Gene: ABAT

18
GABA-AT|GABAT|NPD009
4-aminobutyrate aminotransferase
protein-coding
16p13.2
Ensembl:ENSG00000183044 MIM:137150 Vega:OTTHUMG00000048201 UniprotKB:P80404
NG_008432.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.527e-1 (AD)  6.824e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1273396chr16:8722955 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATPAF10.906
GABBR10.905
SNN0.904
ALDH5A10.901
DCAF110.899
TNPO20.897
FAM168A0.897
ARL30.893
ACO20.889
ARNT20.888

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.777
OR4F29-0.734
BEST3-0.357
SLAMF6-0.352
CCL5-0.335
CHI3L2-0.334
SGMS2-0.334
CLEC6A-0.333
IL24-0.332
TFPI2-0.331

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of ABAT protein22527513
C1185591-bromopropane1-bromopropane results in decreased expression of ABAT protein21925529
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ABAT mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ABAT mRNA"21346803
C0179063-dinitrobenzene3-dinitrobenzene results in increased oxidation of ABAT protein25716674
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ABAT mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ABAT mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
C0137854-amino-5-hexynoic acid4-amino-5-hexynoic acid results in decreased activity of ABAT protein3933514
C0137854-amino-5-hexynoic acid4-amino-5-hexynoic acid results in decreased activity of ABAT protein6108224
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ABAT mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of ABAT mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of ABAT mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of ABAT protein21329376
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ABAT protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ABAT mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ABAT gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ABAT mRNA19770486
D000447AldehydesAldehydes results in increased expression of ABAT mRNA25014914
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ABAT mRNA28522335
C010845aluminum chloridealuminum chloride results in decreased activity of ABAT protein11696403
D005680gamma-Aminobutyric Acid[Vigabatrin results in decreased activity of ABAT protein] which results in increased abundance of gamma-Aminobutyric Acid12748807
D005680gamma-Aminobutyric Acid[Vigabatrin results in decreased activity of ABAT protein] which results in increased abundance of gamma-Aminobutyric Acid11468302
D000625Aminooxyacetic AcidAminooxyacetic Acid results in decreased activity of ABAT protein3933514
D000625Aminooxyacetic AcidAminooxyacetic Acid results in decreased activity of ABAT protein6108224
D000639AmitriptylineAmitriptyline results in decreased expression of ABAT mRNA21820738
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ABAT mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ABAT mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ABAT mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ABAT mRNA19770486|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ABAT mRNA22300585
D004958EstradiolEstradiol affects the expression of ABAT mRNA14699072
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of ABAT mRNA17404688
C006780bisphenol Abisphenol A affects the expression of ABAT mRNA21786754
C006780bisphenol Abisphenol A affects the expression of ABAT mRNA20170705
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of ABAT mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of ABAT mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of ABAT protein28903499
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of ABAT mRNA25607892
C018475butyraldehydebutyraldehyde results in increased expression of ABAT mRNA26079696
D002104CadmiumCadmium results in increased oxidation of ABAT protein24496640
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ABAT mRNA17961207
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of ABAT promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ABAT mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ABAT mRNA17484886
D000068579CelecoxibCelecoxib results in increased expression of ABAT mRNA28201806
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ABAT mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of ABAT mRNA12851107
D003042CocaineABAT mRNA results in increased susceptibility to Cocaine10850552
D003042Cocaine[Vigabatrin results in decreased activity of ABAT protein] inhibits the reaction [Cocaine results in increased abundance of Dopamine]9723781
D003300CopperCopper results in decreased expression of ABAT mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of ABAT mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of ABAT mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of ABAT mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of ABAT mRNA23830897
