| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| MXD3 | 0.669 |
| GUSB | 0.642 |
| ASIC3 | 0.62 |
| CDHR5 | 0.617 |
| TAZ | 0.609 |
| FAM193B | 0.608 |
| TRPV1 | 0.607 |
| CCDC84 | 0.604 |
| RDH16 | 0.601 |
| PTPRCAP | 0.589 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| SAMD15 | -0.41 |
| RAB39A | -0.384 |
| APOOL | -0.381 |
| BEND4 | -0.366 |
| NEK2 | -0.366 |
| METTL24 | -0.342 |
| RAB23 | -0.333 |
| HS6ST3 | -0.333 |
| RGS8 | -0.331 |
| SLC9A7 | -0.331 |
| ID | Drug Name | Drug Type | CAS Num | Status | Role |
|---|---|---|---|---|---|
| DB00246 | Ziprasidone | Small Molecule | 146939-27-7 | Approved | Target |
| DB00248 | Cabergoline | Small Molecule | 81409-90-7 | Approved | Target |
| DB00268 | Ropinirole | Small Molecule | 91374-21-9 | Approved|Investigational | Target |
| DB00334 | Olanzapine | Small Molecule | 132539-06-1 | Approved|Investigational | Target |
| DB00363 | Clozapine | Small Molecule | 5786-21-0 | Approved | Target |
| DB00372 | Thiethylperazine | Small Molecule | 1420-55-9 | Withdrawn | Target |
| DB00408 | Loxapine | Small Molecule | 1977-10-2 | Approved | Target |
| DB00409 | Remoxipride | Small Molecule | 80125-14-0 | Approved|Withdrawn | Target |
| DB00413 | Pramipexole | Small Molecule | 104632-26-0 | Approved|Investigational | Target |
| DB00420 | Promazine | Small Molecule | 58-40-2 | Approved | Target |
| DB00477 | Chlorpromazine | Small Molecule | 50-53-3 | Approved|Investigational | Target |
| DB00543 | Amoxapine | Small Molecule | 14028-44-5 | Approved | Target |
| DB00589 | Lisuride | Small Molecule | 18016-80-3 | Approved|Investigational | Target |
| DB00714 | Apomorphine | Small Molecule | 58-00-4 | Approved|Investigational | Target |
| DB00734 | Risperidone | Small Molecule | 106266-06-2 | Approved|Investigational | Target |
| DB00777 | Propiomazine | Small Molecule | 362-29-8 | Approved | Target |
| DB00988 | Dopamine | Small Molecule | 51-61-6 | Approved | Target |
| DB01186 | Pergolide | Small Molecule | 66104-22-1 | Approved|Investigational|Withdrawn | Target |
| DB01200 | Bromocriptine | Small Molecule | 25614-03-3 | Approved|Investigational | Target |
| DB01224 | Quetiapine | Small Molecule | 111974-69-7 | Approved | Target |
| DB01235 | Levodopa | Small Molecule | 59-92-7 | Approved | Target |
| DB01238 | Aripiprazole | Small Molecule | 129722-12-9 | Approved|Investigational | Target |
| DB01267 | Paliperidone | Small Molecule | 144598-75-4 | Approved | Target |
| DB01403 | Methotrimeprazine | Small Molecule | 60-99-1 | Approved|Investigational | Target |
| DB04908 | Flibanserin | Small Molecule | 167933-07-5 | Approved|Investigational | Target |
| DB04946 | Iloperidone | Small Molecule | 133454-47-4 | Approved | Target |
| DB05271 | Rotigotine | Small Molecule | 99755-59-6 | Approved | Target |
| DB06216 | Asenapine | Small Molecule | 65576-45-6 | Approved | Target |
| DB06477 | Sumanirole | Small Molecule | 179386-43-7 | Investigational | Target |
| DB08922 | Perospirone | Small Molecule | 150915-41-6 | Approved | Target |
| DB09286 | Pipamperone | Small Molecule | 1893-33-0 | Approved|Investigational | Target |
| DB12061 | Pardoprunox | Small Molecule | 269718-84-5 | Investigational | Target |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C570533 | 1-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)-4-((6-fluoropyridin-3-yl)methyl)piperazine | "1-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)-4-((6-fluoropyridin-3-yl)methyl)piperazine binds to DRD4 protein" | 22039961 |
| C477900 | 2-(4-(4-chlorophenyl)piperazin-1-ylmethyl)pyrazolo(1,5-a)-pyridine | "2-(4-(4-chlorophenyl)piperazin-1-ylmethyl)pyrazolo(1,5-a)-pyridine binds to and results in decreased activity of DRD4 protein" | 15007532 |
| C099630 | 3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine | "3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein" | 16415089 |
| C099630 | 3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine | "[3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein] inhibits the reaction [Naloxone results in increased abundance of Cyclic AMP]" | 15542745 |
| C099630 | 3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine | "[3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein] which results in increased activity of DDC protein" | 16415089 |
| C099630 | 3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine | "3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein" | 15542745|1572929 |
| C039167 | 3-N-methylspiperone | 3-N-methylspiperone binds to DRD4 protein | 10215675 |
| C039167 | 3-N-methylspiperone | Cadmium inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | 10215675 |
| C039167 | 3-N-methylspiperone | Copper inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | 10215675 |
| C039167 | 3-N-methylspiperone | Gold inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | 10215675 |
| C039167 | 3-N-methylspiperone | Mercury inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | 10215675 |
| C039167 | 3-N-methylspiperone | Silver inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | 10215675 |
| C039167 | 3-N-methylspiperone | Zinc inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | 10215675 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD4 mRNA" | 27188386 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD4 mRNA" | 27188386 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD4 mRNA" | 27188386 |
| C459179 | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide | "[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD4 mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD4 mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD4 mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD4 mRNA" | 27188386 |
| C516138 | (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine | "[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD4 mRNA" | 27188386 |
| C416534 | 7-fluoro-2-oxo-4-(2-(4-(thieno(3,2-c)pyridin-4-yl)piperazin-1-yl)ethyl)-1,2-dihydroquinoline-1-acetamide | "7-fluoro-2-oxo-4-(2-(4-(thieno(3,2-c)pyridin-4-yl)piperazin-1-yl)ethyl)-1,2-dihydroquinoline-1-acetamide affects the activity of DRD4 protein" | 23611293 |
| C409874 | 7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine | "7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine binds to and results in decreased activity of DRD4 protein" | 12447918 |
| C095427 | A 86929 | A 86929 binds to DRD4 protein alternative form | 8558425 |
| D020106 | Acrylamide | Acrylamide results in increased expression of DRD4 mRNA | 28959563 |
| D000242 | Cyclic AMP | "[3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein] inhibits the reaction [Naloxone results in increased abundance of Cyclic AMP]" | 15542745 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of DRD4 mRNA | 16483693 |
| C037689 | benzamide | benzamide analog binds to DRD4 protein | 10638823 |
| C053541 | bicalutamide | bicalutamide results in decreased expression of DRD4 mRNA | 19587329 |
| C053541 | bicalutamide | FSHB protein inhibits the reaction [bicalutamide results in decreased expression of DRD4 protein] | 19587329 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of DRD4 mRNA | 15079872 |
| D002104 | Cadmium | Cadmium inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | 10215675 |
| D019256 | Cadmium Chloride | Cadmium Chloride results in increased expression of DRD4 mRNA | 24982889 |
| D020111 | Chlorodiphenyl (54% Chlorine) | Chlorodiphenyl (54% Chlorine) results in decreased expression of DRD4 mRNA | 21472459 |
| D020111 | Chlorodiphenyl (54% Chlorine) | Quercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of DRD4 mRNA] | 21472459 |
| D004390 | Chlorpyrifos | Chlorpyrifos affects the expression of DRD4 mRNA | 17452286|1881221 |
