Gene: AGTR1

185
AG2S|AGTR1B|AT1|AT1AR|AT1B|AT1BR|AT1R|AT2R1|HAT1R
angiotensin II receptor type 1
protein-coding
3q24
Ensembl:ENSG00000144891 MIM:106165 Vega:OTTHUMG00000159503 UniprotKB:P30556
NG_008468.1
PubMed
0   ANCO-SNPs
ND
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.751e-1 (AD)  2.210e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04240493chr3:148414664AGTR1Promoter6.679e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRNDE0.856
SIM10.856
IRX50.847
FOXB10.843
SIX60.842
HMX20.84
LHX50.84
OTP0.839
NTS0.835
HMX30.823

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANKRD24-0.52
SOHLH1-0.509
MPPED1-0.501
CA7-0.497
SCRT1-0.495
NEUROD2-0.493
KCNH3-0.489
EXTL1-0.489
EMX1-0.488
CABP1-0.488

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00177ValsartanSmall Molecule137862-53-4Approved|InvestigationalTarget
DB00275OlmesartanSmall Molecule144689-24-7Approved|InvestigationalTarget
DB00678LosartanSmall Molecule114798-26-4ApprovedTarget
DB00796Candesartan cilexetilSmall Molecule145040-37-5ApprovedTarget
DB00876EprosartanSmall Molecule133040-01-4ApprovedTarget
DB00966TelmisartanSmall Molecule144701-48-4Approved|InvestigationalTarget
DB01029IrbesartanSmall Molecule138402-11-6Approved|InvestigationalTarget
DB01342ForasartanSmall Molecule145216-43-9ExperimentalTarget
DB01347SaprisartanSmall Molecule146623-69-0ExperimentalTarget
DB01349TasosartanSmall Molecule145733-36-4ApprovedTarget
DB05739CYT006-AngQbBiotechDrug-InvestigationalTarget
DB08822Azilsartan medoxomilSmall Molecule863031-21-4Approved|InvestigationalTarget
DB09279FimasartanSmall Molecule247257-48-3Approved|InvestigationalTarget
DB11842Angiotensin IISmall Molecule4474-91-3Approved|InvestigationalTarget
DB13919CandesartanSmall Molecule139481-59-7ExperimentalTarget
ID Drug Name Action PubMed
C4001841-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of AGTR1 mRNA16386258
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl results in increased expression of AGTR1 mRNA"21925196
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AGTR1 mRNA"14962509
C5610583-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-2-ethyl-5-isobutyl-7-methyl-3H-imidazo(4,5-b)pyridine"3-(5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-2-ethyl-5-isobutyl-7-methyl-3H-imidazo(4,5-b)pyridine binds to and results in decreased activity of AGTR1 protein"21557540
D000082AcetaminophenAcetaminophen results in decreased expression of AGTR1 mRNA21420995|2223033
D000111AcetylcysteineAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of AGTR1 mRNA]23603059
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AGTR1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AGTR1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AGTR1 gene27153756
D000447AldehydesAldehydes results in decreased expression of AGTR1 mRNA25014914
D000450Aldosterone[Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone9124547
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of AGTR1 mRNA21298039
D000806Angiotensin-Converting Enzyme InhibitorsAngiotensin-Converting Enzyme Inhibitors results in increased expression of AGTR1 mRNA9533614
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of AGTR1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of AGTR1 mRNA26705709
C015001arsenitearsenite results in increased methylation of AGTR1 promoter23974009
D001194AsbestosAsbestos results in decreased expression of AGTR1 mRNA22398240
C044946benazepril[AGT gene polymorphism co-treated with AGTR1 gene polymorphism] affects the susceptibility to benazepril21449848
C044946benazeprilbenazepril inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]15157388
D004958EstradiolEstradiol inhibits the reaction [AGT protein results in increased expression of AGTR1 mRNA]16097371
D004958EstradiolEstradiol inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]16097371
D004958EstradiolEstradiol results in decreased expression of AGTR1 mRNA15159206|2010694
D004958EstradiolEstradiol results in increased expression of AGTR1 mRNA17021606
C006780bisphenol Abisphenol A results in increased expression of AGTR1 mRNA27685785
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of AGTR1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of AGTR1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of AGTR1 mRNA22079614
C018475butyraldehydebutyraldehyde results in decreased expression of AGTR1 mRNA26079696
