Gene info: ID 1814

Gene: DRD3

GENE ID: 1814

Synonyms: D3DR|ETM1|FET1

Description: dopamine receptor D3

Gene type: protein-coding

Location: 3q13.31

dbXrefs: Ensembl:ENSG00000151577 MIM:126451 Vega:OTTHUMG00000159334 UniprotKB:P35462

RefSeq: NG_008842.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 40

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.150e-1 (AD) 7.466e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GPR101	0.985
ENTHD1	0.982
SAG	0.98
DGKK	0.967
AMBN	0.962
CHAT	0.949
GPR1	0.945
TMPRSS6	0.945
SLC35D3	0.941
ZBED2	0.936

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SLC17A7	-0.411
SYTL2	-0.385
NANOS3	-0.373
NEUROD2	-0.346
GALNT9	-0.339
ALDH1A1	-0.329
SOHLH1	-0.326
NXPH3	-0.316
TNNT2	-0.314
NTNG2	-0.309

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00246	Ziprasidone	Small Molecule	146939-27-7	Approved	Target
DB00248	Cabergoline	Small Molecule	81409-90-7	Approved	Target
DB00268	Ropinirole	Small Molecule	91374-21-9	Approved\|Investigational	Target
DB00334	Olanzapine	Small Molecule	132539-06-1	Approved\|Investigational	Target
DB00363	Clozapine	Small Molecule	5786-21-0	Approved	Target
DB00370	Mirtazapine	Small Molecule	85650-52-8	Approved	Target
DB00391	Sulpiride	Small Molecule	15676-16-1	Approved\|Investigational	Target
DB00408	Loxapine	Small Molecule	1977-10-2	Approved	Target
DB00409	Remoxipride	Small Molecule	80125-14-0	Approved\|Withdrawn	Target
DB00413	Pramipexole	Small Molecule	104632-26-0	Approved\|Investigational	Target
DB00477	Chlorpromazine	Small Molecule	50-53-3	Approved\|Investigational	Target
DB00502	Haloperidol	Small Molecule	52-86-8	Approved	Target
DB00543	Amoxapine	Small Molecule	14028-44-5	Approved	Target
DB00589	Lisuride	Small Molecule	18016-80-3	Approved\|Investigational	Target
DB00714	Apomorphine	Small Molecule	58-00-4	Approved\|Investigational	Target
DB00734	Risperidone	Small Molecule	106266-06-2	Approved\|Investigational	Target
DB00988	Dopamine	Small Molecule	51-61-6	Approved	Target
DB01100	Pimozide	Small Molecule	2062-78-4	Approved	Target
DB01184	Domperidone	Small Molecule	57808-66-9	Approved\|Investigational	Target
DB01186	Pergolide	Small Molecule	66104-22-1	Approved\|Investigational\|Withdrawn	Target
DB01200	Bromocriptine	Small Molecule	25614-03-3	Approved\|Investigational	Target
DB01224	Quetiapine	Small Molecule	111974-69-7	Approved	Target
DB01235	Levodopa	Small Molecule	59-92-7	Approved	Target
DB01238	Aripiprazole	Small Molecule	129722-12-9	Approved\|Investigational	Target
DB01239	Chlorprothixene	Small Molecule	113-59-7	Approved\|Investigational\|Withdrawn	Target
DB01267	Paliperidone	Small Molecule	144598-75-4	Approved	Target
DB01392	Yohimbine	Small Molecule	146-48-5	Approved\|Investigational	Target
DB01403	Methotrimeprazine	Small Molecule	60-99-1	Approved\|Investigational	Target
DB04946	Iloperidone	Small Molecule	133454-47-4	Approved	Target
DB05271	Rotigotine	Small Molecule	99755-59-6	Approved	Target
DB05766	ACP-104	Small Molecule	-	Investigational	Target
DB06016	Cariprazine	Small Molecule	839712-12-8	Approved\|Investigational	Target
DB06148	Mianserin	Small Molecule	24219-97-4	Approved\|Investigational	Target
DB06216	Asenapine	Small Molecule	65576-45-6	Approved	Target
DB06288	Amisulpride	Small Molecule	71675-85-9	Approved\|Investigational	Target
DB06454	Sarizotan	Small Molecule	351862-32-3	Investigational	Target
DB06477	Sumanirole	Small Molecule	179386-43-7	Investigational	Target
DB09014	Captodiame	Small Molecule	486-17-9	Approved\|Investigational	Target
DB09207	AS-8112	Small Molecule	-	Experimental	Target
DB09223	Blonanserin	Small Molecule	132810-10-7	Approved\|Investigational	Target
DB09286	Pipamperone	Small Molecule	1893-33-0	Approved\|Investigational	Target
DB12061	Pardoprunox	Small Molecule	269718-84-5	Investigational	Target
DB12478	Piribedil	Small Molecule	3605-01-4	Investigational	Target
DB13025	Tiapride	Small Molecule	51012-32-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C014843	1,2,3,4-tetrahydroisoquinoline	"1,2,3,4-tetrahydroisoquinoline analog binds to DRD3 protein"	15185375
C461261	(1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate)	DRD3 protein results in increased susceptibility to (1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate)	19497322
C060229	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]]"	19217379
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of DRD3 mRNA"	25614096
C094012	3-(3-cyanophenyl)-N-n-propylpiperidine	3-(3-cyanophenyl)-N-n-propylpiperidine binds to and results in decreased activity of DRD3 protein	11080548
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD3 protein"	10728880
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"[3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD3 protein] which results in decreased susceptibility to Cocaine"	18566292
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to DRD3 protein"	15203435
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"[3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol co-treated with Cocaine] affects the localization of DRD3 protein"	18566292
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"bisphenol A inhibits the reaction [3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to DRD3 protein]"	15203435
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"SB 277011 inhibits the reaction [[3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD3 protein] which results in decreased susceptibility to Cocaine]"	18566292
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to DRD3 protein"	10700011
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol results in increased activity of DRD3 protein"	19217379
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"[3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol results in increased activity of DRD3 protein] which results in increased phosphorylation of MAPK1 protein"	19217379
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"Ionomycin inhibits the reaction [[3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol results in increased activity of DRD3 protein] which results in increased phosphorylation of MAPK1 protein]"	19217379
C062458	3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol	"3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD3 protein"	11522464\|1507563
C104750	3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole	3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole binds to and results in decreased activity of DRD3 protein	10728880
C039167	3-N-methylspiperone	3-N-methylspiperone binds to DRD3 protein	10215675
C039167	3-N-methylspiperone	Cadmium inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]	10215675
C039167	3-N-methylspiperone	Copper inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]	10215675
C039167	3-N-methylspiperone	Gold inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]	10215675
C039167	3-N-methylspiperone	Mercury inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]	10215675
C039167	3-N-methylspiperone	Silver inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]	10215675
C039167	3-N-methylspiperone	Zinc inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]	10215675
C416545	4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline	"4,4a,5,6,7,8,8a,9-octahydro-5-propyl-1H-pyrzolo(3,4-g)quinoline binds to and results in increased activity of DRD3 protein"	7936204
C008745	4,4'-bisphenol F	"4,4'-bisphenol F results in decreased expression of DRD3 mRNA"	26186136
C477197	4-iodo-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)cinnamoylamide	4-iodo-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)cinnamoylamide binds to DRD3 protein	12930150
C086335	(5,6-dimethoxyindan-2-yl)dipropylamine	"(5,6-dimethoxyindan-2-yl)dipropylamine binds to and results in decreased activity of DRD3 protein"	10728880
C086335	(5,6-dimethoxyindan-2-yl)dipropylamine	"(5,6-dimethoxyindan-2-yl)dipropylamine binds to and results in decreased activity of DRD3 protein"	10432116
C051171	5-methoxy-1-methyl-2-(n-propylamino)tetralin	5-methoxy-1-methyl-2-(n-propylamino)tetralin binds to and results in decreased activity of DRD3 protein	10728880
C031349	7-hydroxy-2-N,N-dipropylaminotetralin	"7-hydroxy-2-N,N-dipropylaminotetralin binds to and results in increased activity of DRD3 protein"	10728880
C031349	7-hydroxy-2-N,N-dipropylaminotetralin	"7-hydroxy-2-N,N-dipropylaminotetralin results in increased activity of DRD3 protein"	15203435
C031349	7-hydroxy-2-N,N-dipropylaminotetralin	"bisphenol A inhibits the reaction [7-hydroxy-2-N,N-dipropylaminotetralin results in increased activity of DRD3 protein]"	15203435
C031349	7-hydroxy-2-N,N-dipropylaminotetralin	"7-hydroxy-2-N,N-dipropylaminotetralin binds to DRD3 protein"	10700011\|7878047
C031349	7-hydroxy-2-N,N-dipropylaminotetralin	"7-hydroxy-2-N,N-dipropylaminotetralin inhibits the reaction [Cocaine affects the activity of DRD3 protein]"	15100700
C031349	7-hydroxy-2-N,N-dipropylaminotetralin	"Oxidopamine inhibits the reaction [7-hydroxy-2-N,N-dipropylaminotetralin binds to DRD3 protein]"	7878047
C031349	7-hydroxy-2-N,N-dipropylaminotetralin	"7-hydroxy-2-N,N-dipropylaminotetralin binds to and results in increased activity of DRD3 protein"	10217549\|1037979
C409874	7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine	"7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine binds to DRD3 protein"	15183906
C090812	7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan	"7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in decreased activity of DRD3 protein"	10728880
C090812	7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan	"7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in increased activity of DRD3 protein"	10683862
C090812	7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan	"nafadotride inhibits the reaction [7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in increased activity of DRD3 protein]"	10683862
C090812	7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan	"7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to DRD3 protein"	10700011
C090812	7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan	"7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in decreased activity of DRD3 protein"	9085054
C095427	A 86929	A 86929 binds to DRD3 protein	8558425
D020106	Acrylamide	Acrylamide analog binds to DRD3 protein	15185375
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of DRD3 gene	27153756
D000639	Amitriptyline	Amitriptyline results in increased expression of DRD3 mRNA	21820738
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of DRD3 mRNA	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of DRD3 mRNA	18681898
D000661	Amphetamine	Amphetamine results in decreased expression of DRD3 mRNA	12711089
D000661	Amphetamine	Amphetamine results in decreased expression of DRD3 protein	12711089
D000661	Amphetamine	DRD3 protein results in increased susceptibility to Amphetamine	12711089
C559317	ANA 12 compound	ANA 12 compound inhibits the reaction [Ethanol results in increased expression of DRD3]	24584330
D001058	Apomorphine	DRD3 protein results in increased susceptibility to Apomorphine	19497322
D001058	Apomorphine	Apomorphine binds to and results in increased activity of DRD3 protein	7936204
D000068180	Aripiprazole	Aripiprazole binds to DRD3 protein	18363460
D001280	Atrazine	Atrazine results in increased expression of DRD3 mRNA	22378314
D001418	Baclofen	Baclofen results in decreased expression of DRD3 mRNA	7878047
C037689	benzamide	benzamide analog binds to and results in decreased activity of DRD3 protein	10591881\|1237343
C037689	benzamide	[benzamide analog binds to and results in decreased activity of DRD3 protein] which affects the susceptibility to Cocaine	10591881
C037689	benzamide	benzamide analog binds to DRD3 protein	10638823
C039108	benzo(f)quinoline	benzo(f)quinoline analog binds to DRD3 protein	19053758
D004958	Estradiol	Estradiol affects the expression of DRD3 mRNA	12008023
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of DRD3 mRNA	26186136
C006780	bisphenol A	"bisphenol A inhibits the reaction [3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to DRD3 protein]"	15203435
C006780	bisphenol A	"bisphenol A inhibits the reaction [7-hydroxy-2-N,N-dipropylaminotetralin results in increased activity of DRD3 protein]"	15203435
C006780	bisphenol A	bisphenol A results in decreased activity of DRD3 protein	16045194
C006780	bisphenol A	bisphenol A affects the expression of DRD3 mRNA	26141625
C006780	bisphenol A	bisphenol A results in decreased expression of DRD3 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of DRD3 mRNA	26141625
C120565	BP 897	BP 897 binds to and results in increased activity of DRD3 protein	10432116
C120565	BP 897	BP 897 binds to DRD3 protein	12930150
C120565	BP 897	BP 897 inhibits the reaction [iodosulpride binds to DRD3 protein]	10432116
C120565	BP 897	DRD3 results in increased susceptibility to BP 897	10432116\|1124958
C120565	BP 897	BP 897 binds to and results in decreased activity of DRD3 protein	11249586\|1585883
C120565	BP 897	BP 897 binds to and results in increased activity of DRD3 protein	10683862\|1124958
D001971	Bromocriptine	[1-Methyl-4-phenylpyridinium co-treated with Bromocriptine] results in decreased expression of DRD3 mRNA	17000468
D001971	Bromocriptine	Bromocriptine results in decreased expression of DRD3 mRNA	17000468
D002104	Cadmium	Cadmium inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]	10215675
D002118	Calcium	Calcium results in increased phosphorylation of DRD3 protein	19217379
C051347	CGS 15855A	CGS 15855A binds to and results in increased activity of DRD3 protein	10728880
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of DRD3 mRNA	21472459
D020111	Chlorodiphenyl (54% Chlorine)	Quercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of DRD3 mRNA]	21472459
D003024	Clozapine	DRD3 gene polymorphism results in decreased susceptibility to Clozapine	20029384
D003024	Clozapine	DRD3 protein affects the susceptibility to Clozapine	20029384
D003024	Clozapine	DRD3 protein affects the reaction [Clozapine results in increased expression of FOSB protein alternative form]	15579174
D003024	Clozapine	Clozapine binds to DRD3 protein	7520908
D003042	Cocaine	Cocaine results in decreased expression of DRD3 protein	19723785
D003042	Cocaine	DRD3 affects the susceptibility to Cocaine	10523822
D003042	Cocaine	[benzamide analog binds to and results in decreased activity of DRD3 protein] which affects the susceptibility to Cocaine	10591881
D003042	Cocaine	[eticlopride binds to and results in decreased activity of DRD3 protein] which affects the susceptibility to Cocaine	10591881
D003042	Cocaine	[fluoroclebopride binds to and results in decreased activity of DRD3 protein] which affects the susceptibility to Cocaine	10591881
D003042	Cocaine	[Haloperidol binds to and results in decreased activity of DRD3 protein] which affects the susceptibility to Cocaine	10591881
D003042	Cocaine	[Spiperone binds to and results in decreased activity of DRD3 protein] which affects the susceptibility to Cocaine	10591881
D003042	Cocaine	"[3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD3 protein] which results in decreased susceptibility to Cocaine"	18566292
D003042	Cocaine	"[3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol co-treated with Cocaine] affects the localization of DRD3 protein"	18566292
D003042	Cocaine	Cocaine promotes the reaction [DRD3 protein results in decreased expression of FOS protein]	15056714
D003042	Cocaine	Cocaine promotes the reaction [DRD3 protein results in decreased expression of NEO1 protein]	15056714
D003042	Cocaine	Cocaine promotes the reaction [DRD3 protein results in decreased expression of PDYN protein]	15056714
D003042	Cocaine	Cocaine promotes the reaction [DRD3 protein results in decreased expression of SYT7 protein]	15056714
D003042	Cocaine	Cocaine promotes the reaction [DRD3 protein results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]	15056714
D003042	Cocaine	Cocaine promotes the reaction [DRD3 protein results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]	15056714
D003042	Cocaine	Cocaine results in increased expression of DRD3 mRNA	12099907
D003042	Cocaine	DRD3 affects the susceptibility to Cocaine	20456009
D003042	Cocaine	DRD3 protein affects the reaction [Cocaine results in increased expression of NTS mRNA]	11120399
D003042	Cocaine	DRD3 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]	10943692
D003042	Cocaine	DRD3 protein inhibits the reaction [Cocaine results in increased expression of PDYN protein]	10943692
D003042	Cocaine	DRD3 protein results in decreased susceptibility to Cocaine	10943692
D003042	Cocaine	"SB 277011 inhibits the reaction [[3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD3 protein] which results in decreased susceptibility to Cocaine]"	18566292
D003042	Cocaine	"7-hydroxy-2-N,N-dipropylaminotetralin inhibits the reaction [Cocaine affects the activity of DRD3 protein]"	15100700
D003042	Cocaine	Cocaine affects the activity of DRD3 protein	15100700
D003042	Cocaine	Cocaine affects the expression of DRD3 protein	20435100
D003042	Cocaine	Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]	19217379
D003042	Cocaine	Cocaine results in increased activity of DRD3 protein	19046384
D003042	Cocaine	Cocaine results in increased expression of DRD3 mRNA	16026479
D003042	Cocaine	DRD3 results in decreased susceptibility to Cocaine	16026479
D003042	Cocaine	KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]	19217379
D003078	Colchicine	Colchicine results in decreased expression of DRD3 mRNA	7878047
D003300	Copper	Copper inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]	10215675
D003471	Cuprizone	Cuprizone results in increased expression of DRD3 mRNA	27523638
D004026	Dieldrin	Dieldrin results in increased expression of DRD3 mRNA	18812211
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
D007980	Levodopa	"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Levodopa] results in increased expression of DRD3 protein"	12740572
D007980	Levodopa	[Levodopa co-treated with Oxidopamine] results in increased expression of DRD3 mRNA	17241287
D007980	Levodopa	[Levodopa co-treated with Oxidopamine] results in increased expression of DRD3 protein	19118628
D004298	Dopamine	Dopamine results in increased activity of DRD3 protein	19046384
D004298	Dopamine	DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]	19217379
D004298	Dopamine	DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK3 protein]	19217379
D004298	Dopamine	[Ionomycin co-treated with CAMK2A protein] inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]]	19217379
D004298	Dopamine	NGB 2904 inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]]	19217379
D004298	Dopamine	NGB 2904 inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK3 protein]]	19217379
D004298	Dopamine	[Raclopride binds to and results in decreased activity of DRD3 protein] which results in increased abundance of Dopamine	15341276
C476326	((E)-N-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)butyl)-3-phenylacrylamide	"((E)-N-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)butyl)-3-phenylacrylamide binds to and results in decreased activity of DRD3 protein"	12740572
C476326	((E)-N-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)butyl)-3-phenylacrylamide	"((E)-N-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)butyl)-3-phenylacrylamide binds to and results in decreased activity of DRD3 protein"	19369551
D000431	Ethanol	ANA 12 compound inhibits the reaction [Ethanol results in increased expression of DRD3]	24584330
D000431	Ethanol	DRD3 protein affects the susceptibility to Ethanol	19096829
D000431	Ethanol	Ethanol results in increased expression of DRD3	24584330
C045989	eticlopride	eticlopride binds to and results in decreased activity of DRD3 protein	10591881
C045989	eticlopride	[eticlopride binds to and results in decreased activity of DRD3 protein] which affects the susceptibility to Cocaine	10591881
D018683	Excitatory Amino Acid Agents	Dizocilpine Maleate inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
D018683	Excitatory Amino Acid Agents	Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]	19217379
D018683	Excitatory Amino Acid Agents	KN 93 inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
C083673	fluoroclebopride	fluoroclebopride binds to and results in decreased activity of DRD3 protein	10591881
C083673	fluoroclebopride	[fluoroclebopride binds to and results in decreased activity of DRD3 protein] which affects the susceptibility to Cocaine	10591881
D005473	Fluoxetine	DRD3 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine]	20021991
C071658	FPL 64176	FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]	19217379
C071658	FPL 64176	Nifedipine inhibits the reaction [FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
C069837	fullerene C60	fullerene C60 results in decreased expression of DRD3 mRNA	19167457
D006046	Gold	Gold inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]	10215675
C408390	GR 218231	GR 218231 binds to and results in decreased activity of DRD3 protein	10728880
D006220	Haloperidol	DRD3 protein binds to Haloperidol analog	14552778
