNMT1 mRNA	22160880
C008261	lead acetate	lead acetate results in increased expression of DNMT1 protein	23246732
C038753	leptomycin B	[leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of DNMT1 mRNA	20803015
C038753	leptomycin B	leptomycin B results in decreased expression of DNMT1 mRNA	20803015
C002385	linsidomine	linsidomine results in increased oxidation of DNMT1 protein	28086193
C482199	lipopolysaccharide, E coli O55-B5	"DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the expression of SOCS1 mRNA]"	24440346
C482199	lipopolysaccharide, E coli O55-B5	"DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the expression of SOCS1 protein]"	24440346
C482199	lipopolysaccharide, E coli O55-B5	"DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]"	24440346
C482199	lipopolysaccharide, E coli O55-B5	"DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]"	24440346
C482199	lipopolysaccharide, E coli O55-B5	"DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]"	24440346
C482199	lipopolysaccharide, E coli O55-B5	"DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]"	24440346
C482199	lipopolysaccharide, E coli O55-B5	"DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of JAK2 protein]"	24440346
C482199	lipopolysaccharide, E coli O55-B5	"DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of STAT3 protein]"	24440346
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of DNMT1 mRNA"	24440346
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of DNMT1 protein"	24440346
C482199	lipopolysaccharide, E coli O55-B5	"SOCS1 mutant form inhibits the reaction [DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]"	24440346
C482199	lipopolysaccharide, E coli O55-B5	"SOCS1 mutant form inhibits the reaction [DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]"	24440346
C482199	lipopolysaccharide, E coli O55-B5	"SOCS1 mutant form inhibits the reaction [DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of JAK2 protein]]"	24440346
C482199	lipopolysaccharide, E coli O55-B5	"SOCS1 mutant form inhibits the reaction [DNMT1 mutant form inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of STAT3 protein]]"	24440346
D008274	Magnesium	Magnesium promotes the reaction [epigallocatechin gallate results in decreased activity of DNMT1 protein]	16037419
D008274	Magnesium	Magnesium results in decreased activity of DNMT1 protein	16037419
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of DNMT1 mRNA	20353558
D008694	Methamphetamine	Methamphetamine results in decreased expression of DNMT1 mRNA	17254711
D008694	Methamphetamine	Methamphetamine results in increased expression of DNMT1 mRNA	17254711
D008713	Methimazole	Methimazole results in decreased expression of DNMT1 mRNA	17399805
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency co-treated with sodium arsenite] results in decreased expression of DNMT1 mRNA	20978746
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DNMT1 mRNA	20978746
D008748	Methylcholanthrene	[Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of and affects the localization of DNMT1 protein	21163286
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of DNMT1 mRNA	19636072
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of DNMT1 protein	26558463
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of DNMT1 protein	11912126
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased degradation of DNMT1 protein	11912126
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of DNMT1 mRNA	18191877
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of DNMT1 protein	18191877
D015655	1-Methyl-4-phenylpyridinium	[1-Methyl-4-phenylpyridinium results in increased expression of DNMT1 protein] which results in increased transport of Iron	18191877
D016685	Mitomycin	Mitomycin results in decreased expression of DNMT1 protein	27032448
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of DNMT1 mRNA	22401849
C020300	monomethylarsonic acid	monomethylarsonic acid results in decreased expression of DNMT1 mRNA	17481689
D009151	Mustard Gas	Mustard Gas results in increased expression of DNMT1 mRNA	26392148
C040015	myricetin	[myricetin co-treated with COMT protein] results in decreased activity of DNMT1 protein	16037419
C040015	myricetin	myricetin results in decreased activity of DNMT1 protein	16037419
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of DNMT1 mRNA"	25554681
C000621033	napabucasin	napabucasin results in decreased expression of DNMT1 mRNA	25605917
D009532	Nickel	Nickel results in increased expression of DNMT1 mRNA	25583101
C017558	nickel sulfide	DNMT1 mutant form inhibits the reaction [nickel sulfide results in decreased expression of MIR152 mRNA]	23125218
C017558	nickel sulfide	MIR152 mRNA inhibits the reaction [nickel sulfide results in increased expression of DNMT1]	23125218
C017558	nickel sulfide	nickel sulfide promotes the reaction [DNMT1 protein binds to MIR152 promoter]	23125218
C017558	nickel sulfide	nickel sulfide results in increased expression of DNMT1	23125218
C508801	NSC 303530	NSC 303530 binds to DNMT1 protein	16420053
C508801	NSC 303530	NSC 303530 results in decreased activity of DNMT1 protein	16420053
C508802	NSC 401077	NSC 401077 binds to DNMT1 protein	16420053
C508802	NSC 401077	NSC 401077 results in decreased activity of DNMT1 protein	16420053
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of DNMT1 mRNA	20971185
C025589	ochratoxin A	decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 mRNA]	29080797
C025589	ochratoxin A	decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 protein]	29080797
C025589	ochratoxin A	ochratoxin A results in increased expression of DNMT1 mRNA	29080797
C025589	ochratoxin A	ochratoxin A results in increased expression of DNMT1 protein	29080797
D019319	Okadaic Acid	Okadaic Acid promotes the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of and results in increased activity of DNMT1 protein]	23775084
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of DNMT1 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in decreased expression of DNMT1 mRNA	26516004
D010100	Oxygen	Oxygen deficiency results in increased expression of DNMT1 protein	18314485
D010126	Ozone	DNMT1 gene polymorphism affects the susceptibility to Ozone	27219456
D052638	Particulate Matter	Particulate Matter results in decreased expression of DNMT1 protein	26942697
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of DNMT1 mRNA	23892564
C494474	perchlorate	perchlorate results in increased expression of DNMT1 mRNA	17399805
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of DNMT1 protein	26879310
D010634	Phenobarbital	Phenobarbital affects the expression of DNMT1 mRNA	19482888\|2309116
D010634	Phenobarbital	Phenobarbital results in decreased expression of DNMT1 protein	28495587
D010634	Phenobarbital	Phenobarbital results in increased expression of DNMT1 mRNA	25247799
D010634	Phenobarbital	Phenobarbital results in increased expression of DNMT1 protein	25247799
C121565	pifithrin	pifithrin inhibits the reaction [Azacitidine results in decreased expression of DNMT1 mRNA]	15547111
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of DNMT1 mRNA	22484513
C006253	pirinixic acid	pirinixic acid results in decreased expression of DNMT1 mRNA	17426115
C006253	pirinixic acid	pirinixic acid results in decreased expression of DNMT1 protein	18639561
D010894	Piroxicam	Piroxicam results in increased expression of DNMT1 mRNA	21858171
D010936	Plant Extracts	Plant Extracts results in increased expression of DNMT1 mRNA	23557933
D011078	Polychlorinated Biphenyls	"[Polychlorinated Biphenyls co-treated with Polychlorinated Dibenzodioxins co-treated with Dibenzofurans, Polychlorinated] results in decreased expression of DNMT1 mRNA"	15858227
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in decreased expression of DNMT1 mRNA	19636072
D000072317	Polychlorinated Dibenzodioxins	"[Polychlorinated Biphenyls co-treated with Polychlorinated Dibenzodioxins co-treated with Dibenzofurans, Polychlorinated] results in decreased expression of DNMT1 mRNA"	15858227
C023617	pregna-4,17-diene-3,16-dione	"pregna-4,17-diene-3,16-dione results in decreased expression of DNMT1 mRNA"	23593078
C023617	pregna-4,17-diene-3,16-dione	"pregna-4,17-diene-3,16-dione results in decreased expression of DNMT1 protein"	23593078
D011342	Procainamide	Procainamide results in decreased activity of DNMT1 protein	21958292
C479580	procyanidin B2	procyanidin B2 results in increased expression of DNMT1 mRNA	25839702
D011441	Propylthiouracil	Propylthiouracil results in increased expression of DNMT1 mRNA	17399805
C107773	pterostilbene	[resveratrol co-treated with pterostilbene] results in decreased expression of DNMT1 mRNA	26459286
D011794	Quercetin	Curcumin promotes the reaction [Quercetin results in increased activity of DNMT1 protein]	27132804
D011794	Quercetin	[Quercetin co-treated with COMT protein] results in decreased activity of DNMT1 protein	16037419
D011794	Quercetin	Quercetin promotes the reaction [Curcumin results in increased activity of DNMT1 protein]	27132804
D011794	Quercetin	Quercetin results in decreased expression of DNMT1 mRNA	20596804
D011794	Quercetin	Quercetin results in increased activity of DNMT1 protein	27132804
D011794	Quercetin	Quercetin results in increased expression of DNMT1 mRNA	21632981
D011794	Quercetin	"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 protein]"	21294050
