Gene: DRD1

1812
DADR|DRD1A
dopamine receptor D1
protein-coding
5q35.2
Ensembl:ENSG00000184845 MIM:126449 Vega:OTTHUMG00000130557 UniprotKB:P21728
NG_011802.1
PubMed
CD|OD|ND|AD
37   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.278e-1 (AD)  2.614e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNA40.921
CACNA1E0.921
ANO30.914
GPR120.905
ARPP210.892
ST8SIA30.89
WSCD20.889
CNNM10.884
ASPHD20.881
SHISA90.879

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.572
COPZ2-0.54
RAB13-0.514
YES1-0.513
TFPI2-0.507
MBNL3-0.501
WWTR1-0.496
ASB4-0.49
CSAG1-0.49
FZD10-0.486

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00246ZiprasidoneSmall Molecule146939-27-7ApprovedTarget
DB00248CabergolineSmall Molecule81409-90-7ApprovedTarget
DB00268RopiniroleSmall Molecule91374-21-9Approved|InvestigationalTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00353MethylergometrineSmall Molecule113-42-8ApprovedTarget
DB00363ClozapineSmall Molecule5786-21-0ApprovedTarget
DB00372ThiethylperazineSmall Molecule1420-55-9WithdrawnTarget
DB00397PhenylpropanolamineSmall Molecule14838-15-4Approved|WithdrawnTarget
DB00408LoxapineSmall Molecule1977-10-2ApprovedTarget
DB00413PramipexoleSmall Molecule104632-26-0Approved|InvestigationalTarget
DB00420PromazineSmall Molecule58-40-2ApprovedTarget
DB00477ChlorpromazineSmall Molecule50-53-3Approved|InvestigationalTarget
DB00502HaloperidolSmall Molecule52-86-8ApprovedTarget
DB00508TriflupromazineSmall Molecule146-54-3ApprovedTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00589LisurideSmall Molecule18016-80-3Approved|InvestigationalTarget
DB00623FluphenazineSmall Molecule69-23-8ApprovedTarget
DB00679ThioridazineSmall Molecule50-52-2Approved|WithdrawnTarget
DB00714ApomorphineSmall Molecule58-00-4Approved|InvestigationalTarget
DB00734RisperidoneSmall Molecule106266-06-2Approved|InvestigationalTarget
DB00777PropiomazineSmall Molecule362-29-8ApprovedTarget
DB00800FenoldopamSmall Molecule67227-56-9ApprovedTarget
DB00805MinaprineSmall Molecule25905-77-5ApprovedTarget
DB00850PerphenazineSmall Molecule58-39-9ApprovedTarget
DB00875FlupentixolSmall Molecule2709-56-0Approved|Investigational|WithdrawnTarget
DB00988DopamineSmall Molecule51-61-6ApprovedTarget
DB01038CarphenazineSmall Molecule2622-30-2WithdrawnTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB01063AcetophenazineSmall Molecule2751-68-0ApprovedTarget
DB01186PergolideSmall Molecule66104-22-1Approved|Investigational|WithdrawnTarget
DB01200BromocriptineSmall Molecule25614-03-3Approved|InvestigationalTarget
DB01224QuetiapineSmall Molecule111974-69-7ApprovedTarget
DB01235LevodopaSmall Molecule59-92-7ApprovedTarget
DB01238AripiprazoleSmall Molecule129722-12-9Approved|InvestigationalTarget
DB01239ChlorprothixeneSmall Molecule113-59-7Approved|Investigational|WithdrawnTarget
DB01267PaliperidoneSmall Molecule144598-75-4ApprovedTarget
DB01403MethotrimeprazineSmall Molecule60-99-1Approved|InvestigationalTarget
DB01608PropericiazineSmall Molecule2622-26-6Approved|InvestigationalTarget
DB01614AcepromazineSmall Molecule61-00-7ApprovedTarget
DB01621PipotiazineSmall Molecule39860-99-6Approved|InvestigationalTarget
DB01622ThioproperazineSmall Molecule316-81-4ApprovedTarget
DB01623ThiothixeneSmall Molecule3313-26-6ApprovedTarget
DB01624ZuclopenthixolSmall Molecule53772-83-1Approved|InvestigationalTarget
DB04946IloperidoneSmall Molecule133454-47-4ApprovedTarget
DB05271RotigotineSmall Molecule99755-59-6ApprovedTarget
DB06216AsenapineSmall Molecule65576-45-6ApprovedTarget
DB09286PipamperoneSmall Molecule1893-33-0Approved|InvestigationalTarget
DB12093TetrahydropalmatineSmall Molecule483-14-7InvestigationalTarget
DB12890DihydrexidineSmall Molecule123039-93-0InvestigationalTarget
DB00248CabergolineSmall Molecule81409-90-7ApprovedTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00370MirtazapineSmall Molecule85650-52-8ApprovedTarget
DB00408LoxapineSmall Molecule1977-10-2ApprovedTarget
DB00458ImipramineSmall Molecule50-49-7ApprovedTarget
DB00477ChlorpromazineSmall Molecule50-53-3Approved|InvestigationalTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00568CinnarizineSmall Molecule298-57-7Approved|InvestigationalTarget
DB00696ErgotamineSmall Molecule113-15-5ApprovedTarget
DB00726TrimipramineSmall Molecule739-71-9ApprovedTarget
DB00988DopamineSmall Molecule51-61-6ApprovedTarget
DB06148MianserinSmall Molecule24219-97-4Approved|InvestigationalTarget
DB09097QuinagolideSmall Molecule87056-78-8Approved|InvestigationalTarget
DB09225ZotepineSmall Molecule26615-21-4Approved|Investigational|WithdrawnTarget
ID Drug Name Action PubMed
C1185591-bromopropane1-bromopropane results in decreased expression of DRD1 mRNA19576243
C0448461H-3-benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-"1H-3-benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl- binds to and results in decreased activity of DRD1 protein"8892103
C0013691-hydroxy-3-amino-2-pyrrolidone"[[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine"7906944
C1072381-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine"1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]"20956312
C1072381-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine"1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]"20956312
C1072381-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine"1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]"20956312
C1072381-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine"1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]"20956312
C0453922-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine"2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine binds to DRD1 protein"9723970
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of DRD1 mRNA"26186136
C0773587-benzylidenenaltrexone7-benzylidenenaltrexone binds to and results in decreased activity of DRD1 protein19482038
C4165347-fluoro-2-oxo-4-(2-(4-(thieno(3,2-c)pyridin-4-yl)piperazin-1-yl)ethyl)-1,2-dihydroquinoline-1-acetamide"7-fluoro-2-oxo-4-(2-(4-(thieno(3,2-c)pyridin-4-yl)piperazin-1-yl)ethyl)-1,2-dihydroquinoline-1-acetamide affects the activity of DRD1 protein"23611293
C4098747-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine"7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine binds to and results in decreased activity of DRD1 protein"12447918|1518390
C4098747-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine"7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine binds to DRD1 protein"21888437
C4345848-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine"8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [SCH 23390 binds to DRD1 protein]"11927170
C065380A 68930A 68930 affects the localization of DRD1 protein15985612
C065380A 68930A 68930 binds to and results in increased activity of DRD1 protein15985612
C065380A 68930SCH 23390 inhibits the reaction [A 68930 affects the localization of DRD1 protein]15985612
C065380A 68930A 68930 binds to and results in increased activity of DRD1 protein14960337
C065380A 68930[A 68930 binds to and results in increased activity of DRD1 protein] which affects the susceptibility to Amphetamine14960337
C061450A 69024A 69024 binds to and results in decreased activity of DRD1 protein1418306
C079415A 77636A 77636 affects the localization of DRD1 protein15985612
C079415A 77636A 77636 binds to and results in increased activity of DRD1 protein15985612
C079415A 77636SCH 23390 inhibits the reaction [A 77636 affects the localization of DRD1 protein]15985612
C079415A 77636SCH 23390 inhibits the reaction [A 77636 results in increased activity of DRD1 protein]15985612
C079415A 77636A 77636 binds to and results in increased activity of DRD1 protein7901395|9270571
C095427A 86929A 86929 promotes the reaction [DRD1 protein results in increased chemical synthesis of Cyclic AMP]8558425
C095427A 86929A 86929 results in increased activity of DRD1 protein8558425
C095427A 86929A 86929 affects the localization of DRD1 protein15985612
C095427A 86929A 86929 binds to and results in increased activity of DRD1 protein15985612