C017160cypermethrincypermethrin results in decreased activity of ABAT protein24220872
C017180decamethrindecamethrin affects the activity of ABAT protein15189238
D003907DexamethasoneDexamethasone results in increased expression of ABAT mRNA25047013
C016366dibenzothiophenedibenzothiophene results in increased expression of ABAT mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ABAT mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ABAT mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ABAT mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of ABAT mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of ABAT mRNA16002434
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of ABAT mRNA25380136
D004221Disulfiram[Ethanol co-treated with Disulfiram] results in decreased activity of ABAT protein9591243
D004221Disulfiram[Ethanol co-treated with Disulfiram] results in decreased expression of ABAT mRNA9591243
D004298Dopamine[Vigabatrin results in decreased activity of ABAT protein] inhibits the reaction [Cocaine results in increased abundance of Dopamine]9723781
C118739entinostatentinostat results in increased expression of ABAT mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of ABAT mRNA25607892
D000431EthanolEthanol results in increased expression of ABAT mRNA24355176
D000431Ethanol[Ethanol co-treated with Disulfiram] results in decreased activity of ABAT protein9591243
D000431Ethanol[Ethanol co-treated with Disulfiram] results in decreased expression of ABAT mRNA9591243
C020619ethanolamine O-sulfateethanolamine O-sulfate results in decreased activity of ABAT protein3933514
C020619ethanolamine O-sulfateethanolamine O-sulfate results in decreased activity of ABAT protein6108224
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ABAT mRNA20170705
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ABAT mRNA18936297
D018120FinasterideFinasteride results in decreased expression of ABAT protein27750143
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ABAT mRNA20938992
C039281furanfuran results in increased methylation of ABAT gene22079235
D019833GenisteinESR2 promotes the reaction [Genistein results in decreased expression of ABAT protein]20884965
D019833GenisteinGenistein results in decreased expression of ABAT protein20884965
D005897GlafenineGlafenine results in decreased expression of ABAT mRNA24136188
D017313FenretinideFenretinide results in decreased expression of ABAT mRNA28973697
C475919hydroxytamoxifenhydroxytamoxifen results in decreased expression of ABAT mRNA16849584
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ABAT mRNA27392435
C045463leflunomideleflunomide results in decreased expression of ABAT mRNA28988120
D018021Lithium ChlorideLithium Chloride results in decreased expression of ABAT mRNA15711924
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of ABAT protein20060493
D008701MethapyrileneMethapyrilene results in decreased expression of ABAT mRNA16393664|2327439
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ABAT mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ABAT mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ABAT mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ABAT mRNA25380136
C051752nefazodonenefazodone results in decreased expression of ABAT mRNA24136188
C012655nimesulidenimesulide results in decreased expression of ABAT mRNA24136188
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ABAT mRNA27935865
C025589ochratoxin Aochratoxin A results in decreased expression of ABAT mRNA18417182
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of ABAT mRNA25607892
D000073878Palm OilPalm Oil results in increased expression of ABAT mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ABAT mRNA26272509
C046012pentanalpentanal results in increased expression of ABAT mRNA26079696
D010433PentylenetetrazoleABAT mRNA results in increased susceptibility to Pentylenetetrazole10850552
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ABAT protein26178269
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ABAT protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ABAT mRNA19162173
D026023PermethrinPermethrin affects the activity of ABAT protein15189238
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ABAT mRNA26272509
D010695PhlorhizinPhlorhizin results in decreased expression of ABAT mRNA22538082
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of ABAT mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ABAT mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of ABAT mRNA17164430|1916217
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ABAT mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ABAT mRNA19162173
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of ABAT mRNA17404688
C005556propionaldehydepropionaldehyde results in increased expression of ABAT mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of ABAT mRNA24780913
