Gene: DPYSL2

1808
CRMP-2|CRMP2|DHPRP2|DRP-2|DRP2|N2A3|ULIP-2|ULIP2
dihydropyrimidinase like 2
protein-coding
8p21.2
Ensembl:ENSG00000092964 MIM:602463 Vega:OTTHUMG00000099439 UniprotKB:Q16555
NG_030020.1
PubMed
0   ANCO-SNPs
ND|AD
2   
5.009e-2 (AD)  2.250e-1 (ND)   (Frontal_Cortex)
6.342e-1 (AD)  1.764e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WBP20.933
HNRNPL0.924
ADD10.916
STAU10.912
UBE2R20.91
PSAP0.91
VPS4A0.908
UBAP10.908
CTSD0.907
MARK30.907

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.812
OR4F29-0.79
KLRB1-0.277
IL2RB-0.277
TBX21-0.26
TFPI2-0.26
KLRF1-0.259
EVA1A-0.255
FCRL3-0.254
DPPA4-0.252

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5179431-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone"1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone results in increased phosphorylation of DPYSL2 protein"27026707
C0780921-piperonylpiperazine1-piperonylpiperazine results in increased expression of DPYSL2 mRNA26821219
C0112692,5-hexanedione"2,5-hexanedione results in decreased expression of DPYSL2 protein"19033394
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of DPYSL2 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of DPYSL2 mRNA]28655636
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DPYSL2 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal binds to DPYSL2 protein19374891
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DPYSL2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of DPYSL2 mRNA25704631
D000082AcetaminophenAcetaminophen results in increased expression of DPYSL2 protein22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DPYSL2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DPYSL2 mRNA19770486
D015766Albendazole[Ivermectin co-treated with Albendazole] results in increased expression of DPYSL2 mRNA16861626
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DPYSL2 mRNA16483693
D001104ArbutinArbutin results in decreased expression of DPYSL2 mRNA17103032
C006632arsenic trioxidearsenic trioxide affects the expression of DPYSL2 protein19364129
C006632arsenic trioxidearsenic trioxide results in increased expression of DPYSL2 mRNA20458559
D001280AtrazineAtrazine results in decreased expression of DPYSL2 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of DPYSL2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DPYSL2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DPYSL2 mRNA21632981|2623829
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of DPYSL2 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DPYSL2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DPYSL2 mRNA22228805
C038328BEP protocolBEP protocol results in increased expression of DPYSL2 mRNA18987330
D004958EstradiolEstradiol results in increased phosphorylation of DPYSL2 protein27026707
C006780bisphenol Abisphenol A results in increased expression of DPYSL2 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of DPYSL2 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DPYSL2 promoter23359474
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased phosphorylation of DPYSL2 protein22174045
C025703bleomycetinbleomycetin results in decreased expression of DPYSL2 mRNA21040473
D002065BuspironeBuspirone results in decreased expression of DPYSL2 mRNA24136188
D002220CarbamazepineCarbamazepine affects the expression of DPYSL2 mRNA24752500
D002994ClofibrateClofibrate affects the expression of DPYSL2 mRNA16081524
C018021cobaltous chloridecobaltous chloride results in decreased expression of DPYSL2 mRNA19320972
D003042Cocaine[Cocaine affects the activity of PRKACA protein] which affects the phosphorylation of DPYSL2 protein19457111
D016572CyclosporineCyclosporine results in decreased expression of DPYSL2 mRNA25562108
C403944cynandione Acynandione A results in decreased expression of DPYSL2 protein22309483
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DPYSL2 promoter23359474
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DPYSL2 mRNA21266533
D002945CisplatinCisplatin results in increased expression of DPYSL2 mRNA27594783
D004008DiclofenacDiclofenac affects the expression of DPYSL2 mRNA24752500
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DPYSL2 promoter23359474
C014476diethyl maleatediethyl maleate results in decreased reduction of DPYSL2 protein19843705
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of DPYSL2 mRNA19638242
C039060dihydroartemisinindihydroartemisinin analog binds to DPYSL2 protein modified form26340163
D004050DitiocarbDitiocarb results in increased expression of DPYSL2 protein22874009
D004237DiuronDiuron results in decreased expression of DPYSL2 mRNA25152437
D007980Levodopa"Levodopa inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of DPYSL2 protein]"23562983
D015025ZearalenoneZearalenone results in decreased expression of DPYSL2 protein25058043
D018120FinasterideFinasteride results in increased expression of DPYSL2 protein27750143
C039281furanfuran results in decreased methylation of DPYSL2 gene27387713
C039281furanfuran results in increased expression of DPYSL2 mRNA27387713
D005839GentamicinsGentamicins results in increased expression of DPYSL2 mRNA22061828
D005839GentamicinsGentamicins results in increased expression of DPYSL2 protein22061828
D055768Halogenated Diphenyl EthersHalogenated Diphenyl Ethers results in decreased expression of DPYSL2 protein24239914
C492448ICG 001ICG 001 results in increased expression of DPYSL2 mRNA26191083
C503753Indolinone AIndolinone A results in decreased phosphorylation of DPYSL2 protein15712243
C503753Indolinone AIndolinone A results in increased phosphorylation of DPYSL2 protein15838870
D007529IsoflavonesIsoflavones results in increased expression of DPYSL2 mRNA17374662
D007559Ivermectin[Ivermectin co-treated with Albendazole] results in increased expression of DPYSL2 mRNA16861626
C544151jinfukangjinfukang results in increased expression of DPYSL2 mRNA27392435
C008261lead acetatelead acetate results in increased expression of DPYSL2 protein20797405
C045463leflunomideleflunomide results in decreased expression of DPYSL2 mRNA28988120
D008148LovastatinLovastatin results in increased expression of DPYSL2 mRNA20493250
D008627Mercuric ChlorideMercuric Chloride affects the expression of DPYSL2 protein21458406
D008694MethamphetamineMethamphetamine affects the expression of DPYSL2 protein19826936
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of DPYSL2 protein"23562983
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Levodopa inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of DPYSL2 protein]"23562983
C008493methylselenic acidmethylselenic acid results in increased expression of DPYSL2 mRNA18548127
D008777MethyltestosteroneMethyltestosterone results in increased expression of DPYSL2 mRNA29191790
D009020MorphineMorphine deficiency affects the reaction [Morphine results in decreased expression of DPYSL2 protein]23056601
D009020MorphineMorphine results in decreased expression of DPYSL2 protein23056601
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DPYSL2 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DPYSL2 mRNA"25554681|2562005
C031721naphthalene[naphthalene co-treated with CFTR gene mutant form] results in decreased expression of DPYSL2 protein19438287
C461488N-benzylpiperazineN-benzylpiperazine results in increased expression of DPYSL2 mRNA26821219
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of DPYSL2 mRNA19812364
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of DPYSL2 mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of DPYSL2 mRNA"21673326
D010100OxygenOxygen deficiency results in decreased expression of DPYSL2 protein25937538
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of DPYSL2 mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of DPYSL2 mRNA28655636
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of DPYSL2 protein19954255
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of DPYSL2 protein19954255|2561625
D010862PilocarpinePilocarpine results in increased expression of DPYSL2 protein17366478
D010894PiroxicamPiroxicam results in decreased expression of DPYSL2 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of DPYSL2 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in increased expression of DPYSL2 protein23718831
D017035PravastatinPravastatin results in increased expression of DPYSL2 mRNA27225895
D017035PravastatinPravastatin results in increased expression of DPYSL2 mRNA27225895
D011794QuercetinQuercetin results in decreased expression of DPYSL2 mRNA21632981
D015474IsotretinoinIsotretinoin results in increased expression of DPYSL2 mRNA20436886
D012715Sesame OilSesame Oil results in decreased expression of DPYSL2 mRNA29191790
D012822Silicon DioxideSilicon Dioxide results in increased expression of DPYSL2 mRNA18685790
C080703SK&F 83959SK&F 83959 results in decreased expression of DPYSL2 protein25852303
D053260SootSoot results in decreased expression of DPYSL2 mRNA22461453
C075117squalestatin 1squalestatin 1 results in increased expression of DPYSL2 mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of DPYSL2 mRNA27225895
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of DPYSL2 mRNA27914987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DPYSL2 mRNA21570461
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of DPYSL2 protein"25852303
D013853ThioacetamideThioacetamide results in increased expression of DPYSL2 mRNA23411599
C009495titanium dioxidetitanium dioxide analog results in increased expression of DPYSL2 mRNA25111187
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DPYSL2 mRNA22363418|2806579
D014212TretinoinTretinoin inhibits the reaction [PAX3 protein binds to DPYSL2 promoter]17229153
D014212TretinoinTretinoin inhibits the reaction [TFAP2A protein binds to DPYSL2 promoter]17229153
D014212TretinoinTretinoin results in decreased expression of DPYSL2 mRNA17229153
D014212TretinoinTretinoin results in decreased expression of DPYSL2 protein17229153
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DPYSL2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of DPYSL2 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DPYSL2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of DPYSL2 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased methylation of DPYSL2 gene29154799
D014638VanadatesVanadates results in increased expression of DPYSL2 mRNA22714537
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of DPYSL2 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of DPYSL2 mRNA28655636
D014859WarfarinWarfarin results in increased expression of DPYSL2 mRNA20493250

