Gene info: ID 1848

Gene: DUSP6

GENE ID: 1848

Synonyms: HH19|MKP3|PYST1

Description: dual specificity phosphatase 6

Gene type: protein-coding

Location: 12q21.33

dbXrefs: Ensembl:ENSG00000139318 MIM:602748 Vega:OTTHUMG00000169912 UniprotKB:Q16828

RefSeq: NG_033915.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.346e-1 (AD) 7.941e-2 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg01242903	chr12:89744877	DUSP6	Gene body	6.974e-4	Alcohol use disorders	26763658
cg20722088	chr12:89742886	DUSP6		3.300e-12	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ETV5	0.829
DUSP4	0.825
BDNF	0.81
CORO1A	0.757
FMNL1	0.753
SPATA2L	0.752
ST8SIA5	0.75
ARL4D	0.736
SYT12	0.735
VGF	0.734

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FXYD3	-0.428
SYTL4	-0.42
OR4F5	-0.409
OTOS	-0.401
C10orf105	-0.393
ROM1	-0.381
MYOM1	-0.373
OR4F29	-0.37
HVCN1	-0.369
UHRF1	-0.362

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of DUSP6 mRNA"	19850644\|2890350
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of DUSP6 mRNA]"	19850644
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of DUSP6 mRNA	28329830
C032668	1-nitropyrene	1-nitropyrene results in increased expression of DUSP6 mRNA	19041380
C029141	2,2,5,7,8-pentamethyl-1-hydroxychroman	"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of DUSP6 mRNA"	21920950
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DUSP6 mRNA"	19114083
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of DUSP6 mRNA"	16984957
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of DUSP6 mRNA"	20713471
C019499	2-nitrofluorene	2-nitrofluorene results in decreased expression of DUSP6 mRNA	15890375
C023035	3,4,5,3',4'-pentachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of DUSP6 mRNA"	16984957
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of DUSP6 mRNA"	23196670
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of DUSP6 mRNA	21983209
C026137	3-hydroxyacetanilide	3-hydroxyacetanilide results in decreased expression of DUSP6 mRNA	18544908
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of DUSP6 mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP6 mRNA"	27188386
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of DUSP6 mRNA	15890375
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP6 mRNA"	27188386
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of DUSP6 mRNA"	26238291
D000082	Acetaminophen	Acetaminophen results in increased expression of DUSP6 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of DUSP6 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of DUSP6 mRNA	18544908
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of DUSP6 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DUSP6 mRNA]	17585979
D020106	Acrylamide	Acrylamide results in decreased expression of DUSP6 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of DUSP6 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of DUSP6 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of DUSP6 mRNA	21641981\|2210060
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of DUSP6 mRNA	15890375
D000447	Aldehydes	Aldehydes results in increased expression of DUSP6 mRNA	25014914
D019386	Alendronate	Alendronate affects the expression of DUSP6 mRNA	16079270
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of DUSP6 mRNA	28522335
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of DUSP6 mRNA	16483693
D000841	Anisomycin	Anisomycin results in decreased expression of DUSP6 mRNA	24247028
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of DUSP6 mRNA	24449571
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of DUSP6 mRNA"	17331233\|2575705
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of DUSP6 mRNA"	18314537\|1868714
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of DUSP6 protein"	18314537
D017638	Asbestos, Crocidolite	"MAPK14 protein promotes the reaction [Asbestos, Crocidolite results in increased expression of DUSP6 protein]"	18314537
D017638	Asbestos, Crocidolite	"SB 203580 inhibits the reaction [Asbestos, Crocidolite results in increased expression of DUSP6 mRNA]"	18314537
D001205	Ascorbic Acid	Ascorbic Acid results in decreased expression of DUSP6 mRNA	15372504
D001241	Aspirin	Aspirin results in increased expression of DUSP6 mRNA	12800193
D001280	Atrazine	Atrazine results in decreased expression of DUSP6 mRNA	22378314
D001374	Azacitidine	Azacitidine results in increased expression of DUSP6 mRNA	21245298
C406592	azaspiracid	azaspiracid results in increased expression of DUSP6 mRNA	28939011
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of DUSP6 mRNA	19737606
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DUSP6 mRNA	20106945\|2231617
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DUSP6 mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DUSP6 mRNA"	20018196
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of DUSP6 mRNA"	26238291
D004958	Estradiol	Estradiol affects the expression of DUSP6 mRNA	23557687
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of DUSP6 mRNA	20660070
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DUSP6 mRNA	19619570
D004958	Estradiol	Estradiol results in increased expression of DUSP6 mRNA	19619570
C044887	beta-methylcholine	beta-methylcholine affects the expression of DUSP6 mRNA	21179406
C006780	bisphenol A	bisphenol A results in increased expression of DUSP6 mRNA	27685785
C006780	bisphenol A	bisphenol A results in decreased expression of DUSP6 mRNA	25594700
C006780	bisphenol A	bisphenol A results in increased expression of DUSP6 mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of DUSP6 mRNA	24247028
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of DUSP6 mRNA	22079614
D001973	Bromodeoxyuridine	[Bromodeoxyuridine co-treated with furan] results in increased expression of DUSP6 mRNA	24910943
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of DUSP6 mRNA	17003459
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of DUSP6 mRNA	15336504
C018475	butyraldehyde	butyraldehyde results in increased expression of DUSP6 mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of DUSP6 mRNA	22562489
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of DUSP6 mRNA	25993096
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of DUSP6 mRNA	20360939
D000001	Calcimycin	Calcimycin results in increased expression of DUSP6 mRNA	25451590
D000001	Calcimycin	shikonin inhibits the reaction [Calcimycin results in increased expression of DUSP6 mRNA]	25451590
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of DUSP6 mRNA	27339419
D002273	Carcinogens	Carcinogens results in increased expression of DUSP6 mRNA	16316942
C054133	casticin	casticin results in decreased expression of DUSP6 mRNA	28444820
D002509	Cephaloridine	Cephaloridine affects the expression of DUSP6 mRNA	18172885
D002706	Chlordan	Chlordan results in decreased expression of DUSP6 mRNA	23153324
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of DUSP6 mRNA	27793765
D002922	Ciguatoxins	Ciguatoxins affects the expression of DUSP6 mRNA	18353800
C012843	cinnamic aldehyde	cinnamic aldehyde results in decreased expression of DUSP6 mRNA	17178418
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of DUSP6 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DUSP6 mRNA]	17585979
D003024	Clozapine	Clozapine results in decreased expression of DUSP6 mRNA	15860345
C018021	cobaltous chloride	cobaltous chloride results in increased expression of DUSP6 mRNA	19376846
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of DUSP6 mRNA	21139344
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of DUSP6 mRNA	15467011
D003300	Copper	Copper results in increased expression of DUSP6 mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in increased expression of DUSP6 mRNA	19549813
C423222	cotylenin A	cotylenin A results in increased expression of DUSP6 mRNA	16129123
C402665	CP 31398	CP 31398 results in increased expression of DUSP6 mRNA	15155752
D003471	Cuprizone	Cuprizone results in decreased expression of DUSP6 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of DUSP6 mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of DUSP6 mRNA	20106945
C515055	darinaparsin	darinaparsin results in decreased expression of DUSP6 protein	25316819
C014347	decitabine	decitabine affects the expression of DUSP6 mRNA	17145863
C014347	decitabine	decitabine results in increased expression of DUSP6 mRNA	19151715
D013759	Dronabinol	Dronabinol results in increased expression of DUSP6 mRNA	15454482
D013759	Dronabinol	Dronabinol results in decreased expression of DUSP6 mRNA	21955143
D003703	Demecolcine	Demecolcine results in increased expression of DUSP6 mRNA	23649840
C007262	deoxynivalenol	deoxynivalenol results in decreased expression of DUSP6 mRNA	24247028
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of DUSP6 mRNA]	27941970
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of DUSP6 mRNA	28628672
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of DUSP6 mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of DUSP6 mRNA	21266533\|2174549
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of DUSP6 mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of DUSP6 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of DUSP6 protein	21996734
D002945	Cisplatin	DUSP6 inhibits the reaction [Cisplatin results in increased expression of ERCC1 mRNA]	21996734
D002945	Cisplatin	DUSP6 inhibits the reaction [Cisplatin results in increased expression of ERCC4 mRNA]	21996734
D002945	Cisplatin	DUSP6 protein results in decreased susceptibility to Cisplatin	21499306
D002945	Cisplatin	DUSP6 results in increased susceptibility to Cisplatin	21996734
D002945	Cisplatin	Cisplatin results in decreased expression of DUSP6 mRNA	18172885
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of DUSP6 mRNA	26924002
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in increased expression of DUSP6 mRNA	17490981
D004041	Dietary Fats	Dietary Fats affects the expression of DUSP6 mRNA	19680557
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate affects the expression of DUSP6 mRNA	19850644
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of DUSP6 mRNA	24535843
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of DUSP6 mRNA	20360939
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of DUSP6 mRNA	15171707
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of DUSP6 mRNA	15890375
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in decreased expression of DUSP6 mRNA	15890375\|2538013
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of DUSP6 mRNA	26924002
D004147	Dioxins	Dioxins affects the expression of DUSP6 mRNA	20463971
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA]	11701771
D004317	Doxorubicin	Doxorubicin results in decreased expression of DUSP6 mRNA	21040762
D004317	Doxorubicin	[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of DUSP6 mRNA	21040762
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DUSP6 mRNA	22079256
D000431	Ethanol	Ethanol results in decreased expression of DUSP6 mRNA	21955143
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of DUSP6 mRNA	16079270
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of DUSP6 mRNA	28329830
D005472	Fluorouracil	Fluorouracil results in increased expression of DUSP6 mRNA	16510598
D005485	Flutamide	Flutamide results in increased expression of DUSP6 mRNA	24136188
D004397	Fonofos	Fonofos results in increased methylation of DUSP6 promoter	22847954
D005557	Formaldehyde	Formaldehyde results in increased expression of DUSP6 mRNA	23416264\|2766457
C039281	furan	[Bromodeoxyuridine co-treated with furan] results in increased expression of DUSP6 mRNA	24910943
C039281	furan	furan results in increased expression of DUSP6 mRNA	24183702\|2491094
D019833	Genistein	Genistein results in decreased expression of DUSP6 mRNA	22228119
D019833	Genistein	Genistein results in increased expression of DUSP6 mRNA	23019147
D005947	Glucose	Glucose results in increased expression of DUSP6 mRNA	17178593
D006220	Haloperidol	Haloperidol results in decreased expression of DUSP6 mRNA	15860345
C014026	hexamethylene bisacetamide	hexamethylene bisacetamide results in decreased expression of DUSP6 protein mutant form	17569113
D017313	Fenretinide	Fenretinide results in increased expression of DUSP6 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of DUSP6 mRNA	20044591
D007213	Indomethacin	Indomethacin results in decreased expression of DUSP6 mRNA	16984733
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of DUSP6 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP6 mRNA	25613284
C051890	irinotecan	irinotecan affects the expression of DUSP6 mRNA	20097248
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of DUSP6 mRNA	28628672
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of DUSP6 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of DUSP6 mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of DUSP6 mRNA	17085751
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of DUSP6 mRNA	23086925
C561695	(+)-JQ1 compound	[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of DUSP6 mRNA	25119042
C410337	K 7174	K 7174 results in increased expression of DUSP6 mRNA	24086573
C031895	lead chromate	lead chromate results in increased expression of DUSP6 mRNA	23584427
C045463	leflunomide	leflunomide results in increased expression of DUSP6 mRNA	28988120
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of DUSP6 mRNA	25890327
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of DUSP6 mRNA	25613284
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of DUSP6 mRNA	21641980
D008694	Methamphetamine	Dizocilpine Maleate inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA]	11701771
D008694	Methamphetamine	Methamphetamine results in increased expression of DUSP6 mRNA	11701771
D008694	Methamphetamine	[SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA]	11701771
D008701	Methapyrilene	Methapyrilene results in decreased expression of DUSP6 mRNA	15890375
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of DUSP6 mRNA	20713471
C002950	methylformamide	methylformamide analog results in increased expression of DUSP6 mRNA	17040096
C002950	methylformamide	methylformamide results in increased expression of DUSP6 mRNA	17040096
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of DUSP6 mRNA	23458150
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of DUSP6 mRNA	28001369
C030957	methylmercury II	methylmercury II results in increased expression of DUSP6 mRNA	17905399
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DUSP6 mRNA"	19285098
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of DUSP6 mRNA	24810058
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of DUSP6 mRNA	16809437
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of DUSP6 mRNA	26924002
D009020	Morphine	Morphine results in increased expression of DUSP6 mRNA	21955143
C500085	muraglitazar	muraglitazar results in decreased expression of DUSP6 mRNA	21515302
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of DUSP6 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of DUSP6 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of DUSP6 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of DUSP6 mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of DUSP6 mRNA	25380136
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of DUSP6 mRNA	19812364
C022838	nickel chloride	nickel chloride results in increased expression of DUSP6 mRNA	17312168
D009538	Nicotine	Nicotine results in increased expression of DUSP6 mRNA	17456735\|2195514
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of DUSP6 mRNA	17616710
C464660	obeticholic acid	obeticholic acid results in increased expression of DUSP6 mRNA	27939613
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of DUSP6 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of DUSP6 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of DUSP6 mRNA	26516004
D010278	Parathion	Parathion results in increased methylation of DUSP6 promoter	22847954
D052638	Particulate Matter	Particulate Matter results in increased expression of DUSP6 mRNA	24769257
C506614	PD 0325901	[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of DUSP6 mRNA	25119042
C506614	PD 0325901	PD 0325901 results in decreased expression of DUSP6 mRNA	25119042
D010396	Penicillamine	Penicillamine results in increased expression of DUSP6 mRNA	19575532
C046012	pentanal	pentanal results in increased expression of DUSP6 mRNA	26079696
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of DUSP6 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of DUSP6 mRNA	19162173
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of DUSP6 mRNA	17097637
D026023	Permethrin	Permethrin results in increased expression of DUSP6 mRNA	19017407
D010634	Phenobarbital	Phenobarbital affects the expression of DUSP6 mRNA	19159669
D010634	Phenobarbital	NR1I3 protein promotes the reaction [Phenobarbital results in increased expression of DUSP6 mRNA]	19850644
D010634	Phenobarbital	Phenobarbital affects the expression of DUSP6 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of DUSP6 mRNA	19850644
D010634	Phenobarbital	Phenobarbital affects the expression of DUSP6 mRNA	19162173
D010656	Phenylephrine	DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of EIF4EBP1 protein]	15757502
D010656	Phenylephrine	DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]	15757502
D010656	Phenylephrine	DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]	15757502
D010656	Phenylephrine	DUSP6 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of RPS6KB1 protein]	15757502
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP6 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of DUSP6 mRNA	26272509
D010795	Phthalic Acids	Phthalic Acids results in increased expression of DUSP6 mRNA	15728792
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in decreased expression of DUSP6 mRNA	15890375\|2248451
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DUSP6 mRNA	19710929
C006253	pirinixic acid	pirinixic acid affects the expression of DUSP6 mRNA	19850644
C006253	pirinixic acid	pirinixic acid results in decreased expression of DUSP6 mRNA	17426115
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of DUSP6 mRNA]	19850644
C006253	pirinixic acid	pirinixic acid results in decreased expression of DUSP6 mRNA	15890375\|1916217
D010938	Plant Oils	Plant Oils results in increased expression of DUSP6 mRNA	23370395
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of DUSP6 mRNA	21334430
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DUSP6 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of DUSP6 mRNA	22079256
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile affects the expression of DUSP6 mRNA	19162173
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of DUSP6 mRNA	20660070
D011374	Progesterone	Progesterone results in decreased expression of DUSP6 mRNA	20864642
D011374	Progesterone	Progesterone results in increased expression of DUSP6 mRNA	18037150
C005556	propionaldehyde	propionaldehyde results in increased expression of DUSP6 mRNA	26079696
D011794	Quercetin	Quercetin results in decreased expression of DUSP6 mRNA	21632981
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of DUSP6 mRNA	16079270
C093642	SB 203580	"SB 203580 inhibits the reaction [Asbestos, Crocidolite results in increased expression of DUSP6 mRNA]"	18314537
C534628	SCH 23390	[SCH 23390 binds to and results in decreased activity of DRD1 protein] inhibits the reaction [Methamphetamine results in increased expression of DUSP6 mRNA]	11701771
D012601	Scopolamine Hydrobromide	Scopolamine Hydrobromide results in decreased expression of DUSP6 mRNA	17540011
C410733	scriptaid	scriptaid affects the expression of DUSP6 mRNA	18813790
C009250	sevoflurane	sevoflurane affects the expression of DUSP6 mRNA	15967596
C016101	shikonin	shikonin inhibits the reaction [Calcimycin results in increased expression of DUSP6 mRNA]	25451590
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of DUSP6 mRNA	25351596
D012906	Smoke	Smoke results in increased expression of DUSP6 mRNA	21095227
C009277	sodium arsenate	sodium arsenate results in decreased expression of DUSP6 mRNA	23922661
C017947	sodium arsenite	sodium arsenite results in decreased expression of DUSP6 mRNA	12377979
C016104	sodium bichromate	sodium bichromate results in increased expression of DUSP6 mRNA	22561333
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in decreased expression of DUSP6 mRNA	16214533
C105686	SU 5402	SU 5402 results in decreased expression of DUSP6 mRNA	15255957
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of DUSP6 mRNA	21641980
D000952	Antigens, Polyomavirus Transforming	"Antigens, Polyomavirus Transforming results in increased expression of DUSP6 mRNA"	26680231
C013698	tallow	tallow affects the expression of DUSP6 mRNA	19680557
C012568	terbufos	terbufos results in increased methylation of DUSP6 promoter	22847954
C501413	tesaglitazar	tesaglitazar results in decreased expression of DUSP6 mRNA	21515302
D013739	Testosterone	Testosterone results in decreased expression of DUSP6 mRNA	20600201\|2166921
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DUSP6 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DUSP6 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DUSP6 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of DUSP6 mRNA	19619570\|1968428
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DUSP6 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of DUSP6 mRNA	15328365\|1968428
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DUSP6 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP6 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in decreased expression of DUSP6 mRNA	22378314
D019284	Thapsigargin	Thapsigargin results in increased expression of DUSP6 mRNA	24247028
C009495	titanium dioxide	titanium dioxide affects the expression of DUSP6 mRNA	17656681
C009495	titanium dioxide	titanium dioxide results in increased expression of DUSP6 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of DUSP6 mRNA	28065790
D014050	Toluene	Toluene results in decreased expression of DUSP6 mRNA	22166486
D014050	Toluene	Toluene results in increased expression of DUSP6 mRNA	22166486
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of DUSP6 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of DUSP6 mRNA	25729387
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in increased expression of DUSP6 mRNA"	17951470
D014212	Tretinoin	Tretinoin results in increased expression of DUSP6 mRNA	16012519\|1612912
C012589	trichostatin A	trichostatin A results in decreased expression of DUSP6 mRNA	26272509
C057693	troglitazone	troglitazone results in decreased expression of DUSP6 mRNA	21515302
D014415	Tunicamycin	Tunicamycin results in decreased expression of DUSP6 mRNA	22378314
D014520	Urethane	Urethane results in increased expression of DUSP6 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of DUSP6 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of DUSP6 mRNA	23179753\|2493525
D014635	Valproic Acid	Valproic Acid results in increased expression of DUSP6 mRNA	28001369\|2915479
C066075	vanadium pentoxide	vanadium pentoxide affects the expression of DUSP6 mRNA	17459161
C100058	vanillin	vanillin results in decreased expression of DUSP6 mRNA	17178418
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of DUSP6 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of DUSP6 mRNA	19015723
C025643	vinclozolin	vinclozolin results in decreased expression of DUSP6 mRNA	20566332
C025643	vinclozolin	vinclozolin results in increased expression of DUSP6 mRNA	23869203
D002762	Cholecalciferol	Cholecalciferol results in decreased expression of DUSP6 mRNA	16508948
D002762	Cholecalciferol	Cholecalciferol results in increased expression of DUSP6 mRNA	17170073
D024483	Vitamin K 3	Vitamin K 3 affects the expression of DUSP6 mRNA	20044591
C088658	zoledronic acid	zoledronic acid results in decreased expression of DUSP6 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004725	protein tyrosine phosphatase activity	-	TAS	-
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	-	IBA	21873635
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	-	TAS	-
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	-	IBA	21873635
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	-	IDA	8670865

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0000187	activation of MAPK activity	-	TAS	-
GO:0000188	inactivation of MAPK activity	-	IDA	8670865
GO:0006470	protein dephosphorylation	-	IBA	21873635
GO:0009953	dorsal/ventral pattern formation	-	IBA	21873635
GO:0014070	response to organic cyclic compound	-	IEA	-
GO:0030154	cell differentiation	-	IEA	-
GO:0035335	peptidyl-tyrosine dephosphorylation	-	IDA	8670865
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	-	IBA	21873635
GO:0042493	response to drug	-	IEA	-
GO:0042663	regulation of endodermal cell fate specification	-	IBA	21873635
GO:0043065	positive regulation of apoptotic process	-	IBA	21873635
GO:0043065	positive regulation of apoptotic process	-	IDA	10846176
GO:0051409	response to nitrosative stress	-	IEP	10846176
GO:0060420	regulation of heart growth	-	IBA	21873635
GO:0070373	negative regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:0070373	negative regulation of ERK1 and ERK2 cascade	-	IMP	18771677
GO:0070848	response to growth factor	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	TAS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	IDA	8670865 9788880
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-112409	RAF-independent MAPK1/3 activation	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	TAS
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	TAS
R-HSA-166166	MyD88-independent TLR4 cascade	TAS
R-HSA-166520	Signaling by NTRKs	TAS
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	TAS
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	TAS
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	TAS
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	TAS
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	TAS
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	TAS
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-168898	Toll-Like Receptors Cascades	TAS
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	TAS
R-HSA-187037	Signaling by NTRK1 (TRKA)	TAS
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	TAS
R-HSA-198753	ERK/MAPK targets	TAS
R-HSA-202670	ERKs are inactivated	TAS
R-HSA-448424	Interleukin-17 signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	TAS
R-HSA-450294	MAP kinase activation	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5675221	Negative regulation of MAPK pathway	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS
R-HSA-937061	TRIF(TICAM1)-mediated TLR4 signaling	TAS
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	TAS
R-HSA-975155	MyD88 dependent cascade initiated on endosome	TAS
R-HSA-975871	MyD88 cascade initiated on plasma membrane	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
18824881	Synchronous and metachronous extrapancreatic malignant neoplasms in patients with intraductal papillary-mucinous neoplasm of the pancreas. (2008)	Ishida M	Pancreatology
28231233	Association of Topoisomerase II (TOP2A) and Dual-Specificity Phosphatase 6 (DUSP6) Single Nucleotide Polymorphisms with Radiation Treatment Response and Prognosis of Lung Cancer in Han Chinese. (2017 Feb 23)	Wang TL	Med Sci Monit
27113098	CPEB4 and IRF4 expression in peripheral mononuclear cells are potential prognostic factors for advanced lung cancer. (2017 Feb)	Wu YY	J Formos Med Assoc
21680106	Differential expression of DUSP6 with expression of ERK and Ki-67 in non-small cell lung carcinoma. (2011 Jul 15)	Lee H	Pathol Res Pract
23027623	MAP kinase genes and colon and rectal cancer. (2012 Dec)	Slattery ML	Carcinogenesis