Gene: DSC2

1824
ARVD11|CDHF2|DG2|DGII/III|DSC3
desmocollin 2
protein-coding
18q12.1
Ensembl:ENSG00000134755 MIM:125645 Vega:OTTHUMG00000131981 UniprotKB:Q02487
NG_008208.2
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.060e-2 (AD)  3.084e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LIMS10.83
DSE0.817
ZNF2170.815
ANO60.812
SLC11A10.809
TLR20.804
MR10.803
OSMR0.797
CD1630.796
SERPINB10.796

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.474
TMEM179-0.461
ABCC12-0.454
SLC7A4-0.441
RTN4R-0.44
WNT7A-0.44
CPLX3-0.439
ADRA1D-0.434
HR-0.428
MAGIX-0.427

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DSC2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DSC2 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of DSC2 mRNA]"19467301
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of DSC2 mRNA16788091
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of DSC2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
C496492abrineabrine results in decreased expression of DSC2 mRNA22595364
D000082AcetaminophenAcetaminophen affects the expression of DSC2 mRNA17562736
D000086AcetazolamideAcetazolamide results in increased expression of DSC2 mRNA19274763
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DSC2 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of DSC2 mRNA24449571
C006632arsenic trioxideDSC2 protein results in decreased susceptibility to arsenic trioxide20707922
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DSC2 mRNA23735875
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of DSC2 mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of DSC2 mRNA24758408
D004958EstradiolEstradiol results in increased expression of DSC2 mRNA24052564
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of DSC2 mRNA]24052564
C006780bisphenol Abisphenol A results in decreased expression of DSC2 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of DSC2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DSC2 mRNA25993096
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DSC2 mRNA20938992
D002857ChromiumChromium results in increased expression of DSC2 mRNA21437242
D002994ClofibrateClofibrate affects the expression of DSC2 mRNA17585979
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of DSC2 mRNA20971185
D003375CoumestrolCoumestrol results in decreased expression of DSC2 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of DSC2 mRNA27989131
D003561CytarabineCytarabine results in decreased expression of DSC2 mRNA21198554
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DSC2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DSC2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of DSC2 mRNA27392435
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of DSC2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of DSC2 mRNA19467301
D002117CalcitriolCalcitriol results in decreased expression of DSC2 mRNA21592394
D002117CalcitriolCalcitriol results in increased expression of DSC2 mRNA26485663
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of DSC2 mRNA21592394
D004317DoxorubicinDMD protein affects the reaction [Doxorubicin results in increased expression of DSC2 mRNA]17888722
D004317DoxorubicinDoxorubicin results in increased expression of DSC2 mRNA17888722
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of DSC2 promoter27415467
D000431Ethanol[ochratoxin A co-treated with Ethanol] results in increased expression of DSC2 mRNA16622519
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DSC2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DSC2 mRNA12072388|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DSC2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DSC2 mRNA17557909
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DSC2 mRNA20938992
D005897GlafenineGlafenine results in increased expression of DSC2 mRNA24136188
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DSC2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of DSC2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DSC2 mRNA24796395
D007840LatexLatex analog results in increased expression of DSC2 mRNA24768652
C008261lead acetatelead acetate results in decreased expression of DSC2 mRNA22609695
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of DSC2 mRNA12057914
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of DSC2 mRNA26378955
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of DSC2 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DSC2 mRNA27188386
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of DSC2 mRNA"26251327
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of DSC2 mRNA22401849
D009151Mustard GasMustard Gas results in increased expression of DSC2 mRNA25102026
D009151Mustard GasMustard Gas results in increased expression of DSC2 mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DSC2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DSC2 mRNA"25620056
C051752nefazodonenefazodone results in increased expression of DSC2 mRNA24136188
D009532NickelNickel results in increased expression of DSC2 mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of DSC2 mRNA19167457
C012655nimesulidenimesulide results in increased expression of DSC2 mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of DSC2 mRNA20971185
C025589ochratoxin A[ochratoxin A co-treated with Ethanol] results in increased expression of DSC2 mRNA16622519
C025589ochratoxin Aochratoxin A results in decreased expression of DSC2 mRNA16857307
C025589ochratoxin Aochratoxin A results in increased expression of DSC2 mRNA16622519
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of DSC2 mRNA26272509
D010634PhenobarbitalPhenobarbital affects the expression of DSC2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of DSC2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DSC2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of DSC2 mRNA18445702
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of DSC2 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of DSC2 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in increased expression of DSC2 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of DSC2 mRNA21632981
C059514resveratrolresveratrol results in increased expression of DSC2 mRNA11588890
D015474IsotretinoinIsotretinoin results in decreased expression of DSC2 mRNA20436886
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of DSC2 mRNA19244175
D012643SeleniumSelenium results in decreased expression of DSC2 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of DSC2 mRNA25895662
D012906SmokeSmoke results in decreased expression of DSC2 mRNA21095227
C017947sodium arsenitesodium arsenite results in increased expression of DSC2 mRNA22714537
D018038Sodium SeleniteSodium Selenite results in decreased expression of DSC2 mRNA18175754
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of DSC2 mRNA26378955
D013629TamoxifenTamoxifen affects the expression of DSC2 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of DSC2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of DSC2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DSC2 mRNA23152189
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DSC2 mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of DSC2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of DSC2 mRNA]24052564
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DSC2 mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of DSC2 mRNA28973375
D013853ThioacetamideThioacetamide results in increased expression of DSC2 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DSC2 mRNA27404394
D014118Toxins, Biological"Toxins, Biological affects the expression of DSC2 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of DSC2 mRNA21934132
D014212TretinoinTretinoin results in increased expression of DSC2 mRNA16236135|1660451
D014212TretinoinTretinoin results in increased expression of DSC2 mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of DSC2 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of DSC2 mRNA28973697
D014520UrethaneUrethane results in decreased expression of DSC2 mRNA28818685
C406224valdecoxibvaldecoxib results in increased expression of DSC2 mRNA24136188
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of DSC2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DSC2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of DSC2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of DSC2 mRNA17963808
D014638VanadatesVanadates results in decreased expression of DSC2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DSC2 gene25560391
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of DSC2 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of DSC2 mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSC2 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of DSC2 mRNA26272509
D015034Zinc OxideZinc Oxide analog results in increased expression of DSC2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI21062920  
GO:0086083cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication-IC23863954  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-TAS2037591  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0009267cellular response to starvation-IEA-  
GO:0031424keratinization-TAS-  
GO:0070268cornification-TAS-  
GO:0086042cardiac muscle cell-cardiac muscle cell adhesion-IMP21062920  
GO:0086073bundle of His cell-Purkinje myocyte adhesion involved in cell communication-IMP23863954  
GO:0086091regulation of heart rate by cardiac conduction-IMP23863954  
GO:0098911regulation of ventricular cardiac muscle cell action potential-IMP23863954  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-TAS-  
GO:0005886plasma membrane-IDA23863954  
GO:0005886plasma membrane-TAS-  
GO:0005913cell-cell adherens junction-IEA-  
GO:0014704intercalated disc-IDA21062920  21220045  23863954  
GO:0016021integral component of membrane-IEA-  
GO:0030057desmosome-IDA21062920  21220045  
GO:0031410cytoplasmic vesicle-IDA21062920  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
KEGG ID KEGG Term
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal