Gene: AGRP

181
AGRT|ART|ASIP2
agouti related neuropeptide
protein-coding
16q22.1
Ensembl:ENSG00000159723 MIM:602311 Vega:OTTHUMG00000137509 UniprotKB:O00253
NG_011501.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.375e-1 (AD)  5.337e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPP1R14B0.477
LOXL10.449
HCRT0.445
NXT10.436
GAST0.43
GSC0.425
NTS0.424
MGARP0.422
DLK10.422
LHX50.421

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCAPG2-0.323
ZNF33A-0.275
PCDHB9-0.275
CAPN14-0.274
RGS7BP-0.272
RASGRF2-0.269
TMEM86A-0.268
CYP27C1-0.267
KLF8-0.266
MYO16-0.264

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of AGRP mRNA"29112739
C5112952,2',4,4'-tetrabromodiphenyl ether"ESR1 gene mutant form inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of AGRP mRNA]"29112739
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of AGRP protein21418339
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AGRP mRNA16483693
D001151ArsenicArsenic affects the methylation of AGRP gene25304211
D001280AtrazineAtrazine results in decreased expression of AGRP mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of AGRP mRNA22323515
D001507BeclomethasoneBeclomethasone results in increased expression of AGRP mRNA23656298
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of AGRP mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AGRP mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AGRP mRNA21839799
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AGRP mRNA20061341
C006780bisphenol A[bisphenol A co-treated with Dietary Fats] results in increased expression of AGRP mRNA23493373
D002166CamptothecinAGRP mRNA results in decreased susceptibility to Camptothecin25269479
D002569CeruleninCerulenin results in increased expression of AGRP mRNA11289036
D002737ChloropreneChloroprene results in increased expression of AGRP mRNA23125180
D003300CopperCopper deficiency results in increased expression of AGRP mRNA26033743
D019327Copper SulfateCopper Sulfate results in decreased expression of AGRP mRNA19549813
D003847DeoxyglucoseDeoxyglucose results in increased expression of AGRP mRNA10683841
D004041Dietary Fats[bisphenol A co-treated with Dietary Fats] results in increased expression of AGRP mRNA23493373
D004041Dietary FatsDietary Fats results in decreased expression of AGRP mRNA22715380
D019422Dietary SucroseDietary Sucrose results in increased expression of AGRP mRNA26033743
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of AGRP mRNA24834073
D005411Flame RetardantsESR1 gene mutant form inhibits the reaction [Flame Retardants results in increased expression of AGRP mRNA]29112739
D005485FlutamideFlutamide inhibits the reaction [Testosterone results in increased expression of AGRP protein]21418339
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of AGRP mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of AGRP mRNA25613284
D009020MorphineMorphine results in increased expression of AGRP mRNA20144693
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AGRP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AGRP mRNA"25554681
C076029olanzapineolanzapine results in increased expression of AGRP protein21695181
D011192Potassium DichromatePotassium Dichromate results in decreased expression of AGRP mRNA23608068
C089730rosiglitazonerosiglitazone results in increased expression of AGRP mRNA25596134
C089730rosiglitazonerosiglitazone results in increased expression of AGRP mRNA25788674
C089730rosiglitazonerosiglitazone results in increased expression of AGRP mRNA25788674
C017947sodium arsenitesodium arsenite results in increased expression of AGRP mRNA25610880
D013311StreptozocinINS protein inhibits the reaction [Streptozocin results in increased expression of AGRP mRNA]20219977
D013311StreptozocinStreptozocin results in increased expression of AGRP mRNA20219977
D013739TestosteroneFlutamide inhibits the reaction [Testosterone results in increased expression of AGRP protein]21418339
D013739TestosteroneTestosterone results in increased expression of AGRP protein21418339
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AGRP mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AGRP mRNA15977195
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of AGRP mRNA15977195
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of AGRP mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of AGRP mRNA20133372
C005445triphenyl phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of AGRP mRNA"29112739
C016805tris(1,3-dichloro-2-propyl)phosphate"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of AGRP mRNA"29112739
D014317Tritolyl Phosphates"[tris(1,3-dichloro-2-propyl)phosphate co-treated with triphenyl phosphate co-treated with Tritolyl Phosphates] results in increased expression of AGRP mRNA"29112739

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-TAS10318826  
GO:0005184neuropeptide hormone activity-IDA15927146  
GO ID GO Term Qualifier Evidence PubMed
GO:0007218neuropeptide signaling pathway-IDA15927146  
GO:0007623circadian rhythm-IEA-  
GO:0007631feeding behavior-TAS9751529  
GO:0008343adult feeding behavior-IEA-  
GO:0009755hormone-mediated signaling pathway-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0032868response to insulin-IEA-  
GO:0042755eating behavior-IEA-  
GO:0048571long-day photoperiodism-IEA-  
GO:0060135maternal process involved in female pregnancy-IEA-  
GO:0060259regulation of feeding behavior-IDA15927146  
GO:0060259regulation of feeding behavior-IMP9311920  
GO:2000253positive regulation of feeding behavior-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA15927146  
GO:0005796Golgi lumen-IDA15927146  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
hsa04920Adipocytokine signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17443794Nicotine regulates mRNA expression of feeding peptides in the arcuate nucleus in neonatal rat pups. (2007 Feb 15)Huang LZDev Neurobiol
15520048Increased fasting plasma ghrelin levels during alcohol abstinence. (2005 Jan-Feb)Kim DJAlcohol Alcohol