Gene: DRD2

1813
D2DR|D2R
dopamine receptor D2
protein-coding
11q23.2
Ensembl:ENSG00000149295 MIM:126450 Vega:OTTHUMG00000167717 UniprotKB:P14416
NG_008841.1
PubMed
CD|OD|ND|AD
359   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.530e-2 (AD)  7.448e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTOF0.889
SLC35D30.889
GPR1010.887
AMBN0.881
DRD30.881
DGKK0.879
SLC18A30.878
SAG0.876
TMPRSS60.876
CHAT0.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYTL2-0.33
ALDH1A1-0.326
RNF182-0.266
UNC13C-0.263
ZIC2-0.245
MSX1-0.228
NANOS3-0.223
SLC17A7-0.222
CDKN2C-0.216
TFAP2C-0.214

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00182AmphetamineSmall Molecule300-62-9Approved|Illicit|InvestigationalTarget
DB00246ZiprasidoneSmall Molecule146939-27-7ApprovedTarget
DB00248CabergolineSmall Molecule81409-90-7ApprovedTarget
DB00268RopiniroleSmall Molecule91374-21-9Approved|InvestigationalTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00363ClozapineSmall Molecule5786-21-0ApprovedTarget
DB00370MirtazapineSmall Molecule85650-52-8ApprovedTarget
DB00372ThiethylperazineSmall Molecule1420-55-9WithdrawnTarget
DB00391SulpirideSmall Molecule15676-16-1Approved|InvestigationalTarget
DB00408LoxapineSmall Molecule1977-10-2ApprovedTarget
DB00409RemoxiprideSmall Molecule80125-14-0Approved|WithdrawnTarget
DB00413PramipexoleSmall Molecule104632-26-0Approved|InvestigationalTarget
DB00420PromazineSmall Molecule58-40-2ApprovedTarget
DB00433ProchlorperazineSmall Molecule58-38-8ApprovedTarget
DB00450DroperidolSmall Molecule548-73-2ApprovedTarget
DB00458ImipramineSmall Molecule50-49-7ApprovedTarget
DB00477ChlorpromazineSmall Molecule50-53-3Approved|InvestigationalTarget
DB00490BuspironeSmall Molecule36505-84-7Approved|InvestigationalTarget
DB00502HaloperidolSmall Molecule52-86-8ApprovedTarget
DB00508TriflupromazineSmall Molecule146-54-3ApprovedTarget
DB00540NortriptylineSmall Molecule72-69-5ApprovedTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00568CinnarizineSmall Molecule298-57-7Approved|InvestigationalTarget
DB00589LisurideSmall Molecule18016-80-3Approved|InvestigationalTarget
DB00623FluphenazineSmall Molecule69-23-8ApprovedTarget
DB00679ThioridazineSmall Molecule50-52-2Approved|WithdrawnTarget
DB00696ErgotamineSmall Molecule113-15-5ApprovedTarget
DB00714ApomorphineSmall Molecule58-00-4Approved|InvestigationalTarget
DB00726TrimipramineSmall Molecule739-71-9ApprovedTarget
DB00734RisperidoneSmall Molecule106266-06-2Approved|InvestigationalTarget
DB00777PropiomazineSmall Molecule362-29-8ApprovedTarget
DB00805MinaprineSmall Molecule25905-77-5ApprovedTarget
DB00831TrifluoperazineSmall Molecule117-89-5Approved|InvestigationalTarget
DB00850PerphenazineSmall Molecule58-39-9ApprovedTarget
DB00875FlupentixolSmall Molecule2709-56-0Approved|Investigational|WithdrawnTarget
DB00915AmantadineSmall Molecule768-94-5ApprovedTarget
DB00933MesoridazineSmall Molecule5588-33-0Approved|InvestigationalTarget
DB00934MaprotilineSmall Molecule10262-69-8Approved|InvestigationalTarget
DB00988DopamineSmall Molecule51-61-6ApprovedTarget
DB01038CarphenazineSmall Molecule2622-30-2WithdrawnTarget
DB01043MemantineSmall Molecule19982-08-2Approved|InvestigationalTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB01063AcetophenazineSmall Molecule2751-68-0ApprovedTarget
DB01069PromethazineSmall Molecule60-87-7Approved|InvestigationalTarget
DB01100PimozideSmall Molecule2062-78-4ApprovedTarget
DB01142DoxepinSmall Molecule1668-19-5Approved|InvestigationalTarget
DB01151DesipramineSmall Molecule50-47-5Approved|InvestigationalTarget
DB01184DomperidoneSmall Molecule57808-66-9Approved|InvestigationalTarget
DB01186PergolideSmall Molecule66104-22-1Approved|Investigational|WithdrawnTarget
DB01200BromocriptineSmall Molecule25614-03-3Approved|InvestigationalTarget
DB01221KetamineSmall Molecule6740-88-1ApprovedTarget
DB01224QuetiapineSmall Molecule111974-69-7ApprovedTarget
DB01233MetoclopramideSmall Molecule364-62-5Approved|InvestigationalTarget
DB01235LevodopaSmall Molecule59-92-7ApprovedTarget
DB01238AripiprazoleSmall Molecule129722-12-9Approved|InvestigationalTarget
DB01239ChlorprothixeneSmall Molecule113-59-7Approved|Investigational|WithdrawnTarget
DB01267PaliperidoneSmall Molecule144598-75-4ApprovedTarget
DB01392YohimbineSmall Molecule146-48-5Approved|InvestigationalTarget
DB01403MethotrimeprazineSmall Molecule60-99-1Approved|InvestigationalTarget
DB01425AlizaprideSmall Molecule59338-93-1ApprovedTarget
DB01549RolicyclidineSmall Molecule2201-39-0Experimental|IllicitTarget
DB01614AcepromazineSmall Molecule61-00-7ApprovedTarget
DB01618MolindoneSmall Molecule7416-34-4ApprovedTarget
DB01621PipotiazineSmall Molecule39860-99-6Approved|InvestigationalTarget
DB01622ThioproperazineSmall Molecule316-81-4ApprovedTarget
DB01623ThiothixeneSmall Molecule3313-26-6ApprovedTarget
DB01624ZuclopenthixolSmall Molecule53772-83-1Approved|InvestigationalTarget
DB04599AniracetamSmall Molecule72432-10-1ExperimentalTarget
DB04842FluspirileneSmall Molecule1841-19-6Approved|InvestigationalTarget
DB04844TetrabenazineSmall Molecule58-46-8Approved|InvestigationalTarget
DB04857BrasofensineSmall Molecule171655-91-7InvestigationalTarget
DB04888BifeprunoxSmall Molecule350992-10-8InvestigationalTarget
DB04889BicifadineSmall Molecule71195-57-8InvestigationalTarget
DB04924ItoprideSmall Molecule122898-67-3InvestigationalTarget
DB04946IloperidoneSmall Molecule133454-47-4ApprovedTarget
DB05271RotigotineSmall Molecule99755-59-6ApprovedTarget
DB05316PimavanserinSmall Molecule706779-91-1Approved|InvestigationalTarget
DB05687BL-1020Small Molecule-InvestigationalTarget
DB05766ACP-104Small Molecule-InvestigationalTarget
DB06016CariprazineSmall Molecule839712-12-8Approved|InvestigationalTarget
DB06077LumateperoneSmall Molecule313368-91-1InvestigationalTarget
DB06144SertindoleSmall Molecule106516-24-9Approved|Investigational|WithdrawnTarget
DB06148MianserinSmall Molecule24219-97-4Approved|InvestigationalTarget
DB06216AsenapineSmall Molecule65576-45-6ApprovedTarget
DB06229OcaperidoneSmall Molecule129029-23-8InvestigationalTarget
DB06288AmisulprideSmall Molecule71675-85-9Approved|InvestigationalTarget
DB06454SarizotanSmall Molecule351862-32-3InvestigationalTarget
DB06477SumaniroleSmall Molecule179386-43-7InvestigationalTarget
DB08815LurasidoneSmall Molecule367514-87-2Approved|InvestigationalTarget
DB08922PerospironeSmall Molecule150915-41-6ApprovedTarget
DB09018BromoprideSmall Molecule4093-35-0Approved|InvestigationalTarget
DB09097QuinagolideSmall Molecule87056-78-8Approved|InvestigationalTarget
DB09128BrexpiprazoleSmall Molecule913611-97-9Approved|InvestigationalTarget
DB09194EtoperidoneSmall Molecule52942-31-1WithdrawnTarget
DB09207AS-8112Small Molecule-ExperimentalTarget
DB09223BlonanserinSmall Molecule132810-10-7Approved|InvestigationalTarget
DB09224MelperoneSmall Molecule3575-80-2Approved|InvestigationalTarget
DB09225ZotepineSmall Molecule26615-21-4Approved|Investigational|WithdrawnTarget
DB09286PipamperoneSmall Molecule1893-33-0Approved|InvestigationalTarget
DB12061PardoprunoxSmall Molecule269718-84-5InvestigationalTarget
DB12093TetrahydropalmatineSmall Molecule483-14-7InvestigationalTarget
DB12478PiribedilSmall Molecule3605-01-4InvestigationalTarget
DB12518RacloprideSmall Molecule84225-95-6InvestigationalTarget
DB13025TiaprideSmall Molecule51012-32-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C461261(1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate)DRD2 protein results in increased susceptibility to (1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate)19497322
C1185591-bromopropane1-bromopropane results in decreased expression of DRD2 mRNA19576243
C0317962,10,11-trihydroxy-N-n-propylnoraporphine"2,10,11-trihydroxy-N-n-propylnoraporphine binds to and results in increased activity of DRD2 protein"16325000
C0453922-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine"2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine binds to DRD2 protein"9723970
C0413692-(N-phenethyl-N-propyl)amino-5-hydroxytetralin2-(N-phenethyl-N-propyl)amino-5-hydroxytetralin binds to and results in increased activity of DRD2 protein8892103
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol affects the localization of DRD2 protein"22791651
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol promotes the reaction [HTR2A protein binds to DRD2 protein]"22791651
C0546493-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in decreased expression of DRD2 mRNA"22791651
C0940123-(3-cyanophenyl)-N-n-propylpiperidine3-(3-cyanophenyl)-N-n-propylpiperidine binds to and results in decreased activity of DRD2 protein11080548
C0624583,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol"3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD2 protein"10728880
C0624583,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol"3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD2 protein"10728880
C0624583,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol"3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to DRD2 protein"10700011
C0624583,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol"3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD2 protein"10683862|1152246
C1047503-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole binds to and results in decreased activity of DRD2 protein10728880
C1047503-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole binds to and results in decreased activity of DRD2 protein16407246|1681428
C480819(3-exo)-8-benzoyl-N-(((2S)7-chloro-2,3-dihydro-1,4-benzodioxin-1-yl)methyl)-8-azabicyclo(3.2.1)octane-3-methanamine monohydrochloride"(3-exo)-8-benzoyl-N-(((2S)7-chloro-2,3-dihydro-1,4-benzodioxin-1-yl)methyl)-8-azabicyclo(3.2.1)octane-3-methanamine monohydrochloride binds to and results in decreased activity of DRD2 protein"12902993
C0391673-N-methylspiperone3-N-methylspiperone binds to DRD2 protein9109525
C0391673-N-methylspiperoneAluminum inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
C0391673-N-methylspiperoneCadmium inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
C0391673-N-methylspiperoneCopper inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
C0391673-N-methylspiperoneGadolinium inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
C0391673-N-methylspiperoneLanthanum inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
C0391673-N-methylspiperoneZinc Acetate inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
C0391673-N-methylspiperonezinc chloride inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
C0391673-N-methylspiperoneZinc Sulfate inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
C4165454,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline"4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline binds to and results in increased activity of DRD2 protein"1347779|1977176|
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD2 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of DRD2 protein20570720
C5014744-OH-2',3,3',4',5'-pentachlorobiphenyl"4-OH-2',3,3',4',5'-pentachlorobiphenyl results in increased expression of DRD2 mRNA"22996836
C5014744-OH-2',3,3',4',5'-pentachlorobiphenyl"4-OH-2',3,3',4',5'-pentachlorobiphenyl results in increased expression of DRD2 protein"22996836
C086335(5,6-dimethoxyindan-2-yl)dipropylamine"(5,6-dimethoxyindan-2-yl)dipropylamine binds to and results in decreased activity of DRD2 protein"10728880
C0511715-methoxy-1-methyl-2-(n-propylamino)tetralin5-methoxy-1-methyl-2-(n-propylamino)tetralin binds to and results in decreased activity of DRD2 protein10728880
C0833745-propylamino-5,6-dihydro-4H-imidazo(4,5,1-ij)quinolin-2(1H)-one"5-propylamino-5,6-dihydro-4H-imidazo(4,5,1-ij)quinolin-2(1H)-one binds to and results in increased activity of DRD2 protein"7663983
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD2 mRNA"27188386
C4616576-methoxymianserin6-methoxymianserin binds to DRD2 protein12109911
C0313497-hydroxy-2-N,N-dipropylaminotetralin"7-hydroxy-2-N,N-dipropylaminotetralin binds to and results in increased activity of DRD2 protein"10728880
C0313497-hydroxy-2-N,N-dipropylaminotetralin"7-hydroxy-2-N,N-dipropylaminotetralin binds to and results in increased activity of DRD2 protein"10728880
C0313497-hydroxy-2-N,N-dipropylaminotetralin"7-hydroxy-2-N,N-dipropylaminotetralin binds to DRD2 protein"10700011
C0313497-hydroxy-2-N,N-dipropylaminotetralin"7-hydroxy-2-N,N-dipropylaminotetralin binds to and results in increased activity of DRD2 protein"10217549|1616352
C4098747-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine"7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine binds to and results in decreased activity of DRD2 protein"12447918
C0908127-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan"7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in decreased activity of DRD2 protein"10728880
C0908127-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan"7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in increased activity of DRD2 protein"10683862
C0908127-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan"7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to DRD2 protein"10700011
C0813208-(3-chlorostyryl)caffeineDRD2 protein affects the susceptibility to 8-(3-chlorostyryl)caffeine11172060
C0813208-(3-chlorostyryl)caffeineDRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]11172060
C4345848-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine"8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Spiperone binds to DRD2 protein]"11927170
C095427A 86929A 86929 binds to DRD2 protein alternative form8558425
C095427A 86929A 86929 results in increased activity of DRD2 protein alternative form8558425
C095427A 86929A 86929 binds to DRD2 protein8558425
C043877acamprosateDRD2 affects the susceptibility to acamprosate19523047
D000082AcetaminophenAcetaminophen results in increased expression of DRD2 mRNA26690555
C100162acetophenazineacetophenazine binds to DRD2 protein6147851
D000242Cyclic AMPepigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]17958328
D000242Cyclic AMP[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]17958328
D000242Cyclic AMPCCKBR protein affects the reaction [[quinelorane binds to and results in increased activity of DRD2 protein] which results in decreased abundance of Cyclic AMP]11880531
D000242Cyclic AMP[quinelorane binds to and results in increased activity of DRD2 protein] which results in decreased abundance of Cyclic AMP11880531
D000336AerosolsAerosols results in decreased expression of DRD2 mRNA25265048
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DRD2 mRNA26260870
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of DRD2 mRNA"20224926
C014959albiflorinalbiflorin affects the expression of DRD226475043
C033968alizapridealizapride binds to and results in decreased activity of DRD2 protein2571179|8103596
C033968alizapridealizapride binds to DRD2 protein2901473
C050408alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanolalpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol inhibits the reaction [EEDQ results in decreased expression of DRD2 protein]7513362
C542924alpha-pyrrolidinovalerophenone[alpha-pyrrolidinovalerophenone results in increased secretion of Dopamine] results in increased activity of [DRD1 protein co-treated with DRD2 protein]24418703
D000535AluminumAluminum inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
C010845aluminum chloridealuminum chloride results in decreased expression of DRD2 protein17984145
C014983amitrazamitraz inhibits the reaction [Spiperone binds to DRD2 protein]2833825
D017311AmlodipineAmlodipine inhibits the reaction [Raclopride binds to DRD2 protein]9533112
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DRD2 mRNA16483693
D000657AmoxapineAmoxapine binds to DRD2 protein11180191
D003913DextroamphetamineDextroamphetamine results in decreased expression of DRD2 protein10024013
D000661AmphetamineDRD2 SNP affects the susceptibility to Amphetamine19968402
D000661AmphetamineAmphetamine results in increased expression of DRD2 mRNA16916582
D000661AmphetamineAmphetamine results in increased expression of DRD2 mRNA alternative form17026527
D000661AmphetamineCACNA1D protein affects the reaction [Amphetamine results in increased expression of DRD2 mRNA alternative form]17026527
D000661AmphetamineDRD2 results in increased susceptibility to Amphetamine11790512
D000661AmphetamineAmphetamine inhibits the reaction [Spiperone binds to DRD2 protein]2018630
D000661AmphetamineAmphetamine results in decreased expression of DRD2 mRNA15183010|1914507
D000661AmphetamineAmphetamine results in decreased expression of DRD2 protein19145071
D000661AmphetamineAmphetamine results in increased activity of DRD2 protein7861147
D000661AmphetamineAmphetamine results in increased activity of DRD2 protein11224544
D047310ApigeninApigenin inhibits the reaction [Rotenone results in decreased expression of DRD2 protein]28389404
D001058Apomorphine[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole8103921
D001058ApomorphineDRD2 protein results in increased susceptibility to Apomorphine19497322
D001058ApomorphineRaclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]8103921
D001058ApomorphineSCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]8103921
D001058ApomorphineDRD2 protein affects the susceptibility to Apomorphine14639100|2571179
D001058ApomorphineRisperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein]7520908
D001058ApomorphineApomorphine binds to and results in increased activity of DRD2 protein10448923|1347779
D001073AprindineAprindine binds to DRD2 protein9808703
C119325arachidonyl-2-chloroethylamidearachidonyl-2-chloroethylamide results in decreased expression of DRD2 mRNA22791651
D000068180AripiprazoleAripiprazole binds to and results in increased activity of DRD2 protein17069544
D000068180Aripiprazole[Aripiprazole binds to and results in increased activity of DRD2 protein] which results in increased susceptibility to Methamphetamine17327886
D000068180AripiprazoleAripiprazole binds to and affects the activity of DRD2 protein16806092
D000068180AripiprazoleAripiprazole binds to and results in increased activity of DRD2 protein15830832|1596057
D000068180AripiprazoleAripiprazole binds to DRD2 protein18363460
C032739aroclor 1221aroclor 1221 results in increased expression of DRD2 mRNA26620572
D001151ArsenicArsenic results in increased expression of DRD2 mRNA24019935
D001280AtrazineAtrazine results in decreased expression of DRD2 mRNA25929836
D001280AtrazineAtrazine affects the activity of DRD2 protein11071396
D001381AzepinesAzepines analog binds to and results in decreased activity of DRD2 protein12593651
D001381AzepinesAzepines analog binds to and results in decreased activity of DRD2 protein12593651
D001464Barium"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester inhibits the reaction [DRD2 protein results in decreased transport of Barium]"11124974
D001464Barium[DRD2 protein affects the abundance of Calcium] which results in decreased transport of Barium11124974
D001464BariumDRD2 protein affects the reaction [N-n-propylnorapomorphine analog results in decreased transport of Barium]11124974
D001464BariumDRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]11124974
D001464BariumDRD2 protein results in decreased transport of Barium11124974
D001464Barium[DRD2 protein results in increased activity of PLCB1 protein] which results in decreased transport of Barium11124974
D001464BariumNifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]]11124974
D001545Benserazide[Oxidopamine co-treated with levodopa methyl ester] inhibits the reaction [Benserazide results in increased expression of DRD2 protein]19399396
C037689benzamidebenzamide analog binds to and results in decreased activity of DRD2 protein12373430
C037689benzamidebenzamide analog binds to DRD2 protein10638823
D001549BenzamidesBenzamides analog binds to and results in decreased activity of DRD2 protein12130853
D001549BenzamidesBenzamides analog binds to and results in decreased activity of DRD2 protein8676355
C031000benzimidazolebenzimidazole analog binds to DRD2 protein15237387
D001562BenzimidazolesBenzimidazoles analog binds to DRD2 protein21509803
C039108benzo(f)quinolinebenzo(f)quinoline analog binds to DRD2 protein19053758
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DRD2 mRNA21839799
D004958EstradiolEstradiol results in increased expression of DRD2 mRNA12008023
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in decreased expression of DRD2 mRNA25270620
C006780bisphenol Abisphenol A promotes the reaction [Raclopride binds to DRD2 protein]20169576
C006780bisphenol Abisphenol A results in decreased expression of DRD2 mRNA24066056|2518105
C006780bisphenol Abisphenol A results in increased methylation of DRD2 gene28505145
C120565BP 897BP 897 inhibits the reaction [N-n-propylnorapomorphine binds to DRD2 protein]10432116
C120565BP 897BP 897 binds to and results in decreased activity of DRD2 protein16005579
D001971BromocriptineBromocriptine affects the expression of DRD2 mRNA20063113
D001971BromocriptineDRD2 polymorphism results in increased susceptibility to Bromocriptine16901644
D001971BromocriptineBromocriptine results in decreased expression of DRD2 mRNA15781964
D001971BromocriptineBromocriptine results in increased expression of DRD2 mRNA15781964
D001971Bromocriptine[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA15781964
D001971BromocriptineBromocriptine binds to and results in increased activity of DRD2 mRNA1534540
D001971BromocriptineBromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]15781964
D001971BromocriptineBromocriptine results in decreased expression of DRD2 mRNA15781964
D001971BromocriptineDRD2 protein affects the susceptibility to Bromocriptine8103596
D001971BromocriptineBromocriptine binds to and results in decreased activity of DRD2 protein11752888|1680385
D001971BromocriptineBromocriptine binds to and results in increased activity of DRD2 protein10626749|1068386