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004157dihydropyrimidinase activity-TAS8973361  
GO:0005515protein binding-IPI16260607  19235893  21900206  25416956  
GO:0008017microtubule binding-IEA-  
GO:0042802identical protein binding-IPI21516116  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006139nucleobase-containing compound metabolic process-TAS8973361  
GO:0006897endocytosis-IMP20801876  
GO:0007010cytoskeleton organization-ISS-  
GO:0007165signal transduction-TAS8973361  
GO:0007399nervous system development-TAS8973361  
GO:0007411axon guidance-IEA-  
GO:0007420brain development-IEA-  
GO:0030516regulation of axon extension-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA20801876  
GO:0005829cytosol-TAS-  
GO:0005874microtubulecolocalizes_withIDA20801876  
GO:0005886plasma membrane-IDA-  
GO:0016020membranecolocalizes_withIDA20801876  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-373755Semaphorin interactionsTAS
R-HSA-373760L1CAM interactionsTAS
R-HSA-399956CRMPs in Sema3A signalingTAS
R-HSA-422475Axon guidanceTAS
R-HSA-437239Recycling pathway of L1TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23846846Association between DPYSL2 gene polymorphisms and alcohol dependence in Caucasian samples. (2014 Jan)Taylor AJ Neural Transm (Vienna)
27084846Lung tissue proteomics identifies elevated transglutaminase 2 levels in stable chronic obstructive pulmonary disease. (2016 Jun 1)Ohlmeier SAm J Physiol Lung Cell Mol Physiol