Gene: DTNB

1838
-
dystrobrevin beta
protein-coding
2p23.3
Ensembl:ENSG00000138101 MIM:602415 Vega:OTTHUMG00000152129 UniprotKB:O60941
NC_000002.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.469e-1 (AD)  3.838e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26179134chr2:25897613DTNB5.110e-8Maternal smoking in pregnancy27040690
cg02068690chr2:25600451DTNB4.100e-14Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STOML10.954
KATNB10.949
PGP0.947
GNG30.947
P4HTM0.947
KLHL220.946
BSCL20.945
OTUB10.944
PIN10.943
CALM30.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.59
OR4F29-0.558
WWTR1-0.511
CNN2-0.504
REST-0.504
TFPI2-0.499
CLEC2B-0.486
LATS2-0.483
KIAA0040-0.482
KCNJ15-0.481

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DTNB mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DTNB mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DTNB mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DTNB mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DTNB mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DTNB mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DTNB mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of DTNB mRNA"23196670
D000082AcetaminophenAcetaminophen results in increased expression of DTNB mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of DTNB mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of DTNB mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DTNB mRNA]17585979
D001280AtrazineAtrazine affects the expression of DTNB mRNA25929836
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DTNB mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DTNB mRNA26238291
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of DTNB mRNA]22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DTNB mRNA"26238291
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of DTNB mRNA26496021
D001629BezafibrateBezafibrate results in decreased expression of DTNB mRNA18787029
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of DTNB mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of DTNB mRNA25181051
D004390ChlorpyrifosChlorpyrifos results in decreased expression of DTNB mRNA18668222
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of DTNB mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DTNB mRNA]17585979
D003907DexamethasoneDexamethasone results in increased expression of DTNB mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DTNB mRNA21266533
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DTNB mRNA18164116
D002117CalcitriolCalcitriol results in increased expression of DTNB mRNA26485663
D004237DiuronDiuron results in decreased expression of DTNB mRNA21551480
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DTNB protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DTNB mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DTNB mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DTNB mRNA17942748
C069837fullerene C60fullerene C60 results in increased expression of DTNB mRNA19167457
C039281furanfuran results in increased methylation of DTNB gene22079235
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of DTNB mRNA19376150
C503753Indolinone AIndolinone A results in increased expression of DTNB mRNA15712243
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DTNB mRNA25613284
C028007nickel monoxidenickel monoxide results in increased expression of DTNB mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of DTNB mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of DTNB mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DTNB mRNA"25510870
C006253pirinixic acidpirinixic acid results in increased expression of DTNB mRNA18301758|2381119
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of DTNB mRNA21334430
D011374ProgesteroneProgesterone results in increased expression of DTNB mRNA23012394
D012999SomanSoman results in decreased expression of DTNB mRNA19281266
D013629TamoxifenTamoxifen affects the expression of DTNB mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DTNB mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DTNB mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DTNB mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DTNB mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DTNB mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of DTNB mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of DTNB mRNA25729387
D019772TopotecanTopotecan results in increased expression of DTNB mRNA25729387
D014635Valproic AcidValproic Acid affects the expression of DTNB mRNA25979313

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9395493  10545507  16189514  21516116  25416956  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
7654778Gas-phase cigarette smoke inhibits plasma lecithin-cholesterol acyltransferase activity by modification of the enzyme's free thiols. (1995 Aug 24)Bielicki JKBiochim Biophys Acta
11326967[Effects of smoking on the lipid peroxides antioxidation and alpha 1-antitrypsin]. (1998 Apr)Zhao YXZhonghua Jie He He Hu Xi Za Zhi