Gene: DVL2

1856
-
dishevelled segment polarity protein 2
protein-coding
17p13.1
Ensembl:ENSG00000004975 MIM:602151 Vega:OTTHUMG00000102155 UniprotKB:O14641
NG_033038.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.976e-1 (AD)  1.133e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AKT20.928
NUMA10.92
HDAC60.915
NDOR10.911
ZSWIM80.911
SYVN10.905
MAU20.903
WDR590.902
COG70.899
UCKL10.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.614
OR4F29-0.571
MTRNR2L9-0.254
HMHB1-0.251
KLRC2-0.246
OR6C74-0.242
MTRNR2L6-0.237
KLRB1-0.229
OR4F16-0.227
LCE2A-0.225

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0484603-deazaneplanocin[3-deazaneplanocin co-treated with trichostatin A] affects the expression of DVL2 protein18538736
C4931774-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased phosphorylation of DVL2 protein"21602191
D000082AcetaminophenAcetaminophen affects the expression of DVL2 mRNA25064622
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DVL2 gene27153756
D000638AmiodaroneAmiodarone affects the expression of DVL2 mRNA25064622
D001285AtropineAtropine inhibits the reaction [Parathion results in increased expression of DVL2 protein]17390078
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of DVL2 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DVL2 mRNA15034205
C044887beta-methylcholinebeta-methylcholine affects the expression of DVL2 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of DVL2 mRNA29275510
C006780bisphenol Abisphenol A results in increased methylation of DVL2 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DVL2 mRNA28628672
C032688boric acidboric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of DVL2 mRNA]28285642
D002746ChlorpromazineChlorpromazine affects the expression of DVL2 mRNA25064622
D004390ChlorpyrifosChlorpyrifos affects the expression of DVL2 mRNA18502319
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DVL2 gene20938992
D016572CyclosporineCyclosporine affects the expression of DVL2 mRNA25064622
C014347decitabinedecitabine affects the expression of DVL2 mRNA27915011
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DVL2 mRNA28628672
D003907Dexamethasoneboric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of DVL2 mRNA]28285642
D003907Dexamethasone[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of DVL2 mRNA28285642
D003907Dexamethasonesodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of DVL2 mRNA]28285642
D003976DiazinonDiazinon affects the expression of DVL2 mRNA18502319
D004041Dietary FatsDietary Fats results in increased expression of DVL2 mRNA25016146
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in decreased expression of DVL2 mRNA16623957
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DVL2 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DVL2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DVL2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DVL2 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DVL2 gene20938992
C007845gingerolgingerol results in increased expression of DVL2 mRNA26498061
C492448ICG 001ICG 001 results in increased expression of DVL2 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DVL2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of DVL2 mRNA28628672
D0150561-Methyl-3-isobutylxanthineboric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of DVL2 mRNA]28285642
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of DVL2 mRNA28285642
D0150561-Methyl-3-isobutylxanthinesodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of DVL2 mRNA]28285642
C544151jinfukangjinfukang results in increased expression of DVL2 mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DVL2 gene20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DVL2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DVL2 mRNA"25620056
D009534NiclosamideNiclosamide results in decreased expression of DVL2 protein19772353|2153176
D009538NicotineNicotine results in decreased expression of DVL2 mRNA16949557
D010269ParaquatParaquat affects the expression of DVL2 mRNA25064622
D010269ParaquatParaquat results in decreased expression of DVL2 mRNA26887261
D010278ParathionAtropine inhibits the reaction [Parathion results in increased expression of DVL2 protein]17390078
D010278ParathionParathion results in increased expression of DVL2 protein17390078
D052638Particulate MatterParticulate Matter results in increased expression of DVL2 mRNA28412507
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DVL2 mRNA19710929
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of DVL2 mRNA21427059
C538809sodium pentaboratesodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in decreased expression of DVL2 mRNA]28285642
D013629TamoxifenTamoxifen affects the expression of DVL2 mRNA17555576
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of DVL2 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DVL2 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DVL2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DVL2 mRNA15034205
