Gene: DOK1

1796
P62DOK|pp62
docking protein 1
protein-coding
2p13.1
Ensembl:ENSG00000115325 MIM:602919 Vega:OTTHUMG00000129956 UniprotKB:Q99704
NG_050617.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.463e-2 (AD)  7.568e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FCGRT0.871
TSPO0.847
TGFB10.84
DDAH20.839
SIPA10.824
EMILIN10.823
EMP30.822
RAB130.818
TMEM176B0.815
CHST140.812

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPEF1-0.574
ZNF860-0.56
KCNB2-0.559
CALHM1-0.558
GPR61-0.557
SPHKAP-0.548
CDH8-0.54
ABCC12-0.537
GABRG3-0.537
TYRP1-0.537

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of DOK1 mRNA17562736
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DOK1 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of DOK1 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DOK1 mRNA20938992
C014347decitabinedecitabine results in increased expression of DOK1 mRNA21856257
D003907DexamethasoneDexamethasone results in increased expression of DOK1 mRNA22733784
D003976DiazinonDiazinon results in increased methylation of DOK1 gene22964155
D002945CisplatinCisplatin results in decreased expression of DOK1 mRNA27392435
D002945CisplatinDOK1 results in increased susceptibility to Cisplatin21856257
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of DOK1 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DOK1 mRNA]17854601
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DOK1 mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DOK1 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DOK1 mRNA20938992
C039281furanfuran results in increased methylation of DOK1 gene22079235
D019833GenisteinGenistein results in decreased expression of DOK1 mRNA21048042
D000068877Imatinib MesylateImatinib Mesylate results in decreased phosphorylation of DOK1 protein19366808
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DOK1 mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DOK1 mRNA20938992
C028007nickel monoxidenickel monoxide results in increased expression of DOK1 mRNA19167457
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DOK1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DOK1 mRNA22079256
C513428pyrachlostrobinpyrachlostrobin results in increased expression of DOK1 mRNA27029645
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of DOK1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DOK1 mRNA23806026
D012999SomanSoman results in increased expression of DOK1 mRNA19281266
C471405sorafenibsorafenib results in decreased phosphorylation of DOK1 protein19366808
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DOK1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DOK1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DOK1 mRNA25613284
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DOK1 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased methylation of DOK1 gene29154799
D014810Vitamin EVitamin E results in increased expression of DOK1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16273093  22190034  22252131  23822091  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS9008160  10799545  
GO:0007166cell surface receptor signaling pathway-TAS10799545  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IEA-  
GO:0007265Ras protein signal transduction-IEA-  
GO:0007411axon guidance-TAS-  
GO:0045742positive regulation of epidermal growth factor receptor signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA23822091  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-162582Signal TransductionTAS
R-HSA-422475Axon guidanceTAS
R-HSA-8848021Signaling by PTK6TAS
R-HSA-8849469PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1TAS
R-HSA-8853659RET signalingTAS
R-HSA-9006927Signaling by Non-Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21146512Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake. (2011 Apr)Lambert MPJ Hepatol