D001971BromocriptineBromocriptine results in increased activity of DRD2 protein9777039
C006820bromperidolDRD2 promoter polymorphism affects the susceptibility to bromperidol11505224
D002069ButaclamolButaclamol binds to DRD2 protein6147851
D002069ButaclamolButaclamol binds to DRD2 protein18457824
C047047cabergolinecabergoline binds to and results in increased activity of DRD2 protein14673879|1799268
D002104CadmiumCadmium inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
D002110CaffeineDRD2 polymorphism affects the susceptibility to Caffeine18305461
D002110CaffeineDRD2 protein results in increased susceptibility to Caffeine11172060
D002110Caffeine"Caffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]]"16889759
D002118Calcium[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium8032591
D002118Calcium[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium8032591
D002118CalciumSulpiride inhibits the reaction [[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]8032591
D002118CalciumSulpiride inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]8032591
D002118Calcium[DRD2 protein affects the abundance of Calcium] which results in decreased transport of Barium11124974
D002220CarbamazepineCarbamazepine results in decreased expression of DRD2 protein16478526
C018861carbetapentanecarbetapentane binds to DRD2 protein10888308
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of DRD2 mRNA25270620
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of DRD2 mRNA16644059
C012145CF 25397CF 25397 binds to and results in increased activity of DRD2 protein10683862
C051347CGS 15855ACGS 15855A binds to and results in increased activity of DRD2 protein10728880
C051347CGS 15855ACGS 15855A binds to and results in increased activity of DRD2 protein10728880
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of DRD2 mRNA21472459
D020111Chlorodiphenyl (54% Chlorine)Quercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of DRD2 mRNA]21472459
D002746ChlorpromazineChlorpromazine binds to DRD2 protein6147851
D002746ChlorpromazineChlorpromazine results in decreased activity of DRD2 protein23611293
D002746ChlorpromazineDRD2 polymorphism results in decreased susceptibility to Chlorpromazine15694263
D002749ChlorprothixeneChlorprothixene analog binds to DRD2 protein8101879
D002749ChlorprothixeneChlorprothixene binds to DRD2 protein8101879
D004390ChlorpyrifosChlorpyrifos results in decreased expression of DRD2 mRNA17452286
D002936CinnarizineCinnarizine binds to DRD2 protein11180191
D002936CinnarizineCinnarizine binds to DRD2 protein7503767
D002936CinnarizineCinnarizine inhibits the reaction [nemonapride binds to DRD2 protein]7503767
D002997ClomipramineClomipramine results in increased expression of DRD2 protein20619828
D003024ClozapineClozapine binds to DRD2 protein6147851
D003024ClozapineClozapine binds to DRD2 protein11997696|1352677
D003024Clozapine[Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein15286066
D003024ClozapineDRD2 gene affects the susceptibility to Clozapine15830237
D003024ClozapineDRD2 gene polymorphism affects the susceptibility to Clozapine16278074
D003024ClozapineDRD2 gene SNP results in increased susceptibility to Clozapine20375926
D003024ClozapineClozapine binds to DRD2 protein alternative form12476322
D003024Clozapine[Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA15781964
D003024ClozapineClozapine results in decreased expression of DRD2 mRNA17266109
D003024ClozapineBromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]15781964
D003024ClozapineClozapine analog binds to DRD2 protein11997696
D003024ClozapineClozapine binds to and results in decreased activity of DRD2 protein16033416
D003024Clozapine[Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein16033416
D003024ClozapineClozapine binds to DRD2 protein9723970
D003024ClozapineClozapine promotes the reaction [Dopamine binds to DRD2 protein]15716360
D003024ClozapineClozapine results in decreased expression of DRD2 mRNA15781964
D003024ClozapineDRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]16144542
D003024ClozapineDRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]16144542
D003024ClozapineDRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]16144542
D003024ClozapineDRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]16144542
D003024ClozapineDRD2 protein affects the susceptibility to Clozapine11997696
D003024ClozapineClozapine binds to and results in decreased activity of DRD2 protein9111066
D003024ClozapineClozapine binds to DRD2 protein7520908
D003042CocaineCocaine affects the reaction [Raclopride binds to DRD2]15010698
D003042CocaineCocaine results in decreased expression of DRD2 mRNA18000554
D003042CocaineCocaine results in decreased expression of DRD2 protein11126397|1972378
D003042CocaineDRD2 polymorphism results in increased susceptibility to Cocaine17671965
D003042CocaineDRD2 protein results in decreased susceptibility to Cocaine11923462
D003042CocaineDRD2 results in increased susceptibility to Cocaine11790512
D003042CocainePDYN protein affects the reaction [Cocaine affects the expression of DRD2 protein]17532787
D003042CocaineCocaine affects the expression of DRD217544385
D003042CocaineCocaine affects the expression of DRD2 mRNA12892653|1899054
D003042CocaineCocaine affects the expression of DRD2 protein20435100
D003042CocaineCocaine affects the reaction [Spiperone binds to DRD2 protein]17161392
D003042CocaineCocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]20729865
D003042CocaineCocaine results in decreased expression of DRD2 mRNA18305460
D003042CocaineCocaine results in decreased expression of DRD2 protein18305460
D003042CocaineCocaine results in increased activity of DRD2 protein19046384
D003042CocaineCocaine results in increased expression of DRD2 mRNA15042275
D003042CocaineCocaine results in increased expression of DRD2 protein11602327|1504951
D003042CocaineDRD2 protein affects the susceptibility to Cocaine2213551
D003042CocaineMethadone affects the reaction [Cocaine affects the expression of DRD2 mRNA]18990547
D003042CocaineSpiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]20729865
D005576Colforsinepigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]17958328
D005576Colforsin[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]17958328
D003300CopperCopper deficiency results in increased expression of DRD2 mRNA26033743
D003300CopperCopper inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
C007168cyanazinecyanazine affects the activity of DRD2 protein11071396
C021166cyclo(leucylglycine)cyclo(leucylglycine) inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]8115415
D003520CyclophosphamideCyclophosphamide binds to DRD2 protein11180191
D016572CyclosporineCyclosporine promotes the reaction [Domperidone binds to DRD2 protein]12673668
D016572CyclosporineCyclosporine results in decreased expression of DRD2 mRNA25270620
C037304cyhalothrincyhalothrin results in decreased expression of DRD2 mRNA28495607
C037304cyhalothrincyhalothrin results in decreased expression of DRD2 protein22366556|2849560
C017160cypermethrincypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
C017160cypermethrincypermethrin promotes the reaction [cypermethrin results in decreased expression of DRD2 mRNA]25288152
C017160cypermethrincypermethrin promotes the reaction [cypermethrin results in decreased expression of DRD2 protein]25288152
C017160cypermethrincypermethrin results in decreased expression of DRD2 mRNA25288152
C017160cypermethrincypermethrin results in decreased expression of DRD2 protein25288152
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of DRD2 mRNA23914054
C017180decamethrindecamethrin results in decreased expression of DRD2 mRNA25912032
C017180decamethrindecamethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
D013759DronabinolDronabinol results in decreased expression of DRD221820648
C011741demethylchlordimeformdemethylchlordimeform inhibits the reaction [Spiperone binds to DRD2 protein]2833825
D003976DiazinonDiazinon affects the expression of DRD2 mRNA18812211
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DRD2 mRNA15620428
D004006DichlorvosDichlorvos results in decreased activity of DRD2 protein12186780
D004006DichlorvosNimodipine inhibits the reaction [Dichlorvos results in decreased activity of DRD2 protein]12186780
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of DRD2 mRNA28871463
D002117CalcitriolCalcitriol promotes the reaction [VDR protein results in decreased expression of DRD2 mRNA]27450565
D004110DiltiazemDiltiazem inhibits the reaction [Raclopride binds to DRD2 protein]9533112
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of DRD2 mRNA27638505
C006208dironyldironyl binds to DRD2 protein11543991
C006208dironyldironyl binds to and results in increased activity of DRD2 protein1681090|8098931
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD2 mRNA]17434604
D004294DomperidoneCyclosporine promotes the reaction [Domperidone binds to DRD2 protein]12673668
D004294DomperidoneDomperidone binds to DRD2 protein12673668
D004294DomperidoneDomperidone binds to and results in decreased activity of DRD2 protein10626749|1207143
D004294DomperidoneDomperidone binds to DRD2 protein12130853
D004294DomperidoneDomperidone binds to and results in decreased activity of DRD2 protein12673668|1294656
D007980Levodopa"Levodopa inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DRD2 mRNA]"8915594
D004298Dopamine[Dopamine co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein27717053
D004298Dopamine[Dopamine co-treated with Raclopride] promotes the reaction [Dopamine binds to DRD2 protein]19439595
D004298Dopamine[alpha-pyrrolidinovalerophenone results in increased secretion of Dopamine] results in increased activity of [DRD1 protein co-treated with DRD2 protein]24418703
D004298DopamineDopamine binds to DRD2 protein alternative form12476322
D004298DopamineClozapine promotes the reaction [Dopamine binds to DRD2 protein]15716360
D004298DopamineCocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]20729865
D004298Dopaminecypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
D004298DopamineDBH protein affects the reaction [Dopamine binds to DRD2 protein]15716360
D004298Dopaminedecamethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
D004298DopamineDopamine binds to DRD2 protein15716360
D004298DopamineDopamine promotes the reaction [Oxidopamine binds to DRD2 protein]16480889
D004298DopamineDopamine results in increased activity of DRD2 protein19046384
D004298DopamineDRD2 mutant form inhibits the reaction [Dopamine results in decreased expression of IL10 protein]25818600
D004298DopamineDRD2 mutant form inhibits the reaction [Dopamine results in decreased expression of TGFB1 protein]25818600
D004298DopamineDRD2 mutant form inhibits the reaction [Dopamine results in decreased expression of VEGFA protein]25818600
D004298DopamineDRD2 mutant form inhibits the reaction [Dopamine results in increased expression of TNF protein]25818600
D004298DopamineDRD2 protein affects the susceptibility to Dopamine8103596
D004298DopamineDRD4 protein affects the reaction [Dopamine binds to DRD2 protein]15716360
D004298Dopamineestradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
D004298DopamineEthanol affects the reaction [Dopamine binds to DRD2 protein]15716360
D004298DopamineGRK6 protein affects the reaction [Dopamine binds to DRD2 protein]15716360
D004298DopamineHaloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
D004298DopamineHaloperidol promotes the reaction [Dopamine binds to DRD2 protein]15716360
D004298Dopamineolanzapine promotes the reaction [Dopamine binds to DRD2 protein]15716360
D004298DopamineQuetiapine Fumarate promotes the reaction [Dopamine binds to DRD2 protein]15716360
D004298Dopamine[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine10936494
D004298Dopamine[Raclopride binds to and results in decreased activity of DRD2 protein] which results in increased abundance of Dopamine15341276
D004298Dopamine[Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [Dopamine results in decreased susceptibility to Pilocarpine]15140183
D004298DopamineRisperidone promotes the reaction [Dopamine binds to DRD2 protein]15716360
D004298DopamineSpiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]20729865
D004298Dopaminetautomycin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
D004298DopamineTea inhibits the reaction [Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]]16480889
D004298DopamineDopamine results in increased activity of DRD2 protein18005069
D018491Dopamine AgonistsDopamine Agonists binds to DRD2 protein11543991
C000470EEDQalpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol inhibits the reaction [EEDQ results in decreased expression of DRD2 protein]7513362
C000470EEDQEEDQ results in decreased expression of DRD2 protein7513362
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]17958328
C074283estradiol 3-benzoateestradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
D000431Ethanol[Haloperidol binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Ethanol19120057
D000431EthanolEthanol affects the reaction [Dopamine binds to DRD2 protein]15716360
D000431EthanolEthanol results in increased expression of DRD2 mRNA18713641
C521336ethyl 4-(4-((2-hydroxy-3-(4-hydroxy-3-((methylsulfonyl)amino)phenoxy)propyl)amino)cyclohexyl)benzoateethyl 4-(4-((2-hydroxy-3-(4-hydroxy-3-((methylsulfonyl)amino)phenoxy)propyl)amino)cyclohexyl)benzoate affects the activity of DRD2 protein23611293
C045989eticloprideeticlopride results in decreased activity of DRD2 protein27920206
C045989eticloprideeticlopride results in decreased activity of DRD2 protein2213551
C045989eticloprideeticlopride binds to and results in decreased activity of DRD2 protein14498848|1602370
C045989eticloprideeticlopride results in decreased activity of DRD2 protein19996296
D005231Fatty Acids, Unsaturated"Fatty Acids, Unsaturated deficiency results in decreased expression of DRD2 mRNA"11916751
D005231Fatty Acids, Unsaturated"Fatty Acids, Unsaturated deficiency results in increased expression of DRD2 mRNA"11916751
C071320FCE 23884FCE 23884 binds to and results in decreased activity of DRD2 protein8723141
C047360felbamatefelbamate inhibits the reaction [Haloperidol affects the activity of DRD2 protein]7845605
C065065FLB 457FLB 457 binds to DRD2 protein18058087
D005444FlunarizineFlunarizine binds to DRD28794996
D005444FlunarizineFlunarizine inhibits the reaction [Raclopride binds to DRD2 protein]9533112
D005444FlunarizineFlunarizine binds to DRD2 protein7503767
D005444FlunarizineFlunarizine inhibits the reaction [nemonapride binds to DRD2 protein]7503767
C083673fluoroclebopridefluoroclebopride binds to DRD2 protein10638823
D005473FluoxetineFluoxetine affects the expression of DRD226475043
D005473FluoxetineFluoxetine results in decreased expression of DRD2 mRNA11981225
D005476FluphenazineFluphenazine binds to DRD2 protein6147851
D005476FluphenazineFluphenazine binds to DRD2 protein17606915
D005476FluphenazineFluphenazine binds to and results in decreased activity of DRD2 protein1833784
C053619fluphenazine-N-mustardfluphenazine-N-mustard results in decreased activity of DRD2 protein7476901
D005557FormaldehydeDizocilpine Maleate inhibits the reaction [Formaldehyde results in increased expression of DRD2 mRNA]17434604
D005557FormaldehydeFormaldehyde results in increased expression of DRD2 mRNA17434604
C069837fullerene C60fullerene C60 results in decreased expression of DRD2 mRNA19167457
C039281furanfuran results in decreased expression of DRD2 mRNA25539665
D005682GadoliniumGadolinium inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
C408390GR 218231GR 218231 binds to and results in decreased activity of DRD2 protein10728880
D006220HaloperidolHaloperidol binds to DRD2 protein6147851
D006220HaloperidolDRD2 protein binds to Haloperidol14552778
D006220HaloperidolDRD2 protein binds to Haloperidol analog14552778
D006220HaloperidolHaloperidol affects the activity of DRD2 protein23611293
D006220HaloperidolHaloperidol binds to DRD2 protein11997696|2036189
D006220HaloperidolHaloperidol results in increased expression of DRD2 mRNA20730801
D006220HaloperidolHaloperidol results in increased expression of DRD2 protein20730801
D006220HaloperidolThioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]20730801
D006220HaloperidolThioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]20730801
D006220HaloperidolDRD2 affects the susceptibility to Haloperidol10720636
D006220HaloperidolDRD2 protein affects the susceptibility to Haloperidol11172060
D006220HaloperidolHaloperidol binds to and results in decreased activity of DRD2 protein19120057
D006220Haloperidol[Haloperidol binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Ethanol19120057
D006220HaloperidolHaloperidol binds to DRD28794996
D006220HaloperidolHaloperidol binds to DRD2 protein9808703
D006220HaloperidolHaloperidol binds to DRD2 protein alternative form12476322
D006220HaloperidolHaloperidol results in increased expression of DRD2 protein2945998
D006220Haloperidol[Haloperidol results in increased expression of DRD2 protein] which results in decreased susceptibility to Pentobarbital2945998
D006220Haloperidolcyclo(leucylglycine) inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]8115415
D006220HaloperidolDRD2 protein affects the reaction [Haloperidol results in increased expression of CTNNB1 protein]16144542
D006220HaloperidolDRD2 protein affects the reaction [Haloperidol results in increased expression of DVL3 protein]16144542
D006220HaloperidolDRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3A protein]16144542
D006220HaloperidolDRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3B protein]16144542
D006220Haloperidolfelbamate inhibits the reaction [Haloperidol affects the activity of DRD2 protein]7845605
D006220HaloperidolHaloperidol binds to and results in decreased activity of DRD2 protein1380082|16033416
D006220Haloperidol[Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein16033416
D006220HaloperidolHaloperidol binds to DRD2 protein12191584|1361536
D006220HaloperidolHaloperidol inhibits the reaction [iodosulpride binds to DRD2 protein]7878047
D006220HaloperidolHaloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
D006220HaloperidolHaloperidol inhibits the reaction [Spiperone binds to DRD2 protein]11927170
D006220HaloperidolHaloperidol promotes the reaction [Dopamine binds to DRD2 protein]15716360
D006220HaloperidolHaloperidol results in increased expression of DRD21351265
D006220HaloperidolHaloperidol results in increased expression of DRD2 mRNA7878047
D006220HaloperidolHaloperidol results in increased expression of DRD2 protein18295747|8115415
D006220Haloperidolzinc chloride inhibits the reaction [Haloperidol binds to DRD2 protein]9109525
D006220HaloperidolHaloperidol affects the activity of DRD2 protein7845605
D006220HaloperidolHaloperidol binds to and results in decreased activity of DRD2 protein10613497|1365866
D006220HaloperidolHaloperidol binds to DRD2 protein7520908
D003932HeroinHeroin results in decreased expression of DRD2 protein11126397
D012701SerotoninSerotonin inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]20887679
D012701SerotoninSerotonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein]20887679
C426805idobenzamideidobenzamide binds to DRD2 protein15469457
C045105iodosulprideHaloperidol inhibits the reaction [iodosulpride binds to DRD2 protein]7878047
C045105iodosulprideiodosulpride binds to DRD2 protein7878047
D007501Iron[manganese chloride co-treated with Iron deficiency] results in increased expression of DRD2 protein22479410
C554161JB-788JB-788 binds to and results in decreased activity of DRD2 protein20580787
C554161JB-788JB-788 inhibits the reaction [Quinpirole binds to and results in increased activity of DRD2 protein]20580787
D007608Kainic AcidDRD2 protein results in decreased susceptibility to Kainic Acid11860278
C047781lamotrigineDRD2 protein results in increased susceptibility to lamotrigine20021991
D007811LanthanumLanthanum inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
D007854LeadDRD2 gene polymorphism results in increased susceptibility to Lead21205584
C008261lead acetate[lead acetate co-treated with Morphine] results in increased expression of DRD2 mRNA23702354
C008261lead acetate[lead acetate co-treated with Morphine] results in increased expression of DRD2 protein23702354
C008261lead acetatelead acetate results in increased expression of DRD2 mRNA23702354
C008261lead acetatelead acetate results in increased expression of DRD2 protein23702354
C090111LEK 8829LEK 8829 binds to and results in decreased activity of DRD2 protein15138661
C035420levodopa methyl ester[Oxidopamine co-treated with levodopa methyl ester] inhibits the reaction [Benserazide results in increased expression of DRD2 protein]19399396
D001556LindaneLindane results in increased expression of DRD2 mRNA25572523
D008090LisurideLisuride binds to and results in increased activity of DRD2 protein10379793|1068386
D008094LithiumLithium results in decreased expression of DRD2 protein16478526
D008152LoxapineLoxapine binds to DRD2 protein6147851
D008152LoxapineLoxapine analog binds to DRD2 protein9723970
D008152LoxapineLoxapine binds to DRD2 protein9723970
D008152LoxapineLoxapine binds to DRD2 protein8101879
D000069056Lurasidone HydrochlorideLurasidone Hydrochloride binds to and results in decreased activity of DRD2 protein20404009
D008344Maneb[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA23017109
D008345ManganeseManganese results in decreased expression of DRD2 mRNA20224926
C025340manganese chloridemanganese chloride results in decreased expression of DRD2 protein24969583
C025340manganese chlorideMelatonin promotes the reaction [manganese chloride results in decreased expression of DRD2 protein]24969583
C025340manganese chloride[manganese chloride co-treated with Iron deficiency] results in increased expression of DRD2 protein22479410
