Gene: JAG1

182
AGS|AGS1|AHD|AWS|CD339|HJ1|JAGL1
jagged 1
protein-coding
20p12.2
Ensembl:ENSG00000101384 MIM:601920 Vega:OTTHUMG00000031872 UniprotKB:P78504
NG_007496.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.482e-1 (AD)  2.563e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7267595chr20:10663202 (GRCh38.p7)A>C / A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CALD10.833
LAMC10.822
SVIL0.815
KDELC20.811
FN10.81
RNF144B0.81
PROS10.805
TRIM380.804
COL4A10.803
NEDD40.802

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYADML2-0.474
DRD5-0.437
BCL11A-0.433
SLC7A4-0.427
ABCC12-0.426
NEUROD6-0.416
SPEF1-0.408
ADTRP-0.402
LYPD8-0.402
DLK2-0.4

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1053511-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of JAG1 protein"23284745
C0331461-hydroxypyrene1-hydroxypyrene results in decreased expression of JAG1 mRNA22989670
C0293501-naphthol1-naphthol results in decreased expression of JAG1 mRNA22989670
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of JAG1 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of JAG1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of JAG1 mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of JAG1 mRNA"20406850
C0281452'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]27989784
C0281452'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased expression of JAG1 protein27989784
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAG1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAG1 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of JAG1 mRNA"26238291
C0913759-phenanthrol9-phenanthrol results in decreased expression of JAG1 mRNA22989670
D000082AcetaminophenAcetaminophen results in increased expression of JAG1 mRNA29067470
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Particulate Matter results in increased expression of JAG1 mRNA]20974985
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of JAG1 mRNA]20974985
D000111AcetylcysteineAcetylcysteine results in decreased expression of JAG1 mRNA16084531
D016604Aflatoxin B1Aflatoxin B1 affects the expression of JAG1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of JAG1 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of JAG1 mRNA19770486
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]]29094188
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of JAG1 promoter]29094188
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of JAG1 mRNA]29094188
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of JAG1 promoter]29094188
C011512alpha-naphthoflavonealpha-naphthoflavone results in decreased methylation of JAG1 promoter29094188
D000643Ammonium ChlorideAmmonium Chloride affects the expression of JAG1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of JAG1 mRNA24449571
C015001arsenitearsenite results in decreased expression of JAG1 mRNA18633435
C015001arsenitearsenite results in decreased expression of JAG1 protein18633435
C015001arsenite[arsenite results in decreased expression of JAG1 protein] which results in decreased expression of HES1 mRNA18633435
C015001arseniteJAG1 protein inhibits the reaction [arsenite results in decreased expression of IVL mRNA]18633435
C015001arseniteJAG1 protein inhibits the reaction [arsenite results in decreased expression of KRT10 mRNA]18633435
C015001arsenitetyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of JAG1 mRNA]18633435
C015001arsenitetyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of JAG1 protein]18633435
D001205Ascorbic AcidAscorbic Acid results in decreased expression of JAG1 mRNA15305145
D001379AzathioprineAzathioprine results in increased expression of JAG1 mRNA22623647
C547126AZM551248AZM551248 results in decreased expression of JAG1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of JAG1 mRNA22178795
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of JAG1 mRNA16269432|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of JAG1 mRNA19770486|2071347
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of JAG1 mRNA22228805
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of JAG1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of JAG1 mRNA22989670|2301914
D004958EstradiolEstradiol results in increased expression of JAG1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of JAG1 protein22113133
C006780bisphenol Abisphenol A results in decreased expression of JAG1 mRNA22576693
C006780bisphenol Abisphenol A results in increased expression of JAG1 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of JAG1 mRNA28628672
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of JAG1 mRNA25607892
C006780bisphenol Abisphenol A results in increased expression of JAG1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of JAG1 mRNA22079614
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of JAG1 mRNA25607892
D002101Cacodylic AcidCacodylic Acid results in decreased expression of JAG1 mRNA17720352
D019256Cadmium ChlorideCadmium Chloride results in increased expression of JAG1 protein25118938
D019256Cadmium ChlorideJAG1 mutant form inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]25118938
D019256Cadmium ChlorideJAG1 mutant form inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]25118938
C100187chloropicrinchloropicrin affects the expression of JAG1 mRNA26352163
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of JAG1 mRNA16197558
D002994ClofibrateClofibrate results in increased expression of JAG1 mRNA23811191
D019327Copper SulfateCopper Sulfate results in increased expression of JAG1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of JAG1 mRNA"19167446
D003375CoumestrolCoumestrol results in decreased expression of JAG1 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of JAG1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of JAG1 mRNA19770486
D000069439DasatinibDasatinib results in increased expression of JAG1 mRNA20579391
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of JAG1 mRNA28628672
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of JAG1 mRNA]18449946
D002945CisplatinCisplatin results in increased expression of JAG1 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of JAG1 mRNA28302478
D004026DieldrinDieldrin results in increased expression of JAG1 mRNA20438755
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of JAG1 protein22113133
D004391DustDust results in increased expression of JAG1 mRNA15735009
D004642Emodin2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine promotes the reaction [Emodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]]27989784
D004642EmodinEmodin inhibits the reaction [TGFB1 protein results in increased expression of JAG1 protein]27989784
D004642EmodinEmodin results in decreased expression of JAG1 protein27989784
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of JAG1 mRNA25607892
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of JAG1 mRNA16084531
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of JAG1 mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of JAG1 mRNA17557909
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of JAG1 mRNA23649840
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of JAG1 gene16724327
D005419FlavonoidsFlavonoids results in increased expression of JAG1 mRNA18035473
D005472FluorouracilFluorouracil results in increased expression of JAG1 mRNA16510598
D005473FluoxetineFluoxetine results in increased expression of JAG1 mRNA19801843
D005473FluoxetineFluoxetine results in increased expression of JAG1 protein19801843
D005557FormaldehydeFormaldehyde results in increased expression of JAG1 mRNA23649840
C039281furanfuran results in decreased methylation of JAG1 gene27387713
C039281furanfuran results in increased expression of JAG1 mRNA27387713
C106014geduningedunin results in decreased expression of JAG1 mRNA17010675
D017313FenretinideFenretinide results in decreased expression of JAG1 mRNA28973697
C029424hydrazinehydrazine results in decreased expression of JAG1 mRNA15282401
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of JAG1 mRNA20044591
C031927hydroquinonehydroquinone results in decreased expression of JAG1 mRNA22960397
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of JAG1 mRNA19376150
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of JAG1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of JAG1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of JAG1 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of JAG1 mRNA24796395
C410337K 7174K 7174 results in increased expression of JAG1 mRNA24086573
C045463leflunomideleflunomide results in increased expression of JAG1 mRNA28988120
C052901lemongrass oillemongrass oil affects the expression of JAG1 mRNA25976427
C533894LG 100815LG 100815 results in increased expression of JAG1 mRNA16951191
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of JAG1 mRNA"21843347
C440499lipopolysaccharide, Escherichia coli O111 B4"pyrazolanthrone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of JAG1 mRNA]"21843347
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of JAG1 mRNA]18449946
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of JAG1 mRNA18449946
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of JAG1 mRNA26378955
D008466MechlorethamineMechlorethamine results in increased expression of JAG1 mRNA17107856
D008627Mercuric ChlorideMercuric Chloride results in increased expression of JAG1 mRNA16507785
D008727MethotrexateMethotrexate results in increased expression of JAG1 mRNA17379860
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of JAG1 mRNA20713471
D008748Methylcholanthrenealpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]]29094188
D008748Methylcholanthrenealpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of JAG1 promoter]29094188
D008748Methylcholanthrenealpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of JAG1 mRNA]29094188
D008748Methylcholanthrenealpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of JAG1 promoter]29094188
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]29094188
D008748MethylcholanthreneMethylcholanthrene results in increased acetylation of JAG1 promoter29094188
D008748MethylcholanthreneMethylcholanthrene results in increased expression of JAG1 mRNA29094188
D008748MethylcholanthreneMethylcholanthrene results in increased methylation of JAG1 promoter29094188
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of JAG1 mRNA28001369
C406082monomethylarsonous acidmonomethylarsonous acid affects the expression of JAG1 mRNA20886546
C001478N(6)-(delta(2)-isopentenyl)adenineN(6)-(delta(2)-isopentenyl)adenine results in increased expression of JAG1 mRNA16129123
C000621033napabucasinnapabucasin results in decreased expression of JAG1 mRNA25605917
C022838nickel chloridenickel chloride results in increased expression of JAG1 mRNA17312168
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of JAG1 mRNA"18633435
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of JAG1 protein"18633435
C570897NSC668394NSC668394 results in increased expression of JAG1 mRNA27137931
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of JAG1 mRNA"16951191
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in increased expression of JAG1 mRNA25607892
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of JAG1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of JAG1 mRNA25729387
D010269ParaquatParaquat affects the expression of JAG1 mRNA24053911
D052638Particulate MatterAcetylcysteine inhibits the reaction [Particulate Matter results in increased expression of JAG1 mRNA]20974985
D052638Particulate MatterParticulate Matter results in decreased expression of JAG1 mRNA22178795
D052638Particulate MatterParticulate Matter results in increased expression of JAG1 mRNA20974985
D052638Particulate MatterTSLP protein affects the reaction [Particulate Matter results in increased expression of JAG1 mRNA]20974985
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of JAG1 mRNA26705709
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of JAG1 protein26879310
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of JAG1 mRNA17097637
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of JAG1 mRNA22039516
D010634PhenobarbitalPhenobarbital affects the expression of JAG1 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of JAG1 mRNA23091169
D010654Phenylbutyrates"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of JAG1 protein"23284745
C049032pinosylvinpinosylvin results in increased expression of JAG1 mRNA23333577
D010938Plant OilsPlant Oils results in increased expression of JAG1 mRNA23370395
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of JAG1 mRNA22714537
C432165pyrazolanthrone"pyrazolanthrone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of JAG1 mRNA]"21843347
D011794QuercetinQuercetin results in increased expression of JAG1 mRNA21632981
C004532quinonequinone results in decreased expression of JAG1 mRNA22960397
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of JAG1 mRNA19059307
C541923sandostatinLARsandostatinLAR results in increased expression of JAG1 mRNA17210224
D012822Silicon DioxideSilicon Dioxide results in decreased expression of JAG1 mRNA25351596
D012834SilverSilver results in increased expression of JAG1 mRNA26014281
D020123SirolimusSirolimus results in decreased expression of JAG1 protein20038814
D020123SirolimusSirolimus results in decreased expression of JAG1 protein20038814
C009277sodium arsenatesodium arsenate results in increased expression of JAG1 mRNA21795629
D012969Sodium FluorideSodium Fluoride results in increased expression of JAG1 mRNA27862939
D053260SootSoot results in decreased expression of JAG1 mRNA22461453
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of JAG1 mRNA26378955
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of JAG1 mRNA19059307
D013739TestosteroneTestosterone results in decreased expression of JAG1 mRNA19693291
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of JAG1 mRNA25172293
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of JAG1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of JAG1 mRNA19619570|2010694
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of JAG1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of JAG1 mRNA19770486|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of JAG1 mRNA16214954|2597527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of JAG1 mRNA22298810
D013752TetracyclineTetracycline results in increased expression of JAG1 mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of JAG1 mRNA25613284
C020809tetrathiomolybdatetetrathiomolybdate analog results in increased expression of JAG1 mRNA19323979
C009495titanium dioxidetitanium dioxide results in decreased expression of JAG1 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of JAG1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of JAG1 mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in increased expression of JAG1 mRNA"17951470
D014212Tretinoin"[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of JAG1 protein"23284745
D014212TretinoinTretinoin results in decreased expression of JAG1 mRNA15894607|2193413
D014212TretinoinTretinoin results in decreased expression of JAG1 mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAG1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of JAG1 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of JAG1 mRNA24935251|2670570
C050414tripterinetripterine results in decreased expression of JAG1 mRNA17010675
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of JAG1 mRNA"26179874
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of JAG1 mRNA]18633435
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of JAG1 protein]18633435
D014520UrethaneUrethane results in increased expression of JAG1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of JAG1 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of JAG1 mRNA26272509|2915479
D014635Valproic AcidValproic Acid results in increased expression of JAG1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased expression of JAG1 mRNA20546886
D014638VanadatesVanadates results in increased expression of JAG1 mRNA22714537
D001335Vehicle EmissionsAcetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of JAG1 mRNA]20974985
D001335Vehicle EmissionsTSLP protein affects the reaction [Vehicle Emissions results in increased expression of JAG1 mRNA]20974985
D001335Vehicle EmissionsVehicle Emissions results in increased expression of JAG1 mRNA20974985
C025643vinclozolinvinclozolin results in increased expression of JAG1 mRNA23034163
D024483Vitamin K 3Vitamin K 3 affects the expression of JAG1 mRNA20044591
D015029ZeranolZeranol results in increased expression of JAG1 protein22113133

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005112Notch binding-IPI11006133  
GO:0005112Notch binding-NAS9268641  
GO:0005198structural molecule activity-NAS10679295  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI18660822  23086448  
GO:0005543phospholipid binding-IMP22465068  
GO:0008083growth factor activity-NAS11067884  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-NAS8955070  
GO:0001709cell fate determination-NAS9207788  
GO:0001953negative regulation of cell-matrix adhesion-IDA11549580  
GO:0001974blood vessel remodeling-IEA-  
GO:0002011morphogenesis of an epithelial sheet-IEA-  
GO:0002456T cell mediated immunity-IMP23086448  
GO:0003180aortic valve morphogenesis-NAS20951801  
GO:0003184pulmonary valve morphogenesis-IMP9207787  20437614  
GO:0003215cardiac right ventricle morphogenesis-ISS-  
GO:0007219Notch signaling pathway-IMP19682396  
GO:0007219Notch signaling pathway-NAS9268641  
GO:0007219Notch signaling pathway-TAS-  
GO:0007399nervous system development-NAS8923452  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0022408negative regulation of cell-cell adhesion-IDA11549580  
GO:0030097hemopoiesis-NAS10329626  
GO:0030216keratinocyte differentiation-NAS12107827  
GO:0030336negative regulation of cell migration-IDA11549580  
GO:0032495response to muramyl dipeptide-IEA-  
GO:0035909aorta morphogenesis-ISS-  
GO:0042127regulation of cell proliferation-NAS10329626  
GO:0042491inner ear auditory receptor cell differentiation-IEA-  
GO:0045445myoblast differentiation-NAS10329626  
GO:0045446endothelial cell differentiation-NAS10329626  
GO:0045599negative regulation of fat cell differentiation-IEA-  
GO:0045602negative regulation of endothelial cell differentiation-IEA-  
GO:0045639positive regulation of myeloid cell differentiation-IEA-  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0045669positive regulation of osteoblast differentiation-IEA-  
GO:0045747positive regulation of Notch signaling pathway-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP20437614  
GO:0060317cardiac epithelial to mesenchymal transition-ISS-  
GO:0060411cardiac septum morphogenesis-ISS-  
GO:0061073ciliary body morphogenesis-IEA-  
GO:0061156pulmonary artery morphogenesis-IMP9207787  
GO:0061309cardiac neural crest cell development involved in outflow tract morphogenesis-ISS-  
GO:0061314Notch signaling involved in heart development-IC9207787  
GO:0061314Notch signaling involved in heart development-IMP20437614  
GO:0061444endocardial cushion cell development-ISS-  
GO:0072006nephron development-ISS-  
GO:0072015glomerular visceral epithelial cell development-ISS-  
GO:0072017distal tubule development-IEA-  
GO:0072070loop of Henle development-IEA-  
GO:0097150neuronal stem cell population maintenance-IEP19682396  
GO:2000737negative regulation of stem cell differentiation-IMP19682396  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS11427524  
GO:0005886plasma membrane-IDA20437614  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS11427524  
GO:0005912adherens junction-ISS-  
GO:0016020membranecolocalizes_withIMP22465068  
GO:0016020membrane-TAS9268641  
GO:0016324apical plasma membrane-ISS-  
KEGG ID KEGG Term
hsa04330Notch signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-157118Signaling by NOTCHIEA
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1980145Signaling by NOTCH2IEA
R-HSA-1980150Signaling by NOTCH4TAS
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2660825Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation MutantTAS
R-HSA-2660826Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation MutantTAS
R-HSA-2691230Signaling by NOTCH1 HD Domain Mutants in CancerTAS
R-HSA-2691232Constitutive Signaling by NOTCH1 HD Domain MutantsTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-2979096NOTCH2 Activation and Transmission of Signal to the NucleusIEA
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878159Transcriptional regulation by RUNX3TAS
R-HSA-8941856RUNX3 regulates NOTCH signalingTAS
R-HSA-9012852Signaling by NOTCH3IEA
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusIEA
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25962154Downregulation of notch signaling pathway in late preterm and term placentas from pregnancies complicated by preeclampsia. (2015)Fragkiadaki PPLoS One
19106307Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease. (2009 Mar 15)Tilley AEAm J Respir Crit Care Med