C037219	quinoline	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [quinoline analog results in increased degradation of DNMT1 protein]	19417133
C037219	quinoline	quinoline analog results in increased degradation of DNMT1 protein	19417133
C037219	quinoline	quinoline analog results in decreased activity of DNMT1 protein	19417133
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of DNMT1 mRNA	19167446
C059514	resveratrol	[resveratrol co-treated with pterostilbene] results in decreased expression of DNMT1 mRNA	26459286
C059514	resveratrol	resveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]	20631324
C059514	resveratrol	resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]	22197621
C059514	resveratrol	resveratrol results in decreased expression of DNMT1 mRNA	21801466\|2359307
C059514	resveratrol	resveratrol results in decreased expression of DNMT1 protein	23593078
C059514	resveratrol	resveratrol results in decreased expression of DNMT1 protein	25505154
C059514	resveratrol	resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]	24136580
C041376	rosmarinic acid	rosmarinic acid results in decreased expression of DNMT1 protein	21078381
C551539	S110 compound	S110 compound results in decreased expression of DNMT1 protein	17616700
D012643	Selenium	Selenium affects the activity of DNMT1 protein	16632891
C581203	SGI-1027	SGI-1027 results in decreased activity of DNMT1 protein	25525263
D012822	Silicon Dioxide	DNMT1 protein promotes the reaction [Silicon Dioxide results in increased methylation of PARP1 promoter]	22265868
C006235	sinefungin	sinefungin results in decreased activity of DNMT1 protein	23671287
D020123	Sirolimus	[fulvestrant co-treated with Sirolimus] results in decreased expression of DNMT1 mRNA	19016759
C009277	sodium arsenate	sodium arsenate results in decreased expression of DNMT1 mRNA	16882884
C017947	sodium arsenite	[sodium arsenite co-treated with Estradiol] results in decreased expression of DNMT1 mRNA	22952798
C017947	sodium arsenite	sodium arsenite results in decreased expression of DNMT1 mRNA	17107663\|2295279
C017947	sodium arsenite	sodium arsenite results in decreased expression of DNMT1 protein	24570342
C017947	sodium arsenite	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency co-treated with sodium arsenite] results in decreased expression of DNMT1 mRNA	20978746
C017947	sodium arsenite	sodium arsenite affects the expression of DNMT1 mRNA	17558810
C017947	sodium arsenite	sodium arsenite results in increased expression of DNMT1 mRNA	19822182
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of DNMT1 mRNA	27862939
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of DNMT1 mRNA	18676679
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of DNMT1 protein	18676679
D012999	Soman	Soman results in decreased expression of DNMT1 mRNA	19281266
C016766	sulforafan	sulforafan results in decreased expression of DNMT1 mRNA	24466240
D013629	Tamoxifen	[arsenic trioxide co-treated with Tamoxifen] results in decreased expression of DNMT1 mRNA	23159075
D013629	Tamoxifen	[arsenic trioxide co-treated with Tamoxifen] results in decreased expression of DNMT1 protein	23159075
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of DNMT1 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of DNMT1 mRNA	21592394
D013739	Testosterone	[Testosterone co-treated with vinclozolin] results in increased expression of DNMT1 mRNA	20056826
D013739	Testosterone	Testosterone inhibits the reaction [vinclozolin results in decreased expression of DNMT1 mRNA]	20056826
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of DNMT1 mRNA	25732252
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]	20631324
D013749	Tetrachlorodibenzodioxin	resveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]	20631324
D013749	Tetrachlorodibenzodioxin	resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]	22197621
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [DNMT1 protein binds to BRCA1 promoter]	20631324
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]	22197621
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DNMT1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNMT1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DNMT1 mRNA	16611356
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of DNMT1 mRNA	15667827
D013749	Tetrachlorodibenzodioxin	resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]]	24136580
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [DNMT1 protein binds to BRCA1 promoter]	24136580
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DNMT1 mRNA	26455773
D013755	Tetradecanoylphorbol Acetate	[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of and results in increased activity of DNMT1 protein	23775084
