Gene: DPYSL3

1809
CRMP-4|CRMP4|DRP-3|DRP3|LCRMP|ULIP|ULIP-1
dihydropyrimidinase like 3
protein-coding
5q32
Ensembl:ENSG00000113657 MIM:601168 Vega:OTTHUMG00000163437 UniprotKB:Q14195
NC_000005.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.030e-1 (AD)  4.530e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11167990chr5:147412193 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMED100.838
STAT5B0.825
PABPC10.818
MAOB0.805
RSU10.802
CTNNA10.802
SMARCE10.801
KCTD200.798
SYNM0.796
RBM8A0.795

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.696
OR4F29-0.676
LCN1-0.162
SEC14L3-0.161
GRHL2-0.145
PRAMEF8-0.137
HS3ST6-0.124
SERPINC1-0.121
MBD3L3-0.12
RERGL-0.116

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of DPYSL3 mRNA"23829299
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of DPYSL3 protein"21673325
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of DPYSL3 mRNA"21394737
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of DPYSL3 mRNA"23196670
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of DPYSL3 protein"27567155
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of DPYSL3 mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DPYSL3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DPYSL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DPYSL3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DPYSL3 mRNA"27188386
C0005950156,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine"6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine results in increased expression of DPYSL3 protein"28073004
D000082AcetaminophenAcetaminophen results in increased expression of DPYSL3 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of DPYSL3 mRNA17562736
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of DPYSL3 mRNA25596134
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DPYSL3 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DPYSL3 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of DPYSL3 mRNA"22863853
C006632arsenic trioxidearsenic trioxide results in increased expression of DPYSL3 protein25419056
C015001arsenitearsenite results in decreased expression of DPYSL3 mRNA23974009
D001280AtrazineAtrazine results in decreased expression of DPYSL3 mRNA25929836
D001285AtropineAtropine inhibits the reaction [Methyl Parathion results in decreased expression of DPYSL3 mRNA]20826231
D001285AtropineAtropine inhibits the reaction [Methyl Parathion results in decreased expression of DPYSL3 protein]20826231
C547126AZM551248AZM551248 results in increased expression of DPYSL3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DPYSL3 mRNA20064835
D001564Benzo(a)pyrene[Soot co-treated with Benzo(a)pyrene] results in increased expression of DPYSL3 protein24464499
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DPYSL3 mRNA19770486
D004958EstradiolEstradiol results in increased expression of DPYSL3 mRNA19484750
C044887beta-methylcholinebeta-methylcholine affects the expression of DPYSL3 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of DPYSL3 mRNA23146750
C006780bisphenol Abisphenol A results in increased expression of DPYSL3 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of DPYSL3 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of DPYSL3 protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of DPYSL3 mRNA15336504
C584509C646 compoundC646 compound results in decreased expression of DPYSL3 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DPYSL3 mRNA25596134
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of DPYSL3 mRNA17484886
C084597chlorcyclizinechlorcyclizine results in decreased expression of DPYSL3 mRNA21058326
C084597chlorcyclizinechlorcyclizine results in increased expression of DPYSL3 mRNA21058326
C004656chloroacetaldehydechloroacetaldehyde affects the expression of DPYSL3 mRNA25596134
D002737ChloropreneChloroprene results in decreased expression of DPYSL3 mRNA23125180
C059262cidofovircidofovir results in increased expression of DPYSL3 mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of DPYSL3 mRNA25596134
C018021cobaltous chloridecobaltous chloride results in decreased expression of DPYSL3 mRNA19320972
D003042CocaineCocaine affects the expression of DPYSL3 mRNA20187946
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of DPYSL3 mRNA20971185
C029892cupric chloridecupric chloride results in increased expression of DPYSL3 protein22699969
D016572CyclosporineCyclosporine results in increased expression of DPYSL3 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of DPYSL3 mRNA19770486
C089595cylindrospermopsincylindrospermopsin results in decreased expression of DPYSL3 mRNA24921660
D003907DexamethasoneDexamethasone results in decreased expression of DPYSL3 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of DPYSL3 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of DPYSL3 mRNA22733784
D002945CisplatinCisplatin results in decreased expression of DPYSL3 mRNA25596134
D019422Dietary SucroseDietary Sucrose results in increased expression of DPYSL3 mRNA26033743
D004317DoxorubicinDoxorubicin affects the expression of DPYSL3 mRNA15205334
C070609EMD 53998EMD 53998 analog results in decreased expression of DPYSL3 mRNA24977338
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DPYSL3 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DPYSL3 protein20381887
D005411Flame RetardantsFlame Retardants results in decreased expression of DPYSL3 protein18550172
D005411Flame RetardantsFlame Retardants results in increased expression of DPYSL3 protein18550172
D005472FluorouracilFluorouracil affects the expression of DPYSL3 mRNA15205334
D017313FenretinideFenretinide results in increased expression of DPYSL3 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DPYSL3 mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of DPYSL3 mRNA18951874
C492448ICG 001ICG 001 results in decreased expression of DPYSL3 mRNA26191083
