Gene: DSG3

1830
CDHF6|PVA
desmoglein 3
protein-coding
18q12.1
Ensembl:ENSG00000134757 MIM:169615 Vega:OTTHUMG00000131985 UniprotKB:P32926
NC_000018.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.550e-1 (AD)  6.613e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADH70.678
MUC210.666
SERPINB30.655
SPINK50.654
DAZ10.648
KRT780.632
KRT50.624
FGFBP10.605
TACSTD20.604
SERPINB130.599

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDK4-0.329
KIF19-0.303
MYOM1-0.296
HIF3A-0.294
OTOS-0.293
ROM1-0.292
ITGB4-0.291
GMPR-0.29
MT1M-0.29
AZGP1-0.287

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D003913DextroamphetamineDextroamphetamine affects the expression of DSG3 mRNA12205029
D003913DextroamphetamineSOD1 affects the reaction [Dextroamphetamine affects the expression of DSG3 mRNA]12205029
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DSG3 mRNA23735875
C006780bisphenol Abisphenol A results in decreased expression of DSG3 mRNA20678512
C006780bisphenol Abisphenol A results in decreased expression of DSG3 mRNA25181051
D002726Chlorogenic AcidChlorogenic Acid results in decreased expression of DSG3 mRNA20706672
D003300CopperCopper deficiency results in increased expression of DSG3 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of DSG3 mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of DSG3 mRNA26485663
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of DSG3 mRNA20706672
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of DSG3 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of DSG3 mRNA23649840
D019833GenisteinGenistein results in decreased expression of DSG3 mRNA20706672
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of DSG3 mRNA12057914
D008727MethotrexateMethotrexate results in increased expression of DSG3 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DSG3 mRNA23649840
D009151Mustard GasMustard Gas results in increased expression of DSG3 mRNA18955075
D009532NickelNickel results in increased expression of DSG3 mRNA24768652|2558310
C485800osajinosajin results in decreased expression of DSG3 mRNA20706672
D010069Oxadiazoles[Oxadiazoles analog co-treated with FGF2 protein] results in increased expression of DSG3 mRNA23212921
D010069Oxadiazoles[Oxadiazoles analog co-treated with FGF2 protein] results in increased expression of DSG3 protein23212921
C033607puerarinpuerarin results in decreased expression of DSG3 mRNA20706672
C529148rosavinrosavin results in decreased expression of DSG3 mRNA20706672
C078903seocalcitolseocalcitol results in increased expression of DSG3 mRNA12040012
D012906SmokeSmoke results in decreased expression of DSG3 mRNA21095227
C017947sodium arsenitesodium arsenite results in decreased expression of DSG3 mRNA28595984
D012969Sodium FluorideSodium Fluoride results in increased expression of DSG3 mRNA27257137
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DSG3 mRNA23152189
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with FGF2 protein] results in increased expression of DSG3 mRNA23212921
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with FGF2 protein] results in increased expression of DSG3 protein23212921
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DSG3 mRNA27404394
C024746tobacco tartobacco tar results in decreased expression of DSG3 mRNA19559774
C528105trans-3,4'-dimethyl-3-hydroxyflavanone"trans-3,4'-dimethyl-3-hydroxyflavanone results in increased expression of DSG3 protein"26897375

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0031424keratinization-TAS-  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-TAS-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0030057desmosome-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-111465Apoptotic cleavage of cellular proteinsTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-351906Apoptotic cleavage of cell adhesion proteinsTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS
R-HSA-75153Apoptotic execution phaseTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20667405Desmoglein 3 and keratin 10 expressions are reduced by chronic exposure to cigarette smoke in human keratinised oral mucosa explants. (2010 Oct)Donetti EArch Oral Biol