D013755	Tetradecanoylphorbol Acetate	Okadaic Acid promotes the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of and results in increased activity of DNMT1 protein]	23775084
D013755	Tetradecanoylphorbol Acetate	PPP2CA protein affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of and results in increased activity of DNMT1 protein]	23775084
D013755	Tetradecanoylphorbol Acetate	PPP2CB protein affects the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of and results in increased activity of DNMT1 protein]	23775084
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DNMT1 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in increased expression of DNMT1 protein	24648495
C523062	thio-dimethylarsinate	thio-dimethylarsinate results in increased expression of DNMT1 mRNA	27320638
D013974	Thyroxine	Thyroxine results in decreased expression of DNMT1 mRNA	17403546
D013974	Thyroxine	Thyroxine results in increased expression of DNMT1 mRNA	17403546
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of DNMT1 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of DNMT1 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of DNMT1 mRNA	18230668
D014212	Tretinoin	Tretinoin results in decreased expression of DNMT1 mRNA	17273765
D014241	Trichloroethylene	Trichloroethylene results in increased expression of DNMT1 mRNA	22407948
D014241	Trichloroethylene	Trichloroethylene results in increased expression of DNMT1 protein	25549359
D014260	Triclosan	Triclosan results in decreased expression of DNMT1 mRNA	26970259
D014260	Triclosan	Triclosan results in decreased expression of DNMT1 protein	26970259
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of DNMT1 mRNA	19042947
C052920	trimethylarsine oxide	trimethylarsine oxide results in decreased expression of DNMT1 mRNA	17481689
C005445	triphenyl phosphate	triphenyl phosphate results in decreased expression of DNMT1 mRNA	26898711
C057693	troglitazone	troglitazone results in decreased expression of DNMT1 mRNA	19140230
C057693	troglitazone	troglitazone results in decreased expression of DNMT1 mRNA	28973697
D014501	Uranium	Uranium results in increased expression of DNMT1 mRNA	29024790
D014640	Vancomycin	Vancomycin results in decreased expression of DNMT1 mRNA	18930951
C025643	vinclozolin	[Testosterone co-treated with vinclozolin] results in increased expression of DNMT1 mRNA	20056826
C025643	vinclozolin	Testosterone inhibits the reaction [vinclozolin results in decreased expression of DNMT1 mRNA]	20056826
C025643	vinclozolin	vinclozolin results in decreased expression of DNMT1 mRNA	18042343\|2005682
C025643	vinclozolin	vinclozolin results in decreased expression of DNMT1 protein	20056826
C025643	vinclozolin	vinclozolin results in increased expression of DNMT1 mRNA	23034163
C025643	vinclozolin	vinclozolin results in decreased expression of DNMT1 mRNA	22496781
D009536	Niacinamide	"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 mRNA]"	24792773
D009536	Niacinamide	"Niacinamide affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of DNMT1 protein]"	24792773
D014805	Vitamin B 12	[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA	28445388
D002762	Cholecalciferol	Cholecalciferol promotes the reaction [Cladribine results in decreased expression of DNMT1 mRNA]	21801466
D002762	Cholecalciferol	Cholecalciferol results in decreased expression of DNMT1 mRNA	21801466
D002762	Cholecalciferol	Cladribine promotes the reaction [Cholecalciferol results in decreased expression of DNMT1 mRNA]	21801466
C009684	withaferin A	withaferin A results in decreased expression of DNMT1 mRNA	23593078
C009684	withaferin A	withaferin A results in decreased expression of DNMT1 protein	23593078

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0003677	DNA binding	-	IBA	21873635
GO:0003677	DNA binding	-	IDA	18754681
GO:0003723	RNA binding	-	IEA	-
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	-	IBA	21873635
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	-	IDA	21745816
GO:0005515	protein binding	-	IPI	16357870 16983096 17673620 17934516 17972916 19282482 19450230 19798101 21151116 21745816 21947282 22094255 25544563 25753001 27728808
GO:0008270	zinc ion binding	-	IEA	-
GO:0008327	methyl-CpG binding	-	IEA	-
GO:0009008	DNA-methyltransferase activity	-	IDA	18754681
GO:0009008	DNA-methyltransferase activity	-	TAS	-
GO:1990841	promoter-specific chromatin binding	-	IDA	24623306

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0006306	DNA methylation	-	TAS	10888872
GO:0006325	chromatin organization	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0007265	Ras protein signal transduction	-	IMP	24623306
GO:0010216	maintenance of DNA methylation	-	IBA	21873635
