Gene info: ID 1788

Gene: DNMT3A

GENE ID: 1788

Synonyms: DNMT3A2|M.HsaIIIA|TBRS

Description: DNA methyltransferase 3 alpha

Gene type: protein-coding

Location: 2p23.3

dbXrefs: Ensembl:ENSG00000119772 MIM:602769 Vega:OTTHUMG00000094777 UniprotKB:Q9Y6K1

RefSeq: NG_029465.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND

# Publications: 15

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.975e-1 (AD) 2.851e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg05896193	chr2:25563141	DNMT3A	Promoter	2.204e-5	Alcohol use disorders	26763658
cg17742416	chr2:25499619	DNMT3A		7.600e-8	Smoking	27651444
cg20948740	chr2:25475726	DNMT3A		1.340e-11	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZNF587	0.843
EP400	0.826
RAD54L2	0.82
TRRAP	0.819
ASXL1	0.815
ZZEF1	0.811
NOM1	0.808
KMT2D	0.806
CHD8	0.806
SETD5	0.805

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.445
OR4F29	-0.412
KLRC2	-0.242
DIAPH3	-0.221
OR4F16	-0.196
SPRR2E	-0.192
CENPM	-0.183
SPRR2A	-0.182
KLRC3	-0.18
GSDMC	-0.18

