Gene: DUSP8

1850
C11orf81|HB5|HVH-5|HVH8
dual specificity phosphatase 8
protein-coding
11p15.5
Ensembl:ENSG00000184545 MIM:602038 Vega:OTTHUMG00000133348 UniprotKB:Q13202
NC_000011.10
PubMed
0   ANCO-SNPs
AD
1   
3.581e-1 (AD)  3.922e-1 (ND)   (Frontal_Cortex)
5.242e-2 (AD)  8.211e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
JPH30.939
DLGAP40.935
DGKZ0.935
MAP3K100.934
SEMA6B0.934
PIK3R20.93
SYNPO0.929
AGAP30.926
FBXL190.926
DLG40.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.638
OR4F29-0.586
TFPI2-0.445
SEPT10-0.434
VRK2-0.421
VNN2-0.416
DTHD1-0.414
C1orf87-0.411
ANXA13-0.409
CD48-0.408

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of DUSP8 mRNA23792671
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of DUSP8 mRNA28329830
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in increased expression of DUSP8 mRNA18544908
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP8 mRNA"27188386
D000079AcetaldehydeAcetaldehyde results in increased expression of DUSP8 mRNA23416264
D000082AcetaminophenAcetaminophen results in increased expression of DUSP8 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of DUSP8 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of DUSP8 mRNA18544908
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of DUSP8 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DUSP8 mRNA]17585979
D020106AcrylamideAcrylamide results in decreased expression of DUSP8 mRNA28959563
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of DUSP8 mRNA"23195993
D000661AmphetamineAmphetamine results in increased expression of DUSP8 mRNA9813294
D001151ArsenicArsenic results in decreased expression of DUSP8 mRNA27838757
C006632arsenic trioxidearsenic trioxide results in increased expression of DUSP8 mRNA20458559
C015001arsenitearsenite affects the reaction [DUSP8 protein binds to MAPK8 protein]23159405
C015001arsenitearsenite inhibits the reaction [DUSP8 protein binds to MAPK9 protein]23159405
C015001arsenitearsenite promotes the reaction [DUSP8 protein binds to MAPK10 protein]23159405
C015001arsenitearsenite promotes the reaction [DUSP8 protein binds to MAPK8IP3 protein]23159405
C015001arsenitearsenite results in increased phosphorylation of DUSP8 protein23159405
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of DUSP8 mRNA"17331233
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of DUSP8 mRNA"25351596
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DUSP8 mRNA21569818
D004958EstradiolEstradiol results in decreased expression of DUSP8 mRNA19167446
D004958EstradiolEstradiol affects the expression of DUSP8 mRNA15598610
C006780bisphenol Abisphenol A results in decreased expression of DUSP8 mRNA25594700
C006780bisphenol Abisphenol A affects the expression of DUSP8 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of DUSP8 mRNA29097150
D001973Bromodeoxyuridine[Bromodeoxyuridine co-treated with furan] results in increased expression of DUSP8 mRNA24910943
D002110CaffeineCaffeine results in increased expression of DUSP8 mRNA9813294
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP8 mRNA"27188386
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of DUSP8 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DUSP8 mRNA]17585979
D003042Cocaine"5,7-Dihydroxytryptamine inhibits the reaction [Cocaine results in increased expression of DUSP8 mRNA]"9813294
D003042CocaineCocaine results in increased expression of DUSP8 mRNA9813294
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of DUSP8 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of DUSP8 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of DUSP8 mRNA25562108
C007262deoxynivalenoldeoxynivalenol results in increased expression of DUSP8 mRNA23792671
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of DUSP8 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of DUSP8 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DUSP8 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of DUSP8 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of DUSP8 mRNA25016146
D0151165,7-Dihydroxytryptamine"5,7-Dihydroxytryptamine inhibits the reaction [Cocaine results in increased expression of DUSP8 mRNA]"9813294
C521792DMU-212DMU-212 affects the expression of DUSP8 mRNA26428916
D004317DoxorubicinDoxorubicin results in decreased expression of DUSP8 mRNA17888722
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DUSP8 mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DUSP8 mRNA17942748
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of DUSP8 mRNA28329830
D005473FluoxetineFluoxetine results in increased expression of DUSP8 mRNA9813294
D005485FlutamideFlutamide results in increased expression of DUSP8 mRNA24793618
C039281furan[Bromodeoxyuridine co-treated with furan] results in increased expression of DUSP8 mRNA24910943
C039281furanfuran results in increased expression of DUSP8 mRNA24183702|2491094
C004312glycidolglycidol results in decreased expression of DUSP8 mRNA24915197
D017313FenretinideFenretinide results in decreased expression of DUSP8 mRNA28973697
D006851Hydrochloric AcidHydrochloric Acid results in decreased expression of DUSP8 mRNA15046208
C016517indole-3-carbinolindole-3-carbinol affects the expression of DUSP8 mRNA21396975
D007545IsoproterenolIsoproterenol results in decreased expression of DUSP8 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DUSP8 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of DUSP8 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DUSP8 mRNA23086925
C045463leflunomideleflunomide results in increased expression of DUSP8 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of DUSP8 mRNA"18930950
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP8 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of DUSP8 mRNA16507785
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of DUSP8 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of DUSP8 mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DUSP8 mRNA"20188158
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of DUSP8 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of DUSP8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of DUSP8 mRNA"25554681
D009532NickelNickel results in increased expression of DUSP8 mRNA23195993
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of DUSP8 mRNA20971185
D009966OrphenadrineOrphenadrine affects the expression of DUSP8 mRNA23665939
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of DUSP8 mRNA18593933
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DUSP8 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of DUSP8 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DUSP8 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of DUSP8 mRNA20813756
D010938Plant OilsPlant Oils results in increased expression of DUSP8 mRNA23370395
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of DUSP8 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of DUSP8 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of DUSP8 mRNA23608068
C059514resveratrolresveratrol results in increased expression of DUSP8 mRNA15280659
D012643SeleniumSelenium results in increased expression of DUSP8 mRNA19244175
D020280SertralineSertraline results in increased expression of DUSP8 mRNA24865413
D012822Silicon DioxideSilicon Dioxide results in increased expression of DUSP8 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of DUSP8 mRNA19073995
D012834SilverSilver results in decreased expression of DUSP8 mRNA27131904
D053260SootSoot results in decreased expression of DUSP8 mRNA26551751
D053260SootSoot results in increased expression of DUSP8 mRNA22461453
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of DUSP8 mRNA"26680231
D013629TamoxifenTamoxifen results in increased expression of DUSP8 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DUSP8 mRNA21570461|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DUSP8 mRNA17942748
D013792ThalidomideThalidomide analog results in increased expression of DUSP8 mRNA20525221
D013853ThioacetamideThioacetamide results in increased expression of DUSP8 mRNA23411599
C009495titanium dioxidetitanium dioxide affects the expression of DUSP8 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of DUSP8 mRNA20133372
D014241TrichloroethyleneTrichloroethylene results in increased expression of DUSP8 mRNA25549359
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of DUSP8 mRNA"18930950
D014635Valproic AcidValproic Acid results in increased expression of DUSP8 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of DUSP8 gene29154799
D014752Vinyl ChlorideVinyl Chloride results in increased expression of DUSP8 mRNA18579281
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of DUSP8 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004725protein tyrosine phosphatase activity-IEA-  
GO:0008138protein tyrosine/serine/threonine phosphatase activity-IBA21873635  
GO:0016791phosphatase activity-ISS-  
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity-IBA21873635  
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000188inactivation of MAPK activity-ISS-  
GO:0006470protein dephosphorylation-IBA21873635  
GO:0016311dephosphorylation-ISS-  
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0005829cytosol-IBA21873635  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-112409RAF-independent MAPK1/3 activationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5675221Negative regulation of MAPK pathwayTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
13129832Investigation of DUSP8 and CALCA in alcohol dependence. (2003 Sep)Hink RLAddict Biol