Gene: DOCK2

1794
IMD40
dedicator of cytokinesis 2
protein-coding
5q35.1
Ensembl:ENSG00000134516 MIM:603122 Vega:OTTHUMG00000130437 UniprotKB:Q92608
NG_051800.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.471e-1 (AD)  7.542e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1316638chr5:170050007 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2306559chr5:169702418 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCKAP1L0.96
SYK0.943
PTPRC0.942
WDFY40.94
BTK0.938
SLC7A70.934
CD330.933
PARVG0.933
TLR60.93
CD370.929

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.407
ATP2C2-0.401
WNT7A-0.393
CPLX3-0.393
ASPDH-0.39
C9orf24-0.388
ZSCAN1-0.386
MARCH4-0.383
MAGIX-0.373
DLK2-0.37

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DOCK2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of DOCK2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DOCK2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DOCK2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DOCK2 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of DOCK2 mRNA28522335
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of DOCK2 mRNA24449571
D001151ArsenicArsenic affects the methylation of DOCK2 gene25304211
C015001arsenitearsenite results in decreased expression of DOCK2 mRNA18191166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DOCK2 mRNA20064835|2049800
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DOCK2 mRNA21569818|2261060
C006780bisphenol Abisphenol A results in decreased expression of DOCK2 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of DOCK2 mRNA25181051
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in decreased expression of DOCK2 mRNA19925653
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of DOCK2 mRNA15336504
D000074262Canola OilCanola Oil metabolite results in decreased expression of DOCK2 mRNA27363782
D002794CholineCholine affects the expression of DOCK2 mRNA17616785
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DOCK2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of DOCK2 mRNA27392435
D002117CalcitriolCalcitriol results in decreased expression of DOCK2 mRNA26485663
C118739entinostatentinostat results in increased expression of DOCK2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DOCK2 mRNA"27188386
D005557FormaldehydeFormaldehyde results in decreased expression of DOCK2 mRNA23649840
C039281furanfuran results in decreased expression of DOCK2 mRNA25539665
C412815GW 4064GW 4064 results in decreased expression of DOCK2 mRNA26655953
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DOCK2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DOCK2 mRNA23086925|2479639
D007854LeadLead results in decreased expression of DOCK2 mRNA19921347
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DOCK2 mRNA"25554681
D009532NickelNickel results in increased expression of DOCK2 mRNA25583101
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of DOCK2 mRNA26705709
D011341ProbucolProbucol promotes the reaction [APOE gene mutant form results in increased expression of DOCK2 mRNA]19394937
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DOCK2 mRNA25895662
D012906SmokeSmoke results in increased expression of DOCK2 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of DOCK2 gene28589171
C016104sodium bichromatesodium bichromate results in decreased expression of DOCK2 mRNA17685462
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DOCK2 mRNA25270620
D013853ThioacetamideThioacetamide results in decreased expression of DOCK2 mRNA23411599
C012589trichostatin Atrichostatin A results in increased expression of DOCK2 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DOCK2 mRNA"26743178
D014635Valproic AcidValproic Acid affects the expression of DOCK2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DOCK2 mRNA24935251|2800136

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IEA-  
GO:0005515protein binding-IPI12134158  15723800  25416956  
GO:0030676Rac guanyl-nucleotide exchange factor activity-IDA10559471  
GO:0042608T cell receptor binding-IDA12176041  
GO ID GO Term Qualifier Evidence PubMed
GO:0001766membrane raft polarization-IEA-  
GO:0001768establishment of T cell polarity-IEA-  
GO:0001771immunological synapse formation-IEA-  
GO:0002277myeloid dendritic cell activation involved in immune response-ISS-  
GO:0006935chemotaxis-IEA-  
GO:0007264small GTPase mediated signal transduction-IEA-  
GO:0030036actin cytoskeleton organization-TAS12176041  
GO:0043312neutrophil degranulation-TAS-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0044351macropinocytosis-ISS-  
GO:0045059positive thymic T cell selection-IEA-  
GO:0045060negative thymic T cell selection-IEA-  
GO:0046633alpha-beta T cell proliferation-IEA-  
GO:0050690regulation of defense response to virus by virus-TAS-  
GO:0050766positive regulation of phagocytosis-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0016020membrane-HDA19946888  
GO:0035580specific granule lumen-TAS-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-162906HIV InfectionTAS
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-1643685DiseaseTAS
R-HSA-164944Nef and signal transductionTAS
R-HSA-164952The role of Nef in HIV-1 replication and disease pathogenesisTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal