Gene info: ID 1813

Gene: DRD2

GENE ID: 1813

Synonyms: D2DR|D2R

Description: dopamine receptor D2

Gene type: protein-coding

Location: 11q23.2

dbXrefs: Ensembl:ENSG00000149295 MIM:126450 Vega:OTTHUMG00000167717 UniprotKB:P14416

RefSeq: NG_008841.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 359

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.530e-2 (AD) 7.448e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OTOF	0.889
SLC35D3	0.889
GPR101	0.887
AMBN	0.881
DRD3	0.881
DGKK	0.879
SLC18A3	0.878
SAG	0.876
TMPRSS6	0.876
CHAT	0.868

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SYTL2	-0.33
ALDH1A1	-0.326
RNF182	-0.266
UNC13C	-0.263
ZIC2	-0.245
MSX1	-0.228
NANOS3	-0.223
SLC17A7	-0.222
CDKN2C	-0.216
TFAP2C	-0.214

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00182	Amphetamine	Small Molecule	300-62-9	Approved\|Illicit\|Investigational	Target
DB00246	Ziprasidone	Small Molecule	146939-27-7	Approved	Target
DB00248	Cabergoline	Small Molecule	81409-90-7	Approved	Target
DB00268	Ropinirole	Small Molecule	91374-21-9	Approved\|Investigational	Target
DB00334	Olanzapine	Small Molecule	132539-06-1	Approved\|Investigational	Target
DB00363	Clozapine	Small Molecule	5786-21-0	Approved	Target
DB00370	Mirtazapine	Small Molecule	85650-52-8	Approved	Target
DB00372	Thiethylperazine	Small Molecule	1420-55-9	Withdrawn	Target
DB00391	Sulpiride	Small Molecule	15676-16-1	Approved\|Investigational	Target
DB00408	Loxapine	Small Molecule	1977-10-2	Approved	Target
DB00409	Remoxipride	Small Molecule	80125-14-0	Approved\|Withdrawn	Target
DB00413	Pramipexole	Small Molecule	104632-26-0	Approved\|Investigational	Target
DB00420	Promazine	Small Molecule	58-40-2	Approved	Target
DB00433	Prochlorperazine	Small Molecule	58-38-8	Approved	Target
DB00450	Droperidol	Small Molecule	548-73-2	Approved	Target
DB00458	Imipramine	Small Molecule	50-49-7	Approved	Target
DB00477	Chlorpromazine	Small Molecule	50-53-3	Approved\|Investigational	Target
DB00490	Buspirone	Small Molecule	36505-84-7	Approved\|Investigational	Target
DB00502	Haloperidol	Small Molecule	52-86-8	Approved	Target
DB00508	Triflupromazine	Small Molecule	146-54-3	Approved	Target
DB00540	Nortriptyline	Small Molecule	72-69-5	Approved	Target
DB00543	Amoxapine	Small Molecule	14028-44-5	Approved	Target
DB00555	Lamotrigine	Small Molecule	84057-84-1	Approved\|Investigational	Target
DB00568	Cinnarizine	Small Molecule	298-57-7	Approved\|Investigational	Target
DB00589	Lisuride	Small Molecule	18016-80-3	Approved\|Investigational	Target
DB00623	Fluphenazine	Small Molecule	69-23-8	Approved	Target
DB00679	Thioridazine	Small Molecule	50-52-2	Approved\|Withdrawn	Target
DB00696	Ergotamine	Small Molecule	113-15-5	Approved	Target
DB00714	Apomorphine	Small Molecule	58-00-4	Approved\|Investigational	Target
DB00726	Trimipramine	Small Molecule	739-71-9	Approved	Target
DB00734	Risperidone	Small Molecule	106266-06-2	Approved\|Investigational	Target
DB00777	Propiomazine	Small Molecule	362-29-8	Approved	Target
DB00805	Minaprine	Small Molecule	25905-77-5	Approved	Target
DB00831	Trifluoperazine	Small Molecule	117-89-5	Approved\|Investigational	Target
DB00850	Perphenazine	Small Molecule	58-39-9	Approved	Target
DB00875	Flupentixol	Small Molecule	2709-56-0	Approved\|Investigational\|Withdrawn	Target
DB00915	Amantadine	Small Molecule	768-94-5	Approved	Target
DB00933	Mesoridazine	Small Molecule	5588-33-0	Approved\|Investigational	Target
DB00934	Maprotiline	Small Molecule	10262-69-8	Approved\|Investigational	Target
DB00988	Dopamine	Small Molecule	51-61-6	Approved	Target
DB01038	Carphenazine	Small Molecule	2622-30-2	Withdrawn	Target
DB01043	Memantine	Small Molecule	19982-08-2	Approved\|Investigational	Target
DB01049	Ergoloid mesylate	Small Molecule	8067-24-1	Approved	Target
DB01063	Acetophenazine	Small Molecule	2751-68-0	Approved	Target
DB01069	Promethazine	Small Molecule	60-87-7	Approved\|Investigational	Target
DB01100	Pimozide	Small Molecule	2062-78-4	Approved	Target
DB01142	Doxepin	Small Molecule	1668-19-5	Approved\|Investigational	Target
DB01151	Desipramine	Small Molecule	50-47-5	Approved\|Investigational	Target
DB01184	Domperidone	Small Molecule	57808-66-9	Approved\|Investigational	Target
DB01186	Pergolide	Small Molecule	66104-22-1	Approved\|Investigational\|Withdrawn	Target
DB01200	Bromocriptine	Small Molecule	25614-03-3	Approved\|Investigational	Target
DB01221	Ketamine	Small Molecule	6740-88-1	Approved	Target
DB01224	Quetiapine	Small Molecule	111974-69-7	Approved	Target
DB01233	Metoclopramide	Small Molecule	364-62-5	Approved\|Investigational	Target
DB01235	Levodopa	Small Molecule	59-92-7	Approved	Target
DB01238	Aripiprazole	Small Molecule	129722-12-9	Approved\|Investigational	Target
DB01239	Chlorprothixene	Small Molecule	113-59-7	Approved\|Investigational\|Withdrawn	Target
DB01267	Paliperidone	Small Molecule	144598-75-4	Approved	Target
DB01392	Yohimbine	Small Molecule	146-48-5	Approved\|Investigational	Target
DB01403	Methotrimeprazine	Small Molecule	60-99-1	Approved\|Investigational	Target
DB01425	Alizapride	Small Molecule	59338-93-1	Approved	Target
DB01549	Rolicyclidine	Small Molecule	2201-39-0	Experimental\|Illicit	Target
DB01614	Acepromazine	Small Molecule	61-00-7	Approved	Target
DB01618	Molindone	Small Molecule	7416-34-4	Approved	Target
DB01621	Pipotiazine	Small Molecule	39860-99-6	Approved\|Investigational	Target
DB01622	Thioproperazine	Small Molecule	316-81-4	Approved	Target
DB01623	Thiothixene	Small Molecule	3313-26-6	Approved	Target
DB01624	Zuclopenthixol	Small Molecule	53772-83-1	Approved\|Investigational	Target
DB04599	Aniracetam	Small Molecule	72432-10-1	Experimental	Target
DB04842	Fluspirilene	Small Molecule	1841-19-6	Approved\|Investigational	Target
DB04844	Tetrabenazine	Small Molecule	58-46-8	Approved\|Investigational	Target
DB04857	Brasofensine	Small Molecule	171655-91-7	Investigational	Target
DB04888	Bifeprunox	Small Molecule	350992-10-8	Investigational	Target
DB04889	Bicifadine	Small Molecule	71195-57-8	Investigational	Target
DB04924	Itopride	Small Molecule	122898-67-3	Investigational	Target
DB04946	Iloperidone	Small Molecule	133454-47-4	Approved	Target
DB05271	Rotigotine	Small Molecule	99755-59-6	Approved	Target
DB05316	Pimavanserin	Small Molecule	706779-91-1	Approved\|Investigational	Target
DB05687	BL-1020	Small Molecule	-	Investigational	Target
DB05766	ACP-104	Small Molecule	-	Investigational	Target
DB06016	Cariprazine	Small Molecule	839712-12-8	Approved\|Investigational	Target
DB06077	Lumateperone	Small Molecule	313368-91-1	Investigational	Target
DB06144	Sertindole	Small Molecule	106516-24-9	Approved\|Investigational\|Withdrawn	Target
DB06148	Mianserin	Small Molecule	24219-97-4	Approved\|Investigational	Target
DB06216	Asenapine	Small Molecule	65576-45-6	Approved	Target
DB06229	Ocaperidone	Small Molecule	129029-23-8	Investigational	Target
DB06288	Amisulpride	Small Molecule	71675-85-9	Approved\|Investigational	Target
DB06454	Sarizotan	Small Molecule	351862-32-3	Investigational	Target
DB06477	Sumanirole	Small Molecule	179386-43-7	Investigational	Target
DB08815	Lurasidone	Small Molecule	367514-87-2	Approved\|Investigational	Target
DB08922	Perospirone	Small Molecule	150915-41-6	Approved	Target
DB09018	Bromopride	Small Molecule	4093-35-0	Approved\|Investigational	Target
DB09097	Quinagolide	Small Molecule	87056-78-8	Approved\|Investigational	Target
DB09128	Brexpiprazole	Small Molecule	913611-97-9	Approved\|Investigational	Target
DB09194	Etoperidone	Small Molecule	52942-31-1	Withdrawn	Target
DB09207	AS-8112	Small Molecule	-	Experimental	Target
DB09223	Blonanserin	Small Molecule	132810-10-7	Approved\|Investigational	Target
DB09224	Melperone	Small Molecule	3575-80-2	Approved\|Investigational	Target
DB09225	Zotepine	Small Molecule	26615-21-4	Approved\|Investigational\|Withdrawn	Target
DB09286	Pipamperone	Small Molecule	1893-33-0	Approved\|Investigational	Target
DB12061	Pardoprunox	Small Molecule	269718-84-5	Investigational	Target
DB12093	Tetrahydropalmatine	Small Molecule	483-14-7	Investigational	Target
DB12478	Piribedil	Small Molecule	3605-01-4	Investigational	Target
DB12518	Raclopride	Small Molecule	84225-95-6	Investigational	Target
DB13025	Tiapride	Small Molecule	51012-32-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C461261	(1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate)	DRD2 protein results in increased susceptibility to (1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate)	19497322
C118559	1-bromopropane	1-bromopropane results in decreased expression of DRD2 mRNA	19576243
C031796	2,10,11-trihydroxy-N-n-propylnoraporphine	"2,10,11-trihydroxy-N-n-propylnoraporphine binds to and results in increased activity of DRD2 protein"	16325000
C045392	2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine	"2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine binds to DRD2 protein"	9723970
C041369	2-(N-phenethyl-N-propyl)amino-5-hydroxytetralin	2-(N-phenethyl-N-propyl)amino-5-hydroxytetralin binds to and results in increased activity of DRD2 protein	8892103
C054649	3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol	"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol affects the localization of DRD2 protein"	22791651
C054649	3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol	"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol promotes the reaction [HTR2A protein binds to DRD2 protein]"	22791651
C054649	3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol	"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased expression of DRD2 mRNA"	22791651
C094012	3-(3-cyanophenyl)-N-n-propylpiperidine	3-(3-cyanophenyl)-N-n-propylpiperidine binds to and results in decreased activity of DRD2 protein	11080548
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD2 protein"	10728880
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD2 protein"	10728880
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to DRD2 protein"	10700011
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD2 protein"	10683862\|1152246
C104750	3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole	3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole binds to and results in decreased activity of DRD2 protein	10728880
C104750	3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole	3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole binds to and results in decreased activity of DRD2 protein	16407246\|1681428
C480819	(3-exo)-8-benzoyl-N-(((2S)7-chloro-2,3-dihydro-1,4-benzodioxin-1-yl)methyl)-8-azabicyclo(3.2.1)octane-3-methanamine monohydrochloride	"(3-exo)-8-benzoyl-N-(((2S)7-chloro-2,3-dihydro-1,4-benzodioxin-1-yl)methyl)-8-azabicyclo(3.2.1)octane-3-methanamine monohydrochloride binds to and results in decreased activity of DRD2 protein"	12902993
C039167	3-N-methylspiperone	3-N-methylspiperone binds to DRD2 protein	9109525
C039167	3-N-methylspiperone	Aluminum inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
C039167	3-N-methylspiperone	Cadmium inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
C039167	3-N-methylspiperone	Copper inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
C039167	3-N-methylspiperone	Gadolinium inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
C039167	3-N-methylspiperone	Lanthanum inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
C039167	3-N-methylspiperone	Zinc Acetate inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
C039167	3-N-methylspiperone	zinc chloride inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
C039167	3-N-methylspiperone	Zinc Sulfate inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
C416545	4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline	"4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline binds to and results in increased activity of DRD2 protein"	1347779\|1977176\|
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD2 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of DRD2 protein	20570720
C501474	4-OH-2',3,3',4',5'-pentachlorobiphenyl	"4-OH-2',3,3',4',5'-pentachlorobiphenyl results in increased expression of DRD2 mRNA"	22996836
C501474	4-OH-2',3,3',4',5'-pentachlorobiphenyl	"4-OH-2',3,3',4',5'-pentachlorobiphenyl results in increased expression of DRD2 protein"	22996836
C086335	(5,6-dimethoxyindan-2-yl)dipropylamine	"(5,6-dimethoxyindan-2-yl)dipropylamine binds to and results in decreased activity of DRD2 protein"	10728880
C051171	5-methoxy-1-methyl-2-(n-propylamino)tetralin	5-methoxy-1-methyl-2-(n-propylamino)tetralin binds to and results in decreased activity of DRD2 protein	10728880
C083374	5-propylamino-5,6-dihydro-4H-imidazo(4,5,1-ij)quinolin-2(1H)-one	"5-propylamino-5,6-dihydro-4H-imidazo(4,5,1-ij)quinolin-2(1H)-one binds to and results in increased activity of DRD2 protein"	7663983
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD2 mRNA"	27188386
C461657	6-methoxymianserin	6-methoxymianserin binds to DRD2 protein	12109911
C031349	7-hydroxy-2-N,N-dipropylaminotetralin	"7-hydroxy-2-N,N-dipropylaminotetralin binds to and results in increased activity of DRD2 protein"	10728880
C031349	7-hydroxy-2-N,N-dipropylaminotetralin	"7-hydroxy-2-N,N-dipropylaminotetralin binds to and results in increased activity of DRD2 protein"	10728880
C031349	7-hydroxy-2-N,N-dipropylaminotetralin	"7-hydroxy-2-N,N-dipropylaminotetralin binds to DRD2 protein"	10700011