C089730rosiglitazonerosiglitazone results in decreased expression of ABAT mRNA25572481
C089730rosiglitazonerosiglitazone results in decreased expression of ABAT mRNA21515302
D012834SilverSilver results in decreased expression of ABAT mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of ABAT gene28589171
C016104sodium bichromatesodium bichromate results in decreased expression of ABAT mRNA25993096
C501413tesaglitazartesaglitazar results in decreased expression of ABAT mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ABAT mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABAT mRNA20959002|2121527
D013853ThioacetamideThioacetamide results in decreased expression of ABAT mRNA23411599
D014212TretinoinTretinoin results in increased expression of ABAT mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ABAT mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of ABAT mRNA21515302
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased methylation of ABAT gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ABAT mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in decreased activity of ABAT protein12093128
D014640VancomycinVancomycin results in increased expression of ABAT mRNA18930951
D020888VigabatrinVigabatrin results in decreased activity of ABAT protein15869561
D020888VigabatrinVigabatrin results in decreased activity of ABAT protein10951220|1274880
D020888Vigabatrin[Vigabatrin results in decreased activity of ABAT protein] which results in increased abundance of gamma-Aminobutyric Acid12748807
D020888Vigabatrin[Vigabatrin results in decreased activity of ABAT protein] inhibits the reaction [Cocaine results in increased abundance of Dopamine]9723781
D020888VigabatrinVigabatrin results in decreased activity of ABAT protein11468302|3933514
D020888Vigabatrin[Vigabatrin results in decreased activity of ABAT protein] which results in increased abundance of gamma-Aminobutyric Acid11468302
D020888VigabatrinVigabatrin results in decreased activity of ABAT protein11267634|1268473
C029297vinylidene chloridevinylidene chloride results in decreased expression of ABAT mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABAT mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038674-aminobutyrate transaminase activity-IBA21873635  
GO:00038674-aminobutyrate transaminase activitycontributes_toIDA15528998  
GO:00038674-aminobutyrate transaminase activity-TAS-  
GO:0030170pyridoxal phosphate binding-IBA21873635  
GO:0030170pyridoxal phosphate binding-IDA15650327  
GO:0032145succinate-semialdehyde dehydrogenase binding-ISS-  
GO:00343864-aminobutyrate:2-oxoglutarate transaminase activity-IEA-  
GO:0042803protein homodimerization activity-IPI15528998  
GO:0046872metal ion binding-IEA-  
GO:0047298(S)-3-amino-2-methylpropionate transaminase activity-IEA-  
GO:0051536iron-sulfur cluster binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0007568aging-IEA-  
GO:0007620copulation-IEA-  
GO:0007626locomotory behavior-IEA-  
GO:0009449gamma-aminobutyric acid biosynthetic process-IEA-  
GO:0009450gamma-aminobutyric acid catabolic process-IBA21873635  
GO:0009450gamma-aminobutyric acid catabolic process-NAS15528998  
GO:0010039response to iron ion-IEA-  
GO:0014053negative regulation of gamma-aminobutyric acid secretion-IEA-  
GO:0021549cerebellum development-IEA-  
GO:0031652positive regulation of heat generation-IEA-  
GO:0032024positive regulation of insulin secretion-IEA-  
GO:0033602negative regulation of dopamine secretion-IEA-  
GO:0035094response to nicotine-IEA-  
GO:0035640exploration behavior-IEA-  
GO:0042135neurotransmitter catabolic process-NAS15528998  
GO:0045471response to ethanol-IEA-  
GO:0045776negative regulation of blood pressure-IEA-  
GO:0045964positive regulation of dopamine metabolic process-IEA-  
GO:0048148behavioral response to cocaine-ISS-  
GO:0070474positive regulation of uterine smooth muscle contraction-IEA-  
GO:0090331negative regulation of platelet aggregation-IEA-  
GO:0097151positive regulation of inhibitory postsynaptic potential-IEA-  
GO:1902722positive regulation of prolactin secretion-IEA-  
GO:1904450positive regulation of aspartate secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005739mitochondrion-ISS-  
GO:0005759mitochondrial matrix-TAS-  
GO:00321444-aminobutyrate transaminase complex-IDA15528998  
GO:0043005neuron projection-IEA-  
KEGG ID KEGG Term
hsa00250Alanine, aspartate and glutamate metabolism
hsa00280Valine, leucine and isoleucine degradation
hsa00410beta-Alanine metabolism
hsa00640Propanoate metabolism
hsa00650Butanoate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-112310Neurotransmitter release cycleTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-888590GABA synthesis, release, reuptake and degradationTAS
R-HSA-916853Degradation of GABATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal