Gene: DUSP4

1846
HVH2|MKP-2|MKP2|TYP
dual specificity phosphatase 4
protein-coding
8p12
Ensembl:ENSG00000120875 MIM:602747 Vega:OTTHUMG00000133395 UniprotKB:Q13115
NC_000008.11
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.520e-1 (AD)  8.518e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24379915chr8:29202958DUSP42.200e-14Smoking27651444
cg07151117chr8:29204954DUSP43.400e-10Smoking27651444
cg18432895chr8:29205555DUSP49.700e-9Smoking27651444
cg07151117chr8:29204954DUSP46.210e-8Tobacco smoking28225026

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DUSP60.825
ETV50.793
SPATA2L0.764
GPR30.758
PER20.755
BDNF0.747
VGF0.746
NPTX20.718
UBASH3B0.694
EGR40.689

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNE4-0.478
NID1-0.465
NFIA-0.459
PELI2-0.457
PPP1R13L-0.455
CLEC2B-0.454
HEYL-0.451
FAM114A1-0.451
ROM1-0.45
TMEM176A-0.443

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of DUSP4 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of DUSP4 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of DUSP4 mRNA"25614096
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of DUSP4 mRNA"20713471
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of DUSP4 mRNA18544908
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DUSP4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DUSP4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DUSP4 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of DUSP4 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DUSP4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DUSP4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DUSP4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of DUSP4 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of DUSP4 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of DUSP4 mRNA18544908
D000111AcetylcysteineAcetylcysteine results in increased expression of DUSP4 mRNA16084531
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DUSP4 mRNA22100608|2715375
D000393Air PollutantsAir Pollutants analog results in increased expression of DUSP4 mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DUSP4 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of DUSP4 mRNA15725085
C015001arsenitearsenite results in increased expression of DUSP4 mRNA18929588
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of DUSP4 mRNA"25757056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of DUSP4 mRNA"25351596
D001280AtrazineAtrazine results in increased expression of DUSP4 mRNA25929836
C028559bathocuproine sulfonatebathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA]]15477007
D001554BenzeneBenzene results in increased expression of DUSP4 mRNA19162166
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of DUSP4 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DUSP4 mRNA19770486|2071347
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DUSP4 mRNA"19150397
D004958EstradiolEstradiol affects the expression of DUSP4 mRNA23557687
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DUSP4 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of DUSP4 mRNA16202921
D004958EstradiolEstradiol results in increased expression of DUSP4 mRNA19153601|1948475
D004958EstradiolEstradiol results in increased expression of DUSP4 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of DUSP4 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of DUSP4 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of DUSP4 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of DUSP4 mRNA20977926
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of DUSP4 mRNA20147733
C018475butyraldehydebutyraldehyde results in increased expression of DUSP4 mRNA26079696
D002104CadmiumCadmium results in increased expression of DUSP4 mRNA22562489
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DUSP4 gene20938992
C015763cumenecumene results in decreased expression of DUSP4 mRNA18648096
C029892cupric chloridecupric chloride results in increased expression of DUSP4 mRNA24650576
D003471CuprizoneCuprizone results in decreased expression of DUSP4 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of DUSP4 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of DUSP4 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of DUSP4 mRNA19770486
C089595cylindrospermopsincylindrospermopsin results in increased expression of DUSP4 mRNA24921660
D003561CytarabineCytarabine results in decreased expression of DUSP4 mRNA19194470
C004742daidzeindaidzein results in decreased expression of DUSP4 mRNA16865672
D003630DaunorubicinDaunorubicin results in increased expression of DUSP4 mRNA26537877|2894005
D003703DemecolcineDemecolcine results in increased expression of DUSP4 mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of DUSP4 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DUSP4 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DUSP4 mRNA21266533
D019422Dietary SucroseDietary Sucrose results in increased expression of DUSP4 mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of DUSP4 mRNA18691550
D004052DiethylnitrosamineIKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of DUSP4 mRNA]18691550
D004052DiethylnitrosamineMAPK14 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of DUSP4 mRNA]18691550
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of DUSP4 mRNA18242016
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of DUSP4 mRNA28939011
D004147DioxinsDioxins affects the expression of DUSP4 mRNA20463971
D004317DoxorubicinDoxorubicin results in increased expression of DUSP4 mRNA26537877|2894005
C118739entinostatentinostat results in decreased expression of DUSP4 mRNA27188386
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of DUSP4 mRNA16084531
D060754EquolEquol results in decreased expression of DUSP4 mRNA16865672
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of DUSP4 mRNA23649840
D005047EtoposideDUSP4 protein affects the susceptibility to Etoposide16217747
C000499ferric oxideferric oxide analog results in increased expression of DUSP4 mRNA25086211
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of DUSP4 mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DUSP4 gene20938992
D004397FonofosFonofos results in increased methylation of DUSP4 promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of DUSP4 mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of DUSP4 mRNA23649840
C039281furanfuran results in decreased expression of DUSP4 mRNA25539665
D019833GenisteinGenistein results in decreased expression of DUSP4 mRNA16865672
C071834glycidamideglycidamide results in increased expression of DUSP4 mRNA23287710
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in increased expression of DUSP4 mRNA16206274
C475919hydroxytamoxifenGPER1 protein affects the reaction [hydroxytamoxifen results in increased expression of DUSP4 mRNA]19153601
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of DUSP4 mRNA19153601
C016517indole-3-carbinolindole-3-carbinol affects the expression of DUSP4 mRNA21396975
D015759Ionomycinbathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA]]15477007
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA25613284
D007529IsoflavonesIsoflavones results in decreased expression of DUSP4 mRNA17374662
D007545IsoproterenolIsoproterenol results in increased expression of DUSP4 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of DUSP4 mRNA26397223
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DUSP4 mRNA23086925
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of DUSP4 mRNA25119042
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of DUSP4 mRNA16880258
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of DUSP4 protein16880258
D008687MetforminMetformin results in increased expression of DUSP4 mRNA19664596
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of DUSP4 gene20938992
D008727MethotrexateDUSP4 protein affects the susceptibility to Methotrexate16217747
D008748MethylcholanthreneMethylcholanthrene results in increased expression of DUSP4 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DUSP4 mRNA23458150
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DUSP4 mRNA28001369
D016685MitomycinDUSP4 protein affects the susceptibility to Mitomycin16217747
D008942MitoxantroneDUSP4 protein affects the susceptibility to Mitoxantrone16217747
D008942MitoxantroneMitoxantrone results in increased expression of DUSP4 mRNA26537877|2894005
C029938nickel sulfatenickel sulfate results in increased expression of DUSP4 mRNA16780908
C507134ON 01910ON 01910 results in increased expression of DUSP4 mRNA22351695
D010081OxazoloneOxazolone results in increased expression of DUSP4 mRNA18242016
D010100OxygenOxygen deficiency results in decreased expression of DUSP4 mRNA26516004
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DUSP4 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of DUSP4 mRNA26272509
D010278ParathionParathion results in increased methylation of DUSP4 promoter22847954
D052638Particulate MatterParticulate Matter results in increased expression of DUSP4 mRNA17450221|2476925
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of DUSP4 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of DUSP4 mRNA25119042
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of DUSP4 mRNA19095052
D010416PentachlorophenolPentachlorophenol results in increased expression of DUSP4 mRNA24642059
C006253pirinixic acidpirinixic acid results in increased expression of DUSP4 mRNA23811191
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DUSP4 mRNA22714537
C020972pyrrolidine dithiocarbamic acidbathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA]]15477007
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA]15477007
D011794QuercetinQuercetin results in increased expression of DUSP4 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of DUSP4 mRNA16497877
C052785rebamipiderebamipide results in increased expression of DUSP4 mRNA15104358
D015474IsotretinoinIsotretinoin results in decreased expression of DUSP4 mRNA20436886
D012402RotenoneRotenone results in increased expression of DUSP4 mRNA19664596
D012834SilverSilver results in increased expression of DUSP4 mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased methylation of DUSP4 gene25199682
D012999SomanSoman results in increased expression of DUSP4 mRNA19281266
C012568terbufosterbufos results in increased methylation of DUSP4 promoter22847954
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of DUSP4 mRNA25172293
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of DUSP4 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DUSP4 mRNA17101203|1961957
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DUSP4 mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DUSP4 mRNA16267337
D013755Tetradecanoylphorbol Acetatebathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA]]15477007
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA25613284
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of DUSP4 mRNA"18242016
D014212TretinoinTretinoin results in increased expression of DUSP4 mRNA18230668
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DUSP4 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of DUSP4 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of DUSP4 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of DUSP4 mRNA19042947
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DUSP4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of DUSP4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of DUSP4 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of DUSP4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of DUSP4 mRNA17963808
D014638VanadatesVanadates results in increased expression of DUSP4 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DUSP4 gene25560391
D014750VincristineVincristine results in increased expression of DUSP4 mRNA23649840
C111237vorinostatvorinostat results in decreased expression of DUSP4 mRNA27188386
C088658zoledronic acidzoledronic acid results in decreased expression of DUSP4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004725protein tyrosine phosphatase activity-IDA7535768  
GO:0004725protein tyrosine phosphatase activity-TAS-  
GO:0005515protein binding-IPI16038800  25241761  
GO:0008138protein tyrosine/serine/threonine phosphatase activity-IBA21873635  
GO:0008330protein tyrosine/threonine phosphatase activity-IDA7535768  
GO:0016791phosphatase activity-IDA24531476  
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity-IBA21873635  
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity-IEA-  
GO:1990439MAP kinase serine/threonine phosphatase activity-IDA7535768  
GO ID GO Term Qualifier Evidence PubMed
GO:0000188inactivation of MAPK activity-IBA21873635  
GO:0000188inactivation of MAPK activity-IDA7535768  
GO:0016311dephosphorylation-IDA24531476  
GO:0035335peptidyl-tyrosine dephosphorylation-IDA7535768  
GO:0035970peptidyl-threonine dephosphorylation-IDA7535768  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IMP7535768  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA7535768  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-112409RAF-independent MAPK1/3 activationTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-166520Signaling by NTRKsTAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-198725Nuclear Events (kinase and transcription factor activation)TAS
R-HSA-198753ERK/MAPK targetsTAS
R-HSA-202670ERKs are inactivatedTAS
R-HSA-448424Interleukin-17 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinasesTAS
R-HSA-450294MAP kinase activationTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5675221Negative regulation of MAPK pathwayTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25629224MAPK genes interact with diet and lifestyle factors to alter risk of breast cancer: the Breast Cancer Health Disparities Study. (2015)Slattery MLNutr Cancer
23027623MAP kinase genes and colon and rectal cancer. (2012 Dec)Slattery MLCarcinogenesis
28500316Establishment of a Strong Link Between Smoking and Cancer Pathogenesis through DNA Methylation Analysis. (2017 May 12)Ma YSci Rep