D006220	Haloperidol	Haloperidol binds to and results in decreased activity of DRD3 protein	10591881
D006220	Haloperidol	[Haloperidol binds to and results in decreased activity of DRD3 protein] which affects the susceptibility to Cocaine	10591881
D006220	Haloperidol	Haloperidol binds to and results in decreased activity of DRD3 protein	16026480
D006220	Haloperidol	Haloperidol binds to DRD3 protein	7520908
C045105	iodosulpride	BP 897 inhibits the reaction [iodosulpride binds to DRD3 protein]	10432116
C045105	iodosulpride	iodosulpride binds to DRD3 protein	10432116
D015759	Ionomycin	[Ionomycin co-treated with CAMK2A protein] inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]]	19217379
D015759	Ionomycin	"Ionomycin inhibits the reaction [[3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol results in increased activity of DRD3 protein] which results in increased phosphorylation of MAPK1 protein]"	19217379
D015759	Ionomycin	Ionomycin promotes the reaction [CAMK2A protein binds to DRD3 protein]	19217379
D015759	Ionomycin	Ionomycin promotes the reaction [CAMK2A protein modified form binds to DRD3 protein]	19217379
D015759	Ionomycin	Ionomycin results in increased phosphorylation of DRD3 protein	19217379
D015759	Ionomycin	KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
D015759	Ionomycin	KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein modified form binds to DRD3 protein]]	19217379
D015759	Ionomycin	KN 93 inhibits the reaction [Ionomycin results in increased phosphorylation of DRD3 protein]	19217379
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of DRD3 mRNA	15182950
C072105	KN 93	KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]	19217379
C072105	KN 93	KN 93 inhibits the reaction [Excitatory Amino Acid Agents promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
C072105	KN 93	KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
C072105	KN 93	KN 93 inhibits the reaction [Ionomycin promotes the reaction [CAMK2A protein modified form binds to DRD3 protein]]	19217379
C072105	KN 93	KN 93 inhibits the reaction [Ionomycin results in increased phosphorylation of DRD3 protein]	19217379
D008628	Mercury	Mercury inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]	10215675
D008694	Methamphetamine	Methamphetamine results in decreased expression of DRD3 protein	19940168
D008694	Methamphetamine	Methamphetamine results in increased activity of DRD3 protein	19046384
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of DRD3 mRNA	21385734
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of DRD3 mRNA	26011545
D015655	1-Methyl-4-phenylpyridinium	[1-Methyl-4-phenylpyridinium co-treated with Bromocriptine] results in decreased expression of DRD3 mRNA	17000468
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of DRD3 mRNA	17000468
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Levodopa] results in increased expression of DRD3 protein"	12740572
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of DRD3 protein"	12740572
C035133	mirtazapine	mirtazapine inhibits the reaction [Quinpirole binds to DRD3 protein]	12523492
C539157	N-(4-(2-(4-(3-cyano-5-trifluoromethylphenyl)piperazin-1-yl)ethyl)cyclohexyl)-3-pyridinesulfonic amide	N-(4-(2-(4-(3-cyano-5-trifluoromethylphenyl)piperazin-1-yl)ethyl)cyclohexyl)-3-pyridinesulfonic amide binds to and results in decreased activity of DRD3 protein	18548231
C526614	N-(4-(2-(8-cyano-1,3a,4,9b-tetrahydro(1)benzopyrano(3,4-c)pyrrol-2(3H)-yl)ethyl)phenyl)acetamide	"N-(4-(2-(8-cyano-1,3a,4,9b-tetrahydro(1)benzopyrano(3,4-c)pyrrol-2(3H)-yl)ethyl)phenyl)acetamide binds to and results in decreased activity of DRD3 protein"	19136017
C497150	N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)but-2-enyl)-4-pyridine-2-ylbenzamide	"N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)but-2-enyl)-4-pyridine-2-ylbenzamide binds to and results in decreased activity of DRD3 protein"	20456290\|2049495
C545833	N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide	"N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide binds to and results in increased activity of DRD3 protein"	20456290
C518644	N-(4-(4-(3-aminocarbonyl-phenyl)-piperazin-1-yl)-butyl)-4-bromo-benzamide	N-(4-(4-(3-aminocarbonyl-phenyl)-piperazin-1-yl)-butyl)-4-bromo-benzamide binds to and results in increased activity of DRD3 protein	17170312
C518644	N-(4-(4-(3-aminocarbonyl-phenyl)-piperazin-1-yl)-butyl)-4-bromo-benzamide	N-(4-(4-(3-aminocarbonyl-phenyl)-piperazin-1-yl)-butyl)-4-bromo-benzamide binds to and results in increased activity of DRD3 protein	17170312
C097285	nafadotride	nafadotride binds to and results in decreased activity of DRD3 protein	10728880
C097285	nafadotride	"nafadotride inhibits the reaction [7-(N,N-dipropylamino)-5,6,7,8-tetrahydronaphtho(2,3-b)dihydro-2,3-furan binds to and results in increased activity of DRD3 protein]"	10683862
C097285	nafadotride	nafadotride binds to and results in decreased activity of DRD3 protein	10432116\|1152246
C116818	NGB 2904	NGB 2904 inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK1 protein]]	19217379
C116818	NGB 2904	NGB 2904 inhibits the reaction [DRD3 protein promotes the reaction [Dopamine results in increased phosphorylation of MAPK3 protein]]	19217379
C116818	NGB 2904	NGB 2904 binds to and results in decreased activity of DRD3 protein	15858839\|1620578
C028007	nickel monoxide	nickel monoxide results in decreased expression of DRD3 mRNA	19167457
D009543	Nifedipine	Nifedipine inhibits the reaction [FPL 64176 promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
C016868	N-n-propyl-N-phenylethyl-4(3-hydroxyphenyl)ethylamine hydrochloride	N-n-propyl-N-phenylethyl-4(3-hydroxyphenyl)ethylamine hydrochloride results in increased activity of DRD3 protein	7936204
D016627	Oxidopamine	[Levodopa co-treated with Oxidopamine] results in increased expression of DRD3 mRNA	17241287
D016627	Oxidopamine	[Levodopa co-treated with Oxidopamine] results in increased expression of DRD3 protein	19118628
D016627	Oxidopamine	"Oxidopamine inhibits the reaction [7-hydroxy-2-N,N-dipropylaminotetralin binds to DRD3 protein]"	7878047
D016627	Oxidopamine	Oxidopamine results in decreased expression of DRD3 mRNA	7878047
C076029	olanzapine	DRD3 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine]	20021991
D000068882	Paliperidone Palmitate	Paliperidone Palmitate binds to DRD3 protein	7520908
D010479	Pergolide	Pergolide binds to and results in increased activity of DRD3 protein	17356338
D010578	Petroleum	Petroleum results in increased expression of DRD3 mRNA	25208076
C000593032	PGW5 compound	PGW5 compound binds to DRD3 protein	24389121
D010627	Phenethylamines	Phenethylamines analog binds to DRD3 protein	16539400
D010880	Piperidines	Piperidines analog binds to and results in decreased activity of DRD3 protein	12413863
D010891	Piribedil	Piribedil binds to and results in increased activity of DRD3 protein	10728880
D059808	Polyphenols	Polyphenols results in decreased expression of DRD3 mRNA	16293270
C061333	pramipexole	pramipexole binds to and results in increased activity of DRD3 protein	10728880
C061333	pramipexole	pramipexole binds to and results in increased activity of DRD3 protein	11261747\|1735633
C005556	propionaldehyde	propionaldehyde results in decreased expression of DRD3 mRNA	26079696
D011794	Quercetin	Quercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of DRD3 mRNA]	21472459
C047726	quinelorane	quinelorane binds to and results in increased activity of DRD3 protein	10728880
C047726	quinelorane	quinelorane binds to and results in increased activity of DRD3 protein	9225306
D019257	Quinpirole	Quinpirole binds to and results in increased activity of DRD3 protein	10683862
D019257	Quinpirole	Quinpirole binds to and results in increased activity of DRD3 protein	14622157
D019257	Quinpirole	mirtazapine inhibits the reaction [Quinpirole binds to DRD3 protein]	12523492
D019257	Quinpirole	Quinpirole binds to and results in increased activity of DRD3 protein	10217549\|1160266
D020891	Raclopride	Raclopride binds to and results in decreased activity of DRD3 protein	15341276\|1928915
D020891	Raclopride	[Raclopride binds to and results in decreased activity of DRD3 protein] which results in increased abundance of Dopamine	15341276
D018967	Risperidone	DRD3 gene SNP results in increased susceptibility to Risperidone	19506579
D018967	Risperidone	DRD3 protein results in increased susceptibility to Risperidone	19997080
D018967	Risperidone	Risperidone binds to DRD3 protein	7520908
C046649	ropinirole	ropinirole binds to and results in increased activity of DRD3 protein	18242171\|1839306
C047508	rotigotine	rotigotine binds to and results in increased activity of DRD3 protein	23165154
C408389	S 33084	S 33084 binds to and results in decreased activity of DRD3 protein	19118628\|1973355
C443959	sarizotan	sarizotan binds to DRD3 protein	14767715
C409982	SB 277011	"SB 277011 inhibits the reaction [[3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol binds to and results in increased activity of DRD3 protein] which results in decreased susceptibility to Cocaine]"	18566292
C409982	SB 277011	SB 277011 binds to and results in decreased activity of DRD3 protein	12417684\|1258938
C534628	SCH 23390	SCH 23390 inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
D012834	Silver	Silver inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]	10215675
C080703	SK&F 83959	"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]]"	19217379
C080703	SK&F 83959	SCH 23390 inhibits the reaction [SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]]	19217379
C080703	SK&F 83959	SK&F 83959 promotes the reaction [CAMK2A protein binds to DRD3 protein]	19217379
D013134	Spiperone	Spiperone binds to DRD3 protein	21999579
D013134	Spiperone	Spiperone binds to and results in decreased activity of DRD3 protein	10591881
D013134	Spiperone	[Spiperone binds to and results in decreased activity of DRD3 protein] which affects the susceptibility to Cocaine	10591881
C014215	tetrahydropalmatine	tetrahydropalmatine binds to DRD3 protein	17361394
D014147	Tramadol	Tramadol results in increased expression of DRD3 protein	15464068
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of DRD3 gene	27618143
C045971	UH 232	UH 232 binds to and results in decreased activity of DRD3 protein	10728880
C045971	UH 232	UH 232 binds to and results in decreased activity of DRD3 protein	7824548
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of DRD3 mRNA"	25208076
D015032	Zinc	Zinc inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]	10215675

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	-	IBA	21873635
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	-	IDA	8301582
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go	-	ISS	-
GO:0004935	adrenergic receptor activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	10692483 16386234 18424554 26460884
GO:0008144	drug binding	-	IDA	8413587
GO:0008144	drug binding	-	ISS	-
GO:0019904	protein domain specific binding	-	IEA	-
GO:0031748	D1 dopamine receptor binding	-	IEA	-
GO:0035240	dopamine binding	-	IBA	21873635
GO:0035240	dopamine binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0001963	synaptic transmission, dopaminergic	-	IBA	21873635
GO:0001963	synaptic transmission, dopaminergic	-	IEA	-
GO:0001975	response to amphetamine	-	IEA	-
GO:0002016	regulation of blood volume by renin-angiotensin	-	IEA	-
GO:0002031	G-protein coupled receptor internalization	-	IDA	18424554
GO:0006874	cellular calcium ion homeostasis	-	IDA	7911712
GO:0006914	autophagy	-	IEA	-
GO:0007186	G-protein coupled receptor signaling pathway	-	IDA	7911712
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	-	IDA	18424554
GO:0007194	negative regulation of adenylate cyclase activity	-	IBA	21873635
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	-	IBA	21873635
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	-	IDA	7907363 8666994 18424554
GO:0007267	cell-cell signaling	-	IBA	21873635
GO:0007611	learning or memory	-	NAS	14681904
GO:0007612	learning	-	NAS	15998189
GO:0007626	locomotory behavior	-	ISS	-
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0008542	visual learning	-	ISS	-
GO:0009636	response to toxic substance	-	IBA	21873635
GO:0014059	regulation of dopamine secretion	-	IBA	21873635
GO:0014059	regulation of dopamine secretion	-	ISS	-
GO:0019216	regulation of lipid metabolic process	-	IEA	-
GO:0032416	negative regulation of sodium:proton antiporter activity	-	IEA	-
GO:0032467	positive regulation of cytokinesis	-	IMP	22888021
GO:0032922	circadian regulation of gene expression	-	ISS	-
GO:0034776	response to histamine	-	IDA	16839358
GO:0035176	social behavior	-	NAS	12860355
GO:0035483	gastric emptying	-	IEA	-
GO:0035815	positive regulation of renal sodium excretion	-	IEA	-
GO:0040014	regulation of multicellular organism growth	-	IEA	-
GO:0042220	response to cocaine	-	IEP	10415668
GO:0042417	dopamine metabolic process	-	IC	8301582
GO:0042493	response to drug	-	IBA	21873635
GO:0042493	response to drug	-	ISS	-
GO:0043066	negative regulation of apoptotic process	-	IEA	-
GO:0043266	regulation of potassium ion transport	-	IBA	21873635
GO:0043278	response to morphine	-	ISS	-
GO:0045187	regulation of circadian sleep/wake cycle, sleep	-	IEA	-
GO:0045471	response to ethanol	NOT	ISS	-
GO:0045776	negative regulation of blood pressure	-	ISS	-
GO:0045840	positive regulation of mitotic nuclear division	-	ISS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0046717	acid secretion	-	ISS	-
GO:0048148	behavioral response to cocaine	-	IBA	21873635
GO:0048148	behavioral response to cocaine	-	IEP	8815892
GO:0048148	behavioral response to cocaine	-	ISS	-
GO:0048149	behavioral response to ethanol	-	IBA	21873635
GO:0048715	negative regulation of oligodendrocyte differentiation	-	ISS	-
GO:0050482	arachidonic acid secretion	-	IDA	8301582
GO:0050709	negative regulation of protein secretion	-	IDA	16839358
GO:0050883	musculoskeletal movement, spinal reflex action	-	ISS	-
GO:0051481	negative regulation of cytosolic calcium ion concentration	-	IBA	21873635
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	-	IBA	21873635
GO:0051584	regulation of dopamine uptake involved in synaptic transmission	-	IC	8301582
GO:0051898	negative regulation of protein kinase B signaling	-	ISS	-
GO:0051967	negative regulation of synaptic transmission, glutamatergic	-	IBA	21873635
GO:0060134	prepulse inhibition	-	IMP	18325483
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway	-	IBA	21873635
GO:0060160	negative regulation of dopamine receptor signaling pathway	-	IEA	-
GO:0060161	positive regulation of dopamine receptor signaling pathway	-	ISS	-
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	-	IBA	21873635
GO:0090325	regulation of locomotion involved in locomotory behavior	-	IEA	-
GO:1901386	negative regulation of voltage-gated calcium channel activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	IDA	16386234 18424554 20531939
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IC	8301582
GO:0005887	integral component of plasma membrane	-	IDA	8413587
GO:0030139	endocytic vesicle	-	IEA	-
GO:0030672	synaptic vesicle membrane	-	IBA	21873635
GO:0042995	cell projection	-	IEA	-
GO:0045177	apical part of cell	-	IEA	-

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375280	Amine ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-390651	Dopamine receptors	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28042871	Acute D3 Antagonist GSK598809 Selectively Enhances Neural Response During Monetary Reward Anticipation in Drug and Alcohol Dependence. (2017 Apr)	Murphy A	Neuropsychopharmacology
17158525	Study of dopamine receptors genes polymorphisms in bipolar patients with comorbid alcohol abuse. (2007 Mar-Apr)	Szczepankiewicz A	Alcohol Alcohol
25660313	Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence. (2015 Apr 1)	Forero DA	Drug Alcohol Depend
