Gene: TRDMT1

1787
DMNT2|DNMT2|MHSAIIP|PUMET|RNMT1
tRNA aspartic acid methyltransferase 1
protein-coding
10p13
Ensembl:ENSG00000107614 MIM:602478 Vega:OTTHUMG00000017745 UniprotKB:O14717
NC_000010.11
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.500e-1 (AD)  6.338e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FKTN0.797
ERI20.77
GSTCD0.769
CARF0.765
WDR350.765
ZNF518A0.754
XPO40.753
WRN0.751
ZNF1380.751
RFX70.746

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.375
OR4F29-0.365
CLDN9-0.277
ANP32C-0.261
C7orf61-0.257
MMP23B-0.247
NANOS2-0.247
ESPNL-0.244
LCN1-0.244
CELSR1-0.244

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00738PentamidineSmall Molecule100-33-4Approved|InvestigationalTarget
DB01752S-adenosyl-L-homocysteineSmall Molecule979-92-0ExperimentalTarget
DB09462GlycerinSmall Molecule56-81-5Approved|InvestigationalTarget
ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRDMT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRDMT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRDMT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRDMT1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TRDMT1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TRDMT1 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TRDMT1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of TRDMT1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRDMT1 mRNA19770486
C006780bisphenol Abisphenol A affects the expression of TRDMT1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TRDMT1 mRNA27571134
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRDMT1 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of TRDMT1 mRNA27793765
D016572CyclosporineCyclosporine results in increased expression of TRDMT1 mRNA27989131
C014347decitabinedecitabine results in decreased expression of TRDMT1 mRNA18676679
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TRDMT1 mRNA17361019|2126653
C014476diethyl maleatediethyl maleate results in decreased expression of TRDMT1 mRNA25270620
D004147DioxinsDioxins affects the expression of TRDMT1 mRNA20463971
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TRDMT1 mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TRDMT1 mRNA23649840
C026098etiracetametiracetam results in decreased expression of TRDMT1 mRNA20345932
C033789fenarimolfenarimol results in decreased expression of TRDMT1 mRNA28970091
C061365flusilazoleflusilazole results in decreased expression of TRDMT1 mRNA28263823
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRDMT1 mRNA20938992
D017313FenretinideFenretinide results in increased expression of TRDMT1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TRDMT1 mRNA25613284
C051890irinotecanirinotecan metabolite results in decreased expression of TRDMT1 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of TRDMT1 mRNA15956246
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of TRDMT1 mRNA27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRDMT1 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TRDMT1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TRDMT1 mRNA23649840
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of TRDMT1 mRNA29162477
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRDMT1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TRDMT1 mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TRDMT1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TRDMT1 mRNA22079256
C045950propiconazolepropiconazole results in increased expression of TRDMT1 mRNA28970091
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TRDMT1 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of TRDMT1 mRNA19822182
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRDMT1 mRNA22574217
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TRDMT1 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of TRDMT1 mRNA27188386
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TRDMT1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of TRDMT1 mRNA24935251|2627250
D014520UrethaneUrethane results in decreased expression of TRDMT1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of TRDMT1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TRDMT1 mRNA23179753|2915479
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TRDMT1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of TRDMT1 mRNA18042343
C111237vorinostatvorinostat results in decreased expression of TRDMT1 mRNA27188386
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TRDMT1 mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IEA-  
GO:0008175tRNA methyltransferase activity-IDA16424344  
GO:0016428tRNA (cytosine-5-)-methyltransferase activity-EXP16424344  18567810  
GO ID GO Term Qualifier Evidence PubMed
GO:0001975response to amphetamine-IEA-  
GO:0006400tRNA modification-TAS-  
GO:0030488tRNA methylation-IDA16424344  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA16424344  
KEGG ID KEGG Term
hsa00270Cysteine and methionine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-6782315tRNA modification in the nucleus and cytosolTAS
R-HSA-72306tRNA processingTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24527678Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex. (2014 Jun)Echeverry-Alzate VBr J Pharmacol