C025340manganese chloridemanganese chloride inhibits the reaction [DRD2 protein binds to Spiperone]21484877
C025340manganese chloridemanganese chloride results in increased expression of DRD223458069
C025340manganese chloridemanganese chloride results in increased expression of DRD2 protein22479410
C025340manganese chloridemanganese chloride results in increased expression of DRD2 protein alternative form21484877
C054218manidipinemanidipine binds to DRD28794996
C054218manidipinemanidipine inhibits the reaction [Raclopride binds to DRD2 protein]9533112
D008550MelatoninMelatonin promotes the reaction [manganese chloride results in decreased expression of DRD2 protein]24969583
D008550MelatoninMelatonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein]18289173
D008555MelittenMelitten inhibits the reaction [Spiperone binds to DRD2 protein]20969853
C548233mephedronemephedrone results in decreased expression of DRD2 protein25817894
D008691MethadoneMethadone affects the reaction [Cocaine affects the expression of DRD2 mRNA]18990547
D008694MethamphetamineDRD2 gene polymorphism results in increased susceptibility to Methamphetamine18555060
D008694MethamphetamineMethamphetamine results in decreased expression of DRD2 protein11126397|1172901
D008694MethamphetamineDRD2 gene results in increased susceptibility to Methamphetamine18363855
D008694MethamphetamineDRD2 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 mRNA]20340177
D008694MethamphetamineDRD2 protein affects the reaction [Methamphetamine results in increased expression of CACNA2D1 protein]20340177
D008694Methamphetamine[Sulpiride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methamphetamine20340177
D008694Methamphetamine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine inhibits the reaction [Methamphetamine affects the activity of DRD2 protein]"18489579
D008694Methamphetamine[Aripiprazole binds to and results in increased activity of DRD2 protein] which results in increased susceptibility to Methamphetamine17327886
D008694MethamphetamineMethamphetamine affects the activity of DRD2 protein18489579
D008694MethamphetamineMethamphetamine inhibits the reaction [Sulpiride binds to DRD2 protein]2891082
D008694MethamphetamineMethamphetamine results in decreased expression of DRD2 protein2891082
D008694MethamphetamineMethamphetamine results in increased activity of DRD2 protein19046384
D008728MethotrimeprazineMethotrimeprazine binds to DRD2 protein8101879
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased activity of DRD2 protein"28790194
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DRD2 mRNA21385734
D018817N-Methyl-3,4-methylenedioxyamphetamine"Caffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]]"16889759
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]"16889759
D008774MethylphenidateMethylphenidate results in decreased expression of DRD2 mRNA22470460
D008774MethylphenidateMethylphenidate affects the expression of DRD2 protein17599397
D008774Methylphenidate[Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methylphenidate11454915
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of DRD2 mRNA26558463
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects the expression of DRD2 protein"1780015
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DRD2 mRNA"15514976|8915594
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DRD2 protein"15514976
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Levodopa inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DRD2 mRNA]"8915594
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DRD2 mRNA"15885624
D008787MetoclopramideMetoclopramide binds to and results in decreased activity of DRD2 protein11561213|2117557
D008787MetoclopramideMetoclopramide binds to DRD2 protein9808703
D008787MetoclopramideMetoclopramide binds to and results in decreased activity of DRD2 protein20519576
D008787MetoclopramideMetoclopramide binds to and results in decreased activity of DRD2 protein17201744|1730366
D008787MetoclopramideMetoclopramide binds to DRD2 protein12130853|1259365
D008787MetoclopramideMetoclopramide results in increased expression of DRD2 protein18457824
D008787MetoclopramideMetoclopramide binds to and results in decreased activity of DRD2 protein21173550|2169103
C035133mirtazapinemirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein]12523492
C001801mitragyninemitragynine binds to DRD2 protein27192616
D008972MolindoneMolindone binds to DRD2 protein6147851
D008972MolindoneMolindone binds to and results in decreased activity of DRD2 protein3283778
D009020MorphineMorphine results in increased expression of DRD2 mRNA17063042
D009020MorphineDRD2 protein affects the susceptibility to Morphine2571179
D009020Morphine[lead acetate co-treated with Morphine] results in increased expression of DRD2 mRNA23702354
D009020Morphine[lead acetate co-treated with Morphine] results in increased expression of DRD2 protein23702354
D009020MorphineMorphine results in decreased expression of DRD2 mRNA15183518
C518313N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine"N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine binds to and results in decreased activity of DRD2 protein"17300168|1969524
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine15140183
C539157N-(4-(2-(4-(3-cyano-5-trifluoromethylphenyl)piperazin-1-yl)ethyl)cyclohexyl)-3-pyridinesulfonic amideN-(4-(2-(4-(3-cyano-5-trifluoromethylphenyl)piperazin-1-yl)ethyl)cyclohexyl)-3-pyridinesulfonic amide binds to and results in decreased activity of DRD2 protein18548231
C097285nafadotridenafadotride binds to and results in decreased activity of DRD2 protein10728880
C097285nafadotridenafadotride binds to and results in decreased activity of DRD2 protein11522464
D009271NaltrexoneDRD2 affects the susceptibility to Naltrexone19523047
C068868naltrindole benzofurannaltrindole benzofuran binds to and results in decreased activity of DRD2 protein19482038
C042631naxagolidenaxagolide binds to and results in increased activity of DRD2 protein1681090|2140595|
C064246NCQ 298NCQ 298 binds to DRD2 protein8804920
C064246NCQ 298NCQ 298 binds to DRD2 protein8804920
C030265nemonaprideDRD2 promoter polymorphism affects the susceptibility to nemonapride11505224
C030265nemonaprideCinnarizine inhibits the reaction [nemonapride binds to DRD2 protein]7503767
C030265nemonaprideFlunarizine inhibits the reaction [nemonapride binds to DRD2 protein]7503767
C030265nemonapridenemonapride binds to DRD2 protein7503767
C407426neurotensin 69Lneurotensin 69L results in increased expression of DRD2 mRNA17113052
C028007nickel monoxidenickel monoxide results in decreased expression of DRD2 mRNA19167457
D009538NicotineDRD2 mRNA results in decreased susceptibility to Nicotine24239691
D009538Nicotine[Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Nicotine1833784
D009543NifedipineNifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]]11124974
D009553NimodipineNimodipine inhibits the reaction [Dichlorvos results in decreased activity of DRD2 protein]12186780
D009585Nitrogen DioxideNitrogen Dioxide results in increased expression of DRD2 mRNA19733627
C014707nitrosobenzylmethylamine[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of DRD2 mRNA12517797
C009074N-n-propylnorapomorphineBP 897 inhibits the reaction [N-n-propylnorapomorphine binds to DRD2 protein]10432116
C009074N-n-propylnorapomorphineN-n-propylnorapomorphine binds to DRD2 protein10432116
C009074N-n-propylnorapomorphineDRD2 protein affects the reaction [N-n-propylnorapomorphine analog results in decreased transport of Barium]11124974
C009074N-n-propylnorapomorphineN-n-propylnorapomorphine binds to DRD2 protein6149133
C009074N-n-propylnorapomorphineRemoxipride inhibits the reaction [N-n-propylnorapomorphine binds to DRD2 protein]6149133
C009074N-n-propylnorapomorphineN-n-propylnorapomorphine binds to and results in increased activity of DRD2 protein10528146|1090024
C016868N-n-propyl-N-phenylethyl-4(3-hydroxyphenyl)ethylamine hydrochlorideN-n-propyl-N-phenylethyl-4(3-hydroxyphenyl)ethylamine hydrochloride results in increased activity of DRD2 protein7936204
C025256nonylphenolnonylphenol results in increased expression of DRD2 mRNA15620428
D009638Norepinephrine[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium8032591
D009638NorepinephrineSulpiride inhibits the reaction [[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]8032591
D009638NorepinephrineNorepinephrine inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]20887679
D009638NorepinephrineNorepinephrine inhibits the reaction [Rotenone results in increased expression of DRD2 protein]20887679
D009638NorepinephrineNorepinephrine results in increased activity of DRD2 protein alternative form8032591
C561226N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate"N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate binds to and results in increased activity of DRD2 protein"21591752
D016627OxidopamineDopamine promotes the reaction [Oxidopamine binds to DRD2 protein]16480889
D016627Oxidopamine[Oxidopamine co-treated with levodopa methyl ester] inhibits the reaction [Benserazide results in increased expression of DRD2 protein]19399396
D016627OxidopamineOxidopamine results in increased expression of DRD2 mRNA19118628
D016627OxidopamineOxidopamine results in increased expression of DRD2 protein19399396
D016627OxidopamineTea inhibits the reaction [Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]]16480889
C076029olanzapineDRD2 gene SNP results in increased susceptibility to olanzapine20375926
C076029olanzapineDRD2 intron SNP results in increased susceptibility to olanzapine21187413
C076029olanzapineolanzapine affects the activity of DRD2 protein10482380
C076029olanzapineolanzapine binds to DRD2 protein10831489|2036189
C076029olanzapineolanzapine results in decreased activity of DRD2 protein11198054
C076029olanzapineolanzapine binds to DRD2 protein24389121
C076029olanzapineolanzapine promotes the reaction [Dopamine binds to DRD2 protein]15716360
C076029olanzapineolanzapine binds to DRD2 protein9754850
C005419oxybutyninoxybutynin binds to DRD2 protein10888308
C084589oxypertineoxypertine results in increased expression of DRD21351265
D000068882Paliperidone PalmitatePaliperidone Palmitate binds to and results in decreased activity of DRD2 protein19713555
D000068882Paliperidone PalmitatePaliperidone Palmitate binds to DRD2 protein22214649
D000068882Paliperidone PalmitatePaliperidone Palmitate binds to DRD2 protein22437487
D000068882Paliperidone PalmitatePaliperidone Palmitate binds to and results in decreased activity of DRD2 protein19066856
D010269Paraquat[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA23017109
D010269ParaquatParaquat affects the expression of DRD2 mRNA15206577
D010269ParaquatParaquat results in increased expression of DRD2 mRNA18198484
C480679pardoprunoxpardoprunox binds to and results in increased activity of DRD2 protein20721904