C031349	7-hydroxy-2-N,N-dipropylaminotetralin	"7-hydroxy-2-N,N-dipropylaminotetralin binds to and results in increased activity of DRD2 protein"	10217549\|1616352
C409874	7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine	"7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine binds to and results in decreased activity of DRD2 protein"	12447918
C090812	7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan	"7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in decreased activity of DRD2 protein"	10728880
C090812	7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan	"7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in increased activity of DRD2 protein"	10683862
C090812	7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan	"7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to DRD2 protein"	10700011
C081320	8-(3-chlorostyryl)caffeine	DRD2 protein affects the susceptibility to 8-(3-chlorostyryl)caffeine	11172060
C081320	8-(3-chlorostyryl)caffeine	DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]	11172060
C434584	8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine	"8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Spiperone binds to DRD2 protein]"	11927170
C095427	A 86929	A 86929 binds to DRD2 protein alternative form	8558425
C095427	A 86929	A 86929 results in increased activity of DRD2 protein alternative form	8558425
C095427	A 86929	A 86929 binds to DRD2 protein	8558425
C043877	acamprosate	DRD2 affects the susceptibility to acamprosate	19523047
D000082	Acetaminophen	Acetaminophen results in increased expression of DRD2 mRNA	26690555
C100162	acetophenazine	acetophenazine binds to DRD2 protein	6147851
D000242	Cyclic AMP	epigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	17958328
D000242	Cyclic AMP	[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	17958328
D000242	Cyclic AMP	CCKBR protein affects the reaction [[quinelorane binds to and results in increased activity of DRD2 protein] which results in decreased abundance of Cyclic AMP]	11880531
D000242	Cyclic AMP	[quinelorane binds to and results in increased activity of DRD2 protein] which results in decreased abundance of Cyclic AMP	11880531
D000336	Aerosols	Aerosols results in decreased expression of DRD2 mRNA	25265048
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of DRD2 mRNA	26260870
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of DRD2 mRNA"	20224926
C014959	albiflorin	albiflorin affects the expression of DRD2	26475043
C033968	alizapride	alizapride binds to and results in decreased activity of DRD2 protein	2571179\|8103596
C033968	alizapride	alizapride binds to DRD2 protein	2901473
C050408	alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol	alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol inhibits the reaction [EEDQ results in decreased expression of DRD2 protein]	7513362
C542924	alpha-pyrrolidinovalerophenone	[alpha-pyrrolidinovalerophenone results in increased secretion of Dopamine] results in increased activity of [DRD1 protein co-treated with DRD2 protein]	24418703
D000535	Aluminum	Aluminum inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
C010845	aluminum chloride	aluminum chloride results in decreased expression of DRD2 protein	17984145
C014983	amitraz	amitraz inhibits the reaction [Spiperone binds to DRD2 protein]	2833825
D017311	Amlodipine	Amlodipine inhibits the reaction [Raclopride binds to DRD2 protein]	9533112
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of DRD2 mRNA	16483693
D000657	Amoxapine	Amoxapine binds to DRD2 protein	11180191
D003913	Dextroamphetamine	Dextroamphetamine results in decreased expression of DRD2 protein	10024013
D000661	Amphetamine	DRD2 SNP affects the susceptibility to Amphetamine	19968402
D000661	Amphetamine	Amphetamine results in increased expression of DRD2 mRNA	16916582
D000661	Amphetamine	Amphetamine results in increased expression of DRD2 mRNA alternative form	17026527
D000661	Amphetamine	CACNA1D protein affects the reaction [Amphetamine results in increased expression of DRD2 mRNA alternative form]	17026527
D000661	Amphetamine	DRD2 results in increased susceptibility to Amphetamine	11790512
D000661	Amphetamine	Amphetamine inhibits the reaction [Spiperone binds to DRD2 protein]	2018630
D000661	Amphetamine	Amphetamine results in decreased expression of DRD2 mRNA	15183010\|1914507
D000661	Amphetamine	Amphetamine results in decreased expression of DRD2 protein	19145071
D000661	Amphetamine	Amphetamine results in increased activity of DRD2 protein	7861147
D000661	Amphetamine	Amphetamine results in increased activity of DRD2 protein	11224544
D047310	Apigenin	Apigenin inhibits the reaction [Rotenone results in decreased expression of DRD2 protein]	28389404
D001058	Apomorphine	[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole	8103921
D001058	Apomorphine	DRD2 protein results in increased susceptibility to Apomorphine	19497322
D001058	Apomorphine	Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]	8103921
D001058	Apomorphine	SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]	8103921
D001058	Apomorphine	DRD2 protein affects the susceptibility to Apomorphine	14639100\|2571179
D001058	Apomorphine	Risperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein]	7520908
D001058	Apomorphine	Apomorphine binds to and results in increased activity of DRD2 protein	10448923\|1347779
D001073	Aprindine	Aprindine binds to DRD2 protein	9808703
C119325	arachidonyl-2-chloroethylamide	arachidonyl-2-chloroethylamide results in decreased expression of DRD2 mRNA	22791651
D000068180	Aripiprazole	Aripiprazole binds to and results in increased activity of DRD2 protein	17069544
D000068180	Aripiprazole	[Aripiprazole binds to and results in increased activity of DRD2 protein] which results in increased susceptibility to Methamphetamine	17327886
D000068180	Aripiprazole	Aripiprazole binds to and affects the activity of DRD2 protein	16806092
D000068180	Aripiprazole	Aripiprazole binds to and results in increased activity of DRD2 protein	15830832\|1596057
D000068180	Aripiprazole	Aripiprazole binds to DRD2 protein	18363460
C032739	aroclor 1221	aroclor 1221 results in increased expression of DRD2 mRNA	26620572
D001151	Arsenic	Arsenic results in increased expression of DRD2 mRNA	24019935
D001280	Atrazine	Atrazine results in decreased expression of DRD2 mRNA	25929836
D001280	Atrazine	Atrazine affects the activity of DRD2 protein	11071396
D001381	Azepines	Azepines analog binds to and results in decreased activity of DRD2 protein	12593651
D001381	Azepines	Azepines analog binds to and results in decreased activity of DRD2 protein	12593651
D001464	Barium	"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester inhibits the reaction [DRD2 protein results in decreased transport of Barium]"	11124974
D001464	Barium	[DRD2 protein affects the abundance of Calcium] which results in decreased transport of Barium	11124974
D001464	Barium	DRD2 protein affects the reaction [N-n-propylnorapomorphine analog results in decreased transport of Barium]	11124974
D001464	Barium	DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]	11124974
D001464	Barium	DRD2 protein results in decreased transport of Barium	11124974
D001464	Barium	[DRD2 protein results in increased activity of PLCB1 protein] which results in decreased transport of Barium	11124974
D001464	Barium	Nifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]]	11124974
D001545	Benserazide	[Oxidopamine co-treated with levodopa methyl ester] inhibits the reaction [Benserazide results in increased expression of DRD2 protein]	19399396
C037689	benzamide	benzamide analog binds to and results in decreased activity of DRD2 protein	12373430
C037689	benzamide	benzamide analog binds to DRD2 protein	10638823
D001549	Benzamides	Benzamides analog binds to and results in decreased activity of DRD2 protein	12130853
D001549	Benzamides	Benzamides analog binds to and results in decreased activity of DRD2 protein	8676355
C031000	benzimidazole	benzimidazole analog binds to DRD2 protein	15237387
D001562	Benzimidazoles	Benzimidazoles analog binds to DRD2 protein	21509803
C039108	benzo(f)quinoline	benzo(f)quinoline analog binds to DRD2 protein	19053758
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of DRD2 mRNA	21839799
D004958	Estradiol	Estradiol results in increased expression of DRD2 mRNA	12008023
C023888	beta-hexachlorocyclohexane	beta-hexachlorocyclohexane results in decreased expression of DRD2 mRNA	25270620
C006780	bisphenol A	bisphenol A promotes the reaction [Raclopride binds to DRD2 protein]	20169576
C006780	bisphenol A	bisphenol A results in decreased expression of DRD2 mRNA	24066056\|2518105
C006780	bisphenol A	bisphenol A results in increased methylation of DRD2 gene	28505145
C120565	BP 897	BP 897 inhibits the reaction [N-n-propylnorapomorphine binds to DRD2 protein]	10432116
C120565	BP 897	BP 897 binds to and results in decreased activity of DRD2 protein	16005579
D001971	Bromocriptine	Bromocriptine affects the expression of DRD2 mRNA	20063113
D001971	Bromocriptine	DRD2 polymorphism results in increased susceptibility to Bromocriptine	16901644
D001971	Bromocriptine	Bromocriptine results in decreased expression of DRD2 mRNA	15781964
D001971	Bromocriptine	Bromocriptine results in increased expression of DRD2 mRNA	15781964
D001971	Bromocriptine	[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA	15781964
D001971	Bromocriptine	Bromocriptine binds to and results in increased activity of DRD2 mRNA	1534540
D001971	Bromocriptine	Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]	15781964
D001971	Bromocriptine	Bromocriptine results in decreased expression of DRD2 mRNA	15781964
D001971	Bromocriptine	DRD2 protein affects the susceptibility to Bromocriptine	8103596
D001971	Bromocriptine	Bromocriptine binds to and results in decreased activity of DRD2 protein	11752888\|1680385
D001971	Bromocriptine	Bromocriptine binds to and results in increased activity of DRD2 protein	10626749\|1068386
D001971	Bromocriptine	Bromocriptine results in increased activity of DRD2 protein	9777039
C006820	bromperidol	DRD2 promoter polymorphism affects the susceptibility to bromperidol	11505224
D002069	Butaclamol	Butaclamol binds to DRD2 protein	6147851
D002069	Butaclamol	Butaclamol binds to DRD2 protein	18457824
C047047	cabergoline	cabergoline binds to and results in increased activity of DRD2 protein	14673879\|1799268
D002104	Cadmium	Cadmium inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
D002110	Caffeine	DRD2 polymorphism affects the susceptibility to Caffeine	18305461
D002110	Caffeine	DRD2 protein results in increased susceptibility to Caffeine	11172060
D002110	Caffeine	"Caffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]]"	16889759
D002118	Calcium	[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium	8032591
D002118	Calcium	[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium	8032591
D002118	Calcium	Sulpiride inhibits the reaction [[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]	8032591
D002118	Calcium	Sulpiride inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]	8032591
D002118	Calcium	[DRD2 protein affects the abundance of Calcium] which results in decreased transport of Barium	11124974
D002220	Carbamazepine	Carbamazepine results in decreased expression of DRD2 protein	16478526
C018861	carbetapentane	carbetapentane binds to DRD2 protein	10888308
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of DRD2 mRNA	25270620
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of DRD2 mRNA	16644059
C012145	CF 25397	CF 25397 binds to and results in increased activity of DRD2 protein	10683862
C051347	CGS 15855A	CGS 15855A binds to and results in increased activity of DRD2 protein	10728880
C051347	CGS 15855A	CGS 15855A binds to and results in increased activity of DRD2 protein	10728880
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of DRD2 mRNA	21472459
D020111	Chlorodiphenyl (54% Chlorine)	Quercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of DRD2 mRNA]	21472459
D002746	Chlorpromazine	Chlorpromazine binds to DRD2 protein	6147851
D002746	Chlorpromazine	Chlorpromazine results in decreased activity of DRD2 protein	23611293
D002746	Chlorpromazine	DRD2 polymorphism results in decreased susceptibility to Chlorpromazine	15694263
D002749	Chlorprothixene	Chlorprothixene analog binds to DRD2 protein	8101879
D002749	Chlorprothixene	Chlorprothixene binds to DRD2 protein	8101879
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of DRD2 mRNA	17452286
D002936	Cinnarizine	Cinnarizine binds to DRD2 protein	11180191
D002936	Cinnarizine	Cinnarizine binds to DRD2 protein	7503767
D002936	Cinnarizine	Cinnarizine inhibits the reaction [nemonapride binds to DRD2 protein]	7503767
D002997	Clomipramine	Clomipramine results in increased expression of DRD2 protein	20619828
D003024	Clozapine	Clozapine binds to DRD2 protein	6147851
D003024	Clozapine	Clozapine binds to DRD2 protein	11997696\|1352677
D003024	Clozapine	[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein	15286066
D003024	Clozapine	DRD2 gene affects the susceptibility to Clozapine	15830237
D003024	Clozapine	DRD2 gene polymorphism affects the susceptibility to Clozapine	16278074
D003024	Clozapine	DRD2 gene SNP results in increased susceptibility to Clozapine	20375926
D003024	Clozapine	Clozapine binds to DRD2 protein alternative form	12476322
D003024	Clozapine	[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA	15781964
D003024	Clozapine	Clozapine results in decreased expression of DRD2 mRNA	17266109
D003024	Clozapine	Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]	15781964
D003024	Clozapine	Clozapine analog binds to DRD2 protein	11997696
D003024	Clozapine	Clozapine binds to and results in decreased activity of DRD2 protein	16033416
D003024	Clozapine	[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein	16033416
D003024	Clozapine	Clozapine binds to DRD2 protein	9723970
D003024	Clozapine	Clozapine promotes the reaction [Dopamine binds to DRD2 protein]	15716360
D003024	Clozapine	Clozapine results in decreased expression of DRD2 mRNA	15781964
D003024	Clozapine	DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]	16144542
D003024	Clozapine	DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]	16144542
D003024	Clozapine	DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]	16144542
D003024	Clozapine	DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]	16144542
D003024	Clozapine	DRD2 protein affects the susceptibility to Clozapine	11997696
D003024	Clozapine	Clozapine binds to and results in decreased activity of DRD2 protein	9111066
D003024	Clozapine	Clozapine binds to DRD2 protein	7520908
D003042	Cocaine	Cocaine affects the reaction [Raclopride binds to DRD2]	15010698
D003042	Cocaine	Cocaine results in decreased expression of DRD2 mRNA	18000554
D003042	Cocaine	Cocaine results in decreased expression of DRD2 protein	11126397\|1972378
D003042	Cocaine	DRD2 polymorphism results in increased susceptibility to Cocaine	17671965
D003042	Cocaine	DRD2 protein results in decreased susceptibility to Cocaine	11923462
D003042	Cocaine	DRD2 results in increased susceptibility to Cocaine	11790512
D003042	Cocaine	PDYN protein affects the reaction [Cocaine affects the expression of DRD2 protein]	17532787
D003042	Cocaine	Cocaine affects the expression of DRD2	17544385
D003042	Cocaine	Cocaine affects the expression of DRD2 mRNA	12892653\|1899054
D003042	Cocaine	Cocaine affects the expression of DRD2 protein	20435100
D003042	Cocaine	Cocaine affects the reaction [Spiperone binds to DRD2 protein]	17161392
D003042	Cocaine	Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]	20729865
D003042	Cocaine	Cocaine results in decreased expression of DRD2 mRNA	18305460
D003042	Cocaine	Cocaine results in decreased expression of DRD2 protein	18305460
D003042	Cocaine	Cocaine results in increased activity of DRD2 protein	19046384
D003042	Cocaine	Cocaine results in increased expression of DRD2 mRNA	15042275
D003042	Cocaine	Cocaine results in increased expression of DRD2 protein	11602327\|1504951
D003042	Cocaine	DRD2 protein affects the susceptibility to Cocaine	2213551
D003042	Cocaine	Methadone affects the reaction [Cocaine affects the expression of DRD2 mRNA]	18990547
D003042	Cocaine	Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]	20729865
D005576	Colforsin	epigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	17958328
D005576	Colforsin	[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	17958328
D003300	Copper	Copper deficiency results in increased expression of DRD2 mRNA	26033743
D003300	Copper	Copper inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
C007168	cyanazine	cyanazine affects the activity of DRD2 protein	11071396
C021166	cyclo(leucylglycine)	cyclo(leucylglycine) inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]	8115415
D003520	Cyclophosphamide	Cyclophosphamide binds to DRD2 protein	11180191
D016572	Cyclosporine	Cyclosporine promotes the reaction [Domperidone binds to DRD2 protein]	12673668
D016572	Cyclosporine	Cyclosporine results in decreased expression of DRD2 mRNA	25270620
C037304	cyhalothrin	cyhalothrin results in decreased expression of DRD2 mRNA	28495607
C037304	cyhalothrin	cyhalothrin results in decreased expression of DRD2 protein	22366556\|2849560
C017160	cypermethrin	cypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
C017160	cypermethrin	cypermethrin promotes the reaction [cypermethrin results in decreased expression of DRD2 mRNA]	25288152
C017160	cypermethrin	cypermethrin promotes the reaction [cypermethrin results in decreased expression of DRD2 protein]	25288152
C017160	cypermethrin	cypermethrin results in decreased expression of DRD2 mRNA	25288152
C017160	cypermethrin	cypermethrin results in decreased expression of DRD2 protein	25288152
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of DRD2 mRNA	23914054
C017180	decamethrin	decamethrin results in decreased expression of DRD2 mRNA	25912032
C017180	decamethrin	decamethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
D013759	Dronabinol	Dronabinol results in decreased expression of DRD2	21820648
C011741	demethylchlordimeform	demethylchlordimeform inhibits the reaction [Spiperone binds to DRD2 protein]	2833825
D003976	Diazinon	Diazinon affects the expression of DRD2 mRNA	18812211
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of DRD2 mRNA	15620428
D004006	Dichlorvos	Dichlorvos results in decreased activity of DRD2 protein	12186780
D004006	Dichlorvos	Nimodipine inhibits the reaction [Dichlorvos results in decreased activity of DRD2 protein]	12186780
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of DRD2 mRNA	28871463
D002117	Calcitriol	Calcitriol promotes the reaction [VDR protein results in decreased expression of DRD2 mRNA]	27450565
D004110	Diltiazem	Diltiazem inhibits the reaction [Raclopride binds to DRD2 protein]	9533112
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of DRD2 mRNA	27638505
C006208	dironyl	dironyl binds to DRD2 protein	11543991
C006208	dironyl	dironyl binds to and results in increased activity of DRD2 protein	1681090\|8098931
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD2 mRNA]	17434604
D004294	Domperidone	Cyclosporine promotes the reaction [Domperidone binds to DRD2 protein]	12673668
D004294	Domperidone	Domperidone binds to DRD2 protein	12673668
D004294	Domperidone	Domperidone binds to and results in decreased activity of DRD2 protein	10626749\|1207143
D004294	Domperidone	Domperidone binds to DRD2 protein	12130853
D004294	Domperidone	Domperidone binds to and results in decreased activity of DRD2 protein	12673668\|1294656
D007980	Levodopa	"Levodopa inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DRD2 mRNA]"	8915594
D004298	Dopamine	[Dopamine co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein	27717053
D004298	Dopamine	[Dopamine co-treated with Raclopride] promotes the reaction [Dopamine binds to DRD2 protein]	19439595
D004298	Dopamine	[alpha-pyrrolidinovalerophenone results in increased secretion of Dopamine] results in increased activity of [DRD1 protein co-treated with DRD2 protein]	24418703
D004298	Dopamine	Dopamine binds to DRD2 protein alternative form	12476322
D004298	Dopamine	Clozapine promotes the reaction [Dopamine binds to DRD2 protein]	15716360
D004298	Dopamine	Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]	20729865
D004298	Dopamine	cypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
D004298	Dopamine	DBH protein affects the reaction [Dopamine binds to DRD2 protein]	15716360
D004298	Dopamine	decamethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
D004298	Dopamine	Dopamine binds to DRD2 protein	15716360
D004298	Dopamine	Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]	16480889
D004298	Dopamine	Dopamine results in increased activity of DRD2 protein	19046384
D004298	Dopamine	DRD2 mutant form inhibits the reaction [Dopamine results in decreased expression of IL10 protein]	25818600
D004298	Dopamine	DRD2 mutant form inhibits the reaction [Dopamine results in decreased expression of TGFB1 protein]	25818600
D004298	Dopamine	DRD2 mutant form inhibits the reaction [Dopamine results in decreased expression of VEGFA protein]	25818600
D004298	Dopamine	DRD2 mutant form inhibits the reaction [Dopamine results in increased expression of TNF protein]	25818600
D004298	Dopamine	DRD2 protein affects the susceptibility to Dopamine	8103596
D004298	Dopamine	DRD4 protein affects the reaction [Dopamine binds to DRD2 protein]	15716360
D004298	Dopamine	estradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
D004298	Dopamine	Ethanol affects the reaction [Dopamine binds to DRD2 protein]	15716360
D004298	Dopamine	GRK6 protein affects the reaction [Dopamine binds to DRD2 protein]	15716360
D004298	Dopamine	Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
D004298	Dopamine	Haloperidol promotes the reaction [Dopamine binds to DRD2 protein]	15716360
D004298	Dopamine	olanzapine promotes the reaction [Dopamine binds to DRD2 protein]	15716360
D004298	Dopamine	Quetiapine Fumarate promotes the reaction [Dopamine binds to DRD2 protein]	15716360
D004298	Dopamine	[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine	10936494
D004298	Dopamine	[Raclopride binds to and results in decreased activity of DRD2 protein] which results in increased abundance of Dopamine	15341276
D004298	Dopamine	[Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [Dopamine results in decreased susceptibility to Pilocarpine]	15140183
D004298	Dopamine	Risperidone promotes the reaction [Dopamine binds to DRD2 protein]	15716360
D004298	Dopamine	Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]	20729865
D004298	Dopamine	tautomycin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
D004298	Dopamine	Tea inhibits the reaction [Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]]	16480889
D004298	Dopamine	Dopamine results in increased activity of DRD2 protein	18005069
D018491	Dopamine Agonists	Dopamine Agonists binds to DRD2 protein	11543991
C000470	EEDQ	alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol inhibits the reaction [EEDQ results in decreased expression of DRD2 protein]	7513362
C000470	EEDQ	EEDQ results in decreased expression of DRD2 protein	7513362
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	17958328
C074283	estradiol 3-benzoate	estradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
D000431	Ethanol	[Haloperidol binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Ethanol	19120057
D000431	Ethanol	Ethanol affects the reaction [Dopamine binds to DRD2 protein]	15716360
D000431	Ethanol	Ethanol results in increased expression of DRD2 mRNA	18713641
C521336	ethyl 4-(4-((2-hydroxy-3-(4-hydroxy-3-((methylsulfonyl)amino)phenoxy)propyl)amino)cyclohexyl)benzoate	ethyl 4-(4-((2-hydroxy-3-(4-hydroxy-3-((methylsulfonyl)amino)phenoxy)propyl)amino)cyclohexyl)benzoate affects the activity of DRD2 protein	23611293
C045989	eticlopride	eticlopride results in decreased activity of DRD2 protein	27920206
C045989	eticlopride	eticlopride results in decreased activity of DRD2 protein	2213551
C045989	eticlopride	eticlopride binds to and results in decreased activity of DRD2 protein	14498848\|1602370
C045989	eticlopride	eticlopride results in decreased activity of DRD2 protein	19996296
D005231	Fatty Acids, Unsaturated	"Fatty Acids, Unsaturated deficiency results in decreased expression of DRD2 mRNA"	11916751
D005231	Fatty Acids, Unsaturated	"Fatty Acids, Unsaturated deficiency results in increased expression of DRD2 mRNA"	11916751
C071320	FCE 23884	FCE 23884 binds to and results in decreased activity of DRD2 protein	8723141
C047360	felbamate	felbamate inhibits the reaction [Haloperidol affects the activity of DRD2 protein]	7845605
C065065	FLB 457	FLB 457 binds to DRD2 protein	18058087
D005444	Flunarizine	Flunarizine binds to DRD2	8794996
D005444	Flunarizine	Flunarizine inhibits the reaction [Raclopride binds to DRD2 protein]	9533112
D005444	Flunarizine	Flunarizine binds to DRD2 protein	7503767
D005444	Flunarizine	Flunarizine inhibits the reaction [nemonapride binds to DRD2 protein]	7503767
C083673	fluoroclebopride	fluoroclebopride binds to DRD2 protein	10638823
D005473	Fluoxetine	Fluoxetine affects the expression of DRD2	26475043
D005473	Fluoxetine	Fluoxetine results in decreased expression of DRD2 mRNA	11981225
D005476	Fluphenazine	Fluphenazine binds to DRD2 protein	6147851
D005476	Fluphenazine	Fluphenazine binds to DRD2 protein	17606915
D005476	Fluphenazine	Fluphenazine binds to and results in decreased activity of DRD2 protein	1833784
C053619	fluphenazine-N-mustard	fluphenazine-N-mustard results in decreased activity of DRD2 protein	7476901
D005557	Formaldehyde	Dizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD2 mRNA]	17434604
D005557	Formaldehyde	Formaldehyde results in increased expression of DRD2 mRNA	17434604
C069837	fullerene C60	fullerene C60 results in decreased expression of DRD2 mRNA	19167457
C039281	furan	furan results in decreased expression of DRD2 mRNA	25539665
D005682	Gadolinium	Gadolinium inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
C408390	GR 218231	GR 218231 binds to and results in decreased activity of DRD2 protein	10728880
D006220	Haloperidol	Haloperidol binds to DRD2 protein	6147851
D006220	Haloperidol	DRD2 protein binds to Haloperidol	14552778
D006220	Haloperidol	DRD2 protein binds to Haloperidol analog	14552778
D006220	Haloperidol	Haloperidol affects the activity of DRD2 protein	23611293
D006220	Haloperidol	Haloperidol binds to DRD2 protein	11997696\|2036189
D006220	Haloperidol	Haloperidol results in increased expression of DRD2 mRNA	20730801
D006220	Haloperidol	Haloperidol results in increased expression of DRD2 protein	20730801
D006220	Haloperidol	Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]	20730801
D006220	Haloperidol	Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]	20730801
D006220	Haloperidol	DRD2 affects the susceptibility to Haloperidol	10720636
D006220	Haloperidol	DRD2 protein affects the susceptibility to Haloperidol	11172060
D006220	Haloperidol	Haloperidol binds to and results in decreased activity of DRD2 protein	19120057
D006220	Haloperidol	[Haloperidol binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Ethanol	19120057
D006220	Haloperidol	Haloperidol binds to DRD2	8794996
D006220	Haloperidol	Haloperidol binds to DRD2 protein	9808703
D006220	Haloperidol	Haloperidol binds to DRD2 protein alternative form	12476322
D006220	Haloperidol	Haloperidol results in increased expression of DRD2 protein	2945998
D006220	Haloperidol	[Haloperidol results in increased expression of DRD2 protein] which results in decreased susceptibility to Pentobarbital	2945998
D006220	Haloperidol	cyclo(leucylglycine) inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]	8115415
D006220	Haloperidol	DRD2 protein affects the reaction [Haloperidol results in increased expression of CTNNB1 protein]	16144542
D006220	Haloperidol	DRD2 protein affects the reaction [Haloperidol results in increased expression of DVL3 protein]	16144542
D006220	Haloperidol	DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3A protein]	16144542
D006220	Haloperidol	DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3B protein]	16144542
D006220	Haloperidol	felbamate inhibits the reaction [Haloperidol affects the activity of DRD2 protein]	7845605
D006220	Haloperidol	Haloperidol binds to and results in decreased activity of DRD2 protein	1380082\|16033416
D006220	Haloperidol	[Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein	16033416
D006220	Haloperidol	Haloperidol binds to DRD2 protein	12191584\|1361536
D006220	Haloperidol	Haloperidol inhibits the reaction [iodosulpride binds to DRD2 protein]	7878047
D006220	Haloperidol	Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
D006220	Haloperidol	Haloperidol inhibits the reaction [Spiperone binds to DRD2 protein]	11927170
D006220	Haloperidol	Haloperidol promotes the reaction [Dopamine binds to DRD2 protein]	15716360
D006220	Haloperidol	Haloperidol results in increased expression of DRD2	1351265
D006220	Haloperidol	Haloperidol results in increased expression of DRD2 mRNA	7878047
D006220	Haloperidol	Haloperidol results in increased expression of DRD2 protein	18295747\|8115415
D006220	Haloperidol	zinc chloride inhibits the reaction [Haloperidol binds to DRD2 protein]	9109525
D006220	Haloperidol	Haloperidol affects the activity of DRD2 protein	7845605
D006220	Haloperidol	Haloperidol binds to and results in decreased activity of DRD2 protein	10613497\|1365866
D006220	Haloperidol	Haloperidol binds to DRD2 protein	7520908
D003932	Heroin	Heroin results in decreased expression of DRD2 protein	11126397
D012701	Serotonin	Serotonin inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]	20887679
D012701	Serotonin	Serotonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein]	20887679
C426805	idobenzamide	idobenzamide binds to DRD2 protein	15469457
C045105	iodosulpride	Haloperidol inhibits the reaction [iodosulpride binds to DRD2 protein]	7878047
C045105	iodosulpride	iodosulpride binds to DRD2 protein	7878047
D007501	Iron	[manganese chloride co-treated with Iron deficiency] results in increased expression of DRD2 protein	22479410
C554161	JB-788	JB-788 binds to and results in decreased activity of DRD2 protein	20580787
C554161	JB-788	JB-788 inhibits the reaction [Quinpirole binds to and results in increased activity of DRD2 protein]	20580787
D007608	Kainic Acid	DRD2 protein results in decreased susceptibility to Kainic Acid	11860278
C047781	lamotrigine	DRD2 protein results in increased susceptibility to lamotrigine	20021991
D007811	Lanthanum	Lanthanum inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
D007854	Lead	DRD2 gene polymorphism results in increased susceptibility to Lead	21205584
C008261	lead acetate	[lead acetate co-treated with Morphine] results in increased expression of DRD2 mRNA	23702354
C008261	lead acetate	[lead acetate co-treated with Morphine] results in increased expression of DRD2 protein	23702354
C008261	lead acetate	lead acetate results in increased expression of DRD2 mRNA	23702354
C008261	lead acetate	lead acetate results in increased expression of DRD2 protein	23702354
C090111	LEK 8829	LEK 8829 binds to and results in decreased activity of DRD2 protein	15138661
C035420	levodopa methyl ester	[Oxidopamine co-treated with levodopa methyl ester] inhibits the reaction [Benserazide results in increased expression of DRD2 protein]	19399396
D001556	Lindane	Lindane results in increased expression of DRD2 mRNA	25572523
D008090	Lisuride	Lisuride binds to and results in increased activity of DRD2 protein	10379793\|1068386
D008094	Lithium	Lithium results in decreased expression of DRD2 protein	16478526
D008152	Loxapine	Loxapine binds to DRD2 protein	6147851
D008152	Loxapine	Loxapine analog binds to DRD2 protein	9723970
D008152	Loxapine	Loxapine binds to DRD2 protein	9723970
D008152	Loxapine	Loxapine binds to DRD2 protein	8101879
D000069056	Lurasidone Hydrochloride	Lurasidone Hydrochloride binds to and results in decreased activity of DRD2 protein	20404009
D008344	Maneb	[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA	23017109
D008345	Manganese	Manganese results in decreased expression of DRD2 mRNA	20224926
C025340	manganese chloride	manganese chloride results in decreased expression of DRD2 protein	24969583
C025340	manganese chloride	Melatonin promotes the reaction [manganese chloride results in decreased expression of DRD2 protein]	24969583
C025340	manganese chloride	[manganese chloride co-treated with Iron deficiency] results in increased expression of DRD2 protein	22479410
C025340	manganese chloride	manganese chloride inhibits the reaction [DRD2 protein binds to Spiperone]	21484877
C025340	manganese chloride	manganese chloride results in increased expression of DRD2	23458069
C025340	manganese chloride	manganese chloride results in increased expression of DRD2 protein	22479410
C025340	manganese chloride	manganese chloride results in increased expression of DRD2 protein alternative form	21484877
C054218	manidipine	manidipine binds to DRD2	8794996
C054218	manidipine	manidipine inhibits the reaction [Raclopride binds to DRD2 protein]	9533112
D008550	Melatonin	Melatonin promotes the reaction [manganese chloride results in decreased expression of DRD2 protein]	24969583
D008550	Melatonin	Melatonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein]	18289173
D008555	Melitten	Melitten inhibits the reaction [Spiperone binds to DRD2 protein]	20969853
C548233	mephedrone	mephedrone results in decreased expression of DRD2 protein	25817894
D008691	Methadone	Methadone affects the reaction [Cocaine affects the expression of DRD2 mRNA]	18990547
D008694	Methamphetamine	DRD2 gene polymorphism results in increased susceptibility to Methamphetamine	18555060
D008694	Methamphetamine	Methamphetamine results in decreased expression of DRD2 protein	11126397\|1172901
D008694	Methamphetamine	DRD2 gene results in increased susceptibility to Methamphetamine	18363855
D008694	Methamphetamine	DRD2 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]	20340177
D008694	Methamphetamine	DRD2 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]	20340177
D008694	Methamphetamine	[Sulpiride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methamphetamine	20340177
D008694	Methamphetamine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine inhibits the reaction [Methamphetamine affects the activity of DRD2 protein]"	18489579
D008694	Methamphetamine	[Aripiprazole binds to and results in increased activity of DRD2 protein] which results in increased susceptibility to Methamphetamine	17327886
D008694	Methamphetamine	Methamphetamine affects the activity of DRD2 protein	18489579
D008694	Methamphetamine	Methamphetamine inhibits the reaction [Sulpiride binds to DRD2 protein]	2891082
D008694	Methamphetamine	Methamphetamine results in decreased expression of DRD2 protein	2891082
D008694	Methamphetamine	Methamphetamine results in increased activity of DRD2 protein	19046384
D008728	Methotrimeprazine	Methotrimeprazine binds to DRD2 protein	8101879
C445068	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased activity of DRD2 protein"	28790194
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of DRD2 mRNA	21385734
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"Caffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]]"	16889759
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]"	16889759
D008774	Methylphenidate	Methylphenidate results in decreased expression of DRD2 mRNA	22470460
D008774	Methylphenidate	Methylphenidate affects the expression of DRD2 protein	17599397
D008774	Methylphenidate	[Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methylphenidate	11454915
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of DRD2 mRNA	26558463
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects the expression of DRD2 protein"	1780015
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DRD2 mRNA"	15514976\|8915594
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DRD2 protein"	15514976
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Levodopa inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DRD2 mRNA]"	8915594
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DRD2 mRNA"	15885624
D008787	Metoclopramide	Metoclopramide binds to and results in decreased activity of DRD2 protein	11561213\|2117557
D008787	Metoclopramide	Metoclopramide binds to DRD2 protein	9808703
D008787	Metoclopramide	Metoclopramide binds to and results in decreased activity of DRD2 protein	20519576
D008787	Metoclopramide	Metoclopramide binds to and results in decreased activity of DRD2 protein	17201744\|1730366
D008787	Metoclopramide	Metoclopramide binds to DRD2 protein	12130853\|1259365
D008787	Metoclopramide	Metoclopramide results in increased expression of DRD2 protein	18457824
D008787	Metoclopramide	Metoclopramide binds to and results in decreased activity of DRD2 protein	21173550\|2169103
C035133	mirtazapine	mirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein]	12523492
C001801	mitragynine	mitragynine binds to DRD2 protein	27192616
D008972	Molindone	Molindone binds to DRD2 protein	6147851
D008972	Molindone	Molindone binds to and results in decreased activity of DRD2 protein	3283778
D009020	Morphine	Morphine results in increased expression of DRD2 mRNA	17063042
D009020	Morphine	DRD2 protein affects the susceptibility to Morphine	2571179
D009020	Morphine	[lead acetate co-treated with Morphine] results in increased expression of DRD2 mRNA	23702354
D009020	Morphine	[lead acetate co-treated with Morphine] results in increased expression of DRD2 protein	23702354
D009020	Morphine	Morphine results in decreased expression of DRD2 mRNA	15183518
C518313	N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine	"N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine binds to and results in decreased activity of DRD2 protein"	17300168\|1969524
C090413	N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide	[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine	15140183
C539157	N-(4-(2-(4-(3-cyano-5-trifluoromethylphenyl)piperazin-1-yl)ethyl)cyclohexyl)-3-pyridinesulfonic amide	N-(4-(2-(4-(3-cyano-5-trifluoromethylphenyl)piperazin-1-yl)ethyl)cyclohexyl)-3-pyridinesulfonic amide binds to and results in decreased activity of DRD2 protein	18548231
C097285	nafadotride	nafadotride binds to and results in decreased activity of DRD2 protein	10728880
C097285	nafadotride	nafadotride binds to and results in decreased activity of DRD2 protein	11522464
D009271	Naltrexone	DRD2 affects the susceptibility to Naltrexone	19523047
C068868	naltrindole benzofuran	naltrindole benzofuran binds to and results in decreased activity of DRD2 protein	19482038
C042631	naxagolide	naxagolide binds to and results in increased activity of DRD2 protein	1681090\|2140595\|
C064246	NCQ 298	NCQ 298 binds to DRD2 protein	8804920
C064246	NCQ 298	NCQ 298 binds to DRD2 protein	8804920
C030265	nemonapride	DRD2 promoter polymorphism affects the susceptibility to nemonapride	11505224
C030265	nemonapride	Cinnarizine inhibits the reaction [nemonapride binds to DRD2 protein]	7503767
C030265	nemonapride	Flunarizine inhibits the reaction [nemonapride binds to DRD2 protein]	7503767
C030265	nemonapride	nemonapride binds to DRD2 protein	7503767
C407426	neurotensin 69L	neurotensin 69L results in increased expression of DRD2 mRNA	17113052
C028007	nickel monoxide	nickel monoxide results in decreased expression of DRD2 mRNA	19167457
D009538	Nicotine	DRD2 mRNA results in decreased susceptibility to Nicotine	24239691
D009538	Nicotine	[Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Nicotine	1833784
D009543	Nifedipine	Nifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]]	11124974
D009553	Nimodipine	Nimodipine inhibits the reaction [Dichlorvos results in decreased activity of DRD2 protein]	12186780
D009585	Nitrogen Dioxide	Nitrogen Dioxide results in increased expression of DRD2 mRNA	19733627
C014707	nitrosobenzylmethylamine	[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of DRD2 mRNA	12517797
C009074	N-n-propylnorapomorphine	BP 897 inhibits the reaction [N-n-propylnorapomorphine binds to DRD2 protein]	10432116
C009074	N-n-propylnorapomorphine	N-n-propylnorapomorphine binds to DRD2 protein	10432116
C009074	N-n-propylnorapomorphine	DRD2 protein affects the reaction [N-n-propylnorapomorphine analog results in decreased transport of Barium]	11124974
C009074	N-n-propylnorapomorphine	N-n-propylnorapomorphine binds to DRD2 protein	6149133
C009074	N-n-propylnorapomorphine	Remoxipride inhibits the reaction [N-n-propylnorapomorphine binds to DRD2 protein]	6149133
C009074	N-n-propylnorapomorphine	N-n-propylnorapomorphine binds to and results in increased activity of DRD2 protein	10528146\|1090024
C016868	N-n-propyl-N-phenylethyl-4(3-hydroxyphenyl)ethylamine hydrochloride	N-n-propyl-N-phenylethyl-4(3-hydroxyphenyl)ethylamine hydrochloride results in increased activity of DRD2 protein	7936204
C025256	nonylphenol	nonylphenol results in increased expression of DRD2 mRNA	15620428
D009638	Norepinephrine	[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium	8032591
D009638	Norepinephrine	Sulpiride inhibits the reaction [[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]	8032591
D009638	Norepinephrine	Norepinephrine inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]	20887679
D009638	Norepinephrine	Norepinephrine inhibits the reaction [Rotenone results in increased expression of DRD2 protein]	20887679
D009638	Norepinephrine	Norepinephrine results in increased activity of DRD2 protein alternative form	8032591
C561226	N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate	"N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate binds to and results in increased activity of DRD2 protein"	21591752
D016627	Oxidopamine	Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]	16480889
D016627	Oxidopamine	[Oxidopamine co-treated with levodopa methyl ester] inhibits the reaction [Benserazide results in increased expression of DRD2 protein]	19399396
D016627	Oxidopamine	Oxidopamine results in increased expression of DRD2 mRNA	19118628
D016627	Oxidopamine	Oxidopamine results in increased expression of DRD2 protein	19399396
D016627	Oxidopamine	Tea inhibits the reaction [Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]]	16480889
C076029	olanzapine	DRD2 gene SNP results in increased susceptibility to olanzapine	20375926
C076029	olanzapine	DRD2 intron SNP results in increased susceptibility to olanzapine	21187413
C076029	olanzapine	olanzapine affects the activity of DRD2 protein	10482380
C076029	olanzapine	olanzapine binds to DRD2 protein	10831489\|2036189
C076029	olanzapine	olanzapine results in decreased activity of DRD2 protein	11198054
C076029	olanzapine	olanzapine binds to DRD2 protein	24389121
C076029	olanzapine	olanzapine promotes the reaction [Dopamine binds to DRD2 protein]	15716360
C076029	olanzapine	olanzapine binds to DRD2 protein	9754850
C005419	oxybutynin	oxybutynin binds to DRD2 protein	10888308
C084589	oxypertine	oxypertine results in increased expression of DRD2	1351265
D000068882	Paliperidone Palmitate	Paliperidone Palmitate binds to and results in decreased activity of DRD2 protein	19713555
D000068882	Paliperidone Palmitate	Paliperidone Palmitate binds to DRD2 protein	22214649
D000068882	Paliperidone Palmitate	Paliperidone Palmitate binds to DRD2 protein	22437487
D000068882	Paliperidone Palmitate	Paliperidone Palmitate binds to and results in decreased activity of DRD2 protein	19066856
D010269	Paraquat	[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA	23017109
D010269	Paraquat	Paraquat affects the expression of DRD2 mRNA	15206577
D010269	Paraquat	Paraquat results in increased expression of DRD2 mRNA	18198484
C480679	pardoprunox	pardoprunox binds to and results in increased activity of DRD2 protein	20721904
D052638	Particulate Matter	[Particulate Matter co-treated with Volatile Organic Compounds] results in decreased expression of DRD2 mRNA	25265048
D010424	Pentobarbital	[Haloperidol results in increased expression of DRD2 protein] which results in decreased susceptibility to Pentobarbital	2945998
D010433	Pentylenetetrazole	[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole	8103921
D010433	Pentylenetetrazole	Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]	8103921
D010433	Pentylenetetrazole	SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]	8103921
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of DRD2 mRNA	26686188
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of DRD2 mRNA	26529483
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of DRD2 protein	26529483
D010479	Pergolide	Pergolide results in increased activity of DRD2 protein	16129789
D010479	Pergolide	Pergolide binds to and results in increased activity of DRD2 protein	11261747\|1735633
C065533	perospirone	perospirone binds to and results in decreased activity of DRD2 protein	1975278
C065533	perospirone	perospirone inhibits the reaction [Spiperone binds to DRD2 protein]	1975278
D010546	Perphenazine	Perphenazine binds to DRD2 protein	6147851
D010546	Perphenazine	Perphenazine binds to and results in decreased activity of DRD2 protein	1365866
C539977	perphenazine GABA ester	perphenazine GABA ester binds to and results in decreased activity of DRD2 protein alternative form	18757185
C000593032	PGW5 compound	PGW5 compound binds to DRD2 protein	24389121
D010622	Phencyclidine	Phencyclidine results in decreased expression of DRD2 mRNA	17266109\|2065955
D010622	Phencyclidine	Phencyclidine results in decreased expression of DRD2 protein	20659557
D010627	Phenethylamines	Phenethylamines analog binds to DRD2 protein	16539400
D010634	Phenobarbital	Phenobarbital results in decreased expression of DRD2 mRNA	25270620
D010862	Pilocarpine	DRD2 protein results in decreased susceptibility to Pilocarpine	11860278
D010862	Pilocarpine	DRD2 protein results in decreased susceptibility to Pilocarpine	1365435
D010862	Pilocarpine	Pilocarpine inhibits the reaction [Spiperone binds to DRD2 protein]	16137708
D010862	Pilocarpine	Pilocarpine promotes the reaction [Spiperone binds to DRD2 protein]	14559291
D010862	Pilocarpine	Pilocarpine results in decreased activity of DRD2 protein	15876489
D010862	Pilocarpine	Pilocarpine results in decreased expression of DRD2 protein	15876489
D010862	Pilocarpine	[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine	15140183
D010862	Pilocarpine	[Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [Dopamine results in decreased susceptibility to Pilocarpine]	15140183
D010862	Pilocarpine	DRD2 protein promotes the reaction [NPY protein results in decreased susceptibility to Pilocarpine]	18005069
D010862	Pilocarpine	[Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [NPY protein results in decreased susceptibility to Pilocarpine]	18005069
D010868	Pimozide	Pimozide binds to DRD2 protein	6147851
D010868	Pimozide	Pimozide binds to and results in decreased activity of DRD2 protein	19958787
D010879	Piperazines	Piperazines analog binds to DRD2 protein	21509803
D010880	Piperidines	Piperidines analog binds to and results in decreased activity of DRD2 protein	12413863
D010891	Piribedil	Piribedil binds to and results in increased activity of DRD2 protein	10728880
D010891	Piribedil	Piribedil binds to and results in increased activity of DRD2 protein	10728880
D010936	Plant Extracts	Plant Extracts results in decreased expression of DRD2 mRNA	23557933
C061333	pramipexole	pramipexole binds to and results in increased activity of DRD2 protein	10728880
C061333	pramipexole	pramipexole binds to and results in increased activity of DRD2 protein	10728880
C061333	pramipexole	pramipexole binds to and results in increased activity of DRD2 protein	10683862\|1126174
C026539	preclamol	preclamol binds to and results in increased activity of DRD2 protein	1681090
D000069583	Pregabalin	Pregabalin results in decreased expression of DRD2 mRNA	22489711
C015586	propiverine	propiverine binds to DRD2 protein	10888308
D001498	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester	"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester inhibits the reaction [DRD2 protein results in decreased transport of Barium]"	11124974
D011725	Pyridines	Pyridines analog binds to and results in decreased activity of DRD2 protein	12593651
D011725	Pyridines	Pyridines analog binds to and results in decreased activity of DRD2 protein	12593651
D011794	Quercetin	Quercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of DRD2 mRNA]	21472459
D000069348	Quetiapine Fumarate	Quetiapine Fumarate promotes the reaction [Dopamine binds to DRD2 protein]	15716360
C047726	quinelorane	quinelorane binds to and results in increased activity of DRD2 protein	10728880
C047726	quinelorane	CCKBR protein affects the reaction [[quinelorane binds to and results in increased activity of DRD2 protein] which results in decreased abundance of Cyclic AMP]	11880531
C047726	quinelorane	[quinelorane binds to and results in increased activity of DRD2 protein] which results in decreased abundance of Cyclic AMP	11880531
C047726	quinelorane	quinelorane binds to and results in increased activity of DRD2 protein	10728880
C047726	quinelorane	quinelorane binds to and results in increased activity of DRD2 protein	10683862\|1188053
D017378	Quinolinic Acid	Quinolinic Acid results in increased expression of DRD2 protein	12207953
D015363	Quinolones	Quinolones analog binds to and results in increased activity of DRD2 protein	9171869
D019257	Quinpirole	Quinpirole binds to and results in increased activity of DRD2 protein	15725338
D019257	Quinpirole	DRD2 protein promotes the reaction [Quinpirole results in decreased expression of POU5F1 mRNA]	27920206
D019257	Quinpirole	DRD2 protein results in increased susceptibility to Quinpirole	27920206
D019257	Quinpirole	epigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	17958328
D019257	Quinpirole	JB-788 inhibits the reaction [Quinpirole binds to and results in increased activity of DRD2 protein]	20580787
D019257	Quinpirole	Quinpirole binds to and results in increased activity of DRD2 protein	20580787
D019257	Quinpirole	[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium	8032591
D019257	Quinpirole	[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]	17958328
D019257	Quinpirole	[Quinpirole co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein	27717053
D019257	Quinpirole	Quinpirole results in increased activity of DRD2 protein	27920206
D019257	Quinpirole	Sulpiride inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]	8032591
D019257	Quinpirole	"DRD2 affects the susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole]"	9547254
D019257	Quinpirole	DRD2 protein affects the reaction [Quinpirole results in increased phosphorylation of CFL1 protein]	27717053
D019257	Quinpirole	DRD2 results in increased susceptibility to Quinpirole	11790512
D019257	Quinpirole	Quinpirole binds to and results in increased activity of DRD2 protein	14622157
D019257	Quinpirole	cypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
D019257	Quinpirole	decamethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
D019257	Quinpirole	DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]	11124974
D019257	Quinpirole	DRD2 protein affects the susceptibility to Quinpirole	12071432
D019257	Quinpirole	estradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
D019257	Quinpirole	Haloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
D019257	Quinpirole	mirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein]	12523492
D019257	Quinpirole	Nifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]]	11124974
D019257	Quinpirole	Quinpirole binds to and results in increased activity of DRD2 protein	1724532
D019257	Quinpirole	[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine	10936494
D019257	Quinpirole	tautomycin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
D019257	Quinpirole	Quinpirole binds to and results in increased activity of DRD2 protein	10217549\|1066990
D019257	Quinpirole	Quinpirole results in increased activity of DRD2 protein alternative form	8032591
D020891	Raclopride	Cocaine affects the reaction [Raclopride binds to DRD2]	15010698
D020891	Raclopride	[Dopamine co-treated with Raclopride] promotes the reaction [Dopamine binds to DRD2 protein]	19439595
D020891	Raclopride	Raclopride binds to DRD2	15010698
D020891	Raclopride	Raclopride binds to DRD2 protein	18058087\|1943959
D020891	Raclopride	Amlodipine inhibits the reaction [Raclopride binds to DRD2 protein]	9533112
D020891	Raclopride	bisphenol A promotes the reaction [Raclopride binds to DRD2 protein]	20169576
D020891	Raclopride	Diltiazem inhibits the reaction [Raclopride binds to DRD2 protein]	9533112
D020891	Raclopride	DRD2 protein alternative form results in increased susceptibility to Raclopride	12476322
D020891	Raclopride	Flunarizine inhibits the reaction [Raclopride binds to DRD2 protein]	9533112
D020891	Raclopride	manidipine inhibits the reaction [Raclopride binds to DRD2 protein]	9533112
D020891	Raclopride	Raclopride binds to DRD2 protein	12673668\|1475680
D020891	Raclopride	Raclopride binds to DRD2 protein alternative form	12476322
D020891	Raclopride	Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]	8103921
D020891	Raclopride	Verapamil inhibits the reaction [Raclopride binds to DRD2 protein]	9533112
D020891	Raclopride	DRD2 protein affects the reaction [Raclopride results in increased expression of CTNNB1 protein]	16144542
D020891	Raclopride	DRD2 protein affects the reaction [Raclopride results in increased expression of GSK3A protein]	16144542
D020891	Raclopride	Raclopride binds to and results in decreased activity of DRD2 protein	15341276\|1554262
D020891	Raclopride	[Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methylphenidate	11454915
D020891	Raclopride	[Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Nicotine	1833784
D020891	Raclopride	[Raclopride binds to and results in decreased activity of DRD2 protein] which results in increased abundance of Dopamine	15341276
D020891	Raclopride	Raclopride binds to DRD2 protein	7901417\|8804920
D020891	Raclopride	Saponins inhibits the reaction [Raclopride binds to DRD2 protein]	16251992
D020891	Raclopride	Raclopride binds to and results in decreased activity of DRD2 protein	10098858\|1043541
D020891	Raclopride	Raclopride binds to and results in increased activity of DRD2 protein	16289883
D020891	Raclopride	Raclopride binds to DRD2 protein	16251992
D017330	Remoxipride	Remoxipride binds to and results in decreased activity of DRD2 protein	1724532\|6149133
D017330	Remoxipride	Remoxipride binds to DRD2 protein	7901417
D017330	Remoxipride	Remoxipride inhibits the reaction [N-n-propylnorapomorphine binds to DRD2 protein]	6149133
D017330	Remoxipride	Remoxipride inhibits the reaction [Spiperone binds to DRD2 protein]	6149133
D017330	Remoxipride	[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine	15140183
D017330	Remoxipride	[Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [Dopamine results in decreased susceptibility to Pilocarpine]	15140183
D017330	Remoxipride	Remoxipride binds to and results in decreased activity of DRD2 protein	20542064\|8103921
D017330	Remoxipride	Remoxipride results in decreased activity of DRD2 protein	15140183\|1800506
D017330	Remoxipride	[Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [NPY protein results in decreased susceptibility to Pilocarpine]	18005069
D012110	Reserpine	DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]	11172060
D012110	Reserpine	Reserpine results in increased expression of DRD2 mRNA	8419537
D012110	Reserpine	Reserpine results in increased expression of DRD2 mRNA alternative form	1331675
D018967	Risperidone	Risperidone binds to and results in decreased activity of DRD2 protein	16948927
D018967	Risperidone	DRD2 gene polymorphism affects the susceptibility to Risperidone	21869689
D018967	Risperidone	DRD2 gene polymorphism results in increased susceptibility to Risperidone	19339912
D018967	Risperidone	DRD2 gene SNP results in increased susceptibility to Risperidone	20375926
D018967	Risperidone	DRD2 protein results in increased susceptibility to Risperidone	21869689
D018967	Risperidone	Risperidone binds to and results in decreased activity of DRD2 protein	19910723
D018967	Risperidone	Risperidone binds to DRD2 protein	10831489\|1571005
D018967	Risperidone	Risperidone binds to DRD2 protein	22214649
D018967	Risperidone	DRD2 protein affects the reaction [Risperidone results in increased expression of CTNNB1 protein]	16144542
D018967	Risperidone	DRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein]	16144542
D018967	Risperidone	DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3A protein]	16144542
D018967	Risperidone	DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein]	16144542
D018967	Risperidone	Risperidone binds to and results in decreased activity of DRD2 protein	1380082\|16033416
D018967	Risperidone	[Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein	16033416
D018967	Risperidone	Risperidone binds to DRD2 protein	12191584\|2243748
D018967	Risperidone	Risperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein]	7520908
D018967	Risperidone	Risperidone promotes the reaction [Dopamine binds to DRD2 protein]	15716360
D018967	Risperidone	Risperidone binds to and results in decreased activity of DRD2 protein	16716128
D018967	Risperidone	Risperidone results in decreased activity of DRD2 protein	7508675
C046649	ropinirole	ropinirole binds to and results in increased activity of DRD2 protein	18393062
D012402	Rotenone	Apigenin inhibits the reaction [Rotenone results in decreased expression of DRD2 protein]	28389404
D012402	Rotenone	Melatonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein]	18289173
D012402	Rotenone	Norepinephrine inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]	20887679
D012402	Rotenone	Norepinephrine inhibits the reaction [Rotenone results in increased expression of DRD2 protein]	20887679
D012402	Rotenone	Rotenone results in decreased expression of DRD2 protein	28389404
D012402	Rotenone	Rotenone results in increased expression of DRD2 mRNA	20887679
D012402	Rotenone	Rotenone results in increased expression of DRD2 protein	18289173\|2088767
D012402	Rotenone	Serotonin inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]	20887679
D012402	Rotenone	Serotonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein]	20887679
C047508	rotigotine	rotigotine binds to and results in increased activity of DRD2 protein	23165154
D012503	Saponins	Saponins inhibits the reaction [Raclopride binds to DRD2 protein]	16251992
C443959	sarizotan	sarizotan binds to DRD2 protein	14767715
C443959	sarizotan	sarizotan binds to DRD2 protein	14767715
C534628	SCH 23390	SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]	8103921
C534628	SCH 23390	SCH 23390 binds to and results in decreased activity of DRD2 protein	9264077
C045359	setoperone	setoperone binds to and results in decreased activity of DRD2 protein	2524857
D019821	Simvastatin	Simvastatin results in increased expression of DRD2 mRNA	15711596
D019821	Simvastatin	Simvastatin results in increased expression of DRD2 protein	15711596
C017947	sodium arsenite	sodium arsenite results in decreased expression of DRD2 mRNA	20699118
C017947	sodium arsenite	sodium arsenite results in increased expression of DRD2 mRNA	25179238
C017947	sodium arsenite	sodium arsenite results in increased expression of DRD2 protein	25179238
D013134	Spiperone	Spiperone binds to and results in decreased activity of DRD2 protein	15725338
D013134	Spiperone	Spiperone binds to DRD2 protein	15237387
D013134	Spiperone	Spiperone binds to DRD2 protein	6147851
D013134	Spiperone	Melitten inhibits the reaction [Spiperone binds to DRD2 protein]	20969853
D013134	Spiperone	Spiperone binds to DRD2 protein	20969853\|2199957
D013134	Spiperone	amitraz inhibits the reaction [Spiperone binds to DRD2 protein]	2833825
D013134	Spiperone	demethylchlordimeform inhibits the reaction [Spiperone binds to DRD2 protein]	2833825
D013134	Spiperone	NR3C1 protein promotes the reaction [Spiperone binds to DRD2 protein]	11226678
D013134	Spiperone	Spiperone binds to DRD2 protein	11226678\|2833825
D013134	Spiperone	"8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Spiperone binds to DRD2 protein]"	11927170
D013134	Spiperone	Amphetamine inhibits the reaction [Spiperone binds to DRD2 protein]	2018630
D013134	Spiperone	"Caffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]]"	16889759
D013134	Spiperone	Cocaine affects the reaction [Spiperone binds to DRD2 protein]	17161392
D013134	Spiperone	Haloperidol inhibits the reaction [Spiperone binds to DRD2 protein]	11927170
D013134	Spiperone	manganese chloride inhibits the reaction [DRD2 protein binds to Spiperone]	21484877
D013134	Spiperone	"N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]"	16889759
D013134	Spiperone	perospirone inhibits the reaction [Spiperone binds to DRD2 protein]	1975278
D013134	Spiperone	Pilocarpine inhibits the reaction [Spiperone binds to DRD2 protein]	16137708
D013134	Spiperone	Pilocarpine promotes the reaction [Spiperone binds to DRD2 protein]	14559291
D013134	Spiperone	Remoxipride inhibits the reaction [Spiperone binds to DRD2 protein]	6149133
D013134	Spiperone	Spiperone binds to DRD2 protein	11927170\|1455929
D013134	Spiperone	Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]	20729865
D013134	Spiperone	Spiperone binds to DRD2 protein	2953603
D013134	Spiperone	DRD2 protein binds to Spiperone	21484877
D013134	Spiperone	Spiperone binds to and results in decreased activity of DRD2 protein	2947255\|8558425\|
D013134	Spiperone	Spiperone binds to DRD2 protein	17161392
C010513	stepholidine	stepholidine binds to and results in decreased activity of DRD2 protein	18521575
D013469	Sulpiride	Sulpiride binds to DRD2 protein	20361897
D013469	Sulpiride	Sulpiride inhibits the reaction [[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]	8032591
D013469	Sulpiride	Sulpiride inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]	8032591
D013469	Sulpiride	[Sulpiride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methamphetamine	20340177
D013469	Sulpiride	Methamphetamine inhibits the reaction [Sulpiride binds to DRD2 protein]	2891082
D013469	Sulpiride	Sulpiride binds to and results in decreased activity of DRD2 protein	8774428
D013469	Sulpiride	Sulpiride binds to DRD2 protein	2901473
D013469	Sulpiride	Sulpiride inhibits the reaction [Tacrolimus affects the activity of DRD2 protein]	15332494
D013469	Sulpiride	Sulpiride results in decreased activity of DRD2 protein	7644023
D013469	Sulpiride	Sulpiride results in increased expression of DRD2	1351265
D013469	Sulpiride	Sulpiride binds to and results in decreased activity of DRD2 protein	10379793\|1044892
D013469	Sulpiride	Sulpiride binds to DRD2 protein	2891082\|9087973
D013469	Sulpiride	Sulpiride results in decreased activity of DRD2 protein	6367362
C012052	sultopride	sultopride binds to DRD2 protein	12191584
D016559	Tacrolimus	Sulpiride inhibits the reaction [Tacrolimus affects the activity of DRD2 protein]	15332494
D016559	Tacrolimus	Tacrolimus affects the activity of DRD2 protein	15332494
C024763	talipexole	talipexole binds to and results in increased activity of DRD2 protein	1365866
C053079	tautomycin	tautomycin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]	10936494
D013662	Tea	Tea inhibits the reaction [Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]]	16480889
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DRD2 mRNA	21570461
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"DRD2 affects the susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole]"	9547254
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine inhibits the reaction [Methamphetamine affects the activity of DRD2 protein]"	18489579
C014215	tetrahydropalmatine	tetrahydropalmatine binds to and results in decreased activity of DRD2 protein	17361394
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]	20730801
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]	20730801
D013881	Thioridazine	Thioridazine binds to DRD2 protein	6147851
D013881	Thioridazine	Thioridazine binds to DRD2 protein	8101879
C050504	tianeptine	tianeptine results in decreased expression of DRD2 mRNA	11981225
D013976	Tiapamil Hydrochloride	Tiapamil Hydrochloride binds to DRD2 protein	9808703
D013976	Tiapamil Hydrochloride	Tiapamil Hydrochloride binds to DRD2 protein	2901473
D013976	Tiapamil Hydrochloride	Tiapamil Hydrochloride binds to and results in decreased activity of DRD2 protein	6858777
D013976	Tiapamil Hydrochloride	Tiapamil Hydrochloride results in decreased activity of DRD2 protein	4074571
D063325	Tiapride Hydrochloride	Tiapride Hydrochloride binds to and results in decreased activity of DRD2 protein	8241609
C052342	topiramate	topiramate results in increased expression of DRD2 mRNA	22489711
D014147	Tramadol	Tramadol results in increased expression of DRD2 protein	15464068
D014212	Tretinoin	Tretinoin promotes the reaction [ZMYND8 protein binds to DRD2 gene]	26655721
D014212	Tretinoin	Tretinoin promotes the reaction [ZMYND8 protein binds to DRD2 promoter]	26655721
D014212	Tretinoin	Tretinoin results in increased expression of DRD2 mRNA	26655721
D014212	Tretinoin	ZMYND8 protein affects the reaction [Tretinoin results in increased expression of DRD2 mRNA]	26655721
C012589	trichostatin A	trichostatin A results in increased expression of DRD2 mRNA	24204683
D014268	Trifluoperazine	Trifluoperazine binds to DRD2 protein	6147851
D014273	Triflupromazine	Triflupromazine binds to DRD2 protein	6147851
C108539	U 95666E	U 95666E binds to and results in increased activity of DRD2 protein	20494958
C045971	UH 232	UH 232 binds to and results in decreased activity of DRD2 protein	10728880
D014635	Valproic Acid	Valproic Acid results in decreased expression of DRD2 protein	16478526
D014635	Valproic Acid	Valproic Acid results in increased expression of DRD2 mRNA	23665938
D014700	Verapamil	Verapamil inhibits the reaction [Raclopride binds to DRD2 protein]	9533112
D014801	Vitamin A	Vitamin A results in decreased expression of DRD2 protein	22274401
D055549	Volatile Organic Compounds	[Particulate Matter co-treated with Volatile Organic Compounds] results in decreased expression of DRD2 mRNA	25265048
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD2 mRNA"	27188386
D015032	Zinc	[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of DRD2 mRNA	12517797