GO:0010216	maintenance of DNA methylation	-	IDA	18754681 21745816
GO:0010424	DNA methylation on cytosine within a CG sequence	-	IBA	21873635
GO:0010628	positive regulation of gene expression	-	IMP	18413740
GO:0010629	negative regulation of gene expression	-	IMP	27021683
GO:0016458	gene silencing	-	IEA	-
GO:0043045	DNA methylation involved in embryo development	-	IEA	-
GO:0045814	negative regulation of gene expression, epigenetic	-	TAS	-
GO:0051571	positive regulation of histone H3-K4 methylation	-	IMP	18413740
GO:0051573	negative regulation of histone H3-K9 methylation	-	IMP	18413740
GO:0071230	cellular response to amino acid stimulus	-	IEA	-
GO:0090116	C-5 methylation of cytosine	-	IEA	-
GO:0090309	positive regulation of methylation-dependent chromatin silencing	-	IMP	24623306
GO:1904707	positive regulation of vascular smooth muscle cell proliferation	-	IMP	27021683
GO:1905460	negative regulation of vascular associated smooth muscle cell apoptotic process	-	IMP	27021683
GO:1905931	negative regulation of vascular smooth muscle cell differentiation involved in phenotypic switching	-	IMP	27021683

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	HDA	16791210
GO:0005634	nucleus	-	IBA	21873635
GO:0005654	nucleoplasm	-	TAS	-
GO:0005657	replication fork	-	IEA	-
GO:0005721	pericentric heterochromatin	-	IEA	-

KEGG ID	KEGG Term
hsa00270	Cysteine and methionine metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-212165	Epigenetic regulation of gene expression	IEA
R-HSA-212165	Epigenetic regulation of gene expression	TAS
R-HSA-212300	PRC2 methylates histones and DNA	TAS
R-HSA-427413	NoRC negatively regulates rRNA expression	IEA
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	IEA
R-HSA-5334118	DNA methylation	IEA
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24762689	[Protein expressions of HDAC1 and DNMT1 in non-small-cell lung cancer and its clinical significance]. (2014 Mar 4)	Feng Y	Zhonghua Yi Xue Za Zhi
19596925	O6-Methylguanine-DNA methyltransferase hypermethylation modulated by 17beta-estradiol in lung cancer cells. (2009 Jul)	Lai JC	Anticancer Res
18852456	Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons. (2008 Oct 21)	Satta R	Proc Natl Acad Sci U S A
29191063	Changes in DNA methylation induced by multi-walled carbon nanotube exposure in the workplace. (2017 Nov - Dec)	Ghosh M	Nanotoxicology
25661292	Perinatal nicotine exposure suppresses PPARgamma epigenetically in lung alveolar interstitial fibroblasts. (2015 Apr)	Gong M	Mol Genet Metab
21395176	[The expression of DNMT1 in laryngeal squamous cell carcinoma and its clinical significance]. (2010 Dec)	Wang J	Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
29568927	miR-185 and miR-29a are similarly expressed in the bronchoalveolar lavage cells in IPF and lung cancer but common targets DNMT1 and COL1A1 show disease specific patterns. (2018 May)	Bibaki E	Mol Med Rep
26317789	LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation. (2015 Sep 22)	Lee CH	Oncotarget
28192769	Disorganization at the stage of schizophrenia clinical outcome: Clinical-biological study. (2017 May)	Nestsiarovich A	Eur Psychiatry
28814981	CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel. (2017)	Morandi L	Clin Epigenetics
27002730	RGS6 as a Novel Therapeutic Target in CNS Diseases and Cancer. (2016 May)	Ahlers KE	AAPS J
26842245	Role of Growth Arrest and DNA Damage-Inducible, Beta in Alcohol-Drinking Behaviors. (2016 Feb)	Gavin DP	Alcohol Clin Exp Res
22248280	Cigarette smoking extract causes hypermethylation and inactivation of WWOX gene in T-24 human bladder cancer cells. (2012)	Yang W	Neoplasma
17140695	Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. (2007 Feb)	Lin RK	Lung Cancer
20093774	The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients. (2010 Feb)	Lin RK	J Clin Invest
16570269	Nicotine induces the fragile histidine triad methylation in human esophageal squamous epithelial cells. (2006 Sep 1)	Soma T	Int J Cancer
24527678	Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex. (2014 Jun)	Echeverry-Alzate V	Br J Pharmacol
25222473	Increased NQO1 but not c-MET and survivin expression in non-small cell lung carcinoma with KRAS mutations. (2014 Sep 12)	Yilmaz A	Int J Environ Res Public Health
20951977	Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas. (2010 Dec)	Daniel FI	Arch Oral Biol
22317856	The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in laryngeal carcinoma. (2012 Jun)	Wang J	Oral Oncol
22901195	4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone induces retinoic acid receptor beta hypermethylation through DNA methyltransferase 1 accumulation in esophageal squamous epithelial cells. (2012)	Wang J	Asian Pac J Cancer Prev