Gene: DUSP7

1849
MKPX|PYST2
dual specificity phosphatase 7
protein-coding
3p21.2
Ensembl:ENSG00000164086 MIM:602749 Vega:OTTHUMG00000157819 UniprotKB:Q16829
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.255e-1 (AD)  2.293e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGEF20.909
DPYSL40.898
RNF2200.898
MARK20.895
PTPRS0.893
MGAT30.891
MPP20.887
RUSC20.886
ZDHHC80.886
KDM2B0.884

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.559
OR4F29-0.512
IL18RAP-0.429
WEE1-0.416
PHEX-0.411
TFPI2-0.41
RGS22-0.405
LRAT-0.404
ALAS2-0.395
FCGR3B-0.393

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DUSP7 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of DUSP7 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of DUSP7 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of DUSP7 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DUSP7 mRNA22100608
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of DUSP7 mRNA"23195993
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of DUSP7 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of DUSP7 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of DUSP7 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in decreased expression of DUSP7 mRNA12558987
D000667AmpicillinAmpicillin results in increased expression of DUSP7 mRNA21632981
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of DUSP7 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of DUSP7 mRNA20458559
C015001arsenitearsenite results in increased expression of DUSP7 mRNA18191166
C006780bisphenol Abisphenol A results in increased methylation of DUSP7 promoter27312807
D002509CephaloridineCephaloridine results in decreased expression of DUSP7 mRNA18500788
D002922CiguatoxinsCiguatoxins affects the expression of DUSP7 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of DUSP7 mRNA19320972
D019327Copper SulfateCopper Sulfate results in decreased expression of DUSP7 mRNA19549813
D003976DiazinonDiazinon results in increased methylation of DUSP7 gene22964155
D002945CisplatinCisplatin results in decreased expression of DUSP7 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of DUSP7 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of DUSP7 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of DUSP7 mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of DUSP7 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of DUSP7 mRNA21592394
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DUSP7 mRNA22079256
C069837fullerene C60fullerene C60 results in decreased expression of DUSP7 mRNA19167457
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of DUSP7 mRNA]17109745
D005944GlucosamineGlucosamine results in decreased expression of DUSP7 mRNA17109745
D005944GlucosamineIL1B affects the reaction [Glucosamine results in decreased expression of DUSP7 mRNA]17109745
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DUSP7 mRNA25613284
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of DUSP7 mRNA16507785
C002950methylformamidemethylformamide analog results in decreased expression of DUSP7 mRNA17040096
C002950methylformamidemethylformamide results in decreased expression of DUSP7 mRNA17040096
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DUSP7 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of DUSP7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DUSP7 mRNA"25554681
D009532NickelNickel results in decreased expression of DUSP7 mRNA23195993
C028007nickel monoxidenickel monoxide results in increased expression of DUSP7 mRNA19167457
D000073878Palm OilPalm Oil results in decreased expression of DUSP7 mRNA18042831
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DUSP7 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of DUSP7 mRNA22079256
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DUSP7 mRNA25895662
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of DUSP7 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of DUSP7 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DUSP7 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of DUSP7 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DUSP7 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DUSP7 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of DUSP7 mRNA27188386
C057693troglitazonetroglitazone results in decreased expression of DUSP7 mRNA28973697
D014520UrethaneUrethane results in increased expression of DUSP7 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of DUSP7 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of DUSP7 gene29154799
D014635Valproic AcidValproic Acid affects the expression of DUSP7 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of DUSP7 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of DUSP7 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of DUSP7 gene25560391
D015032ZincZinc deficiency results in increased expression of DUSP7 mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004725protein tyrosine phosphatase activity-TAS-  
GO:0005515protein binding-IPI12907755  24656772  
GO:0008138protein tyrosine/serine/threonine phosphatase activity-IBA21873635  
GO:0008138protein tyrosine/serine/threonine phosphatase activity-TAS-  
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity-IBA21873635  
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity-IDA9788880  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0000187activation of MAPK activity-TAS-  
GO:0000188inactivation of MAPK activity-IEA-  
GO:0006470protein dephosphorylation-IBA21873635  
GO:0035335peptidyl-tyrosine dephosphorylation-IDA9788880  
GO:0043407negative regulation of MAP kinase activity-IDA9788880  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA9788880  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-112409RAF-independent MAPK1/3 activationTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-166520Signaling by NTRKsTAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-198725Nuclear Events (kinase and transcription factor activation)TAS
R-HSA-198753ERK/MAPK targetsTAS
R-HSA-202670ERKs are inactivatedTAS
R-HSA-448424Interleukin-17 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinasesTAS
R-HSA-450294MAP kinase activationTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5675221Negative regulation of MAPK pathwayTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23027623MAP kinase genes and colon and rectal cancer. (2012 Dec)Slattery MLCarcinogenesis