C503753Indolinone AIndolinone A results in decreased phosphorylation of DPYSL3 protein15712243
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of DPYSL3 mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of DPYSL3 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of DPYSL3 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of DPYSL3 mRNA26752646
D007649KetamineKetamine results in decreased expression of DPYSL3 mRNA20080153
D048628KetolidesKetolides analog results in decreased expression of DPYSL3 mRNA24967691
C025340manganese chloridemanganese chloride results in decreased expression of DPYSL3 mRNA22407947|2569850
D008694MethamphetamineMethamphetamine results in decreased expression of DPYSL3 protein19826936
D008727MethotrexateMethotrexate results in increased expression of DPYSL3 mRNA24449571
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DPYSL3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DPYSL3 mRNA26011545
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of DPYSL3 mRNA28688903
D008743Methyl ParathionAtropine inhibits the reaction [Methyl Parathion results in decreased expression of DPYSL3 mRNA]20826231
D008743Methyl ParathionAtropine inhibits the reaction [Methyl Parathion results in decreased expression of DPYSL3 protein]20826231
D008743Methyl ParathionMethyl Parathion results in decreased expression of DPYSL3 mRNA20826231
D008743Methyl ParathionMethyl Parathion results in decreased expression of DPYSL3 protein20826231
D009020MorphineMorphine deficiency promotes the reaction [Morphine results in decreased expression of DPYSL3 protein]23056601
D009020MorphineMorphine results in decreased expression of DPYSL3 protein23056601
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DPYSL3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DPYSL3 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of DPYSL3 mRNA19812364
D009532NickelNickel results in increased expression of DPYSL3 mRNA24768652|2558310
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of DPYSL3 mRNA20971185
D010100OxygenOxygen deficiency results in increased expression of DPYSL3 mRNA25596134
D010100OxygenOxygen deficiency results in decreased expression of DPYSL3 protein25937538
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of DPYSL3 protein18550172
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of DPYSL3 protein18550172
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of DPYSL3 mRNA19954255
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of DPYSL3 protein19954255
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of DPYSL3 protein19954255|2561625
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of DPYSL3 mRNA18692542
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DPYSL3 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of DPYSL3 mRNA26272509
D011441PropylthiouracilPropylthiouracil results in increased expression of DPYSL3 mRNA24780913
D011794QuercetinQuercetin results in increased expression of DPYSL3 mRNA17103110
C010327salinomycinsalinomycin results in decreased expression of DPYSL3 mRNA19682730
C080703SK&F 83959SK&F 83959 results in decreased expression of DPYSL3 protein25852303
C017947sodium arsenitesodium arsenite affects the methylation of DPYSL3 gene28589171
D053260Soot[Soot co-treated with Benzo(a)pyrene] results in increased expression of DPYSL3 protein24464499
D053260SootSoot results in decreased expression of DPYSL3 protein modified form24464499
D053260SootSoot results in increased expression of DPYSL3 protein modified form24464499
D019284ThapsigarginThapsigargin results in decreased expression of DPYSL3 mRNA22378314
D014212TretinoinTretinoin results in decreased expression of DPYSL3 mRNA21934132
D014212TretinoinTretinoin results in increased expression of DPYSL3 mRNA23724009
C012589trichostatin Atrichostatin A results in decreased expression of DPYSL3 mRNA24935251|2627250
D014415TunicamycinTunicamycin results in decreased expression of DPYSL3 mRNA22378314
D014520UrethaneUrethane results in increased expression of DPYSL3 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DPYSL3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of DPYSL3 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of DPYSL3 mRNA23179753|2800136
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DPYSL3 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of DPYSL3 mRNA26682919
D014810Vitamin EVitamin E results in increased expression of DPYSL3 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21044950  
GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds-IEA-  
GO:0017124SH3 domain binding-ISS-  
GO:0031005filamin binding-IPI25358863  
GO:0035374chondroitin sulfate binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010976positive regulation of neuron projection development-ISS-  
GO:0010977negative regulation of neuron projection development-ISS-  
GO:0030336negative regulation of cell migration-ISS-  
GO:0048666neuron development-IEA-  
GO:0048678response to axon injury-ISS-  
GO:0051017actin filament bundle assembly-ISS-  
GO:0051260protein homooligomerization-ISS-  
GO:0051491positive regulation of filopodium assembly-ISS-  
GO:0051764actin crosslink formation-ISS-  
GO:0071345cellular response to cytokine stimulus-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-ISS-  
GO:0005829cytosol-ISS-  
GO:0005829cytosol-TAS-  
GO:0030027lamellipodium-ISS-  
GO:0030426growth cone-ISS-  
GO:0031941filamentous actin-ISS-  
GO:0044297cell body-ISS-  
GO:0070382exocytic vesiclecolocalizes_withISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-373755Semaphorin interactionsTAS
R-HSA-399956CRMPs in Sema3A signalingTAS
R-HSA-422475Axon guidanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22797725Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population. (2012 Jul 15)Dong JNat Genet