Gene info: ID 1789

Gene: DNMT3B

GENE ID: 1789

Synonyms: ICF|ICF1|M.HsaIIIB

Description: DNA methyltransferase 3 beta

Gene type: protein-coding

Location: 20q11.21

dbXrefs: Ensembl:ENSG00000088305 MIM:602900 Vega:OTTHUMG00000032226 UniprotKB:Q9UBC3

RefSeq: NG_007290.1

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: CD|ND

# Publications: 21

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.917e-2 (AD) 6.119e-2 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2424913	chr20:32786453 (GRCh38.p7)	C>T	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg22052056	chr20:31351813	DNMT3B		3.370e-8	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ECHDC2	0.662
RIPK1	0.658
MAML1	0.648
ZNF789	0.646
POU2F1	0.642
TTLL3	0.642
LY6G5B	0.639
POFUT2	0.637
ZNF662	0.636
TTC31	0.634

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.303
OR4F29	-0.29
BOLA2	-0.244
CLEC3A	-0.231
LIPH	-0.227
PPP1R17	-0.224
CSHL1	-0.214
LCN1	-0.202
SLC27A6	-0.191
METTL11B	-0.185

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in decreased expression of DNMT3B mRNA"	26377693
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of DNMT3B mRNA"	28903501
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DNMT3B mRNA"	25510870
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DNMT3B mRNA"	19114083
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DNMT3B mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DNMT3B mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DNMT3B mRNA"	25510870
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of DNMT3B protein]	26942697
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DNMT3B mRNA"	25510870
C016392	3,3'-diindolylmethane	"3,3'-diindolylmethane results in decreased expression of DNMT3B mRNA"	24466240
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of DNMT3B mRNA	16788091
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of DNMT3B mRNA"	25912373
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNMT3B mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DNMT3B mRNA"	27188386
C041594	4-nonylphenol	[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B mRNA	23626723
C041594	4-nonylphenol	[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein	23626723
C041594	4-nonylphenol	wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein]	23626723
C105260	4-tert-octylphenol	[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B mRNA	23626723
C105260	4-tert-octylphenol	[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein	23626723
C105260	4-tert-octylphenol	wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein]	23626723
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNMT3B mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DNMT3B mRNA"	27188386
C067134	8-oxo-7-hydrodeoxyguanosine	DNMT3B gene SNP affects the abundance of 8-oxo-7-hydrodeoxyguanosine	19896490
D000082	Acetaminophen	Acetaminophen results in increased expression of DNMT3B mRNA	22230336
D019342	Acetic Acid	Acetic Acid results in decreased expression of DNMT3B protein	21296659
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of DNMT3B protein]	26942697
D001151	Arsenic	DNMT3B gene polymorphism affects the metabolism of Arsenic	21247820
C006632	arsenic trioxide	arsenic trioxide results in decreased activity of DNMT3B protein	20596618
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of DNMT3B	20416177
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of DNMT3B mRNA	12667347\|1267900
C006632	arsenic trioxide	arsenic trioxide results in increased expression of DNMT3B mRNA	25534098
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of DNMT3B protein	19679824
D001280	Atrazine	Atrazine results in increased expression of DNMT3B mRNA	25929836
D001379	Azathioprine	Azathioprine results in decreased expression of DNMT3B mRNA	22623647
D053119	Benzophenanthridines	Benzophenanthridines analog results in decreased expression of DNMT3B mRNA	23117580
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of DNMT3B gene	25435355
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DNMT3B mRNA	19770486\|2171566
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of DNMT3B protein]	23395981
D001599	Berberine	Berberine results in decreased expression of DNMT3B mRNA	27311644
D004958	Estradiol	[mono-(2-ethylhexyl)phthalate co-treated with Estradiol] results in increased expression of DNMT3B mRNA	27989758
D004958	Estradiol	[Testosterone co-treated with Estradiol] affects the reaction [bisphenol A results in increased expression of DNMT3B mRNA]	22109888
D004958	Estradiol	[Testosterone co-treated with Estradiol] affects the reaction [estradiol-17 beta-benzoate results in increased expression of DNMT3B mRNA]	22109888
D001622	Betaine	Betaine results in decreased expression of DNMT3B mRNA	22945834
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of DNMT3B mRNA	25912373
C006780	bisphenol A	bisphenol A results in decreased methylation of DNMT3B promoter	27271280
C006780	bisphenol A	bisphenol A results in increased expression of DNMT3B mRNA	27685785
C006780	bisphenol A	bisphenol A affects the methylation of DNMT3B promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of DNMT3B mRNA	22131059\|2750257
C006780	bisphenol A	bisphenol A results in decreased expression of DNMT3B protein	23418087\|2750257
C006780	bisphenol A	bisphenol A results in increased expression of DNMT3B mRNA	23535407
C006780	bisphenol A	fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT3B mRNA]	22131059
C006780	bisphenol A	bisphenol A results in decreased expression of DNMT3B mRNA	25181051\|2574866
C006780	bisphenol A	bisphenol A results in increased expression of DNMT3B mRNA	21827818\|2210988
C006780	bisphenol A	bisphenol A results in increased expression of DNMT3B protein	21827818
C006780	bisphenol A	bisphenol A results in increased methylation of DNMT3B gene	28505145
C006780	bisphenol A	[Testosterone co-treated with Estradiol] affects the reaction [bisphenol A results in increased expression of DNMT3B mRNA]	22109888
C006780	bisphenol A	bisphenol A results in decreased expression of DNMT3B mRNA	28819136
C099813	bromochloroacetic acid	bromochloroacetic acid results in decreased expression of DNMT3B protein	21296659
C038091	butylparaben	butylparaben results in increased expression of DNMT3B mRNA	26888303
D002104	Cadmium	Cadmium results in decreased expression of DNMT3B mRNA	21278052
D002104	Cadmium	Cadmium affects the expression of DNMT3B mRNA	22382075
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of DNMT3B mRNA	17938735\|2544881
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of DNMT3B protein	27984135
D002110	Caffeine	Caffeine results in increased expression of DNMT3B mRNA	25868845
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of DNMT3B mRNA	24763279
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNMT3B protein	20548288
C012843	cinnamic aldehyde	cinnamic aldehyde results in decreased expression of DNMT3B mRNA	17178418
D003042	Cocaine	Cocaine results in decreased expression of DNMT3B mRNA	22438930
D003042	Cocaine	Cocaine results in decreased expression of DNMT3B protein	22438930
D003042	Cocaine	Methionine inhibits the reaction [Cocaine results in decreased expression of DNMT3B mRNA]	22438930
D003042	Cocaine	Methionine inhibits the reaction [Cocaine results in decreased expression of DNMT3B protein]	22438930
D019327	Copper Sulfate	Copper Sulfate results in increased expression of DNMT3B mRNA	19549813
D003474	Curcumin	Curcumin results in decreased expression of DNMT3B mRNA	23593078
D003474	Curcumin	Curcumin analog results in decreased expression of DNMT3B protein	26991801
D016572	Cyclosporine	Cyclosporine results in decreased expression of DNMT3B mRNA	20106945\|2798913
D016572	Cyclosporine	Cyclosporine results in increased expression of DNMT3B mRNA	25562108
D003634	DDT	DDT results in decreased expression of DNMT3B mRNA	19797855
C014347	decitabine	decitabine affects the expression of DNMT3B mRNA	18544619
C014347	decitabine	[decitabine affects the expression of DNMT3B protein] which affects the expression of CDKN1A mRNA	18544619
C014347	decitabine	[decitabine affects the expression of DNMT3B protein] which affects the expression of CDKN1B mRNA	18544619
C014347	decitabine	[decitabine affects the expression of DNMT3B protein] which affects the expression of RB1 mRNA	18544619
C014347	decitabine	decitabine inhibits the reaction [DNMT3B protein binds to GSTM2 promoter]	21246532
C014347	decitabine	decitabine results in decreased expression of DNMT3B mRNA	18676679\|1966237
C014347	decitabine	decitabine results in decreased expression of DNMT3B protein	17991895\|1922100
C014347	decitabine	DNMT3B gene mutant form results in decreased susceptibility to decitabine	23300844
C014347	decitabine	DNMT3B protein affects the reaction [decitabine results in increased expression of CDH1 protein]	16887905
C014347	decitabine	DNMT3B protein affects the reaction [decitabine results in increased expression of JUP protein]	16887905
C014347	decitabine	DNMT3B protein affects the susceptibility to decitabine	17991895
C014347	decitabine	decitabine results in decreased expression of DNMT3B protein	19679824
C014347	decitabine	decitabine affects the expression of DNMT3B mRNA	24447120
D003676	Deferoxamine	Deferoxamine results in decreased expression of DNMT3B mRNA	23483119
D003676	Deferoxamine	Deferoxamine results in increased expression of DNMT3B mRNA	23483119
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of DNMT3B mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of DNMT3B protein	26745512
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of DNMT3B mRNA	27392435
D002945	Cisplatin	DNMT3B protein results in decreased susceptibility to Cisplatin	18314485
D002945	Cisplatin	Cisplatin results in increased phosphorylation of DNMT3B protein	22006019
C000944	dicrotophos	dicrotophos results in increased expression of DNMT3B mRNA	28302478
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of DNMT3B mRNA	20335514
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of DNMT3B mRNA	25280772
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of DNMT3B protein	25280772
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of DNMT3B mRNA	16714842
D002117	Calcitriol	Calcitriol results in decreased expression of DNMT3B mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of DNMT3B mRNA	21592394
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in decreased expression of DNMT3B mRNA	25236440
C029402	diphenylcyclopropenone	diphenylcyclopropenone results in decreased expression of DNMT3B mRNA	25236440
D004391	Dust	Dust results in decreased expression of DNMT3B mRNA	26342214
D004726	Endosulfan	Endosulfan results in increased expression of DNMT3B mRNA	29054638
D004726	Endosulfan	Endosulfan results in increased expression of DNMT3B protein	29054638
C118739	entinostat	entinostat results in increased expression of DNMT3B mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNMT3B mRNA"	27188386
C118739	entinostat	entinostat results in decreased expression of DNMT3B protein	19679824
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of DNMT3B mRNA	25839702
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DNMT3B mRNA	22079256
C010452	estradiol-17 beta-benzoate	estradiol-17 beta-benzoate results in increased expression of DNMT3B mRNA	22109888
C010452	estradiol-17 beta-benzoate	[Testosterone co-treated with Estradiol] affects the reaction [estradiol-17 beta-benzoate results in increased expression of DNMT3B mRNA]	22109888
D000431	Ethanol	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Ethanol results in increased degradation of DNMT3B protein]	23395981
D000431	Ethanol	Ethanol results in decreased expression of DNMT3B protein	23395981
D000431	Ethanol	Ethanol results in increased degradation of DNMT3B protein	23395981
D000431	Ethanol	Ethanol results in increased expression of DNMT3B mRNA	23395981
D005047	Etoposide	DNMT3B protein results in decreased susceptibility to Etoposide	18314485
D005472	Fluorouracil	Fluorouracil results in decreased expression of DNMT3B protein	21296659
D005492	Folic Acid	Folic Acid affects the expression of DNMT3B mRNA	17311948
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNMT3B protein	20548288
D005557	Formaldehyde	Formaldehyde results in decreased expression of DNMT3B mRNA	21745553
D005557	Formaldehyde	Formaldehyde results in decreased expression of DNMT3B protein	21745553
C070081	fulvestrant	fulvestrant inhibits the reaction [bisphenol A results in decreased expression of DNMT3B mRNA]	22131059
C056933	fumonisin B1	fumonisin B1 results in decreased activity of DNMT3B protein	24280379
C056507	gemcitabine	[gemcitabine results in decreased susceptibility to gemcitabine] which results in increased expression of DNMT3B protein	25189999
D019833	Genistein	Genistein results in decreased expression of DNMT3B mRNA	23593078
D019833	Genistein	Genistein results in decreased expression of DNMT3B protein	19221000
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of DNMT3B mRNA	24763279
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins results in decreased expression of DNMT3B mRNA	22749965
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins results in decreased expression of DNMT3B protein	22749965
D006861	Hydrogen Peroxide	DNMT3B protein results in decreased susceptibility to Hydrogen Peroxide	18314485
C031927	hydroquinone	hydroquinone results in decreased expression of DNMT3B mRNA	22245671
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of DNMT3B mRNA	21396975
D007545	Isoproterenol	Isoproterenol results in increased expression of DNMT3B mRNA	21335049
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of DNMT3B mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of DNMT3B mRNA	27392435
D007649	Ketamine	Ketamine results in decreased expression of DNMT3B mRNA	20080153
D007854	Lead	Lead affects the expression of DNMT3B mRNA	28903495
C045463	leflunomide	leflunomide results in decreased expression of DNMT3B mRNA	28988120
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DNMT3B protein	20548288
D008715	Methionine	Methionine inhibits the reaction [Cocaine results in decreased expression of DNMT3B mRNA]	22438930
D008715	Methionine	Methionine inhibits the reaction [Cocaine results in decreased expression of DNMT3B protein]	22438930
D008731	Methoxychlor	Methoxychlor results in increased expression of DNMT3B mRNA	19589859
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of DNMT3B mRNA	19636072
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of DNMT3B mRNA	21664453
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of DNMT3B mRNA	22918959
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of DNMT3B mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DNMT3B mRNA"	26251327
C016599	mono-(2-ethylhexyl)phthalate	[mono-(2-ethylhexyl)phthalate co-treated with Estradiol] results in increased expression of DNMT3B mRNA	27989758
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of DNMT3B mRNA	27989758
C028577	monobutyl phthalate	monobutyl phthalate results in decreased expression of DNMT3B protein	26745512
C091888	monoisoamyl-2,3-dimercaptosuccinate	"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of DNMT3B mRNA]"	19615344
D009151	Mustard Gas	Mustard Gas results in decreased expression of DNMT3B mRNA	26392148
D009151	Mustard Gas	Mustard Gas results in increased expression of DNMT3B mRNA	15674844
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of DNMT3B mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of DNMT3B mRNA"	25620056
D010126	Ozone	DNMT3B gene polymorphism affects the susceptibility to Ozone	27219456
D052638	Particulate Matter	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of DNMT3B protein]	26942697
D052638	Particulate Matter	Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of DNMT3B protein]	26942697
D052638	Particulate Matter	DNMT3B protein affects the reaction [Particulate Matter results in decreased expression of TP53 protein]	26942697
D052638	Particulate Matter	DNMT3B protein affects the reaction [Particulate Matter results in increased methylation of TP53 promoter]	26942697
D052638	Particulate Matter	Particulate Matter results in increased expression of DNMT3B protein	26942697
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of DNMT3B mRNA"	25510870
D010396	Penicillamine	Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of DNMT3B mRNA]	22945834
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of DNMT3B protein	26178269
D010634	Phenobarbital	Phenobarbital affects the expression of DNMT3B mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of DNMT3B mRNA	19270015
D010634	Phenobarbital	Phenobarbital results in decreased expression of DNMT3B mRNA	28495587
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DNMT3B mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of DNMT3B mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in decreased expression of DNMT3B mRNA	20813756
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in decreased expression of DNMT3B mRNA	19636072
D011084	Polycyclic Aromatic Hydrocarbons	Polycyclic Aromatic Hydrocarbons affects the expression of DNMT3B mRNA	23147375
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DNMT3B mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of DNMT3B mRNA	22079256
C023617	pregna-4,17-diene-3,16-dione	"pregna-4,17-diene-3,16-dione results in decreased expression of DNMT3B mRNA"	23593078
C479580	procyanidin B2	procyanidin B2 results in increased expression of DNMT3B mRNA	25839702
D011441	Propylthiouracil	Propylthiouracil results in increased expression of DNMT3B mRNA	24780913
C107773	pterostilbene	pterostilbene promotes the reaction [resveratrol results in decreased expression of DNMT3B mRNA]	26459286
D011791	Quartz	Quartz results in decreased expression of DNMT3B mRNA	27917503
C037219	quinoline	quinoline analog results in decreased activity of DNMT3B protein	19417133
C059514	resveratrol	pterostilbene promotes the reaction [resveratrol results in decreased expression of DNMT3B mRNA]	26459286
C059514	resveratrol	resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT3B protein binds to BRCA1 promoter]]	22197621
C059514	resveratrol	resveratrol results in decreased expression of DNMT3B mRNA	23593078\|2645928
C059514	resveratrol	resveratrol results in increased expression of DNMT3B mRNA	26934322
C059514	resveratrol	resveratrol affects the expression of DNMT3B mRNA	24447120
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of DNMT3B mRNA	21427059
C581203	SGI-1027	SGI-1027 results in decreased activity of DNMT3B protein	25525263
C017947	sodium arsenite	"monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased expression of DNMT3B mRNA]"	19615344
C017947	sodium arsenite	sodium arsenite results in decreased expression of DNMT3B mRNA	19615344
C017947	sodium arsenite	sodium arsenite results in increased expression of DNMT3B mRNA	24570342
C017947	sodium arsenite	sodium arsenite results in increased expression of DNMT3B protein	24570342
C016766	sulforafan	sulforafan results in decreased expression of DNMT3B mRNA	24466240
D013629	Tamoxifen	DNMT3B protein affects the reaction [Tamoxifen results in decreased expression of CXCR4 mRNA]	19019622
D013629	Tamoxifen	DNMT3B protein affects the reaction [Tamoxifen results in decreased expression of CXCR4 protein]	19019622
D013629	Tamoxifen	Tamoxifen results in increased expression of DNMT3B mRNA alternative form	19019622
D013629	Tamoxifen	Tamoxifen results in increased expression of DNMT3B protein alternative form	19019622
D013629	Tamoxifen	Tamoxifen results in decreased expression of DNMT3B mRNA	25123088
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of DNMT3B mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of DNMT3B mRNA	21592394
D013739	Testosterone	[Testosterone co-treated with Estradiol] affects the reaction [bisphenol A results in increased expression of DNMT3B mRNA]	22109888
D013739	Testosterone	[Testosterone co-treated with Estradiol] affects the reaction [estradiol-17 beta-benzoate results in increased expression of DNMT3B mRNA]	22109888
D013739	Testosterone	[Testosterone co-treated with vinclozolin] results in increased expression of DNMT3B mRNA	20056826
D013739	Testosterone	[Testosterone co-treated with vinclozolin] results in increased expression of DNMT3B protein	20056826
D013749	Tetrachlorodibenzodioxin	resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [DNMT3B protein binds to BRCA1 promoter]]	22197621
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [DNMT3B protein binds to BRCA1 promoter]	22197621
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DNMT3B mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DNMT3B mRNA	19770486\|2892240
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of DNMT3B mRNA	26455773
D014212	Tretinoin	Tretinoin results in increased expression of DNMT3B mRNA	20530235
D014212	Tretinoin	Tretinoin results in decreased expression of DNMT3B mRNA	17273765\|2193413
D014212	Tretinoin	Tretinoin results in decreased expression of DNMT3B mRNA	16788091
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of DNMT3B mRNA	28013219
C012589	trichostatin A	trichostatin A affects the expression of DNMT3B mRNA	18544619
C012589	trichostatin A	[trichostatin A affects the expression of DNMT3B protein] which affects the expression of CDKN1A mRNA	18544619
C012589	trichostatin A	[trichostatin A affects the expression of DNMT3B protein] which affects the expression of CDKN1B mRNA	18544619
C012589	trichostatin A	[trichostatin A affects the expression of DNMT3B protein] which affects the expression of RB1 mRNA	18544619
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DNMT3B mRNA"	26179874
D014501	Uranium	Uranium results in increased expression of DNMT3B mRNA	29024790
D014635	Valproic Acid	Valproic Acid affects the expression of DNMT3B mRNA	25979313\|2607246
D014635	Valproic Acid	Valproic Acid affects the expression of DNMT3B mRNA	26072468
D014635	Valproic Acid	Valproic Acid results in decreased expression of DNMT3B mRNA	21427059
C100058	vanillin	vanillin results in decreased expression of DNMT3B mRNA	17178418
C025643	vinclozolin	[Testosterone co-treated with vinclozolin] results in increased expression of DNMT3B mRNA	20056826
C025643	vinclozolin	[Testosterone co-treated with vinclozolin] results in increased expression of DNMT3B protein	20056826
C025643	vinclozolin	vinclozolin results in increased expression of DNMT3B mRNA	20056826
C025643	vinclozolin	vinclozolin results in increased expression of DNMT3B protein	20056826
C025643	vinclozolin	vinclozolin results in decreased expression of DNMT3B mRNA	22496781
C017963	vinyl carbamate	vinyl carbamate results in decreased expression of DNMT3B mRNA	17849452
D024483	Vitamin K 3	Vitamin K 3 affects the expression of DNMT3B mRNA	20044591
C009684	withaferin A	withaferin A results in decreased expression of DNMT3B mRNA	23593078
C009687	wortmannin	wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein]	23626723

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0003677	DNA binding	-	IEA	-
GO:0003682	chromatin binding	-	IEA	-
GO:0003714	transcription corepressor activity	-	IDA	17303076
GO:0003714	transcription corepressor activity	-	IMP	18567530
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	-	IDA	16543361
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	-	NAS	10647011
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	-	TAS	10433969
GO:0005515	protein binding	-	IPI	11735126 16357870 16983096 17303076 18953337 19798101 22094255 24074865 27728808
GO:0009008	DNA-methyltransferase activity	-	NAS	10325416 10555141 11102980
GO:0009008	DNA-methyltransferase activity	-	TAS	-
GO:0042826	histone deacetylase binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	17303076
GO:0001666	response to hypoxia	-	IEA	-
GO:0006306	DNA methylation	-	NAS	10555141 11102980
GO:0006306	DNA methylation	-	TAS	10433969
GO:0009636	response to toxic substance	-	IEA	-
GO:0010212	response to ionizing radiation	-	IEA	-
GO:0010628	positive regulation of gene expression	-	IMP	18413740
GO:0014823	response to activity	-	IEA	-
GO:0031000	response to caffeine	-	IEA	-
GO:0032355	response to estradiol	-	IEA	-
GO:0033189	response to vitamin A	-	IEA	-
GO:0042220	response to cocaine	-	IEA	-
GO:0045666	positive regulation of neuron differentiation	-	IEA	-
GO:0045814	negative regulation of gene expression, epigenetic	-	TAS	-
GO:0051571	positive regulation of histone H3-K4 methylation	-	IMP	18413740
GO:0051573	negative regulation of histone H3-K9 methylation	-	IMP	18413740
GO:0071455	cellular response to hyperoxia	-	IEA	-
GO:0071549	cellular response to dexamethasone stimulus	-	IEA	-
GO:0090116	C-5 methylation of cytosine	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	17303076
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-

