Gene: DSG2

1829
CDHF5|HDGC
desmoglein 2
protein-coding
18q12.1
Ensembl:ENSG00000046604 MIM:125671 Vega:OTTHUMG00000179649 UniprotKB:Q14126
NG_007072.3
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.211e-1 (AD)  7.001e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BMP50.662
SCARA50.658
BMX0.641
MYOCD0.628
TNFRSF190.626
ALX40.625
GPX80.624
PHLDB20.62
PTGDR0.616
C1QTNF70.616

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HHATL-0.41
IZUMO4-0.404
S100A1-0.398
KIAA1755-0.388
NEU4-0.372
NTSR2-0.367
GPR37L1-0.358
SLC25A48-0.357
HES6-0.352
GPT-0.342

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DSG2 mRNA"19114083
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of DSG2 mRNA]"19467301
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of DSG2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of DSG2 protein"25670856
D000082AcetaminophenAcetaminophen results in decreased expression of DSG2 mRNA17585979
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of DSG2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DSG2 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DSG2 mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DSG2 mRNA19770486
C006632arsenic trioxideDSG2 protein results in decreased susceptibility to arsenic trioxide20707922
D001280AtrazineAtrazine results in increased expression of DSG2 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DSG2 mRNA19770486|2222880
D004958EstradiolEstradiol affects the expression of DSG2 mRNA15598610
C006780bisphenol Abisphenol A results in decreased expression of DSG2 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of DSG2 protein20921394
D002509CephaloridineCephaloridine results in increased expression of DSG2 mRNA18500788
D002737ChloropreneChloroprene results in increased expression of DSG2 mRNA23125180
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of DSG2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DSG2 mRNA]17585979
D016572CyclosporineCyclosporine results in increased expression of DSG2 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DSG2 mRNA17361019|2126653
D002945CisplatinCisplatin results in increased expression of DSG2 mRNA27594783
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of DSG2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of DSG2 mRNA19467301
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of DSG2 mRNA20920545
D002117CalcitriolCalcitriol results in increased expression of DSG2 mRNA26485663
C004312glycidolglycidol results in decreased expression of DSG2 mRNA24915197
D017313FenretinideFenretinide results in increased expression of DSG2 mRNA28973697
D007545IsoproterenolIsoproterenol results in decreased expression of DSG2 mRNA20003209
C410337K 7174K 7174 results in increased expression of DSG2 mRNA24086573
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of DSG2 mRNA26378955
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DSG2 mRNA23179753|2718838
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of DSG2 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of DSG2 promoter"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of DSG2 mRNA24810058
C523799MRK 003DSG2 results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DSG2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DSG2 mRNA"25620056
D009532NickelNickel results in decreased expression of DSG2 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of DSG2 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of DSG2 mRNA16780908|2271453
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of DSG2 mRNA26705709
D010634PhenobarbitalPhenobarbital affects the expression of DSG2 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of DSG2 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of DSG2 mRNA18445702
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of DSG2 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of DSG2 mRNA21278054
C059514resveratrolresveratrol results in decreased expression of DSG2 mRNA22610192
D012906SmokeSmoke results in decreased expression of DSG2 mRNA21095227
D012969Sodium Fluoride[Sodium Fluoride co-treated with Sulfur Dioxide] results in decreased expression of DSG2 mRNA27237588
D012969Sodium Fluoride[Sodium Fluoride co-treated with Sulfur Dioxide] results in decreased expression of DSG2 protein27237588
D012969Sodium FluorideSodium Fluoride results in decreased expression of DSG2 mRNA27237588
D012969Sodium FluorideSodium Fluoride results in decreased expression of DSG2 protein27237588|2891852
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of DSG2 mRNA26378955
D013458Sulfur Dioxide[Sodium Fluoride co-treated with Sulfur Dioxide] results in decreased expression of DSG2 mRNA27237588
D013458Sulfur Dioxide[Sodium Fluoride co-treated with Sulfur Dioxide] results in decreased expression of DSG2 protein27237588
D013458Sulfur DioxideSulfur Dioxide results in decreased expression of DSG2 mRNA27237588
D013458Sulfur DioxideSulfur Dioxide results in decreased expression of DSG2 protein27237588
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DSG2 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DSG2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DSG2 mRNA19770486
D013853ThioacetamideThioacetamide results in increased expression of DSG2 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DSG2 mRNA27404394
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of DSG2 mRNA28111298
C528105trans-3,4'-dimethyl-3-hydroxyflavanone"trans-3,4'-dimethyl-3-hydroxyflavanone results in increased expression of DSG2 protein"26897375
D014212TretinoinTretinoin results in increased expression of DSG2 mRNA16236135
C012589trichostatin Atrichostatin A results in increased expression of DSG2 mRNA24935251|2670570
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of DSG2 mRNA17982090
C057693troglitazonetroglitazone results in decreased expression of DSG2 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of DSG2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DSG2 mRNA19101580|2670570
C025643vinclozolinvinclozolin results in decreased expression of DSG2 mRNA23034163
D015032ZincZinc results in decreased expression of DSG2 mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0050839cell adhesion molecule binding-IPI17559062  
GO:0086083cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication-IC16505173  
GO ID GO Term Qualifier Evidence PubMed
GO:0002934desmosome organization-IMP16505173  
GO:0003165Purkinje myocyte development-IMP16505173  
GO:0007155cell adhesion-IDA17559062  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IDA17559062  
GO:0031424keratinization-TAS-  
GO:0032570response to progesterone-IEA-  
GO:0060135maternal process involved in female pregnancy-IEA-  
GO:0070268cornification-TAS-  
GO:0086073bundle of His cell-Purkinje myocyte adhesion involved in cell communication-IMP16505173  
GO:0086091regulation of heart rate by cardiac conduction-IMP16505173  23381804  
GO:0098911regulation of ventricular cardiac muscle cell action potential-IMP16505173  23381804  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-TAS-  
GO:0005886plasma membrane-IDA17559062  20859650  
GO:0005886plasma membrane-TAS-  
GO:0005911cell-cell junction-TAS8143788  
GO:0009986cell surface-HDA19581412  
GO:0014704intercalated disc-IDA23381804  
GO:0016021integral component of membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0016328lateral plasma membrane-IEA-  
GO:0030054cell junction-IDA-  
GO:0030057desmosome-IDA23381804  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-111465Apoptotic cleavage of cellular proteinsTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-351906Apoptotic cleavage of cell adhesion proteinsTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS
R-HSA-75153Apoptotic execution phaseTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget