Gene: DUSP2

1844
PAC-1|PAC1
dual specificity phosphatase 2
protein-coding
2q11.2
Ensembl:ENSG00000158050 MIM:603068 Vega:OTTHUMG00000130456 UniprotKB:Q05923
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.958e-1 (AD)  9.154e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02431562chr2:96809970DUSP24.500e-15Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARL4D0.897
BEND50.84
GPR680.84
KCNF10.818
TMEM1980.815
SYT120.812
RTN4RL20.803
CACNB10.802
SLC39A30.796
LAMB30.795

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARD3B-0.532
MBNL3-0.489
PHEX-0.473
MYOM1-0.472
ASB4-0.456
ZIC4-0.441
CDC14A-0.433
FXYD3-0.43
OLAH-0.425
YES1-0.419

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DUSP2 mRNA"19114083
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of DUSP2 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of DUSP2 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP2 mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of DUSP2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DUSP2 mRNA22100608
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of DUSP2 mRNA21298039
D000966Antimony Potassium TartrateAntimony Potassium Tartrate inhibits the reaction [BMP6 protein results in increased expression of DUSP2 mRNA]28713220
C006632arsenic trioxidearsenic trioxide results in decreased expression of DUSP2 mRNA20458559
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of DUSP2 mRNA"17331233
D001280AtrazineAtrazine results in increased expression of DUSP2 mRNA23358194
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of DUSP2 mRNA26377693
D001554BenzeneBenzene results in decreased expression of DUSP2 mRNA15120971|1512265
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DUSP2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to DUSP2 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DUSP2 mRNA21569818
D004958EstradiolEstradiol affects the expression of DUSP2 mRNA23557687
D004958EstradiolEstradiol results in increased expression of DUSP2 mRNA23019147
C006780bisphenol Abisphenol A results in decreased expression of DUSP2 mRNA28079927
C006780bisphenol Abisphenol A affects the expression of DUSP2 mRNA25181051
D004390ChlorpyrifosChlorpyrifos results in increased expression of DUSP2 mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DUSP2 mRNA20938992
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of DUSP2 mRNA24690739
D003300CopperCopper deficiency results in increased expression of DUSP2 mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of DUSP2 mRNA19549813
D003520CyclophosphamideCyclophosphamide results in decreased expression of DUSP2 mRNA21041162
C014347decitabine[[decitabine co-treated with trichostatin A] affects the methylation of DUSP2 promoter] which affects the expression of DUSP2 mRNA18836996|1883699
D003703DemecolcineDemecolcine results in increased expression of DUSP2 mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of DUSP2 mRNA21041162
D003907DexamethasoneDexamethasone results in increased expression of DUSP2 mRNA22733784
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of DUSP2 mRNA28085963
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of DUSP2 mRNA24690739
C012301domoic aciddomoic acid results in increased expression of DUSP2 mRNA18936300
D004391DustDust results in increased expression of DUSP2 mRNA17805423
D005047EtoposideDUSP2 protein affects the susceptibility to Etoposide16217747
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DUSP2 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of DUSP2 mRNA17938736|2893796
D019833GenisteinGenistein results in increased expression of DUSP2 mRNA23019147
D005947GlucoseGlucose results in increased expression of DUSP2 mRNA17178593
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in decreased expression of DUSP2 mRNA22467014
C010974glyphosateglyphosate results in increased expression of DUSP2 mRNA25636363
D006418HemeHeme metabolite results in decreased expression of DUSP2 mRNA19191707
D006851Hydrochloric AcidHydrochloric Acid results in decreased expression of DUSP2 mRNA15046208
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DUSP2 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP2 mRNA25613284
C051890irinotecanirinotecan metabolite results in increased expression of DUSP2 mRNA15956246
C051890irinotecanirinotecan results in increased expression of DUSP2 mRNA15956246
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DUSP2 mRNA23086925|2675264
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of DUSP2 mRNA25890327
D008558MelphalanMelphalan results in increased expression of DUSP2 mRNA22363485
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP2 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DUSP2 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of DUSP2 mRNA17400583
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of DUSP2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DUSP2 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of DUSP2 mRNA19812364
C028007nickel monoxidenickel monoxide results in increased expression of DUSP2 mRNA19167457
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in increased expression of DUSP2 mRNA"16823509
D043371Fatty Acids, Omega-6"Fatty Acids, Omega-6 results in increased expression of DUSP2 mRNA"16823509
C507134ON 01910ON 01910 results in decreased expression of DUSP2 mRNA22351695
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of DUSP2 mRNA25729387
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of DUSP2 mRNA18593933
C006253pirinixic acidpirinixic acid results in increased expression of DUSP2 mRNA23811191
D010938Plant OilsPlant Oils results in increased expression of DUSP2 mRNA23370395
C019536potassium bromatepotassium bromate affects the expression of DUSP2 mRNA27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of DUSP2 mRNA]27082013
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of DUSP2 mRNA22714537
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DUSP2 mRNA19059307
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of DUSP2 mRNA16497877
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DUSP2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of DUSP2 mRNA19073995
D012834SilverSilver results in increased expression of DUSP2 mRNA26014281
D012834SilverSilver results in decreased expression of DUSP2 mRNA27131904
C017947sodium arsenitesodium arsenite inhibits the reaction [BMP6 protein results in increased expression of DUSP2 mRNA]23566955|2871322
C016104sodium bichromatesodium bichromate results in increased expression of DUSP2 mRNA24612858
D053260SootSoot results in increased expression of DUSP2 mRNA26551751
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in decreased expression of DUSP2 mRNA22467014
D014284TriiodothyronineTetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in decreased expression of DUSP2 mRNA]14761676
D014284Triiodothyronine[Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DUSP2 mRNA14761676
D014284TriiodothyronineTriiodothyronine results in decreased expression of DUSP2 mRNA14761676
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of DUSP2 mRNA19059307
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of DUSP2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DUSP2 mRNA18495758
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Triiodothyronine results in decreased expression of DUSP2 mRNA]14761676
D013749Tetrachlorodibenzodioxin[Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DUSP2 mRNA14761676
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of DUSP2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of DUSP2 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of DUSP2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of DUSP2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of DUSP2 mRNA20530235
D014212TretinoinTretinoin results in increased expression of DUSP2 mRNA23724009
D014212TretinoinTretinoin results in increased expression of DUSP2 mRNA20488242
C011559tributyltintributyltin results in increased expression of DUSP2 mRNA27614199
C012589trichostatin A[[decitabine co-treated with trichostatin A] affects the methylation of DUSP2 promoter] which affects the expression of DUSP2 mRNA18836996|1883699
D014635Valproic AcidValproic Acid results in increased methylation of DUSP2 gene28853863|2915479
D014750VincristineVincristine results in increased expression of DUSP2 mRNA23649840
D024483Vitamin K 3Vitamin K 3 affects the expression of DUSP2 mRNA20044591
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of DUSP2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004725protein tyrosine phosphatase activity-IEA-  
GO:0005515protein binding-IPI21784977  
GO:0008138protein tyrosine/serine/threonine phosphatase activity-IBA21873635  
GO:0008330protein tyrosine/threonine phosphatase activity-TAS8107850  
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity-IBA21873635  
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity-IEA-  
GO:0051019mitogen-activated protein kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000188inactivation of MAPK activity-IBA21873635  
GO:0000188inactivation of MAPK activity-TAS8107850  
GO:0001706endoderm formation-IBA21873635  
GO:0006470protein dephosphorylation-TAS8107850  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-112409RAF-independent MAPK1/3 activationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5675221Negative regulation of MAPK pathwayTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23027623MAP kinase genes and colon and rectal cancer. (2012 Dec)Slattery MLCarcinogenesis