KEGG ID	KEGG Term
hsa00270	Cysteine and methionine metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-212165	Epigenetic regulation of gene expression	IEA
R-HSA-212165	Epigenetic regulation of gene expression	TAS
R-HSA-212300	PRC2 methylates histones and DNA	TAS
R-HSA-427413	NoRC negatively regulates rRNA expression	IEA
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	IEA
R-HSA-5334118	DNA methylation	IEA
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-74160	Gene expression (Transcription)	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16004934	An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection. (2005 Aug 8)	Lin TS	Cancer Lett
26688266	DNA methylation is differentially associated with environmental cadmium exposure based on sex and smoking status. (2016 Feb)	Virani S	Chemosphere
29027179	Association of DNMT3B -283T>C polymorphism with risk of lung and gastric cancer: a case-control study and a meta-analysis. (2018 May)	Feng X	Int J Biol Markers
18801069	Alterations of DNA methylation and clinicopathological diversity of human cancers. (2008 Sep)	Kanai Y	Pathol Int
23788674	A prospective study of duration of smoking cessation and colorectal cancer risk by epigenetics-related tumor classification. (2013 Jul 1)	Nishihara R	Am J Epidemiol
29568927	miR-185 and miR-29a are similarly expressed in the bronchoalveolar lavage cells in IPF and lung cancer but common targets DNMT1 and COL1A1 show disease specific patterns. (2018 May)	Bibaki E	Mol Med Rep
28192769	Disorganization at the stage of schizophrenia clinical outcome: Clinical-biological study. (2017 May)	Nestsiarovich A	Eur Psychiatry
17893234	Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state. (2007 Dec)	Kanai Y	Carcinogenesis
20514408	Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival. (2010 Jul)	Farias LC	Int J Oncol
21796105	Decreased proliferation of adult hippocampal stem cells during cocaine withdrawal: possible role of the cell fate regulator FADD. (2011 Oct)	Garcia-Fuster MJ	Neuropsychopharmacology
22248280	Cigarette smoking extract causes hypermethylation and inactivation of WWOX gene in T-24 human bladder cancer cells. (2012)	Yang W	Neoplasma
25126948	Association of DNA methyltransferases 3A and 3B polymorphisms, and plasma folate levels with the risk of urothelial carcinoma. (2014)	Chung CJ	PLoS One
17929180	Age and gender affect DNMT3a and DNMT3b expression in human liver. (2008 Jun)	Xiao Y	Cell Biol Toxicol
17140695	Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. (2007 Feb)	Lin RK	Lung Cancer
15962389	Single nucleotide polymorphism in DNA methyltransferase 3B promoter and its association with gastric cardiac adenocarcinoma in North China. (2005 Jun 21)	Wang YM	World J Gastroenterol
18023104	DNA methyltransferase 3B promoter polymorphism and its susceptibility to primary hepatocellular carcinoma in the Chinese Han nationality population: a case-control study. (2007 Dec 7)	Wu Y	World J Gastroenterol
28972577	Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence. (2017 Oct 3)	Hancock DB	Mol Psychiatry
12208751	A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer. (2002 Sep 1)	Shen H	Cancer Res
22969923	The DNMT3B -579 G>T promoter polymorphism and risk of lung cancer. (2012 Mar)	Liu H	Exp Ther Med
20951977	Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas. (2010 Dec)	Daniel FI	Arch Oral Biol
29072397	The DNA Methyltransferase 3B -149 Genetic Polymorphism Modulates Lung Cancer Risk from Smoking (2017 Oct 26)	Lai CY	Asian Pac J Cancer Prev