C095427A 86929A 86929 binds to DRD1 protein8558425
C095427A 86929A 86929 promotes the reaction [DRD1 protein results in increased chemical synthesis of Cyclic AMP]8558425
C095427A 86929A 86929 results in increased activity of DRD1 protein8558425
C095427A 86929SCH 23390 inhibits the reaction [A 86929 affects the localization of DRD1 protein]15985612
C095427A 86929SCH 23390 inhibits the reaction [A 86929 results in increased activity of DRD1 protein]15985612
C095427A 86929A 86929 binds to and results in increased activity of DRD1 protein9103530
C095427A 86929[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to A 869298997599
C095427A 86929A 86929 analog binds to and results in increased activity of DRD1 protein15075630
C095427A 86929A 86929 binds to and results in increased activity of DRD1 protein8558425|9103530
C095427A 86929A 86929 promotes the reaction [DRD1 protein results in increased chemical synthesis of Cyclic AMP]8558425
C095427A 86929[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to A 869298997599
C095427A 86929SCH 23390 inhibits the reaction [A 86929 binds to and results in increased activity of DRD1 protein]8558425
C095427A 86929SCH 23390 inhibits the reaction [A 86929 promotes the reaction [DRD1 protein results in increased chemical synthesis of Cyclic AMP]]8558425
C095427A 86929Spiperone inhibits the reaction [A 86929 promotes the reaction [DRD1 protein results in increased chemical synthesis of Cyclic AMP]]8558425
C095427A 86929A 86929 binds to and results in increased activity of DRD1 protein8997599
D000082AcetaminophenAcetaminophen affects the expression of DRD1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of DRD1 mRNA28959563
D000242Cyclic AMPA 86929 promotes the reaction [DRD1 protein results in increased chemical synthesis of Cyclic AMP]8558425
D000242Cyclic AMPA 86929 promotes the reaction [DRD1 protein results in increased chemical synthesis of Cyclic AMP]8558425
D000242Cyclic AMPA 86929 promotes the reaction [DRD1 protein results in increased chemical synthesis of Cyclic AMP]8558425
D000242Cyclic AMPSCH 23390 inhibits the reaction [A 86929 promotes the reaction [DRD1 protein results in increased chemical synthesis of Cyclic AMP]]8558425
D000242Cyclic AMPSCH 23390 inhibits the reaction [Simvastatin promotes the reaction [[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP]]15711596
D000242Cyclic AMPSimvastatin promotes the reaction [[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP]15711596
D000242Cyclic AMP[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP15711596
D000242Cyclic AMPSpiperone inhibits the reaction [A 86929 promotes the reaction [DRD1 protein results in increased chemical synthesis of Cyclic AMP]]8558425
C095428adrogolide hydrochloride[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to adrogolide hydrochloride8997599
C095428adrogolide hydrochlorideadrogolide hydrochloride binds to and results in increased activity of DRD1 protein15075630
C095428adrogolide hydrochlorideadrogolide hydrochloride binds to and results in increased activity of DRD1 protein10227086|1091192
C016601afimoxifeneafimoxifene results in increased expression of DRD1 mRNA19901195
C050408alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanolalpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol inhibits the reaction [EEDQ results in decreased expression of DRD1 protein]7513362
C542924alpha-pyrrolidinovalerophenone[alpha-pyrrolidinovalerophenone results in increased secretion of Dopamine] results in increased activity of [DRD1 protein co-treated with DRD2 protein]24418703
D000535AluminumAluminum inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
C010845aluminum chloridealuminum chloride results in decreased expression of DRD1 protein17984145
D005680gamma-Aminobutyric AcidDRD1 protein promotes the reaction [zonisamide affects the secretion of gamma-Aminobutyric Acid]19482038
D000639AmitriptylineAmitriptyline results in increased expression of DRD1 mRNA16499906
D017311AmlodipineAmlodipine inhibits the reaction [SCH 23390 binds to DRD1 protein]9533112
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DRD1 mRNA16483693
D000657AmoxapineAmoxapine binds to DRD1 protein11180191
D000661AmphetamineAmphetamine results in increased expression of DRD1 mRNA16916582
D000661Amphetamine[A 68930 binds to and results in increased activity of DRD1 protein] which affects the susceptibility to Amphetamine14960337
D000661AmphetamineAmphetamine results in decreased activity of DRD1 protein16554467
D000661AmphetamineAmphetamine results in decreased expression of DRD1 mRNA19145071
D000661AmphetamineAmphetamine results in decreased expression of DRD1 protein19145071
D000661Amphetamine[dihydrexidine binds to and results in increased activity of DRD1 protein] which affects the susceptibility to Amphetamine14960337
D000661Amphetamine[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Amphetamine19733155
C068464anhydroecgonine methyl ester[anhydroecgonine methyl ester co-treated with Cocaine] results in decreased expression of DRD1 protein27129946
D001058ApomorphineApomorphine binds to and results in increased activity of DRD1 protein15985612
D001058ApomorphineSCH 23390 inhibits the reaction [Apomorphine results in increased activity of DRD1 protein]15985612
D001058Apomorphine[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole8103921
D001058ApomorphineRaclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]8103921
D001058ApomorphineSCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]8103921
D001058ApomorphineApomorphine binds to and results in increased activity of DRD1 protein10448923|1347779
D001073AprindineAprindine binds to DRD1 protein9808703
D001545Benserazide[Oxidopamine co-treated with levodopa methyl ester] promotes the reaction [Benserazide results in increased expression of DRD1 protein]19399396
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DRD1 mRNA21839799
C015024benzylamphetaminebenzylamphetamine results in increased expression of DRD1 mRNA29081089
D004958EstradiolEstradiol results in decreased expression of DRD1 mRNA25210133
D004958EstradiolEstradiol results in increased expression of DRD1 mRNA12008023|2006800
D001623BetamethasoneBetamethasone results in increased expression of DRD1 mRNA16638587
D001623BetamethasoneBetamethasone results in increased expression of DRD1 protein16638587
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of DRD1 mRNA26186136
C006780bisphenol Abisphenol A promotes the reaction [DRD1 protein results in increased susceptibility to Methamphetamine]12617968
C006780bisphenol Abisphenol A results in increased activity of DRD1 protein16045194
C006780bisphenol Abisphenol A results in increased expression of DRD1 mRNA12617968
C006780bisphenol Abisphenol A results in decreased expression of DRD1 protein27494678
C006780bisphenol Abisphenol A results in increased expression of DRD1 mRNA26186136
C011686boldineboldine analog binds to DRD1 protein10785418
C011686boldineboldine analog inhibits the reaction [SCH 23390 binds to DRD1 protein]10785418
C018475butyraldehydebutyraldehyde results in decreased expression of DRD1 mRNA26079696
C047047cabergolinecabergoline binds to DRD1 protein16982285
D002104CadmiumCadmium inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
D002118Calcium"[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased abundance of Calcium"14622123
D002220CarbamazepineCarbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY1 protein]19922557
D002220CarbamazepineCarbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY2 protein]19922557
D002220CarbamazepineCarbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY3 protein]19922557
D002220CarbamazepineCarbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY4 protein]19922557
D002220CarbamazepineCarbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY5 protein]19922557
D002220CarbamazepineCarbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY6 protein]19922557
D002220CarbamazepineCarbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY7 protein]19922557
