Gene info: ID 1832

Gene: DSP

GENE ID: 1832

Synonyms: DCWHKTA|DP

Description: desmoplakin

Gene type: protein-coding

Location: 6p24.3

dbXrefs: Ensembl:ENSG00000096696 MIM:125647 Vega:OTTHUMG00000014212 UniprotKB:P15924

RefSeq: NG_008803.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 14

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.429e-1 (AD) 4.170e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SVIL	0.829
ERG	0.821
MECOM	0.814
FOXC1	0.81
EDNRA	0.791
PALMD	0.791
GIMAP8	0.787
MYCT1	0.782
TBX15	0.779
TBX18	0.778

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ASPDH	-0.464
ZNF835	-0.417
MAGIX	-0.397
MYADML2	-0.396
FBLL1	-0.394
TMEM121	-0.394
HAS1	-0.383
SAC3D1	-0.378
FAM43B	-0.374
HAGHL	-0.374

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB11638	Artenimol	Small Molecule	71939-50-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of DSP mRNA"	26377693
C020175	16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione	"16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased expression of DSP mRNA"	20519331
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of DSP mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of DSP mRNA"	21346803
C006551	2-amino-2-methyl-1-propanol	2-amino-2-methyl-1-propanol results in decreased expression of DSP mRNA	25088246
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of DSP protein"	25670856
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSP mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSP mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSP mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSP mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSP mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSP mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSP mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSP mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of DSP mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Dietary Fats results in increased expression of DSP mRNA]	21051528
D020106	Acrylamide	Acrylamide results in increased expression of DSP mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of DSP gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of DSP mRNA	19770486
C006632	arsenic trioxide	arsenic trioxide results in increased expression of DSP protein	25419056
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DSP mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DSP mRNA	22228805\|2719552
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of DSP mRNA	25912373
C006780	bisphenol A	bisphenol A results in decreased expression of DSP mRNA	26063408
C006780	bisphenol A	bisphenol A results in decreased expression of DSP mRNA	25181051
C018475	butyraldehyde	butyraldehyde results in decreased expression of DSP mRNA	26079696
D002104	Cadmium	DSP protein binds to Cadmium	23896426
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of DSP mRNA	23650126
D002994	Clofibrate	Clofibrate results in decreased expression of DSP mRNA	22300585
D003042	Cocaine	Cocaine results in increased expression of DSP protein	17075605
D019327	Copper Sulfate	Copper Sulfate results in increased expression of DSP mRNA	19549813
C014347	decitabine	decitabine inhibits the reaction [Smoke results in decreased expression of DSP mRNA]	21095227
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of DSP mRNA	28628672
C041517	dibenzo(a,l)pyrene	"dibenzo(a,l)pyrene results in increased expression of DSP mRNA"	25908611
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of DSP mRNA	24893172
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of DSP mRNA	21266533
C000944	dicrotophos	dicrotophos results in increased expression of DSP mRNA	28302478
D004041	Dietary Fats	Acetylcysteine inhibits the reaction [Dietary Fats results in increased expression of DSP mRNA]	21051528
D004041	Dietary Fats	Dietary Fats results in increased expression of DSP mRNA	21051528
D004041	Dietary Fats	Ethanol inhibits the reaction [Dietary Fats results in increased expression of DSP mRNA]	21051528
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of DSP mRNA	25242112
C039060	dihydroartemisinin	dihydroartemisinin analog binds to DSP protein	26340163
D002117	Calcitriol	Calcitriol results in increased expression of DSP mRNA	26485663
D004317	Doxorubicin	DSP protein affects the susceptibility to Doxorubicin	16217747
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DSP protein	23301498
D000431	Ethanol	Ethanol inhibits the reaction [Dietary Fats results in increased expression of DSP mRNA]	21051528
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of DSP mRNA	17557909
D005897	Glafenine	Glafenine results in decreased expression of DSP mRNA	24136188
D017313	Fenretinide	Fenretinide results in increased expression of DSP mRNA	28973697
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of DSP mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of DSP mRNA	28628672
C410337	K 7174	K 7174 results in increased expression of DSP mRNA	24086573
D007854	Lead	DSP protein binds to Lead	23896426
C008261	lead acetate	lead acetate results in decreased expression of DSP mRNA	22641619
C045463	leflunomide	leflunomide results in increased expression of DSP mRNA	28988120
C042720	mercuric bromide	mercuric bromide results in increased expression of DSP mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSP mRNA"	27188386
D008694	Methamphetamine	Methamphetamine results in increased expression of DSP mRNA	26307267
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of DSP mRNA	23103053
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of DSP mRNA	23179753\|2718838
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of DSP mRNA	26924002
C523799	MRK 003	DSP results in decreased susceptibility to MRK 003	19903844
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of DSP mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of DSP mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of DSP mRNA"	25554681\|2562005
C025256	nonylphenol	nonylphenol results in decreased expression of DSP mRNA	22982499
C025256	nonylphenol	nonylphenol results in increased expression of DSP protein	19260726
D019319	Okadaic Acid	Okadaic Acid results in increased expression of DSP mRNA	25270620
D010100	Oxygen	Oxygen deficiency results in increased expression of DSP mRNA	20880076
D017239	Paclitaxel	DSP protein affects the susceptibility to Paclitaxel	16217747
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of DSP mRNA	23892564
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in decreased expression of DSP mRNA	22790973
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of DSP mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of DSP mRNA	19429403
D010634	Phenobarbital	Phenobarbital affects the expression of DSP mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of DSP mRNA	19363144
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSP mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of DSP mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in decreased expression of DSP mRNA	18445702
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of DSP mRNA	22714537
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of DSP mRNA	28903501
D011374	Progesterone	NCOA2 protein affects the reaction [Progesterone results in decreased expression of DSP mRNA]	17556502
D011374	Progesterone	Progesterone results in decreased expression of DSP mRNA	17556502\|2223828
C045950	propiconazole	propiconazole results in decreased expression of DSP mRNA	21278054
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of DSP mRNA	25895662
D012906	Smoke	decitabine inhibits the reaction [Smoke results in decreased expression of DSP mRNA]	21095227
D012906	Smoke	Smoke results in decreased expression of DSP mRNA	21095227
C017947	sodium arsenite	sodium arsenite affects the methylation of DSP gene	28589171
C017947	sodium arsenite	sodium arsenite results in decreased expression of DSP mRNA	12634122
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of DSP protein	28918527
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of DSP mRNA	21632981
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DSP mRNA	21570461
D013853	Thioacetamide	Thioacetamide results in increased expression of DSP mRNA	23411599
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of DSP mRNA	27865774
D019772	Topotecan	DSP protein affects the susceptibility to Topotecan	16217747
D014212	Tretinoin	Tretinoin results in increased expression of DSP mRNA	21934132
D014212	Tretinoin	Tretinoin results in increased expression of DSP mRNA	16604517
C032910	triadimefon	triadimefon results in decreased expression of DSP mRNA	26705709
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSP mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of DSP mRNA	24935251\|2627250
C012589	trichostatin A	trichostatin A results in decreased expression of DSP mRNA	15901671
D014520	Urethane	Urethane results in increased expression of DSP mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DSP mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of DSP mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of DSP mRNA	23527032\|2438349
D014635	Valproic Acid	Valproic Acid results in decreased expression of DSP mRNA	15901671
C025643	vinclozolin	vinclozolin affects the expression of DSP mRNA	19015723
D015032	Zinc	DSP protein binds to Zinc	23896426

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22658674
GO:0005080	protein kinase C binding	-	IPI	18474624
GO:0005198	structural molecule activity	-	IBA	21873635
GO:0005198	structural molecule activity	-	IDA	10908733
GO:0005200	structural constituent of cytoskeleton	-	TAS	9887343
GO:0005515	protein binding	-	IPI	10852826 12482924 16917092 17353931 21062920 25225338
GO:0030674	protein binding, bridging	-	IDA	10908733
GO:0045296	cadherin binding	-	IBA	21873635
GO:0050839	cell adhesion molecule binding	-	IEA	-
GO:0086083	cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication	-	IC	12373648
GO:0097110	scaffold protein binding	-	IPI	10852826

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002934	desmosome organization	-	ISS	16917092
GO:0003223	ventricular compact myocardium morphogenesis	-	ISS	16917092
GO:0008544	epidermis development	-	TAS	9887343
GO:0018149	peptide cross-linking	-	IDA	10908733
GO:0030216	keratinocyte differentiation	-	IDA	10908733
GO:0031424	keratinization	-	TAS	-
GO:0034332	adherens junction organization	-	IEA	-
GO:0042060	wound healing	-	IBA	21873635
GO:0042060	wound healing	-	IEA	-
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043588	skin development	-	IBA	21873635
GO:0045104	intermediate filament cytoskeleton organization	-	IBA	21873635
GO:0045109	intermediate filament organization	-	ISS	16917092
GO:0070268	cornification	-	TAS	-
GO:0071896	protein localization to adherens junction	-	ISS	16917092
GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	-	IMP	12373648
GO:0086091	regulation of heart rate by cardiac conduction	-	IMP	12373648
GO:0098609	cell-cell adhesion	-	IBA	21873635
GO:0098911	regulation of ventricular cardiac muscle cell action potential	-	IMP	12373648

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001533	cornified envelope	-	IDA	10908733
GO:0001533	cornified envelope	-	TAS	-
GO:0005634	nucleus	-	HDA	21630459
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005882	intermediate filament	COLOCALIZES_WITH	IBA	21873635
GO:0005882	intermediate filament	colocalizes_with	ISS	16917092
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	IDA	16917092 20859650
GO:0005886	plasma membrane	-	TAS	-
GO:0005916	fascia adherens	-	IEA	-
GO:0014704	intercalated disc	-	IBA	21873635
GO:0014704	intercalated disc	-	IDA	22781308 22889254 23381804
GO:0014704	intercalated disc	-	ISS	-
GO:0016020	membrane	-	IBA	21873635
GO:0016323	basolateral plasma membrane	-	IEA	-
GO:0030054	cell junction	-	IBA	21873635
GO:0030057	desmosome	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 19199708 20458337
GO:0101003	ficolin-1-rich granule membrane	-	TAS	-

KEGG ID	KEGG Term
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-111465	Apoptotic cleavage of cellular proteins	TAS
R-HSA-1266738	Developmental Biology	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-351906	Apoptotic cleavage of cell adhesion proteins	TAS
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-6805567	Keratinization	TAS
R-HSA-6809371	Formation of the cornified envelope	TAS
R-HSA-75153	Apoptotic execution phase	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18028103	Down-regulation of alpha-adrenoceptor expression by lipid-soluble smoke particles through transcriptional factor nuclear factor-kappaB pathway. (2007 Dec)	Zhang W	Basic Clin Pharmacol Toxicol
16651834	The prevalence of neuropathy and relationship with risk factors in diabetic patients: a single-center experience. (2006)	Tamer A	Med Princ Pract
20406207	Up-regulation of G-protein-coupled receptors for endothelin and thromboxane by lipid-soluble smoke particles in renal artery of rat. (2010 Oct)	Xie YH	Basic Clin Pharmacol Toxicol
20716444	Upregulation of contractile endothelin type B receptors by lipid-soluble cigarette smoking particles in rat cerebral arteries via activation of MAPK. (2010 Nov 15)	Sandhu H	Toxicol Appl Pharmacol
23712000	DMSO-soluble cigarette smoke particles alter the expression of endothelin B receptor in rat coronary artery. (2013)	Huang LH	J Vasc Res
17706224	Up-regulation of thromboxane A2 receptor expression by lipid soluble smoking particles through post-transcriptional mechanisms. (2008 Feb)	Zhang W	Atherosclerosis
18625256	Desipramine potentiation of the acute depressant effects of ethanol: modulation by alpha2-adrenoreceptors and stress. (2008 Oct)	Boyce-Rustay JM	Neuropharmacology
10588075	Risk factors for progression of distal symmetric polyneuropathy in type 1 diabetes mellitus. Sorbinil Retinopathy Trial Research Group. (1999 Dec 1)	Christen WG	Am J Epidemiol
16539723	Smoking particles enhance endothelin A and endothelin B receptor-mediated contractions by enhancing translation in rat bronchi. (2006 Mar 15)	Granstrom BW	BMC Pulm Med
27731935	Lipid-soluble Cigarette Smoke Particles Induced Vascular Endothelin Type A Receptor Up-Regulation through Activation of ERK1/2 Signal Pathways. (2017 Apr)	Zhang Y	Basic Clin Pharmacol Toxicol
26682766	Spatiotemporal Variations in Chronic Obstructive Pulmonary Disease Mortality in China: Multilevel Evidence from 2006 to 2012. (2016 Jun)	Yin P	COPD
29066090	Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. (2017 Nov)	Allen RJ	Lancet Respir Med
19436652	Lipid-soluble cigarette smoking particles induce expression of inflammatory and extracellular-matrix-related genes in rat cerebral arteries. (2009)	Vikman P	Vasc Health Risk Manag
15019471	First evidence of Dinophysistoxin-1 ester and carcinogenic polycyclic aromatic hydrocarbons in smoked bivalves collected in the Patagonia fjords. (2004 Feb)	Garcia C	Toxicon