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C517232	1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of DNMT3A mRNA"	24375616
C031763	1,3-butadiene	"1,3-butadiene results in decreased expression of DNMT3A mRNA"	25237060
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DNMT3A mRNA	19933214
C511295	2,2',4,4'-tetrabromodiphenyl ether	"[2,2',4,4'-tetrabromodiphenyl ether co-treated with MECP2 gene polymorphism] results in increased expression of DNMT3A mRNA"	22343140
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DNMT3A mRNA"	19114083
C088860	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]"	24639330
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of DNMT3A mRNA"	18648102
C041594	4-nonylphenol	[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A mRNA	23626723
C041594	4-nonylphenol	[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein	23626723
C041594	4-nonylphenol	wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein]	23626723
C105260	4-tert-octylphenol	[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A mRNA	23626723
C105260	4-tert-octylphenol	[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein	23626723
C105260	4-tert-octylphenol	wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein]	23626723
D000082	Acetaminophen	Acetaminophen affects the expression of DNMT3A mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of DNMT3A mRNA	25607892
D000082	Acetaminophen	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DNMT3A mRNA	25607892
D020106	Acrylamide	Acrylamide results in decreased expression of DNMT3A mRNA	28959563
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT3A protein]	22558281
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA]	18098314
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of DNMT3A gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of DNMT3A mRNA	19770486
D000726	Androgen Antagonists	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DNMT3A mRNA	25607892
D000068180	Aripiprazole	Aripiprazole results in increased expression of DNMT3A mRNA	17868501
D001151	Arsenic	DNMT3A gene SNP affects the susceptibility to Arsenic	27292127
D001151	Arsenic	Arsenic affects the localization of DNMT3A protein	22426358
D001151	Arsenic	Arsenic promotes the reaction [DNMT3A protein binds to MYOG promoter]	22426358
D001151	Arsenic	Arsenic results in increased expression of DNMT3A mRNA	22426358
C006632	arsenic trioxide	arsenic trioxide results in decreased activity of DNMT3A protein	20596618
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of DNMT3A	20416177
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of DNMT3A mRNA	12667347\|1267900
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of DNMT3A protein	22558281
C006632	arsenic trioxide	arsenic trioxide results in increased expression of DNMT3A mRNA	25534098
C006632	arsenic trioxide	S-Adenosylmethionine inhibits the reaction [arsenic trioxide results in decreased expression of DNMT3A protein]	22558281
C015001	arsenite	arsenite results in increased expression of DNMT3A mRNA	18191166
D001280	Atrazine	Atrazine results in decreased expression of DNMT3A mRNA	25929836
D001374	Azacitidine	Azacitidine results in decreased expression of DNMT3A mRNA	15547111
D001374	Azacitidine	pifithrin inhibits the reaction [Azacitidine results in decreased expression of DNMT3A mRNA]	15547111
D001374	Azacitidine	TP53 protein promotes the reaction [Azacitidine results in decreased expression of DNMT3A mRNA]	15547111
D001554	Benzene	Benzene results in increased expression of DNMT3A mRNA	21325737
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of DNMT3A mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DNMT3A mRNA	17879257
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DNMT3A mRNA	20713471
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide promotes the reaction [DNMT3A protein binds to RARB promoter]"	20426865
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"DNMT3A protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of JUN protein]"	20426865
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"DNMT3A protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MAPK1 protein modified form]"	20426865
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"DNMT3A protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MAPK3 protein modified form]"	20426865
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"DNMT3A protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PTGS2 protein modified form]"	20426865
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of DNMT3A protein]	23395981
D004958	Estradiol	Estradiol inhibits the reaction [sodium arsenite results in decreased expression of DNMT3A mRNA]	22952798
D004958	Estradiol	Estradiol results in decreased expression of DNMT3A mRNA	22952798
D004958	Estradiol	sodium arsenite inhibits the reaction [Estradiol results in decreased expression of DNMT3A mRNA]	22952798
D004958	Estradiol	[Testosterone co-treated with Estradiol] affects the reaction [bisphenol A results in increased expression of DNMT3A mRNA]	22109888
D004958	Estradiol	[Testosterone co-treated with Estradiol] affects the reaction [estradiol-17 beta-benzoate results in increased expression of DNMT3A mRNA]	22109888
D001622	Betaine	[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]	28445388
D001622	Betaine	[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA	28445388
C095105	bexarotene	bexarotene results in decreased expression of DNMT3A mRNA	17849452
C006780	bisphenol A	bisphenol A results in decreased expression of DNMT3A mRNA	27183338
C006780	bisphenol A	bisphenol A affects the expression of DNMT3A mRNA	23716699
C006780	bisphenol A	bisphenol A affects the expression of DNMT3A protein	23418087
C006780	bisphenol A	bisphenol A affects the methylation of DNMT3A promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of DNMT3A mRNA	22131059\|2353540
C006780	bisphenol A	bisphenol A results in decreased expression of DNMT3A protein	27502578
C006780	bisphenol A	bisphenol A results in increased expression of DNMT3A mRNA	21980460\|2849603
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]	22131059
C006780	bisphenol A	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DNMT3A promoter	23359474
C006780	bisphenol A	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DNMT3A mRNA	25607892
C006780	bisphenol A	bisphenol A results in decreased expression of DNMT3A mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of DNMT3A mRNA	21827818\|2210988
C006780	bisphenol A	bisphenol A results in increased expression of DNMT3A protein	21827818
C006780	bisphenol A	[Testosterone co-treated with Estradiol] affects the reaction [bisphenol A results in increased expression of DNMT3A mRNA]	22109888
C006780	bisphenol A	[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]	28445388
C006780	bisphenol A	bisphenol A results in decreased expression of DNMT3A mRNA	28445388\|2881913
C038091	butylparaben	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DNMT3A mRNA	25607892
C038091	butylparaben	butylparaben results in increased expression of DNMT3A mRNA	26888303
D002104	Cadmium	Cadmium results in decreased expression of DNMT3A mRNA	21278052
D019256	Cadmium Chloride	Cadmium Chloride results in increased activity of and results in increased expression of DNMT3A protein	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of ERCC1 mRNA	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of MSH2 mRNA	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of OGG1 mRNA	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of XRCC1 mRNA	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of ERCC1 promoter	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of MSH2 promoter	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of OGG1 promoter	22112500
D019256	Cadmium Chloride	[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of XRCC1 promoter	22112500
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of DNMT3A mRNA	22112500\|2544881
D019256	Cadmium Chloride	decitabine inhibits the reaction [Cadmium Chloride results in increased expression of DNMT3A mRNA]	22112500
D019256	Cadmium Chloride	decitabine inhibits the reaction [Cadmium Chloride results in increased expression of DNMT3A protein]	22112500
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of DNMT3A mRNA	22957049
D002110	Caffeine	Caffeine results in increased expression of DNMT3A mRNA	24717552
D002251	Carbon Tetrachloride	DNMT3A protein affects the reaction [Carbon Tetrachloride results in decreased expression of SEPT9 protein]	27939986
D002737	Chloroprene	Chloroprene results in increased expression of DNMT3A mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNMT3A mRNA	20938992
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNMT3A protein	20548288
D002794	Choline	[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]	28445388
D002794	Choline	[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA	28445388
D015283	Citalopram	Citalopram affects the expression of DNMT3A mRNA	21682946
D002994	Clofibrate	Clofibrate results in increased expression of DNMT3A mRNA	17585979
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of DNMT3A mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of DNMT3A mRNA	26577399
D003474	Curcumin	Curcumin results in decreased expression of DNMT3A mRNA	23593078
D003474	Curcumin	Curcumin analog results in decreased expression of DNMT3A protein	26991801
D003513	Cycloheximide	[Cycloheximide co-treated with FASLG protein] results in decreased expression of DNMT3A mRNA	19833194
D003513	Cycloheximide	[Cycloheximide co-treated with FASLG protein] results in decreased expression of DNMT3A protein	19833194
D016572	Cyclosporine	Cyclosporine results in decreased methylation of DNMT3A promoter	27989131
C004742	daidzein	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT3A mRNA	28964809
C013908	daidzin	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT3A mRNA	28964809
D003634	DDT	DDT results in decreased expression of DNMT3A mRNA	19797855
C014347	decitabine	decitabine inhibits the reaction [Cadmium Chloride results in increased expression of DNMT3A mRNA]	22112500
C014347	decitabine	decitabine inhibits the reaction [Cadmium Chloride results in increased expression of DNMT3A protein]	22112500
C014347	decitabine	decitabine inhibits the reaction [DNMT3A protein binds to SPARC promoter]	19177197
C014347	decitabine	decitabine results in decreased expression of DNMT3A mRNA	18676679
C014347	decitabine	decitabine results in decreased expression of DNMT3A protein	17991895\|1917719
C014347	decitabine	DNMT3A protein affects the reaction [decitabine results in increased expression of CDH1 mRNA]	16887905
C014347	decitabine	DNMT3A protein affects the reaction [decitabine results in increased expression of JUP mRNA]	16887905
D003676	Deferoxamine	Deferoxamine results in decreased expression of DNMT3A mRNA	23483119
D003676	Deferoxamine	Deferoxamine results in increased expression of DNMT3A mRNA	23483119
C007262	deoxynivalenol	deoxynivalenol results in increased expression of DNMT3A mRNA	26988607
D003993	Dibutyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DNMT3A promoter	23359474
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of DNMT3A protein	26745512
D003997	Dicarbethoxydihydrocollidine	Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA	18098314
D003997	Dicarbethoxydihydrocollidine	S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA]	18098314
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of DNMT3A mRNA	20335514
D004051	Diethylhexyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DNMT3A promoter	23359474
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of DNMT3A mRNA	25280772
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of DNMT3A protein	25280772
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of and affects the localization of DNMT3A protein	21163286
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of DNMT3A mRNA	16714842\|2431672
D004391	Dust	Dust results in decreased expression of DNMT3A mRNA	26342214
D004726	Endosulfan	Endosulfan results in increased expression of DNMT3A mRNA	29054638
D004726	Endosulfan	Endosulfan results in increased expression of DNMT3A protein	29054638
C038939	enzacamene	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DNMT3A mRNA	25607892
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of DNMT3A mRNA	25839702
C010452	estradiol-17 beta-benzoate	estradiol-17 beta-benzoate results in increased expression of DNMT3A mRNA	22109888
C010452	estradiol-17 beta-benzoate	[Testosterone co-treated with Estradiol] affects the reaction [estradiol-17 beta-benzoate results in increased expression of DNMT3A mRNA]	22109888
D000431	Ethanol	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of DNMT3A protein]	23395981
D000431	Ethanol	Ethanol affects the expression of DNMT3A mRNA	26730594
D000431	Ethanol	Ethanol results in decreased expression of DNMT3A protein	23395981
D000431	Ethanol	Ethanol results in increased degradation of DNMT3A protein	23395981
D000431	Ethanol	Ethanol results in increased expression of DNMT3A mRNA	23395981
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNMT3A mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of DNMT3A mRNA	29097150
D005492	Folic Acid	Folic Acid affects the expression of DNMT3A mRNA	17311948
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNMT3A mRNA	20938992
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNMT3A protein	20548288
D005492	Folic Acid	[sodium arsenite co-treated with Folic Acid] results in decreased expression of DNMT3A mRNA	22959928
D005492	Folic Acid	[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]	28445388
D005492	Folic Acid	[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA	28445388
D005557	Formaldehyde	Formaldehyde results in decreased expression of DNMT3A mRNA	21745553
D005557	Formaldehyde	Formaldehyde results in decreased expression of DNMT3A protein	21745553
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]	22131059
C056933	fumonisin B1	fumonisin B1 results in decreased activity of DNMT3A protein	24280379
D019833	Genistein	Genistein results in decreased expression of DNMT3A mRNA	23593078
D019833	Genistein	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT3A mRNA	28964809
C040641	genistin	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT3A mRNA	28964809
C086566	glycitein	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT3A mRNA	28964809
C433283	glycitin	[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT3A mRNA	28964809
C010974	glyphosate	glyphosate results in increased expression of DNMT3A mRNA	26302742
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins results in decreased expression of DNMT3A mRNA	22749965
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins results in decreased expression of DNMT3A protein	22749965
D017313	Fenretinide	Fenretinide results in decreased expression of DNMT3A mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of DNMT3A mRNA	27655674
C031927	hydroquinone	hydroquinone results in decreased expression of DNMT3A mRNA	22245671
C031927	hydroquinone	hydroquinone results in decreased expression of DNMT3A protein	27979589
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DNMT3A mRNA	25613284
D007545	Isoproterenol	Isoproterenol results in decreased expression of DNMT3A mRNA	20003209
D007545	Isoproterenol	Isoproterenol results in increased expression of DNMT3A protein	24945829
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of DNMT3A mRNA	23086925
C410337	K 7174	K 7174 results in decreased expression of DNMT3A mRNA	24086573
D007854	Lead	Lead results in decreased expression of DNMT3A mRNA	22272629
D007854	Lead	Lead results in decreased expression of DNMT3A protein	22272629
C008261	lead acetate	lead acetate results in decreased expression of DNMT3A protein	21891863
C008261	lead acetate	lead acetate results in decreased expression of DNMT3A protein	23246732
C008261	lead acetate	lead acetate results in increased expression of DNMT3A protein	23246732
C017461	lead nitrate	"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]"	24639330
C017461	lead nitrate	E2F1 protein inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]	24639330
C017461	lead nitrate	lead nitrate results in decreased expression of DNMT3A mRNA	24639330
C017461	lead nitrate	lead nitrate results in decreased expression of DNMT3A protein	24639330
C017461	lead nitrate	tyrphostin AG 1478 inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]	24639330
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNMT3A mRNA	20938992
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNMT3A protein	20548288
D008727	Methotrexate	Methotrexate results in increased expression of DNMT3A mRNA	24449571
D008731	Methoxychlor	Methoxychlor results in decreased expression of DNMT3A mRNA	23303685
D008748	Methylcholanthrene	[Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of and affects the localization of DNMT3A protein	21163286
C002950	methylformamide	methylformamide affects the expression of DNMT3A mRNA	17040096
C002950	methylformamide	methylformamide analog affects the expression of DNMT3A mRNA	17040096
C030589	methylmercury cysteine	methylmercury cysteine results in decreased expression of DNMT3A mRNA	19465457
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DNMT3A mRNA"	20188158
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of DNMT3A protein	26558463
D016685	Mitomycin	Mitomycin results in decreased expression of DNMT3A protein	27032448
C028577	monobutyl phthalate	monobutyl phthalate results in decreased expression of DNMT3A protein	26745512
D009151	Mustard Gas	Mustard Gas results in decreased expression of DNMT3A mRNA	26392148
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of DNMT3A mRNA	15913567
D015058	1-Naphthylisothiocyanate	"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of DNMT3A mRNA]"	15913567
C107010	O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate	"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of DNMT3A mRNA]"	15913567
C025589	ochratoxin A	ochratoxin A results in increased expression of DNMT3A mRNA	29080797
C118580	octylmethoxycinnamate	[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of DNMT3A mRNA	25607892
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of DNMT3A mRNA"	24096037
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of DNMT3A mRNA"	24096037
D010396	Penicillamine	Penicillamine results in decreased expression of DNMT3A mRNA	22945834
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of DNMT3A protein	26178269
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of DNMT3A protein	20621739
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of DNMT3A protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of DNMT3A mRNA	22425687
D010634	Phenobarbital	Phenobarbital affects the expression of DNMT3A mRNA	19482888\|2309116
C121565	pifithrin	pifithrin inhibits the reaction [Azacitidine results in decreased expression of DNMT3A mRNA]	15547111
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of DNMT3A mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of DNMT3A mRNA	18445702
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in decreased expression of DNMT3A mRNA	19636072
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons affects the expression of DNMT3A mRNA	23147375
C023617	pregna-4,17-diene-3,16-dione	"pregna-4,17-diene-3,16-dione results in decreased expression of DNMT3A mRNA"	23593078
C479580	procyanidin B2	procyanidin B2 results in increased expression of DNMT3A mRNA	25839702
C107773	pterostilbene	[resveratrol co-treated with pterostilbene] results in decreased expression of DNMT3A mRNA	26459286
D011791	Quartz	Quartz results in decreased expression of DNMT3A mRNA	27917503
C037219	quinoline	quinoline analog results in decreased activity of DNMT3A protein	19417133
C059514	resveratrol	[resveratrol co-treated with pterostilbene] results in decreased expression of DNMT3A mRNA	26459286
C059514	resveratrol	resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT3A protein binds to BRCA1 promoter]]	22197621
C059514	resveratrol	resveratrol results in decreased expression of DNMT3A mRNA	23593078
C010327	salinomycin	salinomycin results in decreased expression of DNMT3A mRNA	19682730
C581203	SGI-1027	SGI-1027 results in decreased activity of DNMT3A protein	25525263
C006235	sinefungin	sinefungin results in decreased activity of DNMT3A protein	23671287
C017947	sodium arsenite	Estradiol inhibits the reaction [sodium arsenite results in decreased expression of DNMT3A mRNA]	22952798
C017947	sodium arsenite	sodium arsenite inhibits the reaction [Estradiol results in decreased expression of DNMT3A mRNA]	22952798
C017947	sodium arsenite	sodium arsenite results in decreased expression of DNMT3A mRNA	17107663\|2295279
C017947	sodium arsenite	sodium arsenite results in decreased expression of DNMT3A protein	24570342
C017947	sodium arsenite	[sodium arsenite co-treated with Folic Acid] results in decreased expression of DNMT3A mRNA	22959928
C017947	sodium arsenite	sodium arsenite results in increased expression of DNMT3A mRNA	19822182
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of DNMT3A mRNA	18676679
D013629	Tamoxifen	Tamoxifen results in decreased expression of DNMT3A mRNA	25123088
D013739	Testosterone	[Testosterone co-treated with Estradiol] affects the reaction [bisphenol A results in increased expression of DNMT3A mRNA]	22109888
D013739	Testosterone	[Testosterone co-treated with Estradiol] affects the reaction [estradiol-17 beta-benzoate results in increased expression of DNMT3A mRNA]	22109888
D013739	Testosterone	[Testosterone co-treated with vinclozolin] results in increased expression of DNMT3A mRNA	20056826
D013749	Tetrachlorodibenzodioxin	resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT3A protein binds to BRCA1 promoter]]	22197621
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [DNMT3A protein binds to BRCA1 promoter]	22197621
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNMT3A mRNA	17942748
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of DNMT3A mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DNMT3A mRNA	19933214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of DNMT3A mRNA	15328365
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DNMT3A mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DNMT3A mRNA	26455773
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DNMT3A mRNA	25613284
D013849	Thimerosal	Thimerosal results in decreased expression of DNMT3A mRNA	27188386
D014212	Tretinoin	Tretinoin results in decreased expression of DNMT3A mRNA	17273765\|2193413
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of DNMT3A mRNA	22407948\|2554935
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of DNMT3A mRNA	27618143
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of DNMT3A gene	27618143
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of DNMT3A mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DNMT3A mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of DNMT3A mRNA	28973697
C101044	tyrphostin AG 1478	tyrphostin AG 1478 inhibits the reaction [lead nitrate results in decreased expression of DNMT3A mRNA]	24639330
D014501	Uranium	Uranium results in increased expression of DNMT3A mRNA	29024790
D014520	Urethane	Urethane results in decreased expression of DNMT3A mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of DNMT3A mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of DNMT3A mRNA	28001369
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of DNMT3A gene	25560391
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride results in increased expression of DNMT3A mRNA	25423262
C025643	vinclozolin	[Testosterone co-treated with vinclozolin] results in increased expression of DNMT3A mRNA	20056826
C025643	vinclozolin	vinclozolin results in decreased expression of DNMT3A mRNA	18042343
C025643	vinclozolin	vinclozolin results in increased expression of DNMT3A mRNA	20056826
C017963	vinyl carbamate	vinyl carbamate results in increased expression of DNMT3A mRNA	17849452
D014805	Vitamin B 12	[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]	28445388
D014805	Vitamin B 12	[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA	28445388
D014810	Vitamin E	Vitamin E results in decreased expression of DNMT3A mRNA	19244175
C111237	vorinostat	vorinostat results in decreased expression of DNMT3A mRNA	27188386
C009684	withaferin A	withaferin A results in decreased expression of DNMT3A mRNA	23593078
C009687	wortmannin	wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein]	23626723
D015032	Zinc	Zinc deficiency results in increased expression of DNMT3A mRNA	19111725
D015032	Zinc	Zinc deficiency results in increased expression of DNMT3A protein	19111725
D015032	Zinc	Zinc inhibits the reaction [Zinc deficiency results in increased expression of DNMT3A mRNA]	19111725

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0003677	DNA binding	-	IDA	12138111
GO:0003682	chromatin binding	-	IEA	-
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	-	IDA	12138111
GO:0005515	protein binding	-	IPI	16357870 16682412 16983096 17713477 19234465 19798101 19834512 21976679 24074865 25383530 25416956
GO:0009008	DNA-methyltransferase activity	-	TAS	-
GO:0042802	identical protein binding	-	IPI	24656771
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0000278	mitotic cell cycle	-	IEA	-
GO:0006306	DNA methylation	-	IDA	12138111
GO:0006346	methylation-dependent chromatin silencing	-	IEA	-
GO:0006349	regulation of gene expression by genetic imprinting	-	TAS	12138111
GO:0007283	spermatogenesis	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0010212	response to ionizing radiation	-	IEA	-
GO:0010288	response to lead ion	-	IEA	-
GO:0010942	positive regulation of cell death	-	IEA	-
GO:0030182	neuron differentiation	-	IEA	-
GO:0032355	response to estradiol	-	IEA	-
GO:0033189	response to vitamin A	-	IEA	-
GO:0042220	response to cocaine	-	IEA	-
GO:0043045	DNA methylation involved in embryo development	-	IEA	-
GO:0043046	DNA methylation involved in gamete generation	-	IEA	-
GO:0045814	negative regulation of gene expression, epigenetic	-	TAS	-
GO:0071230	cellular response to amino acid stimulus	-	IEA	-
GO:0071361	cellular response to ethanol	-	IEA	-
GO:0071456	cellular response to hypoxia	-	IEA	-
GO:0090116	C-5 methylation of cytosine	-	IEA	-
GO:0097284	hepatocyte apoptotic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000775	chromosome, centromeric region	-	IEA	-
GO:0000791	euchromatin	-	IDA	12138111
GO:0001741	XY body	-	IEA	-
GO:0005634	nucleus	-	IDA	12138111 25743254
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005720	nuclear heterochromatin	-	IEA	-
GO:0005737	cytoplasm	-	IDA	12138111
GO:0016363	nuclear matrix	-	IDA	12138111