D002220CarbamazepineCarbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY8 protein]19922557
D002220CarbamazepineCarbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY9 protein]19922557
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of DRD1 mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of DRD1 mRNA21472459
D020111Chlorodiphenyl (54% Chlorine)Quercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of DRD1 mRNA]21472459
D002746ChlorpromazineChlorpromazine results in decreased activity of DRD1 protein23611293
D004390ChlorpyrifosChlorpyrifos results in increased expression of DRD1 mRNA18812211
D003024ClozapineClozapine binds to DRD1 protein11997696|1352677
D003024ClozapineDRD1 gene polymorphism affects the susceptibility to Clozapine17092969
D003024ClozapineDRD1 protein affects the susceptibility to Clozapine17092969
D003024ClozapineClozapine analog binds to DRD1 protein11997696
D003024ClozapineClozapine results in decreased expression of DRD1 mRNA17266109
D003024ClozapineClozapine binds to DRD1 protein9723970
D003024ClozapineClozapine binds to DRD1 protein7520908
D003042Cocaine"1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]"20956312
D003042Cocaine"1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]"20956312
D003042CocaineCocaine affects the localization of [DRD1 protein binds to SIGMAR1 protein]20956312
D003042Cocaine[Cocaine binds to SIGMAR1 protein] affects the folding of [SIGMAR1 protein binds to DRD1 protein]20956312
D003042CocaineCocaine promotes the reaction [DRD1 protein binds to SIGMAR1 protein]20956312
D003042CocaineCocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]20956312
D003042CocaineCocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]20956312
D003042CocaineSCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]20956312
D003042CocaineSCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]20956312
D003042CocaineCocaine affects the reaction [SCH 23390 binds to DRD1 protein]18769473|9414012
D003042CocaineCocaine results in decreased expression of DRD1 protein9414012
D003042CocaineCocaine promotes the reaction [DRD1 protein results in increased expression of FOS protein]15056714
D003042CocaineCocaine promotes the reaction [DRD1 protein results in increased expression of NEO1 protein]15056714
D003042CocaineCocaine promotes the reaction [DRD1 protein results in increased expression of PDYN protein]15056714
D003042CocaineCocaine promotes the reaction [DRD1 protein results in increased expression of SYT7 protein]15056714
D003042CocaineCocaine promotes the reaction [DRD1 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]15056714
D003042CocaineCocaine promotes the reaction [DRD1 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]15056714
D003042CocaineDRD1 gene mutant form results in decreased susceptibility to Cocaine8001143
D003042CocaineDRD1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]20456009
D003042CocaineDRD1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]20456009
D003042CocaineDRD1 results in increased susceptibility to Cocaine20456009
D003042CocaineCocaine affects the localization of DRD1 protein17202482
D003042Cocaine[anhydroecgonine methyl ester co-treated with Cocaine] results in decreased expression of DRD1 protein27129946
D003042CocaineCocaine affects the expression of DRD1 protein11602327|1504951
D003042CocaineCocaine affects the reaction [SCH 23390 binds to DRD1 protein]17161392
D003042CocaineCocaine results in decreased expression of DRD1 protein27129946
D003042CocaineDRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein]16674926
D003042CocaineDRD1 protein affects the reaction [Cocaine results in increased expression of FOSB protein alternative form]16674926
D003042CocaineDRD1 protein affects the susceptibility to Cocaine2213551
D003042Cocaine[SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Cocaine results in increased expression of FOS protein]11421588
D003300CopperCopper inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
C054531CY 208-243CY 208-243 binds to and results in increased activity of DRD1 protein1681090|1977176|
D003520CyclophosphamideCyclophosphamide binds to DRD1 protein11180191
D016572CyclosporineCyclosporine promotes the reaction [Domperidone binds to DRD1 protein]12673668
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of DRD1 mRNA23640034
C017180decamethrindecamethrin results in decreased expression of DRD1 mRNA25912032
C017180decamethrindecamethrin results in increased expression of DRD1 protein25630971
D013759DronabinolDronabinol results in increased expression of DRD1 mRNA21955143
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DRD1 mRNA15620428
D004008DiclofenacDiclofenac results in increased expression of DRD1 mRNA26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of DRD1 mRNA26924002
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of DRD1 mRNA15620428
C061532dihydrexidinedihydrexidine binds to and results in increased activity of DRD1 protein15985612
C061532dihydrexidineSCH 23390 inhibits the reaction [dihydrexidine results in increased activity of DRD1 protein]15985612
C061532dihydrexidinedihydrexidine binds to and results in increased activity of DRD1 protein14960337|1507563
C061532dihydrexidine[dihydrexidine binds to and results in increased activity of DRD1 protein] which affects the susceptibility to Amphetamine14960337
C061532dihydrexidinedihydrexidine binds to and results in increased activity of DRD1 protein21714510
D004110DiltiazemDiltiazem inhibits the reaction [SCH 23390 binds to DRD1 protein]9533112
C024629dimethyl phthalatedimethyl phthalate affects the expression of DRD1 mRNA26924002
C097827dinapsolinedinapsoline affects the localization of DRD1 protein15985612
C097827dinapsolinedinapsoline binds to and results in increased activity of DRD1 protein15985612
C097827dinapsolineSCH 23390 inhibits the reaction [dinapsoline affects the localization of DRD1 protein]15985612
C097827dinapsolineSCH 23390 inhibits the reaction [dinapsoline results in increased activity of DRD1 protein]15985612
C097827dinapsolinedinapsoline binds to and results in increased activity of DRD1 protein15075630
D016291Dizocilpine Maleate"[[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine"7906944
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD1 mRNA]17434604
D004294DomperidoneCyclosporine promotes the reaction [Domperidone binds to DRD1 protein]12673668
D004294DomperidoneDomperidone binds to DRD1 protein12673668
D007980Levodopa"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Levodopa] results in increased expression of DRD1 protein"15514976
D007980LevodopaDRD1 affects the susceptibility to Levodopa19520364
D007980Levodopa[Levodopa co-treated with Oxidopamine] results in increased expression of DRD1 mRNA19118628
D007980LevodopaLevodopa inhibits the reaction [Oxidopamine results in decreased expression of DRD1 protein]16365282
D004298DopamineDopamine binds to and results in increased activity of DRD1 protein12887611
D004298DopamineDopamine affects the localization of DRD1 protein15985612
D004298DopamineDopamine binds to and results in increased activity of DRD1 protein15985612
D004298DopamineSCH 23390 inhibits the reaction [Dopamine affects the localization of DRD1 protein]15985612
D004298DopamineSCH 23390 inhibits the reaction [Dopamine results in increased activity of DRD1 protein]15985612|2229209
D004298Dopamine[alpha-pyrrolidinovalerophenone results in increased secretion of Dopamine] results in increased activity of [DRD1 protein co-treated with DRD2 protein]24418703
D004298Dopamine[Dopamine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein14622123
D004298DopamineDopamine deficiency inhibits the reaction [SCH 23390 binds to DRD1 protein]12813475
D004298Dopamine[Dopamine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein14622123
D004298DopamineDRD1 protein promotes the reaction [zonisamide affects the secretion of Dopamine]19482038
D004298DopamineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dopamine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein]14622123
D004298DopamineSCH 23390 inhibits the reaction [[Dopamine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]14622123
D004298Dopamine[NTS protein results in increased secretion of Dopamine] which results in increased activity of DRD1 protein12064480
D004298Dopamine[[NTS protein results in increased secretion of Dopamine] which results in increased activity of DRD1 protein] which results in increased phosphorylation of PPP1R1B protein12064480
C058081ecopipamecopipam binds to and results in decreased activity of DRD1 protein1418306
C058081ecopipamecopipam binds to DRD1 protein9109525
C058081ecopipamzinc chloride inhibits the reaction [ecopipam binds to DRD1 protein]9109525
C058081ecopipamecopipam binds to and results in decreased activity of DRD1 protein10379527|1059128
C058081ecopipamecopipam binds to DRD1 protein7753372
C000470EEDQalpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol inhibits the reaction [EEDQ results in decreased expression of DRD1 protein]7513362
C000470EEDQEEDQ results in decreased expression of DRD1 protein7513362
C001162etafenoneetafenone binds to DRD1 protein10888308
D000431EthanolEthanol results in decreased expression of DRD1 mRNA21955143
D000431EthanolEthanol results in decreased expression of DRD1 protein18713641
C007650ethyl acetate"[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to ethyl acetate"9537685
C007650ethyl acetate"[SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to ethyl acetate]"9537685
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of DRD1 gene16495775
D005054Eugenol"[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Eugenol"9537685
C071320FCE 23884FCE 23884 binds to and results in increased activity of DRD1 protein8723141
D018818FenoldopamFenoldopam binds to and results in increased activity of DRD1 protein12887611
D018818FenoldopamDRD1 protein affects the susceptibility to Fenoldopam8103596
D018818FenoldopamFenoldopam binds to and results in increased activity of DRD1 protein1724532
D018818FenoldopamFenoldopam binds to and results in increased activity of DRD1 protein1346161|19406658
D005444FlunarizineFlunarizine binds to DRD18794996
D005444FlunarizineFlunarizine binds to DRD1 protein9533112
D005444FlunarizineFlunarizine inhibits the reaction [SCH 23390 binds to DRD1 protein]9533112
D005475FlupenthixolFlupenthixol binds to DRD1 protein1352677
D005475FlupenthixolFlupenthixol binds to and results in decreased activity of DRD1 protein20519576
D005475FlupenthixolFlupenthixol binds to and results in decreased activity of DRD1 protein2947255|6858777
D005476FluphenazineFluphenazine binds to and results in decreased activity of DRD1 protein1833784
D004397FonofosFonofos results in increased methylation of DRD1 promoter22847954
D005557FormaldehydeDizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD1 mRNA]17434604
D005557FormaldehydeFormaldehyde results in increased expression of DRD1 mRNA17434604
C039281furanfuran results in increased methylation of DRD1 gene22079235
D005682GadoliniumGadolinium inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of DRD1 mRNA21782745
C010974glyphosateglyphosate inhibits the reaction [SCH 23390 binds to DRD1 protein]25522657
D006220HaloperidolHaloperidol affects the activity of DRD1 protein23611293
D006220HaloperidolHaloperidol binds to DRD1 protein16983399
D006220HaloperidolHaloperidol binds to DRD18794996
D006220HaloperidolHaloperidol results in decreased expression of DRD1 mRNA12887421
D006220HaloperidolHaloperidol results in increased expression of DRD1 protein8750706
D006220HaloperidolHaloperidol binds to and results in decreased activity of DRD1 protein1365866
D006220HaloperidolHaloperidol binds to DRD1 protein7520908
D017313FenretinideFenretinide results in increased expression of DRD1 mRNA28973697
D012701SerotoninSerotonin inhibits the reaction [Rotenone results in decreased expression of DRD1 mRNA]20887679
D012701SerotoninSerotonin inhibits the reaction [Rotenone results in decreased expression of DRD1 protein]20887679
D007501Iron[manganese chloride co-treated with Iron deficiency] results in decreased expression of DRD1 protein22479410
D007546IsoquinolinesIsoquinolines affects the localization of DRD1 protein15985612
D007546IsoquinolinesIsoquinolines binds to and results in increased activity of DRD1 protein15985612
D007546IsoquinolinesSCH 23390 inhibits the reaction [Isoquinolines affects the localization of DRD1 protein]15985612
D007546IsoquinolinesSCH 23390 inhibits the reaction [Isoquinolines results in increased activity of DRD1 protein]15985612
D007811LanthanumLanthanum inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
C008261lead acetatelead acetate results in decreased expression of DRD1 mRNA21891863
C090111LEK 8829LEK 8829 binds to and results in increased activity of DRD1 protein15138661
C035420levodopa methyl ester[Oxidopamine co-treated with levodopa methyl ester] promotes the reaction [Benserazide results in increased expression of DRD1 protein]19399396
D008094LithiumDRD1 gene polymorphism affects the susceptibility to Lithium19153942
D008094LithiumDRD1 protein results in increased susceptibility to Lithium19153942
D008152LoxapineLoxapine analog binds to DRD1 protein9723970
D008152LoxapineLoxapine binds to DRD1 protein9723970
C025340manganese chloridemanganese chloride results in decreased expression of DRD1 protein24969583
C025340manganese chlorideMelatonin inhibits the reaction [manganese chloride results in decreased expression of DRD1 protein]24969583
C025340manganese chloride[manganese chloride co-treated with Iron deficiency] results in decreased expression of DRD1 protein22479410
C025340manganese chloridemanganese chloride results in decreased expression of DRD1 protein22479410|2360496
C025340manganese chloridemanganese chloride results in increased expression of DRD123458069
C054218manidipinemanidipine binds to DRD18794996
C054218manidipinemanidipine inhibits the reaction [SCH 23390 binds to DRD1 protein]9533112
D008550MelatoninMelatonin inhibits the reaction [manganese chloride results in decreased expression of DRD1 protein]24969583
D008694MethamphetamineMethamphetamine results in increased expression of DRD1 protein11126397
D008694Methamphetaminebisphenol A promotes the reaction [DRD1 protein results in increased susceptibility to Methamphetamine]12617968
D008694MethamphetamineDRD1 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]20340177
D008694MethamphetamineDRD1 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]20340177
D008694MethamphetamineDRD1 protein results in increased susceptibility to Methamphetamine12617968|1836385
D008694Methamphetamine[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methamphetamine18363855|2034017
D008694Methamphetamine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine inhibits the reaction [Methamphetamine affects the activity of DRD1 protein]"18489579
D008694MethamphetamineMethamphetamine affects the activity of DRD1 protein18489579
D008694MethamphetamineMethamphetamine inhibits the reaction [SCH 23390 binds to DRD1 protein]2891082
D008694MethamphetamineMethamphetamine results in decreased expression of DRD1 protein19444617|2891082
D008694Methamphetamine[SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Methamphetamine results in increased expression of DUSP1 mRNA]11701771
D008694Methamphetamine[SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA]11701771
D008694Methamphetamine[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methamphetamine19733155
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of DRD1 mRNA21782745
D008731MethoxychlorMethoxychlor results in increased methylation of DRD1 gene23303685
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased activity of DRD1 protein"28790194
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DRD1 mRNA21385734
D008774Methylphenidate[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methylphenidate11454915
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects the localization of DRD1 protein"17350277
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Levodopa] results in increased expression of DRD1 protein"15514976
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of DRD1 mRNA"15514976
D008787MetoclopramideMetoclopramide binds to and results in decreased activity of DRD1 protein12887611
C035133mirtazapinemirtazapine results in increased expression of DRD1 mRNA16499906
C517284monomethyl phthalatemonomethyl phthalate affects the expression of DRD1 mRNA26924002
D009020MorphineMorphine results in increased expression of DRD1 mRNA21955143
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide"N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein]"14622123
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dopamine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein]14622123
C407426neurotensin 69Lneurotensin 69L results in increased expression of DRD1 mRNA17113052
D009538NicotineNicotine results in decreased expression of DRD1 mRNA21955143
D009538Nicotine[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Nicotine1833784
C077123NNC 112NNC 112 binds to DRD1 protein12813475
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of DRD1 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of DRD1 mRNA27935865
C076525NO 756NO 756 binds to and results in decreased activity of DRD1 protein1418306
C025256nonylphenolnonylphenol results in decreased expression of DRD1 mRNA15620428
D009638NorepinephrineNorepinephrine inhibits the reaction [Rotenone results in decreased expression of DRD1 mRNA]20887679
D009638NorepinephrineNorepinephrine inhibits the reaction [Rotenone results in decreased expression of DRD1 protein]20887679
C106996NRA 0045NRA 0045 binds to DRD1 protein9223539
C075357odapipamodapipam binds to and results in decreased activity of DRD1 protein14498848
D016627Oxidopamine[Levodopa co-treated with Oxidopamine] results in increased expression of DRD1 mRNA19118628
D016627OxidopamineLevodopa inhibits the reaction [Oxidopamine results in decreased expression of DRD1 protein]16365282
D016627Oxidopamine[Oxidopamine co-treated with levodopa methyl ester] promotes the reaction [Benserazide results in increased expression of DRD1 protein]19399396
D016627OxidopamineOxidopamine results in decreased expression of DRD1 mRNA18707801
D016627OxidopamineOxidopamine results in decreased expression of DRD1 protein16365282
D016627OxidopamineOxidopamine results in increased expression of DRD1 protein19399396
C076029olanzapineolanzapine binds to DRD1 protein24389121
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of DRD1 mRNA18636392
D000068882Paliperidone PalmitatePaliperidone Palmitate binds to DRD1 protein7520908
D010278ParathionParathion results in increased methylation of DRD1 promoter22847954
D010431PentoxifyllinePentoxifylline binds to and results in increased activity of DRD1 protein11234661|6858777
D010433Pentylenetetrazole[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole8103921
D010433PentylenetetrazoleRaclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]8103921
D010433PentylenetetrazoleSCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]8103921
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of DRD1 protein26529483
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of DRD1 mRNA26529483
D010479PergolidePergolide results in increased activity of DRD1 protein16129789
D010479PergolidePergolide binds to and results in increased activity of DRD1 protein11261747|1735633
D010479PergolidePergolide binds to DRD1 protein16982285
D010546PerphenazinePerphenazine binds to and results in decreased activity of DRD1 protein1365866
C000593032PGW5 compoundPGW5 compound binds to DRD1 protein24389121
D010622PhencyclidineNTSR1 gene affects the reaction [Phencyclidine results in decreased expression of DRD1 protein]20659557
D010622PhencyclidinePhencyclidine results in decreased expression of DRD1 mRNA17266109|2065955
D010622PhencyclidinePhencyclidine results in decreased expression of DRD1 protein20659557
D010627PhenethylaminesPhenethylamines analog binds to DRD1 protein16539400
D010830PhysostigminePhysostigmine binds to and results in decreased activity of DRD1 protein9264077
D010862Pilocarpine"[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Pilocarpine"7906944
D010862Pilocarpine"[[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine"7906944
D010862PilocarpineDRD1 protein results in increased susceptibility to Pilocarpine1365435
D010862PilocarpinePilocarpine inhibits the reaction [SCH 23390 binds to DRD1 protein]16137708
D010862PilocarpinePilocarpine results in decreased expression of DRD1 protein15876489
D010862PilocarpinePilocarpine results in increased expression of DRD1 mRNA14656328
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of DRD1 mRNA27935865
C006253pirinixic acidpirinixic acid results in decreased expression of DRD1 mRNA17950772
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of DRD1 mRNA]17950772
D010936Plant ExtractsPlant Extracts results in decreased expression of DRD1 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of DRD1 mRNA23608068
C035988procymidoneprocymidone results in increased expression of DRD1 mRNA15686871
C015586propiverinepropiverine binds to DRD1 protein10888308
D011794QuercetinQuercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of DRD1 mRNA]21472459
D017378Quinolinic AcidQuinolinic Acid results in decreased expression of DRD1 protein12207953
D015363QuinolonesQuinolones analog binds to and results in increased activity of DRD1 protein9171869
D020891RacloprideRaclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]8103921
D012110ReserpineReserpine results in increased expression of DRD1 mRNA8419537
D018967RisperidoneRisperidone binds to DRD1 protein7520908
D012402RotenoneNorepinephrine inhibits the reaction [Rotenone results in decreased expression of DRD1 mRNA]20887679
D012402RotenoneNorepinephrine inhibits the reaction [Rotenone results in decreased expression of DRD1 protein]20887679
D012402RotenoneRotenone results in decreased expression of DRD1 mRNA20887679
D012402RotenoneRotenone results in decreased expression of DRD1 protein20887679
D012402RotenoneSerotonin inhibits the reaction [Rotenone results in decreased expression of DRD1 mRNA]20887679
D012402RotenoneSerotonin inhibits the reaction [Rotenone results in decreased expression of DRD1 protein]20887679
C047508rotigotinerotigotine binds to and results in increased activity of DRD1 protein23165154
C109112SB 222200SB 222200 results in increased expression of DRD1 protein19500601
C534628SCH 23390SCH 23390 binds to DRD1 protein15237387
C534628SCH 23390SCH 23390 binds to and results in decreased activity of DRD1 protein12887611
C534628SCH 23390SCH 23390 binds to DRD1 protein15985612|2199957
C534628SCH 23390SCH 23390 inhibits the reaction [A 68930 affects the localization of DRD1 protein]15985612
C534628SCH 23390SCH 23390 inhibits the reaction [A 77636 affects the localization of DRD1 protein]15985612
C534628SCH 23390SCH 23390 inhibits the reaction [A 77636 results in increased activity of DRD1 protein]15985612
C534628SCH 23390SCH 23390 inhibits the reaction [A 86929 affects the localization of DRD1 protein]15985612
C534628SCH 23390SCH 23390 inhibits the reaction [A 86929 results in increased activity of DRD1 protein]15985612
C534628SCH 23390SCH 23390 inhibits the reaction [Apomorphine results in increased activity of DRD1 protein]15985612
C534628SCH 23390SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]20956312
C534628SCH 23390SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]20956312
C534628SCH 23390SCH 23390 inhibits the reaction [dihydrexidine results in increased activity of DRD1 protein]15985612
C534628SCH 23390SCH 23390 inhibits the reaction [dinapsoline affects the localization of DRD1 protein]15985612
C534628SCH 23390SCH 23390 inhibits the reaction [dinapsoline results in increased activity of DRD1 protein]15985612
C534628SCH 23390SCH 23390 inhibits the reaction [Dopamine affects the localization of DRD1 protein]15985612
C534628SCH 23390SCH 23390 inhibits the reaction [Dopamine results in increased activity of DRD1 protein]15985612|2229209
C534628SCH 23390SCH 23390 inhibits the reaction [Isoquinolines affects the localization of DRD1 protein]15985612
C534628SCH 23390SCH 23390 inhibits the reaction [Isoquinolines results in increased activity of DRD1 protein]15985612
C534628SCH 23390SCH 23390 inhibits the reaction [SK&F 81297 affects the localization of DRD1 protein]15985612
C534628SCH 23390SCH 23390 inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]20956312
C534628SCH 23390SCH 23390 inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]20956312
C534628SCH 23390SCH 23390 inhibits the reaction [SK&F 82958 affects the localization of DRD1 protein]15985612
C534628SCH 23390Cocaine affects the reaction [SCH 23390 binds to DRD1 protein]18769473|9414012
C534628SCH 23390SCH 23390 binds to DRD1 protein18769473|9414012
C534628SCH 23390Amlodipine inhibits the reaction [SCH 23390 binds to DRD1 protein]9533112
C534628SCH 23390Diltiazem inhibits the reaction [SCH 23390 binds to DRD1 protein]9533112
C534628SCH 23390Flunarizine inhibits the reaction [SCH 23390 binds to DRD1 protein]9533112
C534628SCH 23390manidipine inhibits the reaction [SCH 23390 binds to DRD1 protein]9533112
C534628SCH 23390NR3C1 protein promotes the reaction [SCH 23390 binds to DRD1 protein]11226678
C534628SCH 23390SCH 23390 binds to and results in decreased activity of DRD1 protein12617968|1912005
C534628SCH 23390[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to A 869298997599
C534628SCH 23390[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to adrogolide hydrochloride8997599
C534628SCH 23390[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methamphetamine18363855|2034017
C534628SCH 23390SCH 23390 binds to DRD1 protein11226678|1267366
C534628SCH 23390SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]8103921
C534628SCH 23390Verapamil inhibits the reaction [SCH 23390 binds to DRD1 protein]9533112
C534628SCH 23390"8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [SCH 23390 binds to DRD1 protein]"11927170
C534628SCH 23390Aluminum inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
C534628SCH 23390boldine analog inhibits the reaction [SCH 23390 binds to DRD1 protein]10785418
C534628SCH 23390Cadmium inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
C534628SCH 23390Cocaine affects the reaction [SCH 23390 binds to DRD1 protein]17161392
C534628SCH 23390Copper inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
C534628SCH 23390Dopamine deficiency inhibits the reaction [SCH 23390 binds to DRD1 protein]12813475
C534628SCH 23390Gadolinium inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
C534628SCH 23390glyphosate inhibits the reaction [SCH 23390 binds to DRD1 protein]25522657
C534628SCH 23390Lanthanum inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
C534628SCH 23390Methamphetamine inhibits the reaction [SCH 23390 binds to DRD1 protein]2891082
C534628SCH 23390Pilocarpine inhibits the reaction [SCH 23390 binds to DRD1 protein]16137708
C534628SCH 23390SCH 23390 binds to and results in decreased activity of DRD1 protein12946566|1418306
C534628SCH 23390"[SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to ethyl acetate]"9537685
C534628SCH 23390[SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Cocaine results in increased expression of FOS protein]11421588
C534628SCH 23390[SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Methamphetamine results in increased expression of DUSP1 mRNA]11701771
C534628SCH 23390[SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA]11701771
C534628SCH 23390[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to A 869298997599
C534628SCH 23390[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Amphetamine19733155
C534628SCH 23390[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methamphetamine19733155
C534628SCH 23390[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methylphenidate11454915
C534628SCH 23390[SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Nicotine1833784
C534628SCH 23390SCH 23390 binds to DRD1 protein10785418|1192717
C534628SCH 23390"SCH 23390 inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein]"15075630
C534628SCH 23390"SCH 23390 inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]"14622123
C534628SCH 23390SCH 23390 inhibits the reaction [A 86929 binds to and results in increased activity of DRD1 protein]8558425
C534628SCH 23390SCH 23390 inhibits the reaction [A 86929 promotes the reaction [DRD1 protein results in increased chemical synthesis of Cyclic AMP]]8558425
C534628SCH 23390SCH 23390 inhibits the reaction [[Dopamine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]14622123
C534628SCH 23390SCH 23390 inhibits the reaction [Simvastatin promotes the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]]15711596
C534628SCH 23390SCH 23390 inhibits the reaction [Simvastatin promotes the reaction [[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP]]15711596
C534628SCH 23390SCH 23390 inhibits the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]15711596
C534628SCH 23390SCH 23390 inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]14622123
C534628SCH 23390SCH 23390 results in decreased activity of DRD1 protein2213551
C534628SCH 23390Zinc Acetate inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
C534628SCH 23390zinc chloride inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
C534628SCH 23390Zinc Sulfate inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
C534628SCH 23390SCH 23390 affects the activity of DRD1 protein7845605
C534628SCH 23390SCH 23390 binds to and results in decreased activity of DRD1 protein10098858|1037979
C534628SCH 23390SCH 23390 binds to and results in increased activity of DRD1 protein8808155
C534628SCH 23390SCH 23390 binds to DRD1 protein17161392
C534628SCH 23390SCH 23390 results in decreased activity of DRD1 protein17136323|7644023
D020280SertralineSertraline results in increased expression of DRD1 mRNA16499906
D019821SimvastatinSCH 23390 inhibits the reaction [Simvastatin promotes the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]]15711596
D019821SimvastatinSCH 23390 inhibits the reaction [Simvastatin promotes the reaction [[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP]]15711596
D019821SimvastatinSimvastatin promotes the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]15711596
D019821SimvastatinSimvastatin promotes the reaction [[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP]15711596
D019821SimvastatinSimvastatin results in increased expression of DRD1 mRNA15711596
D019821SimvastatinSimvastatin results in increased expression of DRD1 protein15711596
C067114SK&F 77434SK&F 77434 binds to and results in increased activity of DRD1 protein15985612
C067114SK&F 77434SK&F 77434 affects the expression of DRD1 protein11919663
C067113SK&F 81297"1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]"20956312
C067113SK&F 81297"1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]"20956312
C067113SK&F 81297SCH 23390 inhibits the reaction [SK&F 81297 affects the localization of DRD1 protein]15985612
C067113SK&F 81297SCH 23390 inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]]20956312
C067113SK&F 81297SCH 23390 inhibits the reaction [SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]]20956312
C067113SK&F 81297SK&F 81297 affects the localization of DRD1 protein15985612
C067113SK&F 81297SK&F 81297 binds to and results in increased activity of DRD1 protein15985612
C067113SK&F 81297SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]20956312
C067113SK&F 81297SK&F 81297 promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]20956312
C067113SK&F 81297SK&F 81297 binds to and results in increased activity of DRD1 protein10900248|1126821
C099238SKF 82957SKF 82957 binds to and results in increased activity of DRD1 protein15985612
C071262SK&F 82958SCH 23390 inhibits the reaction [SK&F 82958 affects the localization of DRD1 protein]15985612
C071262SK&F 82958SK&F 82958 affects the localization of DRD1 protein15985612
C071262SK&F 82958SK&F 82958 binds to and results in increased activity of DRD1 protein15985612
C071262SK&F 82958SK&F 82958 binds to and results in increased activity of DRD1 protein19500601
C071262SK&F 82958SCH 23390 inhibits the reaction [Simvastatin promotes the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]]15711596
C071262SK&F 82958SCH 23390 inhibits the reaction [Simvastatin promotes the reaction [[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP]]15711596
C071262SK&F 82958SCH 23390 inhibits the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]15711596
C071262SK&F 82958SCH 23390 inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]14622123
C071262SK&F 82958Simvastatin promotes the reaction [SK&F 82958 analog results in increased activity of DRD1 protein]15711596
C071262SK&F 82958Simvastatin promotes the reaction [[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP]15711596
C071262SK&F 82958SK&F 82958 analog results in increased activity of DRD1 protein15711596
C071262SK&F 82958[SK&F 82958 analog results in increased activity of DRD1 protein] which results in increased abundance of Cyclic AMP15711596
C071262SK&F 82958SK&F 82958 binds to and results in increased activity of DRD1 protein11337201|1462212
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein14622123
C071262SK&F 82958Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY1 protein]19922557
C071262SK&F 82958Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY2 protein]19922557
C071262SK&F 82958Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY3 protein]19922557
C071262SK&F 82958Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY4 protein]19922557
C071262SK&F 82958Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY5 protein]19922557
C071262SK&F 82958Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY6 protein]19922557
C071262SK&F 82958Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY7 protein]19922557
C071262SK&F 82958Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY8 protein]19922557
C071262SK&F 82958Carbamazepine inhibits the reaction [[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY9 protein]19922557
C071262SK&F 82958SK&F 82958 binds to and results in increased activity of DRD1 protein10900248|1457338
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY1 protein19922557
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY2 protein19922557
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY3 protein19922557
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY4 protein19922557
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY5 protein19922557
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY6 protein19922557
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY7 protein19922557
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY8 protein19922557
C071262SK&F 82958[SK&F 82958 binds to and results in increased activity of DRD1 protein] which results in increased activity of ADCY9 protein19922557
C080703SK&F 83959SK&F 83959 binds to and results in increased activity of DRD1 protein15985612
C017947sodium arsenitesodium arsenite results in decreased expression of DRD1 mRNA20699118
C017947sodium arsenitesodium arsenite results in increased expression of DRD1 mRNA20699118
D013134SpiperoneSpiperone binds to and results in decreased activity of DRD1 protein12887611
D013134SpiperoneSpiperone inhibits the reaction [A 86929 promotes the reaction [DRD1 protein results in increased chemical synthesis of Cyclic AMP]]8558425
C010513stepholidinestepholidine binds to and results in increased activity of DRD1 protein18521575
D010042OuabainOuabain results in decreased expression of and results in increased phosphorylation of DRD1 protein20132239
D010042OuabainOuabain results in decreased expression of DRD1 mRNA20132239
D010042OuabainOuabain results in increased phosphorylation of and results in decreased expression of DRD1 protein19626329
C094142TAN 67TAN 67 binds to and results in increased activity of DRD1 protein19482038
C012568terbufosterbufos results in increased methylation of DRD1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DRD1 mRNA19901195
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein"15725338
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein"12887611
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein"15985612
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Pilocarpine"7906944
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"[[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Dizocilpine Maleate] co-treated with [1-hydroxy-3-amino-2-pyrrolidone results in increased activity of DRD1 protein]] results in increased susceptibility to Pilocarpine"7906944
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein"14622157
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein"10432116|1462212
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein"14622123
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to ethyl acetate"9537685
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to Eugenol"9537685
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine inhibits the reaction [Methamphetamine affects the activity of DRD1 protein]"18489579
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased abundance of Calcium"14622123
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein"14622123
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein]"14622123
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"[SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased susceptibility to ethyl acetate]"9537685
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"SCH 23390 inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein]"15075630
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"SCH 23390 inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein] which results in increased phosphorylation of CREB1 protein]"14622123
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in decreased activity of DRD1 protein"9666168
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine binds to and results in increased activity of DRD1 protein"10379793|1160266
C014215tetrahydropalmatinetetrahydropalmatine binds to and results in decreased activity of DRD1 protein17361394
D014028Tobacco Smoke PollutionDRD1 gene SNP affects the susceptibility to Tobacco Smoke Pollution25281486
D014635Valproic AcidValproic Acid results in increased methylation of DRD1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of DRD1 mRNA23665938
D014700VerapamilVerapamil inhibits the reaction [SCH 23390 binds to DRD1 protein]9533112
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of DRD1 mRNA27935865
D019345Zinc AcetateZinc Acetate inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
C016837zinc chloridezinc chloride inhibits the reaction [ecopipam binds to DRD1 protein]9109525
C016837zinc chloridezinc chloride inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
D019287Zinc SulfateZinc Sulfate inhibits the reaction [SCH 23390 binds to DRD1 protein]9109525
C022189zonisamideDRD1 protein promotes the reaction [zonisamide affects the secretion of Dopamine]19482038
C022189zonisamideDRD1 protein promotes the reaction [zonisamide affects the secretion of gamma-Aminobutyric Acid]19482038

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001588dopamine neurotransmitter receptor activity, coupled via Gs-IBA21873635  
GO:0001588dopamine neurotransmitter receptor activity, coupled via Gs-IDA2144334  2168520  
GO:0001588dopamine neurotransmitter receptor activity, coupled via Gs-IMP1282671  7838121  
GO:0001965G-protein alpha-subunit binding-IBA21873635  
GO:0004952dopamine neurotransmitter receptor activity-IDA1831904  
GO:0005515protein binding-IPI15569306  27460146  
GO:0035240dopamine binding-IBA21873635  
GO:0035240dopamine binding-IMP1282671  
GO ID GO Term Qualifier Evidence PubMed
GO:0001659temperature homeostasis-IEA-  
GO:0001661conditioned taste aversion-IEA-  
GO:0001662behavioral fear response-IEA-  
