Gene: DSPP

1834
DFNA39|DGI1|DMP3|DPP|DSP
dentin sialophosphoprotein
protein-coding
4q22.1
Ensembl:ENSG00000152591 MIM:125485 Vega:OTTHUMG00000161061 UniprotKB:Q9NZW4
NG_011595.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.000e-2 (AD)  4.954e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4C160.782
OR4C50.777
OR9G10.766
OR5L10.758
CSH10.752
OR5M100.752
OR5K40.752
OR5AS10.751
OR12D20.75
OR4D110.749

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DBP-0.304
FUT9-0.284
HHATL-0.273
TMEM221-0.273
MYBPC1-0.267
TM7SF2-0.256
C1orf53-0.251
OMG-0.25
PLA2G6-0.247
MYADML2-0.246

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of DSPP protein]24102669
D000111AcetylcysteineAcetylcysteine results in increased expression of DSPP mRNA20951298
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of DSPP gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of DSPP mRNA21298039
C010845aluminum chloridealuminum chloride results in decreased expression of DSPP mRNA28266088
C010845aluminum chloridealuminum chloride results in decreased expression of DSPP protein28266088
C010845aluminum chloride[Sodium Fluoride co-treated with aluminum chloride] results in decreased expression of DSPP mRNA28266088
C010845aluminum chloride[Sodium Fluoride co-treated with aluminum chloride] results in decreased expression of DSPP protein28266088
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DSPP mRNA16483693
D001280AtrazineAtrazine results in decreased expression of DSPP mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DSPP mRNA22316170
C006780bisphenol Abisphenol A results in decreased expression of DSPP mRNA25181051
C029892cupric chloridecupric chloride results in decreased expression of DSPP mRNA24650576
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of DSPP mRNA23914054
C014347decitabinedecitabine results in increased expression of DSPP mRNA21856257
D002945CisplatinDSPP protein results in decreased susceptibility to Cisplatin21103065
D019422Dietary SucroseDietary Sucrose results in increased expression of DSPP mRNA26033743
D004317DoxorubicinDoxorubicin results in decreased expression of DSPP mRNA16404146
D004492Edetic AcidEdetic Acid affects the localization of DSPP protein23525114
C070609EMD 53998EMD 53998 analog results in decreased expression of DSPP mRNA24977338
D019833GenisteinGenistein results in decreased methylation of DSPP gene28505145
D005944GlucosamineGlucosamine analog results in decreased expression of DSPP mRNA20458730
D006171Gutta-PerchaGutta-Percha results in decreased expression of DSPP mRNA23791256
C011890kojic acidkojic acid results in decreased expression of DSPP mRNA16595896
C029310lardlard results in increased expression of DSPP mRNA26115784
D008345ManganeseManganese results in increased expression of DSPP mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of DSPP mRNA17175027
D008694MethamphetamineMethamphetamine results in increased expression of DSPP mRNA15644446
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DSPP mRNA"25554681
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [NFIC protein binds to DSPP promoter]"22228435
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of DSPP mRNA"22228435
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of DSPP protein"22228435
C047088phenylamilphenylamil results in increased expression of DSPP mRNA24102669
D011794Quercetin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of DSPP protein]24102669
D011794QuercetinQuercetin results in increased expression of DSPP mRNA24102669
D011794QuercetinQuercetin results in increased expression of DSPP protein24102669
D019821SimvastatinSimvastatin results in increased expression of DSPP mRNA19249597
D012969Sodium Fluoride[Sodium Fluoride co-treated with aluminum chloride] results in decreased expression of DSPP mRNA28266088
D012969Sodium Fluoride[Sodium Fluoride co-treated with aluminum chloride] results in decreased expression of DSPP protein28266088
D012969Sodium FluorideSodium Fluoride results in decreased expression of DSPP mRNA28266088
D012969Sodium FluorideSodium Fluoride results in decreased expression of DSPP protein28266088
D012969Sodium FluorideSodium Fluoride results in increased expression of DSPP mRNA27257137
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DSPP mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to DSPP promoter]19654925
C012589trichostatin Atrichostatin A results in increased expression of DSPP mRNA23562654
D014635Valproic AcidValproic Acid affects the expression of DSPP mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of DSPP mRNA23562654
D015032ZincZinc inhibits the reaction [NFIC protein binds to DSPP promoter]22228435
D015032ZincZinc results in decreased expression of DSPP mRNA22228435
D015032ZincZinc results in decreased expression of DSPP protein22228435

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-TAS8995371  
GO:0005509calcium ion binding-TAS9879917  
GO:0005518collagen binding-TAS9879917  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS8995371  
GO:0001503ossification-TAS9879917  
GO:0007275multicellular organism development-TAS8995371  
GO:0030198extracellular matrix organization-TAS-  
GO:0031214biomineral tissue development-IEA-  
GO:1901329regulation of odontoblast differentiation-ISS15308669  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005737cytoplasm-IDA11856645  
GO:0031012extracellular matrix-TAS8995371  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-3000178ECM proteoglycansTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21851636Effects of exposure to cigarette smoke prior to pregnancy in diabetic rats. (2011 Aug 18)Damasceno DCDiabetol Metab Syndr
21667441Genotoxicity and fetal abnormality in streptozotocin-induced diabetic rats exposed to cigarette smoke prior to and during pregnancy. (2011 Oct)Damasceno DCExp Clin Endocrinol Diabetes