| D002794 | Choline | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DRD4 gene | 20938992 |
| D003024 | Clozapine | Clozapine binds to DRD4 protein | 11997696 |
| D003024 | Clozapine | DRD4 gene polymorphism affects the susceptibility to Clozapine | 16223700 |
| D003024 | Clozapine | Clozapine analog binds to DRD4 protein | 11997696 |
| D003024 | Clozapine | Clozapine binds to DRD4 protein | 7520908 |
| D003042 | Cocaine | DRD4 polymorphism results in increased susceptibility to Cocaine | 17671965 |
| D003042 | Cocaine | Cocaine affects the expression of DRD4 mRNA | 20187946 |
| D003300 | Copper | Copper inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | 10215675 |
| C010902 | decabromobiphenyl ether | decabromobiphenyl ether results in increased expression of DRD4 mRNA | 23914054 |
| D003976 | Diazinon | Diazinon affects the expression of DRD4 mRNA | 17452286 |
| D002945 | Cisplatin | [Cisplatin co-treated with jinfukang] results in decreased expression of DRD4 mRNA | 27392435 |
| D002945 | Cisplatin | Cisplatin results in decreased expression of DRD4 mRNA | 27392435 |
| D004026 | Dieldrin | Dieldrin results in decreased expression of DRD4 mRNA | 18812211 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of DRD4 mRNA | 25016146 |
| D004051 | Diethylhexyl Phthalate | Diethylhexyl Phthalate results in decreased expression of DRD4 mRNA | 15518916 |
| D019813 | 1,2-Dimethylhydrazine | "[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of DRD4 mRNA" | 27840820 |
| D004298 | Dopamine | DRD4 protein affects the reaction [Dopamine binds to DRD2 protein] | 15716360 |
| D005419 | Flavonoids | Flavonoids results in increased expression of DRD4 mRNA | 18035473 |
| D005492 | Folic Acid | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DRD4 gene | 20938992 |
| D006046 | Gold | Gold inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | 10215675 |
| D006220 | Haloperidol | Haloperidol affects the activity of DRD4 protein | 23611293 |
| D006220 | Haloperidol | Haloperidol binds to DRD4 protein | 7520908 |
| D006830 | Hydralazine | [Hydralazine co-treated with Valproic Acid] results in increased expression of DRD4 mRNA | 17183730 |
| C544151 | jinfukang | [Cisplatin co-treated with jinfukang] results in decreased expression of DRD4 mRNA | 27392435 |
| C544151 | jinfukang | jinfukang results in decreased expression of DRD4 mRNA | 27392435 |
| D007654 | Ketoconazole | Ketoconazole inhibits the reaction [FSHB protein results in increased expression of DRD4 mRNA] | 19587329 |
| D007654 | Ketoconazole | Ketoconazole results in decreased expression of DRD4 mRNA | 19587329 |
| D007654 | Ketoconazole | Metribolone inhibits the reaction [Ketoconazole results in decreased expression of DRD4 mRNA] | 19587329 |
| C482199 | lipopolysaccharide, E coli O55-B5 | "lipopolysaccharide, E coli O55-B5 results in increased expression of DRD4 mRNA" | 24972896 |
| D008344 | Maneb | [Paraquat co-treated with Maneb] results in increased expression of DRD4 protein | 22563483 |
| D015122 | Mercaptopurine | Mercaptopurine results in increased expression of DRD4 mRNA | 23358152 |
| C042720 | mercuric bromide | mercuric bromide results in decreased expression of DRD4 mRNA | 26272509 |
| C042720 | mercuric bromide | "[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD4 mRNA" | 27188386 |
| D008628 | Mercury | Mercury inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | 10215675 |
| D008694 | Methamphetamine | DRD4 gene polymorphism affects the susceptibility to Methamphetamine | 19462300 |
| D008694 | Methamphetamine | DRD4 gene polymorphism results in increased susceptibility to Methamphetamine | 15274053 |
| D008694 | Methamphetamine | [NRA 0160 binds to and results in decreased activity of DRD4 protein] which results in decreased susceptibility to Methamphetamine | 10579464 |
| D008715 | Methionine | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DRD4 gene | 20938992 |
| C004925 | methylmercuric chloride | methylmercuric chloride results in decreased expression of DRD4 mRNA | 28001369 |
| D008774 | Methylphenidate | DRD4 promoter mutant form affects the susceptibility to Methylphenidate | 17023870 |
| D015741 | Metribolone | Metribolone inhibits the reaction [Ketoconazole results in decreased expression of DRD4 mRNA] | 19587329 |
| D009020 | Morphine | Morphine results in increased expression of DRD4 mRNA | 15183518 |
| D009270 | Naloxone | "[3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein] inhibits the reaction [Naloxone results in increased abundance of Cyclic AMP]" | 15542745 |
| C106996 | NRA 0045 | NRA 0045 binds to DRD4 protein alternative form | 9223539 |
| C106996 | NRA 0045 | NRA 0045 binds to and results in decreased activity of DRD4 protein | 9179395 |
| C121249 | NRA 0160 | NRA 0160 binds to and results in decreased activity of DRD4 protein | 10579464 |
| C121249 | NRA 0160 | [NRA 0160 binds to and results in decreased activity of DRD4 protein] which results in decreased susceptibility to Methamphetamine | 10579464 |
| D016627 | Oxidopamine | Oxidopamine results in increased expression of DRD4 mRNA | 15303306 |
| C076029 | olanzapine | olanzapine binds to DRD4 protein | 9754850 |
| D000068882 | Paliperidone Palmitate | Paliperidone Palmitate binds to DRD4 protein | 7520908 |
| D010269 | Paraquat | [Paraquat co-treated with Maneb] results in increased expression of DRD4 protein | 22563483 |
| D010269 | Paraquat | Paraquat affects the expression of DRD4 mRNA | 15206577 |
| C000593032 | PGW5 compound | PGW5 compound binds to DRD4 protein | 24389121 |
| D010662 | Phenylmercuric Acetate | "[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD4 mRNA" | 27188386 |
| D010662 | Phenylmercuric Acetate | Phenylmercuric Acetate results in decreased expression of DRD4 mRNA | 26272509 |
| D010852 | Picrotoxin | Picrotoxin results in increased expression of DRD4 mRNA | 15170462 |
| D010936 | Plant Extracts | Plant Extracts results in decreased expression of DRD4 mRNA | 23557933 |
| D011374 | Progesterone | Progesterone results in increased expression of DRD4 mRNA | 22238285 |
| C428725 | pyridaben | pyridaben results in decreased expression of DRD4 mRNA | 22563483 |
| D011794 | Quercetin | Quercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of DRD4 mRNA] | 21472459 |
| D018967 | Risperidone | Risperidone binds to DRD4 protein | 7520908 |
| C046649 | ropinirole | ropinirole binds to and results in increased activity of DRD4 protein | 18393062 |
| C443959 | sarizotan | sarizotan binds to and results in decreased activity of DRD4 protein | 15252265 |
| D012834 | Silver | Silver inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | 10215675 |
| D013134 | Spiperone | Spiperone binds to DRD4 protein | 21999579 |
| C012589 | trichostatin A | "[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD4 mRNA" | 27188386 |
| C012589 | trichostatin A | trichostatin A results in decreased expression of DRD4 mRNA | 24935251|2627250 |
| D014635 | Valproic Acid | [Hydralazine co-treated with Valproic Acid] results in increased expression of DRD4 mRNA | 17183730 |
| D014635 | Valproic Acid | "[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DRD4 mRNA" | 27188386 |
| D014635 | Valproic Acid | Valproic Acid results in decreased expression of DRD4 mRNA | 23179753|2438349 |
| D014635 | Valproic Acid | Valproic Acid results in increased methylation of DRD4 gene | 29154799 |
| C025643 | vinclozolin | vinclozolin results in increased expression of DRD4 mRNA | 15686871 |
| D015032 | Zinc | Zinc inhibits the reaction [3-N-methylspiperone binds to DRD4 protein] | 10215675 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go | - | IDA | 1840645 9003072 |
| GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go | - | IMP | 27659709 |
| GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go | - | ISS | - |
| GO:0004930 | G-protein coupled receptor activity | - | IBA | 21873635 |
| GO:0004952 | dopamine neurotransmitter receptor activity | - | IDA | 8413587 |
| GO:0004993 | G-protein coupled serotonin receptor activity | - | IBA | 21873635 |
| GO:0005515 | protein binding | - | IPI | 12297500 21184734 22723743 |
| GO:0008144 | drug binding | - | IDA | 1319557 1840645 8413587 |
| GO:0015459 | potassium channel regulator activity | - | NAS | 12297500 |
| GO:0017124 | SH3 domain binding | - | IDA | 9843378 |
| GO:0030594 | neurotransmitter receptor activity | - | IBA | 21873635 |
| GO:0035240 | dopamine binding | - | IDA | 1319557 9003072 |
| GO:0042802 | identical protein binding | - | IPI | 21184734 21320289 |
| GO:0046872 | metal ion binding | - | IEA | - |
| GO:0051379 | epinephrine binding | - | IDA | 9003072 |
| GO:0051380 | norepinephrine binding | - | IDA | 9003072 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0000187 | activation of MAPK activity | - | IDA | 9843378 15755724 |
| GO:0001662 | behavioral fear response | - | NAS | 12860355 |
| GO:0001975 | response to amphetamine | - | ISS | - |
| GO:0006874 | cellular calcium ion homeostasis | - | IC | 7921596 |
| GO:0007186 | G-protein coupled receptor signaling pathway | - | TAS | - |
| GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | - | IBA | 21873635 |
| GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway | - | IDA | 7512953 9003072 9843378 |
| GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway | - | IMP | 27659709 |
| GO:0007212 | dopamine receptor signaling pathway | - | IDA | 1840645 |
| GO:0007268 | chemical synaptic transmission | - | IBA | 21873635 |
| GO:0008344 | adult locomotory behavior | - | ISS | - |
| GO:0032417 | positive regulation of sodium:proton antiporter activity | - | IDA | 7512953 |
| GO:0033674 | positive regulation of kinase activity | - | IDA | 15755724 |
| GO:0034776 | response to histamine | - | IDA | 16839358 |
| GO:0035176 | social behavior | - | NAS | 11126393 11409696 |
| GO:0042053 | regulation of dopamine metabolic process | - | ISS | - |
| GO:0042417 | dopamine metabolic process | - | IC | 1840645 |
| GO:0042596 | fear response | - | ISS | - |
| GO:0042752 | regulation of circadian rhythm | - | ISS | - |
| GO:0048148 | behavioral response to cocaine | - | ISS | - |
| GO:0048149 | behavioral response to ethanol | - | TAS | 12888781 |
| GO:0048511 | rhythmic process | - | IEA | - |
| GO:0050482 | arachidonic acid secretion | - | IDA | 7512953 |
| GO:0050709 | negative regulation of protein secretion | - | IDA | 16839358 |
| GO:0051586 | positive regulation of dopamine uptake involved in synaptic transmission | - | IC | 1840645 |
| GO:0060080 | inhibitory postsynaptic potential | - | ISS | - |
| GO:1901386 | negative regulation of voltage-gated calcium channel activity | - | IDA | 7921596 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005886 | plasma membrane | - | IDA | 20531939 |
| GO:0005886 | plasma membrane | - | TAS | - |
| GO:0005887 | integral component of plasma membrane | - | IBA | 21873635 |
| GO:0005887 | integral component of plasma membrane | - | IDA | 8413587 9003072 9843378 15755724 27659709 |
| GO:0016020 | membrane | - | IDA | 7512953 |
| GO:0030425 | dendrite | - | IBA | 21873635 |
| GO:0098794 | postsynapse | - | IEA | - |
| KEGG ID | KEGG Term |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-162582 | Signal Transduction | TAS |
| R-HSA-372790 | Signaling by GPCR | TAS |
| R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | TAS |
| R-HSA-375280 | Amine ligand-binding receptors | TAS |
| R-HSA-388396 | GPCR downstream signalling | TAS |
| R-HSA-390651 | Dopamine receptors | TAS |
| R-HSA-418594 | G alpha (i) signalling events | TAS |
| R-HSA-500792 | GPCR ligand binding | TAS |
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