D052638Particulate Matter[Particulate Matter co-treated with Volatile Organic Compounds] results in decreased expression of DRD2 mRNA25265048
D010424Pentobarbital[Haloperidol results in increased expression of DRD2 protein] which results in decreased susceptibility to Pentobarbital2945998
D010433Pentylenetetrazole[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole8103921
D010433PentylenetetrazoleRaclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]8103921
D010433PentylenetetrazoleSCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]8103921
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of DRD2 mRNA26686188
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of DRD2 mRNA26529483
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of DRD2 protein26529483
D010479PergolidePergolide results in increased activity of DRD2 protein16129789
D010479PergolidePergolide binds to and results in increased activity of DRD2 protein11261747|1735633
C065533perospironeperospirone binds to and results in decreased activity of DRD2 protein1975278
C065533perospironeperospirone inhibits the reaction [Spiperone binds to DRD2 protein]1975278
D010546PerphenazinePerphenazine binds to DRD2 protein6147851
D010546PerphenazinePerphenazine binds to and results in decreased activity of DRD2 protein1365866
C539977perphenazine GABA esterperphenazine GABA ester binds to and results in decreased activity of DRD2 protein alternative form18757185
C000593032PGW5 compoundPGW5 compound binds to DRD2 protein24389121
D010622PhencyclidinePhencyclidine results in decreased expression of DRD2 mRNA17266109|2065955
D010622PhencyclidinePhencyclidine results in decreased expression of DRD2 protein20659557
D010627PhenethylaminesPhenethylamines analog binds to DRD2 protein16539400
D010634PhenobarbitalPhenobarbital results in decreased expression of DRD2 mRNA25270620
D010862PilocarpineDRD2 protein results in decreased susceptibility to Pilocarpine11860278
D010862PilocarpineDRD2 protein results in decreased susceptibility to Pilocarpine1365435
D010862PilocarpinePilocarpine inhibits the reaction [Spiperone binds to DRD2 protein]16137708
D010862PilocarpinePilocarpine promotes the reaction [Spiperone binds to DRD2 protein]14559291
D010862PilocarpinePilocarpine results in decreased activity of DRD2 protein15876489
D010862PilocarpinePilocarpine results in decreased expression of DRD2 protein15876489
D010862Pilocarpine[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine15140183
D010862Pilocarpine[Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [Dopamine results in decreased susceptibility to Pilocarpine]15140183
D010862PilocarpineDRD2 protein promotes the reaction [NPY protein results in decreased susceptibility to Pilocarpine]18005069
D010862Pilocarpine[Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [NPY protein results in decreased susceptibility to Pilocarpine]18005069
D010868PimozidePimozide binds to DRD2 protein6147851
D010868PimozidePimozide binds to and results in decreased activity of DRD2 protein19958787
D010879PiperazinesPiperazines analog binds to DRD2 protein21509803
D010880PiperidinesPiperidines analog binds to and results in decreased activity of DRD2 protein12413863
D010891PiribedilPiribedil binds to and results in increased activity of DRD2 protein10728880
D010891PiribedilPiribedil binds to and results in increased activity of DRD2 protein10728880
D010936Plant ExtractsPlant Extracts results in decreased expression of DRD2 mRNA23557933
C061333pramipexolepramipexole binds to and results in increased activity of DRD2 protein10728880
C061333pramipexolepramipexole binds to and results in increased activity of DRD2 protein10728880
C061333pramipexolepramipexole binds to and results in increased activity of DRD2 protein10683862|1126174
C026539preclamolpreclamol binds to and results in increased activity of DRD2 protein1681090
D000069583PregabalinPregabalin results in decreased expression of DRD2 mRNA22489711
C015586propiverinepropiverine binds to DRD2 protein10888308
D0014983-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester inhibits the reaction [DRD2 protein results in decreased transport of Barium]"11124974
D011725PyridinesPyridines analog binds to and results in decreased activity of DRD2 protein12593651
D011725PyridinesPyridines analog binds to and results in decreased activity of DRD2 protein12593651
D011794QuercetinQuercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of DRD2 mRNA]21472459
D000069348Quetiapine FumarateQuetiapine Fumarate promotes the reaction [Dopamine binds to DRD2 protein]15716360
C047726quineloranequinelorane binds to and results in increased activity of DRD2 protein10728880
C047726quineloraneCCKBR protein affects the reaction [[quinelorane binds to and results in increased activity of DRD2 protein] which results in decreased abundance of Cyclic AMP]11880531
C047726quinelorane[quinelorane binds to and results in increased activity of DRD2 protein] which results in decreased abundance of Cyclic AMP11880531
C047726quineloranequinelorane binds to and results in increased activity of DRD2 protein10728880
C047726quineloranequinelorane binds to and results in increased activity of DRD2 protein10683862|1188053
D017378Quinolinic AcidQuinolinic Acid results in increased expression of DRD2 protein12207953
D015363QuinolonesQuinolones analog binds to and results in increased activity of DRD2 protein9171869
D019257QuinpiroleQuinpirole binds to and results in increased activity of DRD2 protein15725338
D019257QuinpiroleDRD2 protein promotes the reaction [Quinpirole results in decreased expression of POU5F1 mRNA]27920206
D019257QuinpiroleDRD2 protein results in increased susceptibility to Quinpirole27920206
D019257Quinpiroleepigallocatechin gallate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]17958328
D019257QuinpiroleJB-788 inhibits the reaction [Quinpirole binds to and results in increased activity of DRD2 protein]20580787
D019257QuinpiroleQuinpirole binds to and results in increased activity of DRD2 protein20580787
D019257Quinpirole[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium8032591
D019257Quinpirole[Quinpirole binds to and results in increased activity of DRD2 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]17958328
D019257Quinpirole[Quinpirole co-treated with DRD2 protein alternative form] results in increased activity of RHOA protein27717053
D019257QuinpiroleQuinpirole results in increased activity of DRD2 protein27920206
D019257QuinpiroleSulpiride inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]8032591
D019257Quinpirole"DRD2 affects the susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole]"9547254
D019257QuinpiroleDRD2 protein affects the reaction [Quinpirole results in increased phosphorylation of CFL1 protein]27717053
D019257QuinpiroleDRD2 results in increased susceptibility to Quinpirole11790512
D019257QuinpiroleQuinpirole binds to and results in increased activity of DRD2 protein14622157
D019257Quinpirolecypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
D019257Quinpiroledecamethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
D019257QuinpiroleDRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]11124974
D019257QuinpiroleDRD2 protein affects the susceptibility to Quinpirole12071432
D019257Quinpiroleestradiol 3-benzoate inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
D019257QuinpiroleHaloperidol inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
D019257Quinpirolemirtazapine inhibits the reaction [Quinpirole binds to DRD2 protein]12523492
D019257QuinpiroleNifedipine inhibits the reaction [DRD2 protein affects the reaction [Quinpirole results in decreased transport of Barium]]11124974
D019257QuinpiroleQuinpirole binds to and results in increased activity of DRD2 protein1724532
D019257Quinpirole[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine10936494
D019257Quinpiroletautomycin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
D019257QuinpiroleQuinpirole binds to and results in increased activity of DRD2 protein10217549|1066990
D019257QuinpiroleQuinpirole results in increased activity of DRD2 protein alternative form8032591
D020891RacloprideCocaine affects the reaction [Raclopride binds to DRD2]15010698
D020891Raclopride[Dopamine co-treated with Raclopride] promotes the reaction [Dopamine binds to DRD2 protein]19439595
D020891RacloprideRaclopride binds to DRD215010698
D020891RacloprideRaclopride binds to DRD2 protein18058087|1943959
D020891RacloprideAmlodipine inhibits the reaction [Raclopride binds to DRD2 protein]9533112
D020891Raclopridebisphenol A promotes the reaction [Raclopride binds to DRD2 protein]20169576
D020891RacloprideDiltiazem inhibits the reaction [Raclopride binds to DRD2 protein]9533112
D020891RacloprideDRD2 protein alternative form results in increased susceptibility to Raclopride12476322
D020891RacloprideFlunarizine inhibits the reaction [Raclopride binds to DRD2 protein]9533112
D020891Raclopridemanidipine inhibits the reaction [Raclopride binds to DRD2 protein]9533112
D020891RacloprideRaclopride binds to DRD2 protein12673668|1475680
D020891RacloprideRaclopride binds to DRD2 protein alternative form12476322
D020891RacloprideRaclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]8103921
D020891RacloprideVerapamil inhibits the reaction [Raclopride binds to DRD2 protein]9533112
D020891RacloprideDRD2 protein affects the reaction [Raclopride results in increased expression of CTNNB1 protein]16144542
D020891RacloprideDRD2 protein affects the reaction [Raclopride results in increased expression of GSK3A protein]16144542
D020891RacloprideRaclopride binds to and results in decreased activity of DRD2 protein15341276|1554262
D020891Raclopride[Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methylphenidate11454915
D020891Raclopride[Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Nicotine1833784
D020891Raclopride[Raclopride binds to and results in decreased activity of DRD2 protein] which results in increased abundance of Dopamine15341276
D020891RacloprideRaclopride binds to DRD2 protein7901417|8804920
D020891RacloprideSaponins inhibits the reaction [Raclopride binds to DRD2 protein]16251992
D020891RacloprideRaclopride binds to and results in decreased activity of DRD2 protein10098858|1043541
D020891RacloprideRaclopride binds to and results in increased activity of DRD2 protein16289883
D020891RacloprideRaclopride binds to DRD2 protein16251992
D017330RemoxiprideRemoxipride binds to and results in decreased activity of DRD2 protein1724532|6149133
D017330RemoxiprideRemoxipride binds to DRD2 protein7901417
D017330RemoxiprideRemoxipride inhibits the reaction [N-n-propylnorapomorphine binds to DRD2 protein]6149133
D017330RemoxiprideRemoxipride inhibits the reaction [Spiperone binds to DRD2 protein]6149133
D017330Remoxipride[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine15140183