GO:0001932regulation of protein phosphorylation-IEA-  
GO:0001963synaptic transmission, dopaminergic-IEA-  
GO:0001975response to amphetamine-IEA-  
GO:0006606protein import into nucleus-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IDA1282671  
GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway-IDA2144334  11500503  
GO:0007190activation of adenylate cyclase activity-IDA2168520  
GO:0007191adenylate cyclase-activating dopamine receptor signaling pathway-IBA21873635  
GO:0007191adenylate cyclase-activating dopamine receptor signaling pathway-IDA1282671  2144334  2168520  7838121  17760784  18403039  
GO:0007416synapse assembly-ISS-  
GO:0007613memory-IEA-  
GO:0007617mating behavior-ISS-  
GO:0007625grooming behavior-IEA-  
GO:0007628adult walking behavior-ISS-  
GO:0008542visual learning-ISS-  
GO:0010628positive regulation of gene expression-IMP24136195  
GO:0014002astrocyte development-IEA-  
GO:0015872dopamine transport-IEA-  
GO:0019226transmission of nerve impulse-ISS-  
GO:0019228neuronal action potential-IEA-  
GO:0021542dentate gyrus development-IEA-  
GO:0021756striatum development-IEA-  
GO:0021853cerebral cortex GABAergic interneuron migration-ISS-  
GO:0030335positive regulation of cell migration-ISS-  
GO:0030432peristalsis-IEA-  
GO:0035106operant conditioning-IEA-  
GO:0042053regulation of dopamine metabolic process-IEA-  
GO:0042311vasodilation-IEA-  
GO:0042417dopamine metabolic process-IC8301582  
GO:0042493response to drug-ISS-  
GO:0042711maternal behavior-IEA-  
GO:0043268positive regulation of potassium ion transport-ISS-  
GO:0043987histone H3-S10 phosphorylation-IEA-  
GO:0046323glucose import-IEA-  
GO:0046959habituation-IEA-  
GO:0046960sensitization-IEA-  
GO:0048148behavioral response to cocaine-IEA-  
GO:0051281positive regulation of release of sequestered calcium ion into cytosol-IDA1282671  7838121  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IDA1282671  
GO:0051584regulation of dopamine uptake involved in synaptic transmission-IC8301582  
GO:0051968positive regulation of synaptic transmission, glutamatergic-ISS-  
GO:0060134prepulse inhibition-ISS-  
GO:0060158phospholipase C-activating dopamine receptor signaling pathway-IDA1282671  
GO:0060158phospholipase C-activating dopamine receptor signaling pathway-IGI17194762  
GO:0060291long-term synaptic potentiation-IEA-  
GO:0060292long term synaptic depression-IEA-  
GO:0071870cellular response to catecholamine stimulus-IDA18403039  
GO:1903351cellular response to dopamine-IMP24136195  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA11500503  15569306  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IC2144334  
GO:0016021integral component of membrane-IBA21873635  
GO:0060170ciliary membrane-IDA20531939  
GO:0097730non-motile cilium-IDA20531939  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04540Gap junction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375280Amine ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-390651Dopamine receptorsTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17158525Study of dopamine receptors genes polymorphisms in bipolar patients with comorbid alcohol abuse. (2007 Mar-Apr)Szczepankiewicz AAlcohol Alcohol
11347517[Genetics of addictive disorders]. (2000 Nov)Rothhammer FRev Med Chil
25660313Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence. (2015 Apr 1)Forero DADrug Alcohol Depend
26447226Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption. (2016 May)Celorrio DAlcohol Alcohol
22408582Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors. (2011 Dec)Blum KInt J Environ Res Public Health
9603612Mutation screening of the dopamine D1 receptor gene in Tourette's syndrome and alcohol dependent patients. (1998 May 8)Thompson MAm J Med Genet
22495174DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers. (2012 Jul)Lee WPharmacogenet Genomics
25319571Cocaine Withdrawal Impairs mGluR5-Dependent Long-Term Depression in Nucleus Accumbens Shell Neurons of Both Direct and Indirect Pathways. (2015 Dec)Huang CCMol Neurobiol
24078558HIV-related cognitive impairment shows bi-directional association with dopamine receptor DRD1 and DRD2 polymorphisms in substance-dependent and substance-independent populations. (2013 Oct)Jacobs MMJ Neurovirol
25907750Role of the D3 dopamine receptor in nicotine sensitization. (2015 Aug 1)Smith LNBehav Brain Res
24135011Case-control association analysis of dopamine receptor polymorphisms in alcohol dependence: a pilot study in Indian males. (2013 Oct 17)Prasad PBMC Res Notes
19135651Differential allelic expression of dopamine D1 receptor gene (DRD1) is modulated by microRNA miR-504. (2009 Apr 15)Huang WBiol Psychiatry
26059306[Depression and addiction comorbidity: towards a common molecular target?]. (2015 May)Arango-Lievano MMed Sci (Paris)
21083670Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). (2011 Feb)Hack LMAlcohol Clin Exp Res
18341651A haplotype of the DRD1 gene is associated with alcohol dependence. (2008 Apr)Batel PAlcohol Clin Exp Res
29032150Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. (2018 Jan 30)Sundararajan TGene
26810137Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder. (2017 Jan)Pagerols MPharmacogenomics J
12116270Relationship of the delta-opioid receptor gene to heroin abuse in a large Chinese case/control sample. (2002 Jun 1)Xu KAm J Med Genet
8750359Dopamine D1, D2 and D3 receptor genes in alcohol dependence. (1995 Winter)Sander TPsychiatr Genet
25875614Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans. (2015 May)Levran OAnn Hum Genet
27428758Nicotinic cholinergic and dopaminergic receptor mRNA expression in male and female rats with high or low preference for nicotine. (2016 Sep)Gozen OAm J Drug Alcohol Abuse
23873704MicroRNA expression profile and functional analysis reveal that miR-382 is a critical novel gene of alcohol addiction. (2013 Sep)Li JEMBO Mol Med
24001687Acute binge pattern cocaine administration induces region-specific effects in D1-r- and D2-r-expressing cells in eGFP transgenic mice. (2013 Dec 3)Lawhorn CNeuroscience
19179847Genetics of dopamine receptors and drug addiction: a comprehensive review. (2009 Feb)Le Foll BBehav Pharmacol
174669465' UTR polymorphism of dopamine receptor D1 (DRD1) associated with severity and temperament of alcoholism. (2007 Jun 15)Kim DJBiochem Biophys Res Commun
24561386Nucleus accumbens-specific interventions in RGS9-2 activity modulate responses to morphine. (2014 Jul)Gaspari SNeuropsychopharmacology
19563515DRD1 5'UTR variation, sex and early infant stress influence ethanol consumption in rhesus macaques. (2009 Aug)Newman TKGenes Brain Behav
12966314Association between dopamine receptor D1 gene DdeI polymorphism and sensation seeking in alcohol-dependent men. (2003 Aug)Limosin FAlcohol Clin Exp Res
10597426Smoking behavior is under the influence of a major quantitative trait locus on human chromosome 5q. (1999)Duggirala RGenet Epidemiol
9154217Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors. (1997 Jan)Comings DEMol Psychiatry
23976958Dopamine D1 receptor gene variation modulates opioid dependence risk by affecting transition to addiction. (2013)Zhu FPLoS One
25281486A DRD1 polymorphism predisposes to lung cancer among those exposed to secondhand smoke during childhood. (2014 Dec)Robles AICancer Prev Res (Phila)
28524260Presence of ethanol-sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens. (2017 Aug 1)Forstera BJ Physiol
24527678Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex. (2014 Jun)Echeverry-Alzate VBr J Pharmacol
23164614Chronic escalating cocaine exposure, abstinence/withdrawal, and chronic re-exposure: effects on striatal dopamine and opioid systems in C57BL/6J mice. (2013 Apr)Zhang YNeuropharmacology
8892535Lack of allelic association of dopamine D1 and D2 (TaqIA) receptor gene polymorphisms with reduced dopaminergic sensitivity to alcoholism. (1996 Sep)Heinz AAlcohol Clin Exp Res
24927283Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and major depressive disorder. (2014)Korhonen TPLoS One