C081643candesartancandesartan binds to and results in decreased activity of AGTR1 protein21474964
C081643candesartancandesartan binds to and results in decreased activity of AGTR1 protein10525314|1776395
C077793candesartan cilexetilcandesartan cilexetil binds to and results in decreased activity of AGTR1 protein11086231
C077793candesartan cilexetilcandesartan cilexetil results in decreased activity of AGTR1 protein11518847|9853001
D002784CholesterolCholesterol inhibits the reaction [irbesartan results in increased expression of AGTR1 mRNA]19028402
D002784CholesterolCholesterol results in increased expression of AGTR1 mRNA19028402
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of AGTR1 mRNA27344345
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of AGTR1 mRNA27344345
D017315Cilazapril[Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]15331931
D017315CilazaprilCilazapril promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]15331931
D002994ClofibrateClofibrate affects the expression of AGTR1 mRNA16081524
C018021cobaltous chloridecobaltous chloride results in decreased expression of AGTR1 mRNA21825224
C018021cobaltous chloridecobaltous chloride results in decreased expression of AGTR1 protein21825224
C018021cobaltous chloridecobaltous chloride results in increased expression of AGTR1 mRNA25511041
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of AGTR1 mRNA27344345
D016572CyclosporineCyclosporine results in decreased expression of AGTR1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased methylation of AGTR1 promoter27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of AGTR1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AGTR1 mRNA28628672
D003998Dicarboxylic AcidsDicarboxylic Acids results in decreased expression of AGTR1 protein21825224
D004317Doxorubicinbenazepril inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]15157388
D004317Doxorubicin[Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]15331931
D004317DoxorubicinCilazapril promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]15331931
D004317DoxorubicinDoxorubicin results in increased expression of AGTR1 mRNA15331931
D004317DoxorubicinDoxorubicin results in increased expression of AGTR1 protein15157388
D004317DoxorubicinLosartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]15331931
D004317DoxorubicinLosartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]15157388
D015773EnalaprilatEnalaprilat inhibits the reaction [Glucose results in increased expression of AGTR1 protein]16452552
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AGTR1 mRNA22079256
D004837EpinephrineEpinephrine results in decreased expression of AGTR1 mRNA19300450
C068373eprosartaneprosartan binds to and results in decreased activity of AGTR1 protein10451039
D004964EstriolEstriol results in decreased expression of AGTR1 mRNA15159206
D017316FadrozoleFadrozole results in decreased expression of AGTR1 protein18586661
D005557FormaldehydeFormaldehyde results in increased expression of AGTR1 mRNA28937961
D005947GlucoseEnalaprilat inhibits the reaction [Glucose results in increased expression of AGTR1 protein]16452552
D005947GlucoseGlucose results in increased expression of AGTR1 protein16452552
D005999Glycochenodeoxycholic AcidAGTR1 protein promotes the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]23300732
D005999Glycochenodeoxycholic AcidAGTR1 protein promotes the reaction [AGT protein results in decreased susceptibility to Glycochenodeoxycholic Acid]23300732
D017313FenretinideFenretinide results in increased expression of AGTR1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of AGTR1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AGTR1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AGTR1 mRNA25613284
C081309irbesartanAGTR1 gene polymorphism affects the susceptibility to irbesartan11910301
C081309irbesartanirbesartan binds to and results in decreased activity of AGTR1 protein12022239
C081309irbesartanCholesterol inhibits the reaction [irbesartan results in increased expression of AGTR1 mRNA]19028402
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of AGTR1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AGTR1 mRNA28628672
C070967L 158809L 158809 binds to and results in decreased activity of AGTR1 protein10886570
D019808LosartanLosartan binds to and results in decreased activity of AGTR1 protein10821809|1580788
D019808LosartanLosartan results in decreased activity of AGTR1 protein9124547
D019808Losartan[Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone9124547
D019808Losartan[Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form9124547
D019808Losartan[Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein9124547
D019808LosartanLosartan inhibits the reaction [Oxygen deficiency results in increased expression of AGTR1 protein]25511041
D019808LosartanLosartan inhibits the reaction [telmisartan results in decreased activity of AGTR1 protein]8220885
D019808Losartan[Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]15331931
D019808LosartanLosartan binds to and results in decreased activity of AGTR1 protein15809360
D019808LosartanLosartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]15331931
D019808LosartanLosartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]15157388
D019808LosartanLosartan results in increased expression of AGTR1 mRNA9533614
D019808LosartanLosartan binds to and affects the activity of AGTR1 protein14630723
D019808LosartanLosartan binds to and results in decreased activity of AGTR1 protein15816410|1932656
D019808LosartanLosartan results in decreased activity of AGTR1 protein15681704|1689405
D019808Losartan[Losartan results in decreased activity of AGTR1 protein] inhibits the reaction [AGT protein modified form results in increased chemical synthesis of Reactive Oxygen Species]16894058
C042720mercuric bromidemercuric bromide results in increased expression of AGTR1 mRNA27188386
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of AGTR1 mRNA27344345
D009532NickelNickel results in decreased expression of AGTR1 mRNA25583101
D009568NitrendipineAGTR1 gene SNP affects the susceptibility to Nitrendipine8952600
C437965olmesartanolmesartan results in decreased activity of AGTR1 protein17208988
C437965olmesartanolmesartan binds to and results in decreased activity of AGTR1 protein18434761
C437965olmesartanolmesartan results in decreased activity of AGTR1 protein15302986|1559257
D000068557Olmesartan MedoxomilOlmesartan Medoxomil binds to and results in decreased activity of AGTR1 protein15467259|1910251
D000068557Olmesartan MedoxomilOlmesartan Medoxomil results in decreased activity of AGTR1 protein16336959
D010047OvalbuminOvalbumin results in increased expression of AGTR1 protein19080339
D010100OxygenLosartan inhibits the reaction [Oxygen deficiency results in increased expression of AGTR1 protein]25511041
D010100OxygenOxygen deficiency affects the expression of AGTR1 protein25511041
D010100OxygenOxygen deficiency results in decreased expression of AGTR1 protein21825224
D010126OzoneOzone results in increased expression of AGTR1 protein27679563
D010269ParaquatParaquat results in increased expression of AGTR1 mRNA20035857
D010269ParaquatParaquat results in increased expression of AGTR1 protein20035857
C073402PD 123319PD 123319 results in decreased expression of AGTR1 mRNA11705791
C046012pentanalpentanal results in decreased expression of AGTR1 mRNA26079696
D020913PerindoprilAGTR1 gene SNP affects the susceptibility to Perindopril8952600
D010972Platelet Activating FactorPlatelet Activating Factor results in increased expression of AGTR1 mRNA16386258
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AGTR1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of AGTR1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of AGTR1 mRNA22714537
C005556propionaldehydepropionaldehyde results in decreased expression of AGTR1 mRNA26079696
D015237DinoprostDinoprost results in decreased expression of AGTR1 mRNA20484870
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of AGTR1 mRNA]23603059
D011794QuercetinQuercetin results in decreased expression of AGTR1 mRNA21632981
D017382Reactive Oxygen Species[AGT protein modified form affects the activity of AGTR1 protein] which results in increased chemical synthesis of Reactive Oxygen Species16894058
D017382Reactive Oxygen Species[Losartan results in decreased activity of AGTR1 protein] inhibits the reaction [AGT protein modified form results in increased chemical synthesis of Reactive Oxygen Species]16894058
C059514resveratrolresveratrol results in decreased expression of AGTR1 protein18420994
C059514resveratrol[Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in decreased expression of AGTR1 mRNA]18420994
C059514resveratrolresveratrol results in decreased expression of AGTR1 mRNA18420994
C059514resveratrolresveratrol results in decreased expression of AGTR1 protein18420994
C059514resveratrol[resveratrol results in increased activity of SIRT1 protein] which results in decreased expression of AGTR118420994
D015474IsotretinoinIsotretinoin results in increased expression of AGTR1 mRNA19212007
D015474IsotretinoinIsotretinoin results in increased expression of AGTR1 protein19212007
C089730rosiglitazonerosiglitazone inhibits the reaction [AGT protein modified form results in decreased expression of AGTR1 protein]16344371
C089730rosiglitazonerosiglitazone inhibits the reaction [AGT protein modified form results in increased expression of AGTR1 protein]16344371
D022622Shiga Toxin 1[AGT protein modified form co-treated with TNF protein co-treated with Shiga Toxin 1] results in increased expression of AGTR1 mRNA18060435
D022622Shiga Toxin 1[TNF protein co-treated with Shiga Toxin 1] results in increased expression of AGTR1 mRNA18060435
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of AGTR1 mRNA25895662
D019821SimvastatinSimvastatin results in decreased expression of AGTR1 mRNA17513949|1847515
D019821SimvastatinSimvastatin results in decreased expression of AGTR1 mRNA16157767
D019821SimvastatinSimvastatin results in decreased expression of AGTR1 protein16157767
D012906SmokeSmoke results in increased expression of AGTR1 mRNA21095227
C017947sodium arseniteERN1 affects the reaction [sodium arsenite results in increased expression of AGTR1 mRNA]28973481
C017947sodium arseniteHIF1A affects the reaction [sodium arsenite results in increased expression of AGTR1 mRNA]28973481
C017947sodium arsenitesodium arsenite promotes the reaction [[XBP1 protein binds to HIF1A protein] which binds to AGTR1 enhancer]28973481
C017947sodium arsenitesodium arsenite results in increased expression of AGTR1 mRNA22714537|2897348
C017947sodium arsenitesodium arsenite results in increased expression of AGTR1 protein28973481
C017947sodium arseniteXBP1 affects the reaction [sodium arsenite results in increased expression of AGTR1 mRNA]28973481
C017947sodium arseniteAcetylcysteine inhibits the reaction [sodium arsenite results in increased expression of AGTR1 mRNA]23603059
C017947sodium arsenitepyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of AGTR1 mRNA]23603059
C017947sodium arsenitesodium arsenite results in increased expression of AGTR1 mRNA alternative form23603059
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary results in increased expression of AGTR1"26518973
D017673Sodium Chloride, Dietary"Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1]"26518973
D013148SpironolactoneSpironolactone results in decreased expression of AGTR1 protein18586661|1911464
C084178telmisartantelmisartan binds to and results in decreased activity of AGTR1 protein21557540
C084178telmisartanLosartan inhibits the reaction [telmisartan results in decreased activity of AGTR1 protein]8220885
C084178telmisartantelmisartan binds to and results in decreased activity of AGTR1 protein8220885
C084178telmisartantelmisartan binds to AGTR1 protein8220885
C084178telmisartantelmisartan binds to and results in decreased activity of AGTR1 protein9728324
C084178telmisartantelmisartan results in increased expression of AGTR1 mRNA9533614
D013739TestosteroneAGTR1 protein affects the susceptibility to Testosterone22539767
D013739TestosteroneTestosterone results in increased expression of AGTR1 mRNA22539767
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AGTR1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AGTR1 mRNA20106945|2163298
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AGTR1 mRNA25613284
D008063Thioctic Acid"Thioctic Acid inhibits the reaction [Sodium Chloride, Dietary results in increased expression of AGTR1]"26518973
D013974ThyroxineThyroxine results in increased expression of AGTR1 mRNA18093424
D014212TretinoinTretinoin results in decreased expression of AGTR1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of AGTR1 mRNA21934132
C057693troglitazonetroglitazone results in decreased expression of AGTR1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of AGTR1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of AGTR1 mRNA28001369|2915479
D000068756ValsartanValsartan binds to and results in decreased activity of AGTR1 protein28973481
D000068756ValsartanValsartan binds to and results in decreased activity of AGTR1 protein15315341|1583136