D017330Remoxipride[Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [Dopamine results in decreased susceptibility to Pilocarpine]15140183
D017330RemoxiprideRemoxipride binds to and results in decreased activity of DRD2 protein20542064|8103921
D017330RemoxiprideRemoxipride results in decreased activity of DRD2 protein15140183|1800506
D017330Remoxipride[Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [NPY protein results in decreased susceptibility to Pilocarpine]18005069
D012110ReserpineDRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]11172060
D012110ReserpineReserpine results in increased expression of DRD2 mRNA8419537
D012110ReserpineReserpine results in increased expression of DRD2 mRNA alternative form1331675
D018967RisperidoneRisperidone binds to and results in decreased activity of DRD2 protein16948927
D018967RisperidoneDRD2 gene polymorphism affects the susceptibility to Risperidone21869689
D018967RisperidoneDRD2 gene polymorphism results in increased susceptibility to Risperidone19339912
D018967RisperidoneDRD2 gene SNP results in increased susceptibility to Risperidone20375926
D018967RisperidoneDRD2 protein results in increased susceptibility to Risperidone21869689
D018967RisperidoneRisperidone binds to and results in decreased activity of DRD2 protein19910723
D018967RisperidoneRisperidone binds to DRD2 protein10831489|1571005
D018967RisperidoneRisperidone binds to DRD2 protein22214649
D018967RisperidoneDRD2 protein affects the reaction [Risperidone results in increased expression of CTNNB1 protein]16144542
D018967RisperidoneDRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein]16144542
D018967RisperidoneDRD2 protein affects the reaction [Risperidone results in increased expression of GSK3A protein]16144542
D018967RisperidoneDRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein]16144542
D018967RisperidoneRisperidone binds to and results in decreased activity of DRD2 protein1380082|16033416
D018967Risperidone[Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein16033416
D018967RisperidoneRisperidone binds to DRD2 protein12191584|2243748
D018967RisperidoneRisperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein]7520908
D018967RisperidoneRisperidone promotes the reaction [Dopamine binds to DRD2 protein]15716360
D018967RisperidoneRisperidone binds to and results in decreased activity of DRD2 protein16716128
D018967RisperidoneRisperidone results in decreased activity of DRD2 protein7508675
C046649ropiniroleropinirole binds to and results in increased activity of DRD2 protein18393062
D012402RotenoneApigenin inhibits the reaction [Rotenone results in decreased expression of DRD2 protein]28389404
D012402RotenoneMelatonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein]18289173
D012402RotenoneNorepinephrine inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]20887679
D012402RotenoneNorepinephrine inhibits the reaction [Rotenone results in increased expression of DRD2 protein]20887679
D012402RotenoneRotenone results in decreased expression of DRD2 protein28389404
D012402RotenoneRotenone results in increased expression of DRD2 mRNA20887679
D012402RotenoneRotenone results in increased expression of DRD2 protein18289173|2088767
D012402RotenoneSerotonin inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]20887679
D012402RotenoneSerotonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein]20887679
C047508rotigotinerotigotine binds to and results in increased activity of DRD2 protein23165154
D012503SaponinsSaponins inhibits the reaction [Raclopride binds to DRD2 protein]16251992
C443959sarizotansarizotan binds to DRD2 protein14767715
C443959sarizotansarizotan binds to DRD2 protein14767715
C534628SCH 23390SCH 23390 inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]8103921
C534628SCH 23390SCH 23390 binds to and results in decreased activity of DRD2 protein9264077
C045359setoperonesetoperone binds to and results in decreased activity of DRD2 protein2524857
D019821SimvastatinSimvastatin results in increased expression of DRD2 mRNA15711596
D019821SimvastatinSimvastatin results in increased expression of DRD2 protein15711596
C017947sodium arsenitesodium arsenite results in decreased expression of DRD2 mRNA20699118
C017947sodium arsenitesodium arsenite results in increased expression of DRD2 mRNA25179238
C017947sodium arsenitesodium arsenite results in increased expression of DRD2 protein25179238
D013134SpiperoneSpiperone binds to and results in decreased activity of DRD2 protein15725338
D013134SpiperoneSpiperone binds to DRD2 protein15237387
D013134SpiperoneSpiperone binds to DRD2 protein6147851
D013134SpiperoneMelitten inhibits the reaction [Spiperone binds to DRD2 protein]20969853
D013134SpiperoneSpiperone binds to DRD2 protein20969853|2199957
D013134Spiperoneamitraz inhibits the reaction [Spiperone binds to DRD2 protein]2833825
D013134Spiperonedemethylchlordimeform inhibits the reaction [Spiperone binds to DRD2 protein]2833825
D013134SpiperoneNR3C1 protein promotes the reaction [Spiperone binds to DRD2 protein]11226678
D013134SpiperoneSpiperone binds to DRD2 protein11226678|2833825
D013134Spiperone"8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Spiperone binds to DRD2 protein]"11927170
D013134SpiperoneAmphetamine inhibits the reaction [Spiperone binds to DRD2 protein]2018630
D013134Spiperone"Caffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]]"16889759
D013134SpiperoneCocaine affects the reaction [Spiperone binds to DRD2 protein]17161392
D013134SpiperoneHaloperidol inhibits the reaction [Spiperone binds to DRD2 protein]11927170
D013134Spiperonemanganese chloride inhibits the reaction [DRD2 protein binds to Spiperone]21484877
D013134Spiperone"N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]"16889759
D013134Spiperoneperospirone inhibits the reaction [Spiperone binds to DRD2 protein]1975278
D013134SpiperonePilocarpine inhibits the reaction [Spiperone binds to DRD2 protein]16137708
D013134SpiperonePilocarpine promotes the reaction [Spiperone binds to DRD2 protein]14559291
D013134SpiperoneRemoxipride inhibits the reaction [Spiperone binds to DRD2 protein]6149133
D013134SpiperoneSpiperone binds to DRD2 protein11927170|1455929
D013134SpiperoneSpiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]20729865
D013134SpiperoneSpiperone binds to DRD2 protein2953603
D013134SpiperoneDRD2 protein binds to Spiperone21484877
D013134SpiperoneSpiperone binds to and results in decreased activity of DRD2 protein2947255|8558425|
D013134SpiperoneSpiperone binds to DRD2 protein17161392
C010513stepholidinestepholidine binds to and results in decreased activity of DRD2 protein18521575
D013469SulpirideSulpiride binds to DRD2 protein20361897
D013469SulpirideSulpiride inhibits the reaction [[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]8032591
D013469SulpirideSulpiride inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]8032591
D013469Sulpiride[Sulpiride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methamphetamine20340177
D013469SulpirideMethamphetamine inhibits the reaction [Sulpiride binds to DRD2 protein]2891082
D013469SulpirideSulpiride binds to and results in decreased activity of DRD2 protein8774428
D013469SulpirideSulpiride binds to DRD2 protein2901473
D013469SulpirideSulpiride inhibits the reaction [Tacrolimus affects the activity of DRD2 protein]15332494
D013469SulpirideSulpiride results in decreased activity of DRD2 protein7644023
D013469SulpirideSulpiride results in increased expression of DRD21351265
D013469SulpirideSulpiride binds to and results in decreased activity of DRD2 protein10379793|1044892
D013469SulpirideSulpiride binds to DRD2 protein2891082|9087973
D013469SulpirideSulpiride results in decreased activity of DRD2 protein6367362
C012052sultopridesultopride binds to DRD2 protein12191584
D016559TacrolimusSulpiride inhibits the reaction [Tacrolimus affects the activity of DRD2 protein]15332494
D016559TacrolimusTacrolimus affects the activity of DRD2 protein15332494
C024763talipexoletalipexole binds to and results in increased activity of DRD2 protein1365866
C053079tautomycintautomycin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]10936494
D013662TeaTea inhibits the reaction [Dopamine promotes the reaction [Oxidopamine binds to DRD2 protein]]16480889
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DRD2 mRNA21570461
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"DRD2 affects the susceptibility to [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine co-treated with Quinpirole]"9547254
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine inhibits the reaction [Methamphetamine affects the activity of DRD2 protein]"18489579
C014215tetrahydropalmatinetetrahydropalmatine binds to and results in decreased activity of DRD2 protein17361394
D008063Thioctic AcidThioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 mRNA]20730801
D008063Thioctic AcidThioctic Acid inhibits the reaction [Haloperidol results in increased expression of DRD2 protein]20730801
D013881ThioridazineThioridazine binds to DRD2 protein6147851
D013881ThioridazineThioridazine binds to DRD2 protein8101879
C050504tianeptinetianeptine results in decreased expression of DRD2 mRNA11981225
D013976Tiapamil HydrochlorideTiapamil Hydrochloride binds to DRD2 protein9808703
D013976Tiapamil HydrochlorideTiapamil Hydrochloride binds to DRD2 protein2901473
D013976Tiapamil HydrochlorideTiapamil Hydrochloride binds to and results in decreased activity of DRD2 protein6858777
D013976Tiapamil HydrochlorideTiapamil Hydrochloride results in decreased activity of DRD2 protein4074571
D063325Tiapride HydrochlorideTiapride Hydrochloride binds to and results in decreased activity of DRD2 protein8241609
C052342topiramatetopiramate results in increased expression of DRD2 mRNA22489711
D014147TramadolTramadol results in increased expression of DRD2 protein15464068
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to DRD2 gene]26655721
D014212TretinoinTretinoin promotes the reaction [ZMYND8 protein binds to DRD2 promoter]26655721
D014212TretinoinTretinoin results in increased expression of DRD2 mRNA26655721
D014212TretinoinZMYND8 protein affects the reaction [Tretinoin results in increased expression of DRD2 mRNA]26655721
C012589trichostatin Atrichostatin A results in increased expression of DRD2 mRNA24204683
D014268TrifluoperazineTrifluoperazine binds to DRD2 protein6147851
D014273TriflupromazineTriflupromazine binds to DRD2 protein6147851
C108539U 95666EU 95666E binds to and results in increased activity of DRD2 protein20494958
C045971UH 232UH 232 binds to and results in decreased activity of DRD2 protein10728880
D014635Valproic AcidValproic Acid results in decreased expression of DRD2 protein16478526
D014635Valproic AcidValproic Acid results in increased expression of DRD2 mRNA23665938
D014700VerapamilVerapamil inhibits the reaction [Raclopride binds to DRD2 protein]9533112
D014801Vitamin AVitamin A results in decreased expression of DRD2 protein22274401
D055549Volatile Organic Compounds[Particulate Matter co-treated with Volatile Organic Compounds] results in decreased expression of DRD2 mRNA25265048
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD2 mRNA"27188386
D015032Zinc[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of DRD2 mRNA12517797
D015032ZincZinc deficiency results in decreased expression of DRD2 mRNA15173390
D019345Zinc AcetateZinc Acetate inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
C016837zinc chloridezinc chloride inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
C016837zinc chloridezinc chloride inhibits the reaction [Haloperidol binds to DRD2 protein]9109525
D019287Zinc SulfateZinc Sulfate inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]9109525
C092292ziprasidoneziprasidone binds to and results in decreased activity of DRD2 protein7562537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001591dopamine neurotransmitter receptor activity, coupled via Gi/Go-IDA8301582  
GO:0004935adrenergic receptor activity-IBA21873635  
GO:0005515protein binding-IPI10692483  17380124  19632986  
GO:0008144drug binding-IDA8413587  
GO:0035255ionotropic glutamate receptor binding-IEA-  
GO:0042802identical protein binding-IPI18668123  
GO:0042803protein homodimerization activity-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001659temperature homeostasis-ISS-  
GO:0001666response to hypoxia-IEA-  
GO:0001933negative regulation of protein phosphorylation-IEA-  
GO:0001975response to amphetamine-ISS-  
GO:0001976neurological system process involved in regulation of systemic arterial blood pressure-ISS-  
GO:0002027regulation of heart rate-ISS-  
GO:0002028regulation of sodium ion transport-ISS-  
GO:0002031G-protein coupled receptor internalization-IEA-  
GO:0002052positive regulation of neuroblast proliferation-ISS-  
GO:0002092positive regulation of receptor internalization-IEA-  
GO:0006914autophagy-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007195adenylate cyclase-inhibiting dopamine receptor signaling pathway-IDA8666994  26554819  
GO:0007267cell-cell signaling-IBA21873635  
GO:0007270neuron-neuron synaptic transmission-ISS-  
GO:0007409axonogenesis-ISS-  
GO:0007416synapse assembly-ISS-  
GO:0007608sensory perception of smell-ISS-  
GO:0007616long-term memory-IEA-  
GO:0007625grooming behavior-IEA-  
GO:0007626locomotory behavior-ISS-  
GO:0007628adult walking behavior-ISS-  
GO:0008104protein localization-ISS-  
GO:0008285negative regulation of cell proliferation-ISS-  
GO:0008306associative learning-ISS-  
GO:0008542visual learning-ISS-  
GO:0009416response to light stimulus-ISS-  
GO:0010039response to iron ion-IEA-  
GO:0014854response to inactivity-IEA-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0021756striatum development-IEA-  
GO:0021769orbitofrontal cortex development-IEA-  
GO:0021853cerebral cortex GABAergic interneuron migration-ISS-  
GO:0021984adenohypophysis development-ISS-  
GO:0030336negative regulation of cell migration-ISS-  
GO:0030432peristalsis-ISS-  
GO:0031223auditory behavior-IEA-  
GO:0032147activation of protein kinase activity-IEA-  
GO:0032228regulation of synaptic transmission, GABAergic-ISS-  
GO:0032467positive regulation of cytokinesis-IMP22888021  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0033602negative regulation of dopamine secretion-IEA-  
GO:0034776response to histamine-IDA16839358  
GO:0035094response to nicotine-IEA-  
GO:0035810positive regulation of urine volume-IEA-  
GO:0035815positive regulation of renal sodium excretion-IEA-  
GO:0040018positive regulation of multicellular organism growth-IEA-  
GO:0042220response to cocaine-ISS-  
GO:0042321negative regulation of circadian sleep/wake cycle, sleep-IEA-  
GO:0042417dopamine metabolic process-IC8301582  
GO:0042493response to drug-ISS-  
GO:0042756drinking behavior-IEA-  
GO:0043266regulation of potassium ion transport-ISS-  
GO:0043278response to morphine-ISS-  
GO:0043473pigmentation-IEA-  
GO:0043666regulation of phosphoprotein phosphatase activity-IEA-  
GO:0045745positive regulation of G-protein coupled receptor protein signaling pathway-IEA-  
GO:0045776negative regulation of blood pressure-ISS-  
GO:0045824negative regulation of innate immune response-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0046676negative regulation of insulin secretion-IEA-  
GO:0048148behavioral response to cocaine-ISS-  
GO:0048149behavioral response to ethanol-ISS-  
GO:0048169regulation of long-term neuronal synaptic plasticity-ISS-  
GO:0048678response to axon injury-IEA-  
GO:0048755branching morphogenesis of a nerve-ISS-  
GO:0050482arachidonic acid secretion-IDA8301582  
GO:0050709negative regulation of protein secretion-IDA16839358  
GO:0051209release of sequestered calcium ion into cytosol-ISS-  
GO:0051584regulation of dopamine uptake involved in synaptic transmission-IC8301582  
GO:0051586positive regulation of dopamine uptake involved in synaptic transmission-ISS-  
GO:0051823regulation of synapse structural plasticity-IEA-  
GO:0051898negative regulation of protein kinase B signaling-ISS-  
GO:0051898negative regulation of protein kinase B signaling-NAS21711983  
GO:0051967negative regulation of synaptic transmission, glutamatergic-ISS-  
GO:0060079excitatory postsynaptic potential-NAS21711983  
GO:0060124positive regulation of growth hormone secretion-ISS-  
GO:0060134prepulse inhibition-ISS-  
GO:0060158phospholipase C-activating dopamine receptor signaling pathway-IGI17194762  
GO:0060160negative regulation of dopamine receptor signaling pathway-ISS-  
GO:0060548negative regulation of cell death-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IEA-  
GO:0071880adenylate cyclase-activating adrenergic receptor signaling pathway-IBA21873635  
GO:0090325regulation of locomotion involved in locomotory behavior-IEA-  
GO:1900168positive regulation of glial cell-derived neurotrophic factor secretion-IDA23373701  
GO:1900273positive regulation of long-term synaptic potentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-IEA-  
GO:0005886plasma membrane-IDA26554819  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA8413587  
GO:0014069postsynaptic density-IEA-  
GO:0016328lateral plasma membrane-IEA-  
GO:0030139endocytic vesicle-IEA-  
GO:0030424axon-ISS-  
GO:0030425dendrite-ISS-  
GO:0036126sperm flagellum-IEA-  
GO:0043197dendritic spine-IEA-  
GO:0043204perikaryon-IEA-  
GO:0043679axon terminus-IEA-  
GO:0060170ciliary membrane-IDA20531939  
GO:0097730non-motile cilium-IDA20531939  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa04540Gap junction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375280Amine ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-390651Dopamine receptorsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24636783Hypothesizing dopaminergic genetic antecedents in schizophrenia and substance seeking behavior. (2014 May)Blum KMed Hypotheses
1832467No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism. (1991 Oct 2)Gelernter JJAMA
1832466The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. (1991 Oct 2)Comings DEJAMA
15138759Changes in food reward following smoking cessation: a pharmacogenetic investigation. (2004 Aug)Lerman CPsychopharmacology (Berl)
27490263The association of dopamine pathway gene score, nicotine dependence and smoking cessation in a rural male population of Shandong, China. (2016 Sep)Li SAm J Addict
19603545Association of the dopamine D2 receptor gene with alcohol dependence: haplotypes and subgroups of alcoholics as key factors for understanding receptor function. (2009 Jul)Kraschewski APharmacogenet Genomics
12482370[Study on the association between smoking behavior and dopamine receptor D2 gene polymorphisms among lung cancer cases]. (2002 Oct)Qi JZhonghua Liu Xing Bing Xue Za Zhi
19095220Baseline expression of alpha4beta2* nicotinic acetylcholine receptors predicts motivation to self-administer nicotine. (2009 Apr 15)Le Foll BBiol Psychiatry
14643564The A1 allele of the DRD2 gene (TaqI A polymorphisms) is associated with antisocial personality in a sample of alcohol-dependent patients. (2003 Nov)Ponce GEur Psychiatry
24001687Acute binge pattern cocaine administration induces region-specific effects in D1-r- and D2-r-expressing cells in eGFP transgenic mice. (2013 Dec 3)Lawhorn CNeuroscience
21244814Waterpipe Smoking And The DRD2/ANKK1 Genotype. (2010)Radwan GNJ Egypt Public Health Assoc
16426891P300 development during adolescence: effects of DRD2 genotype. (2006 Mar)Berman SMClin Neurophysiol
18563706The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening study. (2009 Mar 5)Styn MAAm J Med Genet B Neuropsychiatr Genet
1478642Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23. (1992 Dec)Eubanks JHGenomics
15066703Polymorphisms of the dopamine D2 receptor, serotonin transporter, and GABA(A) receptor beta(3) subunit genes and alcoholism in Mexican-Americans. (2004 Jan)Konishi TAlcohol
10881203Addiction and its reward process through polymorphisms of the D2 dopamine receptor gene: a review. (2000 Mar)Noble EPEur Psychiatry
11319183Association between the dopamine D2 receptor A2/A2 genotype and smoking behavior in the Japanese. (2001 Apr)Yoshida KCancer Epidemiol Biomarkers Prev
10881206The DRD2 gene and the risk for alcohol dependence in bipolar patients. (2000 Mar)Gorwood PEur Psychiatry
10881204Reappraisal of the association between the DRD2 gene, alcoholism and addiction. (2000 Mar)Gorwood PEur Psychiatry
10881205Association of D2 dopamine receptor and alcohol dehydrogenase 2 genes with Polynesian alcoholics. (2000 Mar)Amadeo SEur Psychiatry
10597409Brain event-related potentials, dopamine D2 receptor gene polymorphism, and smoking. (1999)Anokhin APGenet Epidemiol
27819741Association between dopamine D2 receptor gene polymorphisms and the risk of heroin dependence. (2016 Nov 3)Wang NGenet Mol Res
29464814DRD2 promoter methylation and measures of alcohol reward: functional activation of reward circuits and clinical severity. (2018 Feb 21)Bidwell LCAddict Biol
26153084CYP2B6 rs2279343 polymorphism is associated with smoking cessation success in bupropion therapy. (2015 Sep)Tomaz PREur J Clin Pharmacol
16840287The genetic transmission of alcoholism: implications for prevention. (1993)Noble EPDrug Alcohol Rev
22958175Association of dopamine-related gene alleles, smoking behavior and decline in FEV1 in subjects with COPD: findings from the lung health study. (2012 Dec)Tashkin DPCOPD
19940429Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART). (2009 Nov)Blum KPostgrad Med
12497624D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. (2003 Jan 1)Noble EPAm J Med Genet B Neuropsychiatr Genet
29275025[Genetic factors in alcohol dependence]. (2017 Dec 20)Ramoz NPresse Med
7485260What can the DRD2/alcoholism story teach us about association studies in psychiatric genetics? (1995 Aug 14)Neiswanger KAm J Med Genet
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