D015032	Zinc	Zinc deficiency results in decreased expression of DRD2 mRNA	15173390
D019345	Zinc Acetate	Zinc Acetate inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
C016837	zinc chloride	zinc chloride inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
C016837	zinc chloride	zinc chloride inhibits the reaction [Haloperidol binds to DRD2 protein]	9109525
D019287	Zinc Sulfate	Zinc Sulfate inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]	9109525
C092292	ziprasidone	ziprasidone binds to and results in decreased activity of DRD2 protein	7562537

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	-	IDA	8301582
GO:0004935	adrenergic receptor activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	10692483 17380124 19632986
GO:0008144	drug binding	-	IDA	8413587
GO:0035255	ionotropic glutamate receptor binding	-	IEA	-
GO:0042802	identical protein binding	-	IPI	18668123
GO:0042803	protein homodimerization activity	-	IEA	-
GO:0046982	protein heterodimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001659	temperature homeostasis	-	ISS	-
GO:0001666	response to hypoxia	-	IEA	-
GO:0001933	negative regulation of protein phosphorylation	-	IEA	-
GO:0001975	response to amphetamine	-	ISS	-
GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure	-	ISS	-
GO:0002027	regulation of heart rate	-	ISS	-
GO:0002028	regulation of sodium ion transport	-	ISS	-
GO:0002031	G-protein coupled receptor internalization	-	IEA	-
GO:0002052	positive regulation of neuroblast proliferation	-	ISS	-
GO:0002092	positive regulation of receptor internalization	-	IEA	-
GO:0006914	autophagy	-	IEA	-
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	-	IDA	8666994 26554819
GO:0007267	cell-cell signaling	-	IBA	21873635
GO:0007270	neuron-neuron synaptic transmission	-	ISS	-
GO:0007409	axonogenesis	-	ISS	-
GO:0007416	synapse assembly	-	ISS	-
GO:0007608	sensory perception of smell	-	ISS	-
GO:0007616	long-term memory	-	IEA	-
GO:0007625	grooming behavior	-	IEA	-
GO:0007626	locomotory behavior	-	ISS	-
GO:0007628	adult walking behavior	-	ISS	-
GO:0008104	protein localization	-	ISS	-
GO:0008285	negative regulation of cell proliferation	-	ISS	-
GO:0008306	associative learning	-	ISS	-
GO:0008542	visual learning	-	ISS	-
GO:0009416	response to light stimulus	-	ISS	-
GO:0010039	response to iron ion	-	IEA	-
GO:0014854	response to inactivity	-	IEA	-
GO:0016055	Wnt signaling pathway	-	IEA	-
GO:0021756	striatum development	-	IEA	-
GO:0021769	orbitofrontal cortex development	-	IEA	-
GO:0021853	cerebral cortex GABAergic interneuron migration	-	ISS	-
GO:0021984	adenohypophysis development	-	ISS	-
GO:0030336	negative regulation of cell migration	-	ISS	-
GO:0030432	peristalsis	-	ISS	-
GO:0031223	auditory behavior	-	IEA	-
GO:0032147	activation of protein kinase activity	-	IEA	-
GO:0032228	regulation of synaptic transmission, GABAergic	-	ISS	-
GO:0032467	positive regulation of cytokinesis	-	IMP	22888021
GO:0032922	circadian regulation of gene expression	-	ISS	-
GO:0033602	negative regulation of dopamine secretion	-	IEA	-
GO:0034776	response to histamine	-	IDA	16839358
GO:0035094	response to nicotine	-	IEA	-
GO:0035810	positive regulation of urine volume	-	IEA	-
GO:0035815	positive regulation of renal sodium excretion	-	IEA	-
GO:0040018	positive regulation of multicellular organism growth	-	IEA	-
GO:0042220	response to cocaine	-	ISS	-
GO:0042321	negative regulation of circadian sleep/wake cycle, sleep	-	IEA	-
GO:0042417	dopamine metabolic process	-	IC	8301582
GO:0042493	response to drug	-	ISS	-
GO:0042756	drinking behavior	-	IEA	-
GO:0043266	regulation of potassium ion transport	-	ISS	-
GO:0043278	response to morphine	-	ISS	-
GO:0043473	pigmentation	-	IEA	-
GO:0043666	regulation of phosphoprotein phosphatase activity	-	IEA	-
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway	-	IEA	-
GO:0045776	negative regulation of blood pressure	-	ISS	-
GO:0045824	negative regulation of innate immune response	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0046676	negative regulation of insulin secretion	-	IEA	-
GO:0048148	behavioral response to cocaine	-	ISS	-
GO:0048149	behavioral response to ethanol	-	ISS	-
GO:0048169	regulation of long-term neuronal synaptic plasticity	-	ISS	-
GO:0048678	response to axon injury	-	IEA	-
GO:0048755	branching morphogenesis of a nerve	-	ISS	-
GO:0050482	arachidonic acid secretion	-	IDA	8301582
GO:0050709	negative regulation of protein secretion	-	IDA	16839358
GO:0051209	release of sequestered calcium ion into cytosol	-	ISS	-
GO:0051584	regulation of dopamine uptake involved in synaptic transmission	-	IC	8301582
GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission	-	ISS	-
GO:0051823	regulation of synapse structural plasticity	-	IEA	-
GO:0051898	negative regulation of protein kinase B signaling	-	ISS	-
GO:0051898	negative regulation of protein kinase B signaling	-	NAS	21711983
GO:0051967	negative regulation of synaptic transmission, glutamatergic	-	ISS	-
GO:0060079	excitatory postsynaptic potential	-	NAS	21711983
GO:0060124	positive regulation of growth hormone secretion	-	ISS	-
GO:0060134	prepulse inhibition	-	ISS	-
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	-	IGI	17194762
GO:0060160	negative regulation of dopamine receptor signaling pathway	-	ISS	-
GO:0060548	negative regulation of cell death	-	IEA	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IEA	-
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	-	IBA	21873635
GO:0090325	regulation of locomotion involved in locomotory behavior	-	IEA	-
GO:1900168	positive regulation of glial cell-derived neurotrophic factor secretion	-	IDA	23373701
GO:1900273	positive regulation of long-term synaptic potentiation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001669	acrosomal vesicle	-	IEA	-
GO:0005886	plasma membrane	-	IDA	26554819
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IDA	8413587
GO:0014069	postsynaptic density	-	IEA	-
GO:0016328	lateral plasma membrane	-	IEA	-
GO:0030139	endocytic vesicle	-	IEA	-
GO:0030424	axon	-	ISS	-
GO:0030425	dendrite	-	ISS	-
GO:0036126	sperm flagellum	-	IEA	-
GO:0043197	dendritic spine	-	IEA	-
GO:0043204	perikaryon	-	IEA	-
GO:0043679	axon terminus	-	IEA	-
GO:0060170	ciliary membrane	-	IDA	20531939
GO:0097730	non-motile cilium	-	IDA	20531939

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction
hsa04540	Gap junction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375280	Amine ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-390651	Dopamine receptors	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24636783	Hypothesizing dopaminergic genetic antecedents in schizophrenia and substance seeking behavior. (2014 May)	Blum K	Med Hypotheses
1832467	No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism. (1991 Oct 2)	Gelernter J	JAMA
1832466	The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. (1991 Oct 2)	Comings DE	JAMA
15138759	Changes in food reward following smoking cessation: a pharmacogenetic investigation. (2004 Aug)	Lerman C	Psychopharmacology (Berl)
27490263	The association of dopamine pathway gene score, nicotine dependence and smoking cessation in a rural male population of Shandong, China. (2016 Sep)	Li S	Am J Addict
19603545	Association of the dopamine D2 receptor gene with alcohol dependence: haplotypes and subgroups of alcoholics as key factors for understanding receptor function. (2009 Jul)	Kraschewski A	Pharmacogenet Genomics
12482370	[Study on the association between smoking behavior and dopamine receptor D2 gene polymorphisms among lung cancer cases]. (2002 Oct)	Qi J	Zhonghua Liu Xing Bing Xue Za Zhi
19095220	Baseline expression of alpha4beta2* nicotinic acetylcholine receptors predicts motivation to self-administer nicotine. (2009 Apr 15)	Le Foll B	Biol Psychiatry
14643564	The A1 allele of the DRD2 gene (TaqI A polymorphisms) is associated with antisocial personality in a sample of alcohol-dependent patients. (2003 Nov)	Ponce G	Eur Psychiatry
24001687	Acute binge pattern cocaine administration induces region-specific effects in D1-r- and D2-r-expressing cells in eGFP transgenic mice. (2013 Dec 3)	Lawhorn C	Neuroscience
21244814	Waterpipe Smoking And The DRD2/ANKK1 Genotype. (2010)	Radwan GN	J Egypt Public Health Assoc
16426891	P300 development during adolescence: effects of DRD2 genotype. (2006 Mar)	Berman SM	Clin Neurophysiol
18563706	The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening study. (2009 Mar 5)	Styn MA	Am J Med Genet B Neuropsychiatr Genet
1478642	Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23. (1992 Dec)	Eubanks JH	Genomics
15066703	Polymorphisms of the dopamine D2 receptor, serotonin transporter, and GABA(A) receptor beta(3) subunit genes and alcoholism in Mexican-Americans. (2004 Jan)	Konishi T	Alcohol
10881203	Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: a review. (2000 Mar)	Noble EP	Eur Psychiatry
11319183	Association between the dopamine D2 receptor A2/A2 genotype and smoking behavior in the Japanese. (2001 Apr)	Yoshida K	Cancer Epidemiol Biomarkers Prev
10881206	The DRD2 gene and the risk for alcohol dependence in bipolar patients. (2000 Mar)	Gorwood P	Eur Psychiatry
10881204	Reappraisal of the association between the DRD2 gene, alcoholism and addiction. (2000 Mar)	Gorwood P	Eur Psychiatry
10881205	Association of D2 dopamine receptor and alcohol dehydrogenase 2 genes with Polynesian alcoholics. (2000 Mar)	Amadeo S	Eur Psychiatry
10597409	Brain event-related potentials, dopamine D2 receptor gene polymorphism, and smoking. (1999)	Anokhin AP	Genet Epidemiol
27819741	Association between dopamine D2 receptor gene polymorphisms and the risk of heroin dependence. (2016 Nov 3)	Wang N	Genet Mol Res
29464814	DRD2 promoter methylation and measures of alcohol reward: functional activation of reward circuits and clinical severity. (2018 Feb 21)	Bidwell LC	Addict Biol
26153084	CYP2B6 rs2279343 polymorphism is associated with smoking cessation success in bupropion therapy. (2015 Sep)	Tomaz PR	Eur J Clin Pharmacol
16840287	The genetic transmission of alcoholism: implications for prevention. (1993)	Noble EP	Drug Alcohol Rev
22958175	Association of dopamine-related gene alleles, smoking behavior and decline in FEV1 in subjects with COPD: findings from the lung health study. (2012 Dec)	Tashkin DP	COPD
19940429	Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART). (2009 Nov)	Blum K	Postgrad Med
12497624	D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. (2003 Jan 1)	Noble EP	Am J Med Genet B Neuropsychiatr Genet
29275025	[Genetic factors in alcohol dependence]. (2017 Dec 20)	Ramoz N	Presse Med
7485260	What can the DRD2/alcoholism story teach us about association studies in psychiatric genetics? (1995 Aug 14)	Neiswanger K	Am J Med Genet
19701675	Genetic susceptibility in solvent induced neurobehavioral effects. (2010 Apr)	Godderis L	Neurotox Res
16139486	The TaqIA polymorphism linked to the DRD2 gene is related to lower attention and less inhibitory control in alcoholic patients. (2006 Jan)	Rodriguez-Jimenez R	Eur Psychiatry
28192769	Disorganization at the stage of schizophrenia clinical outcome: Clinical-biological study. (2017 May)	Nestsiarovich A	Eur Psychiatry
17500623	Joint effect of dopaminergic genes on likelihood of smoking following treatment with bupropion SR. (2007 May)	Swan GE	Health Psychol
23443985	DRD2 and ANKK1 gene polymorphisms and alcohol dependence: a case-control study among a Mendelian population of East Asian ancestry. (2013 Jul-Aug)	Suraj Singh H	Alcohol Alcohol
10898923	Functional variant in the DRD2 receptor promoter region and subtypes of alcoholism. (2000 Jun 12)	Parsian A	Am J Med Genet
29032150	Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. (2018 Jan 30)	Sundararajan T	Gene
7748310	The DRD2 dopamine receptor and the candidate gene approach in alcoholism. (1993)	Goldman D	Alcohol Alcohol Suppl
10374739	Chromosome Workshop: chromosomes 11, 14, and 15. (1999 Jun 18)	Craddock N	Am J Med Genet
9034533	Association of the D2 dopamine receptor A1 allele with alcoholism: medical severity of alcoholism and type of controls. (1997 Feb 15)	Lawford BR	Biol Psychiatry
9034534	The dopamine D4 receptor gene (DRD4) is not associated with alcoholism in three Taiwanese populations: six polymorphisms tested separately and as haplotypes. (1997 Feb 15)	Chang FM	Biol Psychiatry
19246443	Association of the DRD2 gene Taq1A polymorphism and smoking behavior: a meta-analysis and new data. (2009 Jan)	Munafo MR	Nicotine Tob Res
27174576	Common Neurogenetic Diagnosis and Meso-Limbic Manipulation of Hypodopaminergic Function in Reward Deficiency Syndrome (RDS): Changing the Recovery Landscape. (2017)	Blum K	Curr Neuropharmacol
9129720	Association between early-onset alcoholism and the dopamine D2 receptor gene. (1997 Apr 18)	Kono Y	Am J Med Genet
22745721	Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study. (2012)	Jutras-Aswad D	PLoS One
25273375	NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence. (2015 Apr)	Bidwell LC	Psychopharmacology (Berl)
8612062	Candidate genes in alcoholism. (1995)	Goldman D	Clin Neurosci
21778150	A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults. (2012 Feb)	Bidwell LC	Nicotine Tob Res
25881752	Lack of association between DRD2 Taq1A gene polymorphism and smoking cessation therapy: a meta-analysis. (2015 Jun)	Choi HD	Int J Clin Pharmacol Ther
