Gene: DR1

1810
NC2|NC2-BETA|NC2B|NCB2
down-regulator of transcription 1
protein-coding
1p22.1
Ensembl:ENSG00000117505 MIM:601482 Vega:OTTHUMG00000010862 UniprotKB:Q01658
NC_000001.11
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.779e-1 (AD)  4.489e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YIPF50.921
DCK0.916
RPAP30.915
BTF3L40.914
AZIN10.914
CNOT70.913
APPL10.913
NUS10.913
CSNK1G30.912
NUDT210.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.559
OR4F29-0.519
PLIN4-0.309
CSAG1-0.297
MTRNR2L10-0.295
NXNL1-0.287
PTGDR2-0.286
TPPP2-0.281
MTRNR2L6-0.28
ACOX2-0.275

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DR1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DR1 mRNA"21346803
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of DR1 mRNA21983209
D000082AcetaminophenAcetaminophen affects the expression of DR1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DR1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DR1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DR1 mRNA19770486
C044887beta-methylcholinebeta-methylcholine affects the expression of DR1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of DR1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of DR1 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of DR1 promoter27334623
C013418bromfenacoumbromfenacoum results in decreased expression of DR1 protein28903499
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DR1 protein24527689
D019256Cadmium ChlorideCadmium Chloride affects the expression of DR1 mRNA18974090
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of DR1 mRNA24763279
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of DR1 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of DR1 mRNA19320972
D019327Copper SulfateCopper Sulfate results in increased expression of DR1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of DR1 mRNA20106945|2556210
D004041Dietary FatsDietary Fats results in increased expression of DR1 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of DR1 mRNA]19030233
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DR1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of DR1 mRNA17108234
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of DR1 mRNA24763279
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DR1 mRNA20044591
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of DR1 mRNA19376150
C492448ICG 001ICG 001 results in decreased expression of DR1 mRNA26191083
C045463leflunomideleflunomide results in increased expression of DR1 mRNA28988120
D008345ManganeseManganese results in decreased expression of DR1 mRNA17175027
C025340manganese chloridemanganese chloride results in decreased expression of DR1 mRNA17175027
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DR1 mRNA23649840
C051752nefazodonenefazodone results in increased expression of DR1 mRNA24136188
C006253pirinixic acidpirinixic acid results in decreased expression of DR1 mRNA23811191
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of DR1 mRNA]19030233
D012643SeleniumSelenium results in decreased expression of DR1 mRNA19244175
C017947sodium arsenitesodium arsenite results in increased expression of DR1 mRNA21457566
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DR1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DR1 mRNA17101203
D014520UrethaneUrethane results in increased expression of DR1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of DR1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of DR1 mRNA23179753
D014810Vitamin EVitamin E results in decreased expression of DR1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001047core promoter binding-IBA21873635  
GO:0001075transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assemblyCONTRIBUTES_TOIBA21873635  
GO:0001129RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly-IBA21873635  
GO:0003677DNA binding-IEA-  
GO:0003713transcription coactivator activityCONTRIBUTES_TOIBA21873635  
GO:0003714transcription corepressor activity-IBA21873635  
GO:0003714transcription corepressor activity-TAS8670811  
GO:0005515protein binding-IPI16189514  18838386  27107014  
GO:0008134transcription factor binding-TAS1339312  
GO:0017025TBP-class protein binding-IBA21873635  
GO:0017025TBP-class protein binding-IDA18838386  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-TAS8670811  
GO:0006338chromatin remodeling-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0043966histone H3 acetylation-IDA18838386  
GO:0045898regulation of RNA polymerase II transcriptional preinitiation complex assembly-IBA21873635  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex-IBA21873635  
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex-IDA18838386  
GO:0017054negative cofactor 2 complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-3214847HATs acetylate histonesIEA
R-HSA-3247509Chromatin modifying enzymesIEA
R-HSA-4839726Chromatin organizationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12857045A clinical study of idiopathic pulmonary fibrosis based on autopsy studies in elderly patients. (2003 Jun)Araki TIntern Med
17212707Human MHC region harbors both susceptibility and protective haplotypes for coronary artery disease. (2007 Jan)Palikhe ATissue Antigens
8066056[Etiology of Crohn disease. Current data]. (1994 Mar 26)Colombel JFPresse Med