D009536Niacinamide[Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in decreased expression of AGTR1 mRNA]18420994
D009536Niacinamide[Niacinamide results in decreased activity of SIRT1 protein] which results in increased expression of AGTR1 mRNA18420994
D015034Zinc OxideZinc Oxide analog results in decreased expression of AGTR1 mRNA27185063

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001596angiotensin type I receptor activity-IDA10993080  
GO:0001596angiotensin type I receptor activity-IPI1378723  
GO:0004945angiotensin type II receptor activity-IDA1567413  15611106  
GO:0005515protein binding-IPI1378723  15611106  19023134  23597562  26460884  
GO:0031711bradykinin receptor binding-IPI10993080  
GO:0046982protein heterodimerization activity-IPI10993080  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-NAS17159080  
GO:0001822kidney development-IMP16116425  
GO:0002018renin-angiotensin regulation of aldosterone production-NAS17159080  
GO:0002034regulation of blood vessel diameter by renin-angiotensin-IC10993080  
GO:0003081regulation of systemic arterial blood pressure by renin-angiotensin-IC1378723  
GO:0007186G-protein coupled receptor signaling pathway-IDA1378723  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-NAS17159080  
GO:0007204positive regulation of cytosolic calcium ion concentration-IDA1567413  
GO:0007266Rho protein signal transduction-IDA15611106  
GO:0010744positive regulation of macrophage derived foam cell differentiation-IC18971559  
GO:0010873positive regulation of cholesterol esterification-IMP18971559  
GO:0019229regulation of vasoconstriction-IC1378723  
GO:0019229regulation of vasoconstriction-IDA15117835  
GO:0019229regulation of vasoconstriction-NAS17159080  
GO:0019722calcium-mediated signaling-IDA1567413  
GO:0032270positive regulation of cellular protein metabolic process-IMP18971559  
GO:0032430positive regulation of phospholipase A2 activity-IMP17069818  
GO:0033864positive regulation of NAD(P)H oxidase activity-TAS17159080  
GO:0034374low-density lipoprotein particle remodeling-NAS17069818  
GO:0035813regulation of renal sodium excretion-NAS17159080  
GO:0038166angiotensin-activated signaling pathway-IDA1567413  
GO:0042127regulation of cell proliferation-NAS17159080  
GO:0050727regulation of inflammatory response-IC1378723  
GO:0050729positive regulation of inflammatory response-TAS17159080  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IDA1567413  
GO:0060326cell chemotaxis-IDA15635042  
GO:0086097phospholipase C-activating angiotensin-activated signaling pathway-IDA1378723  
GO:0097746regulation of blood vessel diameter-IC1378723  
GO:1903589positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis-IGI25850724  
GO:2000379positive regulation of reactive oxygen species metabolic process-TAS17159080  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-IDA19023134  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IC1378723  
GO:0016021integral component of membrane-NAS8135787  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04270Vascular smooth muscle contraction
hsa04614Renin-angiotensin system
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22508051Renin-angiotensin-aldosterone system gene polymorphisms and coronary artery disease: detection of gene-gene and gene-environment interactions. (2012)Jia EZCell Physiol Biochem
16061119Genotypic interactions of renin-angiotensin system genes in myocardial infarction. (2005 Aug 3)Araujo MAInt J Cardiol
25031294A polymorphism in AGT and AGTR1 gene is associated with lead-related high blood pressure. (2015 Dec)Kim HKJ Renin Angiotensin Aldosterone Syst
18413189The effect of polymorphisms in the renin-angiotensin-aldosterone system on diabetic nephropathy risk. (2008 Nov-Dec)Mollsten AJ Diabetes Complications
21316998A polymorphism in the angiotensin II type 1 receptor gene has different effects on the risk of diabetic nephropathy in men and women. (2011 May)Mollsten AMol Genet Metab
19948975Integrative predictive model of coronary artery calcification in atherosclerosis. (2009 Dec 15)McGeachie MCirculation
21657802Influence of renin-angiotensin system gene polymorphisms on the risk of ST-segment-elevation myocardial infarction and association with coronary artery disease risk factors. (2011 Jun 1)Konopka AMol Diagn Ther
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