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in increased expression of DVL2 protein modified form21602191
D013752TetracyclineTetracycline affects the expression of DVL2 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of DVL2 mRNA25064622
D013893ThiramThiram results in decreased expression of DVL2 mRNA20530235
D014118Toxins, Biological"Toxins, Biological affects the expression of DVL2 mRNA"19682533
C012589trichostatin A[3-deazaneplanocin co-treated with trichostatin A] affects the expression of DVL2 protein18538736
D014635Valproic AcidValproic Acid affects the expression of DVL2 mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of DVL2 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DVL2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005109frizzled binding-IBA21873635  
GO:0005109frizzled binding-IPI19388021  
GO:0005109frizzled binding-TAS25424568  
GO:0005515protein binding-IPI10644691  11742073  16189514  16446366  16713569  19249679  
19379695  19465938  19625296  20224554  20412773  20823832  
21245303  21262972  22610794  22773187  23371553  23708998  
25557784  26496610  27107012  27107014  
GO:0019901protein kinase binding-IEA-  
GO:0019904protein domain specific binding-IEA-  
GO:0030674protein binding, bridging-IEA-  
GO:0042802identical protein binding-IPI16189514  27107012  
GO:0043621protein self-association-IEA-  
GO:0048365Rac GTPase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001843neural tube closure-ISS-  
GO:0001934positive regulation of protein phosphorylation-IMP20137080  
GO:0003151outflow tract morphogenesis-ISS-  
GO:0006366transcription by RNA polymerase II-IDA11742073  
GO:0007379segment specification-ISS-  
GO:0007507heart development-ISS-  
GO:0016055Wnt signaling pathway-IGI16446366  
GO:0022007convergent extension involved in neural plate elongation-IEA-  
GO:0034613cellular protein localization-IEA-  
GO:0035329hippo signaling-TAS-  
GO:0035567non-canonical Wnt signaling pathway-IMP19137009  
GO:0035567non-canonical Wnt signaling pathway-TAS25424568  
GO:0043507positive regulation of JUN kinase activity-IDA17593335  
GO:0043507positive regulation of JUN kinase activity-IMP19137009  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0044340canonical Wnt signaling pathway involved in regulation of cell proliferation-IDA18787224  
GO:0045893positive regulation of transcription, DNA-templated-IDA12805222  17593335  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA17593335  
GO:0051259protein complex oligomerization-IEA-  
GO:0060070canonical Wnt signaling pathway-IBA21873635  
GO:0060070canonical Wnt signaling pathway-IDA17593335  
GO:0060070canonical Wnt signaling pathway-TAS25424568  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-IDA12805222  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-NAS24431302  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-TAS-  
GO:0061024membrane organization-TAS-  
GO:0061098positive regulation of protein tyrosine kinase activity-IEA-  
GO:0090090negative regulation of canonical Wnt signaling pathway-TAS-  
GO:0090103cochlea morphogenesis-IEA-  
GO:0090179planar cell polarity pathway involved in neural tube closure-IBA21873635  
GO:0090263positive regulation of canonical Wnt signaling pathway-IEA-  
GO:0150012positive regulation of neuron projection arborization-ISS-  
GO:1904886beta-catenin destruction complex disassembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA9192851  23209302  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0016235aggresome-IDA-  
GO:0016328lateral plasma membrane-IEA-  
GO:0016604nuclear body-IDA-  
GO:0031410cytoplasmic vesicle-IDA23209302  
GO:0045177apical part of cell-IEA-  
GO:0045334clathrin-coated endocytic vesicle-TAS-  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
hsa04330Notch signaling pathway
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-199991Membrane TraffickingTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-201688WNT mediated activation of DVLTAS
R-HSA-2028269Signaling by HippoTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-3858494Beta-catenin independent WNT signalingIEA
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-4086400PCP/CE pathwayIEA
R-HSA-4608870Asymmetric localization of PCP proteinsTAS
R-HSA-4641258Degradation of DVLTAS
R-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membraneTAS
R-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membraneIEA
R-HSA-5099900WNT5A-dependent internalization of FZD4TAS
R-HSA-5368598Negative regulation of TCF-dependent signaling by DVL-interacting proteinsIEA
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosisTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23874538CCN1 secretion induced by cigarette smoking extracts augments IL-8 release from bronchial epithelial cells. (2013)Moon HGPLoS One