KEGG ID	KEGG Term
hsa00270	Cysteine and methionine metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-212165	Epigenetic regulation of gene expression	IEA
R-HSA-212165	Epigenetic regulation of gene expression	TAS
R-HSA-212300	PRC2 methylates histones and DNA	TAS
R-HSA-3214858	RMTs methylate histone arginines	TAS
R-HSA-3247509	Chromatin modifying enzymes	TAS
R-HSA-4839726	Chromatin organization	TAS
R-HSA-5334118	DNA methylation	IEA
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29092026	COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression. (2018 Jan 15)	Nedeljkovic I	Hum Mol Genet
28483762	Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly. (2017 Aug 10)	Zink F	Blood
22248280	Cigarette smoking extract causes hypermethylation and inactivation of WWOX gene in T-24 human bladder cancer cells. (2012)	Yang W	Neoplasma
25126948	Association of DNA methyltransferases 3A and 3B polymorphisms, and plasma folate levels with the risk of urothelial carcinoma. (2014)	Chung CJ	PLoS One
24527678	Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex. (2014 Jun)	Echeverry-Alzate V	Br J Pharmacol
17929180	Age and gender affect DNMT3a and DNMT3b expression in human liver. (2008 Jun)	Xiao Y	Cell Biol Toxicol
17140695	Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. (2007 Feb)	Lin RK	Lung Cancer
16570269	Nicotine induces the fragile histidine triad methylation in human esophageal squamous epithelial cells. (2006 Sep 1)	Soma T	Int J Cancer
29626481	Nicotine induces aberrant hypermethylation of tumor suppressor genes in pancreatic epithelial ductal cells. (2018 May 23)	Jin T	Biochem Biophys Res Commun
28423585	The rs1550117 A>G variant in DNMT3A gene promoter significantly increases non-small cell lung cancer susceptibility in a Han Chinese population. (2017 Apr 4)	Wang J	Oncotarget
26317789	LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation. (2015 Sep 22)	Lee CH	Oncotarget
25222473	Increased NQO1 but not c-MET and survivin expression in non-small cell lung carcinoma with KRAS mutations. (2014 Sep 12)	Yilmaz A	Int J Environ Res Public Health
20951977	Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas. (2010 Dec)	Daniel FI	Arch Oral Biol
23552396	Genetic and non-genetic predictors of LINE-1 methylation in leukocyte DNA. (2013 Jun)	Tajuddin SM	Environ Health Perspect
29100355	Role of DNA methylation in perinatal nicotine-induced development of heart ischemia-sensitive phenotype in rat offspring. (2017 Sep 29)	Ke J	Oncotarget