9702742	Homozygosity at the dopamine D3 receptor gene is associated with opiate dependence. (1998 Jul)	Duaux E	Mol Psychiatry
12218663	No association between the dopamine D3 receptor gene and Korean alcohol dependence. (2002 Sep)	Lee MS	Psychiatr Genet
26447226	Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption. (2016 May)	Celorrio D	Alcohol Alcohol
29357295	Association study of BDNF and DRD3 genes with alcohol use disorder in Schizophrenia. (2018 Apr 3)	Zai CC	Neurosci Lett
21663922	Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium. (2011 Aug 15)	McGuire V	J Neurol Sci
17466074	Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study. (2007 Apr 28)	Ton TG	Behav Brain Funct
16395310	A Ser9Gly polymorphism in the dopamine D3 receptor gene (DRD3) and event-related P300 potentials. (2006 Jun)	Mulert C	Neuropsychopharmacology
17407504	Dopamine receptor genes (DRD2, DRD3 and DRD4) and gene-gene interactions associated with smoking-related behaviors. (2007 Mar)	Vandenbergh DJ	Addict Biol
24776816	DRD3 gene rs6280 polymorphism may be associated with alcohol dependence overall and with Lesch type I alcohol dependence in Koreans. (2014)	Kang SG	Neuropsychobiology
9702743	Dopamine D3 receptor gene variants and substance abuse in schizophrenia. (1998 Jul)	Krebs MO	Mol Psychiatry
15288384	Narcotic antagonists in drug dependence: pilot study showing enhancement of compliance with SYN-10, amino-acid precursors and enkephalinase inhibition therapy. (2004)	Chen TJ	Med Hypotheses
25907750	Role of the D3 dopamine receptor in nicotine sensitization. (2015 Aug 1)	Smith LN	Behav Brain Res
27244229	Peripheral Immune Cell Populations Associated with Cognitive Deficits and Negative Symptoms of Treatment-Resistant Schizophrenia. (2016)	Fernandez-Egea E	PLoS One
24135011	Case-control association analysis of dopamine receptor polymorphisms in alcohol dependence: a pilot study in Indian males. (2013 Oct 17)	Prasad P	BMC Res Notes
26279138	Effect of a D3 receptor antagonist on context-induced reinstatement of nicotine seeking. (2016 Jan 4)	Sabioni P	Prog Neuropsychopharmacol Biol Psychiatry
17671965	Polymorphisms TaqI A of the DRD2, BalI of the DRD3, exon III repeat of the DRD4, and 3' UTR VNTR of the DAT: association with childhood ADHD in male African-Caribbean cocaine dependents? (2007 Dec 5)	Ballon N	Am J Med Genet B Neuropsychiatr Genet
26810137	Pharmacogenetics of methylphenidate response and tolerability in attention-deficit/hyperactivity disorder. (2017 Jan)	Pagerols M	Pharmacogenomics J
28512340	Using an Event-History with Risk-Free Model to Study the Genetics of Alcoholism. (2017 May 16)	Yang HC	Sci Rep
25875614	Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans. (2015 May)	Levran O	Ann Hum Genet
9184311	No association between polymorphisms in the human dopamine D3 and D4 receptors genes and alcoholism. (1997 May 31)	Parsian A	Am J Med Genet
24469594	In vivo imaging of cerebral dopamine D3 receptors in alcoholism. (2014 Jun)	Erritzoe D	Neuropsychopharmacology
19179847	Genetics of dopamine receptors and drug addiction: a comprehensive review. (2009 Feb)	Le Foll B	Behav Pharmacol
11762133	The genetics of addiction: alcohol-dependence and D3 dopamine receptor gene. (2001 Nov)	Gorwood P	Pathol Biol (Paris)
8750359	Dopamine D1, D2 and D3 receptor genes in alcohol dependence. (1995 Winter)	Sander T	Psychiatr Genet
14982687	Reduced dopamine D3 receptor expression in blood lymphocytes of smokers is negatively correlated with daily number of smoked cigarettes: a peripheral correlate of dopaminergic alterations in smokers. (2004 Feb)	Czermak C	Nicotine Tob Res
12893467	No association between D3 dopamine receptor (DRD3) alleles and cocaine dependence. (1996)	Freimer M	Addict Biol
18348205	A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers. (2008 Oct 5)	Huang W	Am J Med Genet B Neuropsychiatr Genet
22309839	Association study of 45 candidate genes in nicotine dependence in Han Chinese. (2012 May)	Wei J	Addict Behav
8825889	Lack of association between alcohol-dependence and D3 dopamine receptor gene in three independent samples. (1995 Dec 18)	Gorwood P	Am J Med Genet
27447243	Association study of DRD2 A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A polymorphisms with alcohol dependence. (2016 Sep 1)	Ragia G	Drug Metab Pers Ther
18552399	Association between the Stin2 VNTR polymorphism of the serotonin transporter gene and treatment outcome in alcohol-dependent patients. (2008 Sep-Oct)	Florez G	Alcohol Alcohol
26246443	The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description. (2015 Sep)	Paterson LM	J Psychopharmacol
26621272	The Key Proteins of Dopaminergic Neurotransmission of Human Peripheral Blood Lymphocytes: Changed mRNA Level in Alcohol Dependence Syndrome. (2015 Dec)	Taraskina AE	Bull Exp Biol Med
15935433	Association between dopamine receptor D3 gene BalI polymorphism and cognitive impulsiveness in alcohol-dependent men. (2005 May)	Limosin F	Eur Psychiatry
19503018	Association analysis between polymorphisms in the dopamine D3 receptor (DRD3) gene and cocaine dependence. (2009 Oct)	Bloch PJ	Psychiatr Genet
10523822	Homozygosity at the dopamine DRD3 receptor gene in cocaine dependence. (1999 Sep)	Comings DE	Mol Psychiatry
24927283	Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and major depressive disorder. (2014)	Korhonen T	PLoS One