23483116	Neuro-Genetics of Reward Deficiency Syndrome (RDS) as the Root Cause of "Addiction Transfer": A New Phenomenon Common after Bariatric Surgery. (2011 Dec 23)	Blum K	J Genet Syndr Gene Ther
19376678	The TaqI A DRD2 polymorphism in type II alcohol dependence: a marker of age at onset or of a familial disease? (2009 Jun)	Pinto E	Alcohol
7550364	Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour. (1995 Jun)	Blum K	Pharmacogenetics
21906503	Different phenotypic and genotypic presentations in alcohol dependence: age at onset matters. (2011 Sep)	Chen YC	J Stud Alcohol Drugs
8886168	Lack of association between TaqI A1 allele of dopamine D2 receptor gene and alcohol-use disorders in atayal natives of Taiwan. (1996 Sep 20)	Chen CH	Am J Med Genet
25319571	Cocaine Withdrawal Impairs mGluR5-Dependent Long-Term Depression in Nucleus Accumbens Shell Neurons of Both Direct and Indirect Pathways. (2015 Dec)	Huang CC	Mol Neurobiol
29093669	Cocaine and Caffeine Effects on the Conditioned Place Preference Test: Concomitant Changes on Early Genes within the Mouse Prefrontal Cortex and Nucleus Accumbens. (2017)	Muniz JA	Front Behav Neurosci
8555738	The dopamine D2 receptor gene TaqI A1 polymorphism and alcoholism in a Mexican population. (1995 Winter)	Cruz C	Arch Med Res
16396745	Evolution of the DRD2 gene haplotype and its association with alcoholism in Mexican Americans. (2005 Jun)	Luo HR	Alcohol
17707567	Specific personality traits and dopamine, serotonin genes in anxiety-depressive alcoholism among Han Chinese in Taiwan. (2007 Oct 1)	Lin SC	Prog Neuropsychopharmacol Biol Psychiatry
23637880	Smoking-specific parenting and smoking onset in adolescence: the role of genes from the dopaminergic system (DRD2, DRD4, DAT1 genotypes). (2013)	Hiemstra M	PLoS One
28512340	Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism. (2017 May 16)	Yang HC	Sci Rep
15203796	The effects of the DRD2 polymorphism on smoking cessation and negative affect: evidence for a pharmacogenetic effect on mood. (2004 Apr)	Cinciripini P	Nicotine Tob Res
11918988	D(2) dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence. (2002 Mar)	Connor JP	Eur Psychiatry
21613303	Do alcohol-dependent individuals with DRD2 A1 allele have an increased risk of relapse? A pilot study. (2011 Sep-Oct)	Dahlgren A	Alcohol Alcohol
17158525	Study of dopamine receptors genes polymorphisms in bipolar patients with comorbid alcohol abuse. (2007 Mar-Apr)	Szczepankiewicz A	Alcohol Alcohol
26410615	An initial investigation of associations between dopamine-linked genetic variation and smoking motives in African Americans. (2015 Nov)	Bidwell LC	Pharmacol Biochem Behav
28507526	Behavioral and Neural Manifestations of Reward Memory in Carriers of Low-Expressing versus High-Expressing Genetic Variants of the Dopamine D2 Receptor. (2017)	Richter A	Front Psychol
25545355	Genetic variants and early cigarette smoking and nicotine dependence phenotypes in adolescents. (2014)	O'Loughlin J	PLoS One
17407504	Dopamine receptor genes (DRD2, DRD3 and DRD4) and gene-gene interactions associated with smoking-related behaviors. (2007 Mar)	Vandenbergh DJ	Addict Biol
25907750	Role of the D3 dopamine receptor in nicotine sensitization. (2015 Aug 1)	Smith LN	Behav Brain Res
24444411	Pharmacogenetics of nicotine addiction: role of dopamine. (2014 Feb)	Herman AI	Pharmacogenomics
19209988	Gene-environment interactions across development: Exploring DRD2 genotype and prenatal smoking effects on self-regulation. (2009 Jan)	Wiebe SA	Dev Psychol
18188764	A cost-effectiveness analysis of genetic testing of the DRD2 Taq1A polymorphism to aid treatment choice for smoking cessation. (2008 Jan)	Welton NJ	Nicotine Tob Res
8750359	Dopamine D1, D2 and D3 receptor genes in alcohol dependence. (1995 Winter)	Sander T	Psychiatr Genet
15542698	Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians. (2004 Oct)	Foley PF	Ann N Y Acad Sci
15545020	IDRD2 TaqIA polymorphism is associated with urinary homovanillic acid levels in a sample of Spanish male alcoholic patients. (2004)	Ponce G	Neurotox Res
12554675	Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. (2003 Feb 1)	Duan J	Hum Mol Genet
15389757	Association of the -141C Del variant of the dopamine D2 receptor (DRD2) with positive family history and suicidality in German alcoholics. (2005 Jan 5)	Johann M	Am J Med Genet B Neuropsychiatr Genet
9735043	DRD2 gene and alcoholism. (1998 Aug 28)	Noble EP	Science
19929252	Pharmacogenetics of D2 dopamine receptor gene in prolactin-secreting pituitary adenomas. (2010 Jan)	Filopanti M	Expert Opin Drug Metab Toxicol
7995569	[The allele A1 at the DRD2 locus on chromosome 11--genetic marker for alcoholism]. (1994 Nov 15)	Gur E	Harefuah
28805974	Effect of single-nucleotide polymorphisms in ADH1B, ADH4, ADH1C, OPRM1, DRD2, BDNF, and ALDH2 genes on alcohol dependence in a Caucasian population. (2017 Aug)	Katsarou MS	Pharmacol Res Perspect
20801583	Could the inter-individual variability in cocaine-induced psychotic effects influence the development of cocaine addiction? Towards a new pharmacogenetic approach to addictions. (2010 Dec)	Brousse G	Med Hypotheses
19373123	Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution. (2009 Jun)	Doehring A	Pharmacogenet Genomics
17761687	Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. (2007 Dec 1)	Yang BZ	Hum Mol Genet
8033754	The dopamine D2 receptor gene: a genetic risk factor in substance abuse. (1994 Feb)	Comings DE	Drug Alcohol Depend
12218663	No association between the dopamine D3 receptor gene and Korean alcohol dependence. (2002 Sep)	Lee MS	Psychiatr Genet
8871803	A genetic linkage study of the D2 dopamine receptor locus in heavy drinking and alcoholism. (1996 Aug)	Cook CC	Br J Psychiatry
16585473	Effect of team sport participation on genetic predisposition to adolescent smoking progression. (2006 Apr)	Audrain-McGovern J	Arch Gen Psychiatry
21663922	Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium. (2011 Aug 15)	McGuire V	J Neurol Sci
17466074	Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study. (2007 Apr 28)	Ton TG	Behav Brain Funct
21997315	ANKK1/DRD2 locus variants are associated with rimonabant efficacy in aiding smoking cessation: pilot data. (2011 Dec)	Wilcox CS	J Investig Med
11256581	The DRD2 gene in psychiatric and neurological disorders and its phenotypes. (2000 Aug)	Noble EP	Pharmacogenomics
17387332	Genetic variation in the dopamine D4 receptor (DRD4) gene and smoking cessation: follow-up of a randomised clinical trial of transdermal nicotine patch. (2008 Apr)	David SP	Pharmacogenomics J
25526961	Genetic influence of dopamine receptor, dopamine transporter, and nicotine metabolism on smoking cessation and nicotine dependence in a Japanese population. (2014 Dec 20)	Ohmoto M	BMC Genet
20554694	Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. (2010 Jul-Aug)	Kovanen L	Alcohol Alcohol
10710227	Family-based study of the association of the dopamine D2 receptor gene (DRD2) with habitual smoking. (2000 Feb 14)	Bierut LJ	Am J Med Genet
27613936	High Prevalence of Smoking in the Roma Population Seems to Have No Genetic Background. (2016 Dec)	Fiatal S	Nicotine Tob Res
11054765	The D(2) dopamine receptor A(1) allele and opioid dependence: association with heroin use and response to methadone treatment. (2000 Oct 9)	Lawford BR	Am J Med Genet
16032443	Polymorphisms in the DBH and DRD2 gene regions and smoking behavior. (2006 Mar)	Freire MT	Eur Arch Psychiatry Clin Neurosci
22046326	'Smoking genes': a genetic association study. (2011)	Verde Z	PLoS One
11054769	Haplotypes at the DRD2 locus and severe alcoholism. (2000 Oct 9)	Noble EP	Am J Med Genet
11236836	Genetic determinants of alcohol addiction and metabolism: a survey in Italy. (2001 Feb)	Pastorelli R	Alcohol Clin Exp Res
12210271	Gender-specific molecular heterosis of dopamine D2 receptor gene (DRD2) for smoking in schizophrenia. (2002 Aug 8)	Lee HS	Am J Med Genet
17928119	Genetics of Lesch's typology of alcoholism. (2008 Feb 15)	Samochowiec J	Prog Neuropsychopharmacol Biol Psychiatry
27447243	Association study of DRD2 A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A polymorphisms with alcohol dependence. (2016 Sep 1)	Ragia G	Drug Metab Pers Ther
21130610	Dose-dependent and sustained effects of varenicline on dopamine D2/3 receptor availability in rats. (2011 Feb)	Crunelle CL	Eur Neuropsychopharmacol
11331109	Stress as a mediating factor in the association between the DRD2 TaqI polymorphism and alcoholism. (2001 Feb)	Madrid GA	Alcohol
23340505	Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction. (2013 Jan 22)	Sullivan D	Transl Psychiatry
18690118	Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative mood. (2008 Sep)	Perkins KA	Behav Pharmacol
12811615	Pharmacogenomics: state of the research and perspectives in clinical application. (2003 May)	Severino G	Neurol Sci
25660313	Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence. (2015 Apr 1)	Forero DA	Drug Alcohol Depend
23635803	ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. (2013 Jul)	Spellicy CJ	Pharmacogenet Genomics
18690117	Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokers. (2008 Sep)	Perkins KA	Behav Pharmacol
16102380	DRD2 genotypes and substance use in adolescent children of alcoholics. (2005 Sep 1)	Conner BT	Drug Alcohol Depend
26447226	Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption. (2016 May)	Celorrio D	Alcohol Alcohol
10893740	[Genetic association between the reduced amplitude of the P300 and the allele A1 of the gene which codifies the D2 dopamine receptor (DRD2) as possible biological markers for alcoholism]. (2000 Apr 16-30)	Nacher V	Rev Neurol
10088049	No association between D2 dopamine receptor (DRD2) "A" system alleles, or DRD2 haplotypes, and posttraumatic stress disorder. (1999 Mar 1)	Gelernter J	Biol Psychiatry
17449448	Association in alcoholic patients between psychopathic traits and the additive effect of allelic forms of the CNR1 and FAAH endocannabinoid genes, and the 3' region of the DRD2 gene. (2007 Jan)	Hoenicka J	Neurotox Res
26449981	Parental smoke exposure and the development of nicotine craving in adolescent novice smokers: the roles of DRD2, DRD4, and OPRM1 genotypes. (2015 Oct 8)	Kleinjan M	BMC Pulm Med
9858031	D2 dopamine receptor and GABA(A) receptor beta3 subunit genes and alcoholism. (1998 Nov 16)	Noble EP	Psychiatry Res
17948902	Dopaminergic mutations: within-family association and linkage in multiplex alcohol dependence families. (2008 Jun 5)	Hill SY	Am J Med Genet B Neuropsychiatr Genet
10327432	D2 dopamine receptor gene (DRD2) allele and haplotype frequencies in alcohol dependent and control subjects: no association with phenotype or severity of phenotype. (1999 Jun)	Gelernter J	Neuropsychopharmacology
9259374	Linkage and association of a functional DRD2 variant [Ser311Cys] and DRD2 markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians. (1997 Jul 25)	Goldman D	Am J Med Genet
18828801	Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence. (2008 Dec)	Yang BZ	Alcohol Clin Exp Res
15457501	Relationship between dopaminergic neurotransmission, alcoholism, and Reward Deficiency syndrome. (2005 Jan 5)	Bowirrat A	Am J Med Genet B Neuropsychiatr Genet
25380208	Association and family studies of DRD2 gene polymorphisms in alcohol dependence syndrome. (2014 Nov 6)	Malecka I	Postepy Hig Med Dosw (Online)
25364629	Caudate Volume in Offspring at Ultra High Risk for Alcohol Dependence: COMT Val158Met, DRD2, Externalizing Disorders, and Working Memory. (2013 Oct 1)	Hill SY	Adv J Mol Imaging
12395869	Association between smoking habits and dopamine receptor D2 taqI A A2 allele in Japanese males: a confirmatory study. (2002 Jul)	Hamajima N	J Epidemiol
22990224	Association between dopamine receptor 2 TaqIA polymorphisms and smoking behavior with an influence of ethnicity: a systematic review and meta-analysis update. (2013 Mar)	Ohmoto M	Nicotine Tob Res
28548579	Genetic Variation of the Mu Opioid Receptor (OPRM1) and Dopamine D2 Receptor (DRD2) is Related to Smoking Differences in Patients with Schizophrenia but not Bipolar Disorder. (Spring 2017)	Hirasawa-Fujita M	Clin Schizophr Relat Psychoses
24892317	Genetic variants associated with addictive behavior in Colombian addicted and non-addicted to heroin or cocaine. (2013 Jan)	Isaza C	Colomb Med (Cali)
22698582	DRD2/ANKK1 TaqIA and SLC6A3 VNTR polymorphisms in alcohol dependence: association and gene-gene interaction study in a population of Central Italy. (2012 Aug 1)	Mignini F	Neurosci Lett
17943029	Alcohol consumption is associated with an interaction between DRD2 exon 8 A/A genotype and self-directedness in males. (2007)	Lucht M	Neuropsychobiology
25139281	Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions. (2015 Feb)	Ma Y	Mol Neurobiol
23238469	Influence of DRD2 and ANKK1 polymorphisms on the manifestation of withdrawal syndrome symptoms in alcohol addiction. (2012)	Grzywacz A	Pharmacol Rep
28937693	Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117). (2017 Oct)	Clarke TK	Mol Psychiatry
20575787	Lack of association of the dopamine D4 receptor gene polymorphism with alcoholism in a Brazilian population. (1999 Apr)	Roman T	Addict Biol
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